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22 p, 2.2 MB |
Paving the way towards an effective treatment for multiple sclerosis : advances in cell therapy
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Mansilla Lopez, Maria Jose (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Presas Rodríguez, Sílvia (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Teniente Serra, Aina (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
González-Larreategui, Íñigo (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Quirant, Bibiana (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Fondelli, Federico (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Djedovic, Neda (University of Belgrade. Department of Immunology, Institute for Biological Research "Siniša Stanković"- National Institute of Republic of Serbia) ;
Iwaszkiewicz-Grześ, D. (Poltreg S.A., Gdańsk, Poland) ;
Chwojnicki, K. (Medical University of Gdańsk. Department of Anaesthesiology & Intensive Care) ;
Miljković, Đ. (University of Belgrade. Department of Immunology, Institute for Biological Research "Siniša Stanković"- National Institute of Republic of Serbia) ;
Trzonkowski, P. (Poltreg S.A., Gdańsk, Poland) ;
Ramo-Tello, Cristina (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Martínez Cáceres, Eva María (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
UDTRIAS.
Multiple sclerosis (MS) is a leading cause of chronic neurological disability in young to middle-aged adults, affecting ~2. 5 million people worldwide. Currently, most therapeutics for MS are systemic immunosuppressive or immunomodulatory drugs, but these drugs are unable to halt or reverse the disease and have the potential to cause serious adverse events. [...]
2021 -  10.1038/s41423-020-00618-z
Cellular and Molecular Immunology, Vol. 18 (may 2021) , p. 1353-1374
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11 p, 2.0 MB |
Optimal response to dimethyl fumarate is mediated by a reduction of Th1-like Th17 cells after 3 months of treatment
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Mansilla Lopez, Maria Jose (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Navarro-Barriuso, Juan (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Presas-Rodríguez, Silvia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Teniente Serra, Aina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Quirant, Bibiana (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Ramo-Tello, Cristina (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Martínez Cáceres, Eva María (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
Dimethyl fumarate (DMF) is one of the most promising therapies for relapsing-remitting multiple sclerosis (RRMS) patients since it has shown immunomodulatory and neuroprotective effects. However, a percentage of RRMS patients do not exhibit an optimal response to DMF. [...]
2019 - 10.1111/cns.13142
CNS neuroscience & therapeutics, Vol. 25 (2019) , p. 995-1005
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14 p, 1.9 MB |
MAP7 and MUCL1 are biomarkers of Vitamin D3-induced tolerogenic dendritic cells in multiple sclerosis patients
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Navarro-Barriuso, Juan (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Mansilla Lopez, Maria Jose (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Quirant, Bibiana (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Ardiaca-Martínez, Alicia (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Teniente Serra, Aina (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Presas-Rodríguez, Silvia (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Ten Brinke, Anja (Amsterdam UMC. University Medical Center) ;
Ramo-Tello, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Martínez Cáceres, Eva María (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
The administration of autologous tolerogenic dendritic cells (tolDC) has become a promising alternative for the treatment of autoimmune diseases, such as multiple sclerosis (MS). Specifically, the use of vitamin D3 for the generation of tolDC (vitD3-tolDC) constitutes one of the most widely studied approaches, as it has evidenced significant immune regulatory properties, both in vitro and in vivo. [...]
2019 - 10.3389/fimmu.2019.01251
Frontiers in immunology, Vol. 10 (June 2019) , art. 1251
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20 p, 3.2 MB |
Clinical and immunological control of experimental autoimmune encephalomyelitis by tolerogenic dendritic cells loaded with MOG-encoding mRNA
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Derdelinckx, Judith (University Hospital Antwerp (Bèlgica)) ;
Mansilla Lopez, Maria Jose (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
De Laere, Maxime (University of Antwerp. Laboratory of Experimental Hematology) ;
Lee, Wai-Ping (University Hospital Antwerp (Bèlgica)) ;
Navarro-Barriuso, Juan (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Wens, Inez (University of Antwerp. Laboratory of Experimental Hematology) ;
Nkansah, Irene (University of Antwerp. Laboratory of Experimental Hematology) ;
Daans, Jasmijn (University of Antwerp. Laboratory of Experimental Hematology) ;
De Reu, Hans (University of Antwerp. Laboratory of Experimental Hematology) ;
Jolanta Keliris, Aneta (University of Antwerp. Bio-Imaging Lab) ;
Van Audekerke, Johan (University of Antwerp. Bio-Imaging Lab) ;
Vanreusel, Verdi (University of Antwerp. Bio-Imaging Lab) ;
Pieters, Zoë (University of Antwerp. Laboratory of Experimental Hematology) ;
Van Der Linden, Annemie (University of Antwerp. Bio-Imaging Lab) ;
Verhoye, Maraleen (University of Antwerp. Bio-Imaging Lab) ;
Molenberghs, Geert (L-BioStat. I-BioStat. KU Leuven) ;
Hens, Niel (University of Antwerp. Centre for Health Economics Research and Modelling Infectious Diseases) ;
Goossens, Herman (University of Antwerp. Laboratory of Medical Microbiology) ;
Willekens, Barbara (University Hospital Antwerp (Bèlgica)) ;
Cras, Patrick (University of Antwerp. Born Bunge Institute) ;
Ponsaerts, Peter (University of Antwerp. Laboratory of Experimental Hematology) ;
Berneman, Zwi (University Hospital Antwerp (Bèlgica)) ;
Martínez Cáceres, Eva María (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Cools, Nathalie (University Hospital Antwerp (Bèlgica))
Background: Although effective in reducing relapse rate and delaying progression, current therapies for multiple sclerosis (MS) do not completely halt disease progression. T cell autoimmunity to myelin antigens is considered one of the main mechanisms driving MS. [...]
2019 - 10.1186/s12974-019-1541-1
Journal of neuroinflammation, Vol. 16 (August 2019) , art. 167
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20 p, 684.6 KB |
Ways forward for tolerance-inducing cellular therapies- An afactt perspective
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ten Brinke, Anja (Sanquin Research. Department of Immunopathology) ;
Martinez-Llordella, Marc (King's College London. Department of Inflammation Biology) ;
Cools, Nathalie (University of Antwerp. Vaccine and Infectious Disease Institute) ;
Hilkens, Catharien M. U. (Newcastle University. Institute of Cellular Medicine) ;
Van Ham, S. Marieke (Sanquin Research. Department of Immunopathology) ;
Sawitzki, Birgit (Charité-Universitaetsmedizin Berlin) ;
Geissler, Edward K. (University Hospital Regensburg. Department of Surgery) ;
Lombardi, Giovanna (King's College London. MRC Centre for Transplantation) ;
Trzonkowski, Piotr (Medical University of Gdansk. Department of Clinical Immunology and Transplantology) ;
Martínez Cáceres, Eva María (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol
Clinical studies with cellular therapies using tolerance-inducing cells, such as tolerogenic antigen-presenting cells (tolAPC) and regulatory T cells (Treg) for the prevention of transplant rejection and the treatment of autoimmune diseases have been expanding the last decade. [...]
2019 - 10.3389/fimmu.2019.00181
Frontiers in immunology, Vol. 10 (Feb. 2019) , art. 181
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12 p, 2.5 MB |
Liposome-based immunotherapy against autoimmune diseases : Therapeutic effect on multiple sclerosis
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Pujol-Autonell, Irma (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Mansilla López, Maria José (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Rodríguez Fernández, Silvia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Cano-Sarabia, Mary (Institut Català de Nanociència i Nanotecnologia) ;
Navarro-Barriuso, Juan (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Ampudia Carrasco, Rosa María (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Rius, Aleix (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
García Jimeno, Sonia (Institut Català de Nanociència i Nanotecnologia) ;
Perna-Barrull, David (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Martínez Cáceres, Eva María (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Maspoch Comamala, Daniel (Institut Català de Nanociència i Nanotecnologia) ;
Vives Pi, Marta (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Based on the ability of apoptosis to induce immunological tolerance, liposomes were generated mimicking apoptotic cells, and they arrest autoimmunity in Type 1 diabetes. Our aim was to validate the immunotherapy in other autoimmune disease: multiple sclerosis. [...]
2017 - 10.2217/nnm-2016-0410
Nanomedicine, Vol. 12, Issue 11 (June 2017) , p. 1231-1242
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14 p, 516.6 KB |
Minimum information about tolerogenic antigen-presenting cells (MITAP): a first step towards reproducibility and standardisation of cellular therapies
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Lord, Phillip (Newcastle University. School of Computing Science) ;
Spiering, Rachel (Newcastle University. Institute of Cellular Medicine) ;
Aguillon, Juan C. (Universidad de Chile. Instituto de Ciencias Biomédicas (ICBM)) ;
Anderson, Amy E. (Newcastle University. Institute of Cellular Medicine) ;
Appel, Silke (University of Bergen. Broegelmann Research Laboratory) ;
Benítez Ribas, Daniel (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ;
Brinke, Anja ten (Sanquin Research (Amsterdam)) ;
Broere, Femke (Utrecht University) ;
Cools, Nathalie (University of Antwerp. Vaccine & Infectious Disease Institute) ;
Cuturi, Maria Cristina (Center for Research in Transplantation and Immunology (Nantes, França)) ;
Diboll, Julie (Newcastle University. Institute of Cellular Medicine) ;
Geissler, Edward K. (University Hospital Regensburg. Department of Surgery) ;
Giannoukakis, Nick (Institute of Cellular Therapeutics (Pittsburgh, Estats Units d'Amèrica)) ;
Gregori, Silvia (San Raffaele Telethon Institute for Gene Therapy (Milà, Itàlia)) ;
Ham, S. Marieke van (Sanquin Research (Amsterdam)) ;
Lattimer, Staci (Newcastle University. School of Computing Science) ;
Marshall, Lindsay (Newcastle University. School of Computing Science) ;
Harry, Rachel A. (Newcastle University. Institute of Cellular Medicine) ;
Hutchinson, James A. (University Hospital Regensburg. Department of Surgery) ;
Isaacs, John D. (Newcastle University. Institute of Cellular Medicine) ;
Joosten, Irma (Radboud University Medical Centre) ;
Kooten, Cees van (Leiden University Medical Centre) ;
López Díaz de Cerio, Ascensión (Clínica Universidad de Navarra) ;
Nikolic, Tatjana (Leiden University Medical Centre) ;
Oral, Haluk Barbaros (Uludag University. Faculty of Medicine) ;
Sofronic Milosavljevic, Ljiljana (University of Belgrade. Institute for the Application of Nuclear Energy) ;
Ritter, Thomas (National University of Ireland) ;
Riquelme, Paloma (University Hospital Regensburg. Department of Surgery) ;
Thomson, Angus W. (University of Pittsburgh School of Medicine) ;
Trucco, Massimo (Institute of Cellular Therapeutics (Pittsburgh, Estats Units d'Amèrica)) ;
Vives Pi, Marta (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Martínez Cáceres, Eva María (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Hilkens, Catharien M. U. (Newcastle University. Institute of Cellular Medicine)
Cellular therapies with tolerogenic antigen-presenting cells (tolAPC) show great promise for the treatment of autoimmune diseases and for the prevention of destructive immune responses after transplantation. [...]
2016 - 10.7717/peerj.2300
PeerJ, Vol. 4 (August 2016) , p. e2300
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11 p, 1.5 MB |
Cryopreserved vitamin D3-tolerogenic dendritic cells pulsed with autoantigens as a potential therapy for multiple sclerosis patients
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Mansilla López, María José (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Contreras-Cardone, Raian (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Navarro-Barriuso, Juan (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Cools, Nathalie (University of Antwerp. Vaccine & Infectious Disease Institute) ;
Berneman, Zwi (University of Antwerp. Vaccine & Infectious Disease Institute) ;
Ramo-Tello, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Martínez Cáceres, Eva María (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Universitat Autònoma de Barcelona.
Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia
BACKGROUND: Tolerogenic dendritic cells (tolDC) have been postulated as a potent immunoregulatory therapy for autoimmune diseases such as multiple sclerosis (MS). In a previous study, we demonstrated that the administration of antigen-specific vitamin D3 (vitD3) tolDC in mice showing clinical signs of experimental autoimmune encephalomyelitis (EAE; the animal model of MS) resulted in abrogation of disease progression. [...]
2016 - 10.1186/s12974-016-0584-9
Journal of neuroinflammation, Vol. 13, No. 113 (May 2016)
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9 p, 1.4 MB |
Clinical use of tolerogenic dendritic cells-harmonization approach in european collaborative effort
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Brinke, Anja ten (Sanquin Blood Supply (Amsterdam)) ;
Hilkens, Catharien M. U. (Newcastle University. Institute of Cellular Medicine) ;
Cools, Nathalie (University of Antwerp. Vaccine & Infectious Disease Institute) ;
Geissler, Edward K. (University Hospital Regensburg. Department of Surgery) ;
Hutchinson, James A. (University Hospital Regensburg. Department of Surgery) ;
Lombardi, Giovanna (King's College (London). MRC Centre for Transplantation) ;
Lord, Phillip (Newcastle University. School of Computing Science) ;
Sawitzki, Birgit (Charité - Universitätsmedizin Berlin) ;
Trzonkowski, Piotr (Medical University of Gdansk. Department of Clinical Immunology and Transplantology) ;
Ham, S. Marieke van (Sanquin Blood Supply (Amsterdam)) ;
Martínez Cáceres, Eva María (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Universitat Autònoma de Barcelona.
Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia
The number of patients with autoimmune diseases and severe allergies and recipients of transplants increases worldwide. Currently, these patients require lifelong administration of immunomodulatory drugs. [...]
2015 - 10.1155/2015/471719
Mediators of Inflammation, 2015, Article ID 471719
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