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Engineered LINE-1 retrotransposition in nondividing human neurons / Macia, Angela (Universidad de Granada) ; Widmann, Thomas J. (Universidad de Granada) ; Heras, Sara R. (Universidad de Granada) ; Ayllon, Veronica (University of Granada) ; Sánchez, Laura (Universidad de Granada) ; Benkaddour-Boumzaouad, Meriem (Universidad de Granada) ; Muñoz-Lopez, Martin (Universidad de Granada) ; Rubio, Alejandro (Universidad de Granada) ; Amador-Cubero, Suyapa (Universidad de Granada) ; Blanco-Jimenez, Eva (Universidad de Granada) ; Garcia-Castro, Javier (Unidad de Biotecnología Celular, ISCIII) ; Menendez, Pablo (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Ng, Philip (Department of Molecular and Human Genetics, Baylor College of Medicine, Houston) ; Muotri, Alysson R. (Hospital San Diego, University of California San Diego, La Jolla) ; Goodier, John L. (Johns Hopkins University School of Medicine, Baltimore) ; Garcia-Perez, Jose L. (University of Edinburgh, Western General Hospital)
Half the human genome is made of transposable elements (TEs), whose ongoing activity continues to impact our genome. LINE-1 (or L1) is an autonomous non-LTR retrotransposon in the human genome, comprising 17% of its genomic mass and containing an average of 80-100 active L1s per average genome that provide a source of inter-individual variation. [...]
2017 - DOI (Digital Object Identifier)

10.1101/gr.206805.116
Genome research, Vol. 27 (march 2017) , p. 335-348

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