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1.
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13 p, 1.4 MB |
Risk Factors, Radiological and Clinical Outcomes in Subclinical and Clinical Pituitary Apoplexy
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Biagetti, Betina (Hospital Universitari Vall d'Hebron) ;
Sarria-Estrada, Silvana (Hospital Universitari Vall d'Hebron) ;
Cordero Asanza, Esteban (Hospital Universitari Vall d'Hebron) ;
Chaachou-Charradi, Anas (Hospital Universitari Vall d'Hebron) ;
Ng-Wong, Yiken Karelys (Hospital Universitari Vall d'Hebron) ;
Cicuendez, Marta (Hospital Universitari Vall d'Hebron) ;
Hernandez, Irene (Hospital Universitari Vall d'Hebron) ;
Rojano-Toimil, Alba (Hospital Universitari Vall d'Hebron) ;
Costa, Pilar (Hospital Universitari Vall d'Hebron) ;
Martinez-Saez, Elena (Hospital Universitari Vall d'Hebron) ;
Casteràs, Anna (Hospital Universitari Vall d'Hebron) ;
Simó Canonge, Rafael (Hospital Universitari Vall d'Hebron) ;
Universitat Autònoma de Barcelona
Pituitary apoplexy (PA) can be symptomatic, namely acute apoplexy (APA), or asymptomatic or subclinical (SPA). To describe the clinical characteristics and evolution of the patients with APA compared to SPA Patients and methods: Retrospective, longitudinal database analysis. [...]
2022 -  10.3390/jcm11247288
Journal of clinical medicine, Vol. 11 (december 2022)
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2.
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10 p, 3.9 MB |
Factors Secreted by Endothelial Progenitor Cells Enhance Neurorepair Responses after Cerebral Ischemia in Mice
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Rosell Novel, Anna (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Morancho, Anna (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Navarro Sobrino, Míriam (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Martinez-Saez, Elena (Hospital Universitari Vall d'Hebron) ;
Hernandez Guillamon, Maria Mar (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Lope-Piedrafita, Silvia (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Barceló, Verónica (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Borràs i Serres, Francesc Enric (Hospital Universitari Vall d'Hebron) ;
Penalba, Anna (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
García Bonilla, Lídia (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Montaner, Joan (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Universitat Autònoma de Barcelona
Cell therapy with endothelial progenitor cells (EPCs) has emerged as a promising strategy to regenerate the brain after stroke. Here, we aimed to investigate if treatment with EPCs or their secreted factors could potentiate angiogenesis and neurogenesis after permanent focal cerebral ischemia in a mouse model of ischemic stroke. [...]
2013 - 10.1371/journal.pone.0073244
PloS one, Vol. 8 (september 2013)
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3.
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6 p, 916.0 KB |
Cerebrospinal fluid-derived circulating tumour DNA better represents the genomic alterations of brain tumours than plasma
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De Mattos-Arruda, Leticia (Universitat Autònoma de Barcelona) ;
Mayor, Regina (Vall d'Hebron Institut d'Oncologia) ;
Ng, Charlotte K. Y. (Memorial Sloan Kettering Cancer Center) ;
Weigelt, Britta (Memorial Sloan Kettering Cancer Center) ;
Martinez-Ricarte, Fran (Universitat Autònoma de Barcelona) ;
Torrejon, Davis (Vall d'Hebron Institut d'Oncologia) ;
Oliveira, Mafalda (Vall d'Hebron Institut d'Oncologia) ;
Arias, Alexandra (Vall d'Hebron Institut d'Oncologia) ;
Raventós, Carolina (Vall d'Hebron Institut d'Oncologia) ;
Tang, Jiabin (Memorial Sloan Kettering Cancer Center) ;
Guerini-Rocco, Elena (Memorial Sloan Kettering Cancer Center) ;
Martinez-Saez, Elena (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Lois, Sergio (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Marín, Oscar (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
de la Cruz, Xavier (Institució Catalana de Recerca i Estudis Avançats) ;
Piscuoglio, Salvatore (Memorial Sloan Kettering Cancer Center) ;
Towers, Russel (Department of Surgery, Memorial Sloan Kettering Cancer Center) ;
Vivancos, Ana (Vall d'Hebron Institut d'Oncologia) ;
Peg, Vicente (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Ramón y Cajal, Santiago (Universitat Autònoma de Barcelona) ;
Carles, Joan (Vall d'Hebron Institut d'Oncologia) ;
Rodon, Jordi (Vall d'Hebron Institut d'Oncologia) ;
González-Cao, María (Quirón Dexeus University Hospital) ;
Tabernero, Josep (Universitat Autònoma de Barcelona) ;
Felip, Enriqueta (Universitat Autònoma de Barcelona) ;
Sahuquillo Barris, Juan (Universitat Autònoma de Barcelona) ;
Berger, Michael F. (Memorial Sloan Kettering Cancer Center) ;
Cortés, Javier (Universitat Autònoma de Barcelona) ;
Reis-Filho, Jorge S. (Memorial Sloan Kettering Cancer Center) ;
Seoane Suárez, Joan (Universitat Autònoma de Barcelona)
Cell-free circulating tumour DNA (ctDNA) in plasma has been shown to be informative of the genomic alterations present in tumours and has been used to monitor tumour progression and response to treatments. [...]
2015 - 10.1038/ncomms9839
Nature communications, Vol. 6 (november 2015)
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4.
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11 p, 2.2 MB |
Circulating tumour DNA from the cerebrospinal fluid allows the characterisation and monitoring of medulloblastoma
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Escudero, Laura (Vall d'Hebron Institut d'Oncologia) ;
Llort, Anna (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Arias, Alexandra (Vall d'Hebron Institut d'Oncologia) ;
Diaz-Navarro, Ander (Centro de Investigación Biomédica en Red de Cáncer) ;
Martinez-Ricarte, Fran (Universitat Autònoma de Barcelona) ;
Rubio-Perez, Carlota (Vall d'Hebron Institut d'Oncologia) ;
Mayor, Regina (Vall d'Hebron Institut d'Oncologia) ;
Caratù, Ginevra (Vall d'Hebron Institut d'Oncologia) ;
Martinez-Saez, Elena (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Vázquez-Méndez, Élida (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Lesende-Rodríguez, Iván (Universidade da Coruña) ;
Hladun, Raquel (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Gros, Luis (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Ramón y Cajal, Santiago (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Poca Pastor, María Antonia (Universitat Autònoma de Barcelona) ;
Puente, Xose S. (Centro de Investigación Biomédica en Red de Cáncer) ;
Sahuquillo Barris, Juan (Universitat Autònoma de Barcelona) ;
Gallego, Soledad (Universitat Autònoma de Barcelona) ;
Seoane Suárez, Joan (Institució Catalana de Recerca i Estudis Avançats)
The molecular characterisation of medulloblastoma, the most common paediatric brain tumour, is crucial for the correct management and treatment of this heterogenous disease. However, insufficient tissue sample, the presence of tumour heterogeneity, or disseminated disease can challenge its diagnosis and monitoring. [...]
2020 - 10.1038/s41467-020-19175-0
Nature communications, Vol. 11 (october 2020)
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5.
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17 p, 3.9 MB |
CN133, a Novel Brain-Penetrating Histone Deacetylase Inhibitor, Hampers Tumor Growth in Patient-Derived Pediatric Posterior Fossa Ependymoma Models
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Antonelli, Roberta (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Jiménez Jiménez, Carlos (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Riley, Misha (Massachusetts General Hospital (Boston)) ;
Servidei, Tiziana (Fondazione Policlinico Universitario "A. Gemelli" (Roma, Itàlia)) ;
Riccardi, Riccardo (Fondazione Policlinico Universitario "A. Gemelli" (Roma, Itàlia)) ;
Soriano, Aroa (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Roma, Josep (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Martinez-Saez, Elena (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Martini, Maurizio (Catholic University of Sacred Heart) ;
Ruggiero, Antonio (Fondazione Policlinico Universitario "A. Gemelli" (Roma, Itàlia)) ;
Moreno, Lucas (Vall d'Hebron Institut d'Oncologia) ;
Sánchez de Toledo Codin, Josep (Vall d'Hebron Institut d'Oncologia) ;
Gallego, Soledad (Vall d'Hebron Institut d'Oncologia) ;
Bové, Jordi (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Hooker, Jacob M. (Massachusetts General Hospital (Boston)) ;
Segura, Miguel F. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Universitat Autònoma de Barcelona
Pediatric ependymoma (EPN) is a highly aggressive tumor of the central nervous system that remains incurable in 40% of cases. In children, the majority of cases develop in the posterior fossa and can be classified into two distinct molecular entities: EPN posterior fossa A (PF-EPN-A) and EPN posterior fossa B (PF-EPN-B). [...]
2020 - 10.3390/cancers12071922
Cancers, Vol. 12 (july 2020)
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6.
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16 p, 1.6 MB |
Integrating clinical, molecular, proteomic and histopathological data within the tissue context : tissunomics
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Ramón y Cajal, Santiago (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Hümmer, Stefan (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Peg, Vicente (Centro de Investigación Biomédica en Red de Cáncer) ;
Matías-Guiu, Xavier (Hospital Universitari de Bellvitge) ;
de Torres, Inés (Hospital Universitari Vall d'Hebron) ;
Castellvi, Josep (Centro de Investigación Biomédica en Red de Cáncer) ;
Martinez-Saez, Elena (Hospital Universitari Vall d'Hebron) ;
Hernandez-Losa, Javier (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Vall d'Hebron Institut de Recerca (VHIR)
Malignant tumours show a marked degree of morphological, molecular and proteomic heterogeneity. This variability is closely related to microenvironmental factors and the location of the tumour. The activation of genetic alterations is very tissue-dependent and only few tumours have distinct genetic alterations. [...]
2019 - 10.1111/his.13828
Histopathology, Vol. 75 (may 2019) , p. 4-19
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7.
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30 p, 7.5 MB |
The Genomic and Immune Landscapes of Lethal Metastatic Breast Cancer
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De Mattos-Arruda, Leticia (Vall d'Hebron Institut d'Oncologia) ;
Sammut, Stephen-John (Department of Oncology and Cancer Research UK Cambridge Institute. Li Ka Shing Centre. University of Cambridge) ;
Ross, Edith M. (Department of Oncology and Cancer Research UK Cambridge Institute. Li Ka Shing Centre. University of Cambridge) ;
Bashford-Rogers, Rachael (Department of Medicine. University of Cambridge) ;
Greenstein, Erez (Weizmann Institute of Science (Israel). Department of Immunology) ;
Markus, Havell (Mayo Clinic Center for Individualized Medicine) ;
Morganella, Sandro (Department of Medical Genetics. The Clinical School. University of Cambridge) ;
Teng, Yvonne (Cancer Molecular Diagnosis Laboratory. NIHR Cambridge Biomedical Research Centre) ;
Maruvka, Yosef (Massachusetts General Hospital (Boston)) ;
Pereira, Bernard (Department of Oncology and Cancer Research UK Cambridge Institute. Li Ka Shing Centre. University of Cambridge) ;
Rueda, Oscar M. (Department of Oncology and Cancer Research UK Cambridge Institute. Li Ka Shing Centre. University of Cambridge) ;
Chin, Suet-Feung (Department of Oncology and Cancer Research UK Cambridge Institute. Li Ka Shing Centre. University of Cambridge) ;
Contente-Cuomo, Tania (Mayo Clinic Center for Individualized Medicine) ;
Mayor, Regina (Centro de Investigación Biomédica en Red de Cáncer) ;
Arias, Alexandra (Vall d'Hebron Institut d'Oncologia) ;
Ali, H. Raza (Department of Oncology and Cancer Research UK Cambridge Institute. Li Ka Shing Centre. University of Cambridge) ;
Cope, Wei (Department of Oncology and Cancer Research UK Cambridge Institute. Li Ka Shing Centre. University of Cambridge) ;
Tiezzi, Daniel (Department of Oncology and Cancer Research UK Cambridge Institute. Li Ka Shing Centre. University of Cambridge) ;
Dariush, Aliakbar (Institute of Astronomy. University of Cambridge) ;
Dias Amarante, Tauanne (Department of Medical Genetics. The Clinical School. University of Cambridge) ;
Reshef, Dan (Weizmann Institute of Science (Israel). Department of Immunology) ;
Ciriaco, Nikaoly (Hospital Universitari Vall d'Hebron) ;
Martinez-Saez, Elena (Hospital Universitari Vall d'Hebron) ;
Peg, Vicente (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Ramón y Cajal, Santiago (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Cortés, Javier (Vall d'Hebron Institut d'Oncologia) ;
Vassiliou, George (Wellcome Trust/MRC Cambridge Stem Cell Institute) ;
Getz, Gad (Massachusetts General Hospital (Boston)) ;
Nik-Zainal, Serena (Department of Medical Genetics. The Clinical School. University of Cambridge) ;
Murtaza, Muhammed (Mayo Clinic Center for Individualized Medicine) ;
Friedman, Nir (Weizmann Institute of Science (Israel). Department of Immunology) ;
Markowetz, Florian (Department of Oncology and Cancer Research UK Cambridge Institute. Li Ka Shing Centre. University of Cambridge) ;
Seoane Suárez, Joan (Vall d'Hebron Institut d'Oncologia) ;
Caldas, Carlos (Cancer Research UK Cambridge Cancer Centre (Regne Unit)) ;
Universitat Autònoma de Barcelona
The detailed molecular characterization of lethal cancers is a prerequisite to understanding resistance to therapy and escape from cancer immunoediting. We performed extensive multi-platform profiling of multi-regional metastases in autopsies from 10 patients with therapy-resistant breast cancer. [...]
2019 - 10.1016/j.celrep.2019.04.098
Cell reports, Vol. 27 Núm. 9 (28 2019) , p. 2690-2708.e10
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8.
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12 p, 8.9 MB |
Expression of Bone Morphogenetic Proteins in Multiple Sclerosis Lesions
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Costa, Carme (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Eixarch, Herena (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Martinez-Saez, Elena (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Calvo-Barreiro, Laura (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Calucho, Maite (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Castro, Zoraida (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Ortega-Aznar, Arantxa (Hospital Universitari Vall d'Hebron) ;
Ramón y Cajal, Santiago (Hospital Universitari Vall d'Hebron) ;
Montalban, Xavier (University of Toronto) ;
Espejo, Carmen (Hospital Universitari Vall d'Hebron) ;
Universitat Autònoma de Barcelona
Bone morphogenetic proteins (BMPs) are secreted proteins that belong to the transforming growth factor-β superfamily. In the adult brain, they modulate neurogenesis, favor astrogliogenesis, and inhibit oligodendrogenesis. [...]
2019 - 10.1016/j.ajpath.2018.11.007
American Journal of Pathology, Vol. 189 Núm. 3 (march 2019) , p. 665-676
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9.
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12 p, 4.1 MB |
Brain ApoA-I, ApoJ and ApoE immunodetection in cerebral amyloid angiopathy
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Camacho, Jessica (Hospital Universitari Vall d'Hebron) ;
Moliné, Teresa (Hospital Universitari Vall d'Hebron) ;
Bonaterra-Pastra, Anna (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Ramon y Cajal, Santiago (Hospital Universitari Vall d'Hebron) ;
Martinez-Saez, Elena (Hospital Universitari Vall d'Hebron) ;
Hernández-Guillamon, Mar (Hospital Universitari Vall d'Hebron)
Cerebral amyloid angiopathy (CAA) is a common cause of lobar intracerebral hemorrhage (ICH) in elderly individuals and it is the result of the cerebrovascular deposition of beta-amyloid (Ab) protein. [...]
2019 - 10.3389/fneur.2019.00187
Frontiers in neurology, Vol. 10 (2019) , p. 187
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10.
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12 p, 1.1 MB |
peIF4E as an independent prognostic factor and a potential therapeutic target in diffuse infiltrating astrocytomas
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Martínez Sáez, Elena (Hospital Universitari Vall d'Hebron) ;
Peg, Vicente (Hospital Universitari Vall d'Hebron) ;
Ortega Aznar, Arantxa (Hospital Universitari Vall d'Hebron) ;
Martínez Ricarte, Francisco (Hospital Universitari Vall d'Hebron) ;
Camacho, Jessica (Hospital Universitari Vall d'Hebron) ;
Hernández Losa, Javier (Hospital Universitari Vall d'Hebron) ;
Ferreres Piñas, Joan Carles (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Ramón y Cajal, Santiago (Hospital Universitari Vall d'Hebron) ;
Universitat Autònoma de Barcelona.
Departament de Ciències Morfològiques
Malignant transformation in tumors is a complex process requiring accumulation of numerous oncogenic abnormalities. Brain tumors show considerable phenotypic and genetic heterogeneity. In a series comprising diffuse infiltrating astrocytomas () and reactive gliosis, we investigated the main factors associated with signaling pathways. [...]
2016 - 10.1002/cam4.817
Cancer Medicine, Vol. 5, issue 9 (Sep. 2016) , p. 2501-2512
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