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1.
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9 p, 1.7 MB |
Switching From a Protease Inhibitor-based Regimen to a Dolutegravir-based Regimen : A Randomized Clinical Trial to Determine the Effect on Peripheral Blood and Ileum Biopsies From Antiretroviral Therapy-suppressed Human Immunodeficiency Virus-infected Individuals
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Morón-López, Sara (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Navarro, Jordi (Institut de Recerca Vall d'Hebron) ;
Jimenez, Montse (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Rutsaert, Sofie (Human Immunodeficiency Virus Cure Research Center, Department of Internal Medicine, Faculty of Medicine and Health Sciences, Ghent University and Ghent University Hospital) ;
Urrea, Víctor (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Puertas, Maria C (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Torrella, Ariadna (Hospital Universitari Vall d'Hebron) ;
De Clercq, Laura (Human Immunodeficiency Virus Cure Research Center, Department of Internal Medicine, Faculty of Medicine and Health Sciences, Ghent University and Ghent University Hospital) ;
Ribas, Bibiana Planas (,Hospital Universitari Vall d'Hebron) ;
Gálvez, Cristina (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Salgado, Maria (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Vandekerckhove, Linos (Human Immunodeficiency Virus Cure Research Center, Department of Internal Medicine, Faculty of Medicine and Health Sciences, Ghent University and Ghent University Hospital) ;
Blanco, Julià (University of Vic-Central University of Catalonia) ;
Crespo, Manel (Infectious Diseases Unit, Internal Medicine Department, Complexo Hospitalario Universitario de Vigo, Instituto de Investigación Sanitaria Galicia Sur) ;
Martinez-Picado, Javier (Catalan Institution for Research and Advanced Studies) ;
Universitat Autònoma de Barcelona
Optimization of combination antiretroviral therapy (cART) can impact the human immunodeficiency virus (HIV) reservoir. We evaluated the effect on the HIV reservoir in peripheral blood and ileum biopsies in patients switching from boosted protease inhibitor (PI/r)-based therapy to dolutegravir (DTG)-based therapy. [...]
2018 -  10.1093/cid/ciy1095
Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America, Vol. 69 (december 2018) , p. 1320-1328
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2.
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25 p, 2.8 MB |
Detailed Characterization of Early HIV-1 Replication Dynamics in Primary Human Macrophages
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Bejarano, David Alejandro (Department of Infectious Diseases, Virology. University of Heidelberg. Heidelberg, Germany) ;
Puertas, Maria C. (Universitat Autònoma de Barcelona. Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Börner, Kathleen (German Center for Infection Research, Partner Site Heidelberg. Heidelberg, Germany) ;
Martinez-Picado, Javier (Catalan Institution for Research and Advanced Studies (ICREA). Barcelona, Spain) ;
Müller, Barbara (Department of Infectious Diseases, Virology, University of Heidelberg. Heidelberg, Germany) ;
Kräusslich, Hans-Georg (German Center for Infection Research, Partner Site Heidelberg. Heidelberg, Germany)
Macrophages are natural target cells of human immunodeficiency virus type 1 (HIV-1). Viral replication appears to be delayed in these cells compared to lymphocytes; however, little is known about the kinetics of early post-entry events. [...]
2018 - 10.3390/v10110620
Viruses, Vol. 10 (november 2018)
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3.
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10 p, 2.1 MB |
Sensitive quantification of the HIV-1 reservoir in gut-associated lymphoid tissue
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Morón López, Sara (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Puertas, Maria C. (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Gálvez, Cristina (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Navarro, Jordi (Hospital Universitari Vall d'Hebron) ;
Carrasco, Anna (Hospital Universitari Mutua de Terrassa) ;
Esteve, Maria (Hospital Universitari Mutua de Terrassa) ;
Manyè, Josep (Institut Germans Trias i Pujol. CIBEREHD) ;
Crespo, Manel (Hospital Universitari Vall d'Hebron) ;
Salgado, Maria (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Martinez Picado, Javier (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa)
Background. The implementation of successful strategies to achieve an HIV cure has become a priority in HIV research. However, the current location and size of HIV reservoirs is still unknown since there are limited tools to evaluate HIV latency in viral sanctuaries such as gut-associated lymphoid tissue (GALT). [...]
2017
PloS one, Vol. 12 Núm. 4 (2017) , p. 1-10
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4.
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15 p, 2.1 MB |
Proteoliposomal formulations of an HIV-1 gp41-based miniprotein elicit a lipid-dependent immunodominant response overlapping the 2F5 binding motif
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Molinos-Albert, Luis Manuel (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Bilbao, Eneritz (Universidad del País Vasco (UPV/EHU). Department of Biochemistry and Molecular Biology) ;
Agulló, Luis (Universitat de Vic. Departament de Biociències) ;
Marfil, Silvia (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
García, Elisabet (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Rodríguez de la Concepción, Maria Luisa (Institut Germans Trias i Pujol) ;
Izquierdo-Useros, Nuria (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Vilaplana, Cristina (Institut Germans Trias i Pujol. Unitat de Tuberculosi Experimental) ;
Nieto-Garai, Jon A. (Universidad del País Vasco (UPV/EHU). Department of Biochemistry and Molecular Biology) ;
Contreras, F. Xabier (Universidad del País Vasco (UPV/EHU). Department of Biochemistry and Molecular Biology) ;
Floor, Martin (Universitat de Vic. Departament de Biociències) ;
Cardona, Pere J. (Institut Germans Trias i Pujol. Unitat de Tuberculosi Experimental) ;
Martínez Picado, Francisco Javier (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Clotet, Bonaventura (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Villà-Freixa, Jordi (Universitat de Vic. Departament de Biociències) ;
Lorizate, Maier (Universidad del País Vasco (UPV/EHU). Department of Biochemistry and Molecular Biology) ;
Carrillo, Jorge (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Blanco, Julià (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa)
The HIV-1 gp41 Membrane Proximal External Region (MPER) is recognized by broadly neutralizing antibodies and represents a promising vaccine target. However, MPER immunogenicity and antibody activity are influenced by membrane lipids. [...]
2017 - 10.1038/srep40800
Scientific reports, gener 2017, p. 1-15
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5.
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11 p, 1018.7 KB |
Evaluation of the immunogenicity and impact on the latent HIV-1 reservoir of a conserved region vaccine, MVA.HIVconsv, in antiretroviral therapy-treated subjects
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Hancock, Gemma ;
Morón-López, Sara (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Kopycinski, Jakub ;
Puertas, Maria C. (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Giannoulatou, Eleni (University of New South Wales) ;
Rose, Annie ;
Salgado, Maria (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Hayton, Emma-Jo ;
Crook, Alison ;
Morgan, Catharine ;
Angus, Brian ;
Chen, Fabian ;
Yang, Hongbing ;
Martinez-Picado, Javier (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Hanke, Tomas ;
Dorrell, Lucy ;
Universitat Autònoma de Barcelona
Introduction : Vaccines may be key components of a curative strategy for HIV-1. We investigated whether a novel immunogen, HIVconsv, designed to re-direct T cell responses to conserved viral epitopes, could impact the HIV-1 reservoir in chronic antiretroviral therapy (ART)-treated subjects when delivered by modified vaccinia virus Ankara (MVA). [...]
2017 - 10.7448/IAS.20.1.21171
Journal of the International AIDS Society, Vol. 20 (may 2017)
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6.
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15 p, 4.1 MB |
Lack of concordance between residual viremia and viral variants driving de novo infection of CD4 + T cells on ART
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Puertas, Maria C. (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Noguera-Julian, Marc (Universitat de Vic - Universitat Central de Catalunya (UVic-UCC), Vic, Spain) ;
Massanella, Marta (Département de Microbiologie, Infectiologie et Immunologie, Centre de Recherche du CHUM et Université de Montréal) ;
Pou, Christian (Department of Cell and Molecular Biology, Karolinska Institutet, Solna, Stockholm Sweden) ;
Buzón, María José (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Clotet, Bonaventura (Universitat de Vic - Universitat Central de Catalunya (UVic-UCC), Vic, Spain) ;
Stevenson, Mario (Division of Infectious Diseases, Department of Medicine, University of Miami Miller School of Medicine, Miami, USA) ;
Paredes, Roger (Universitat de Vic - Universitat Central de Catalunya (UVic-UCC), Vic, Spain) ;
Blanco, Julià (Universitat de Vic - Universitat Central de Catalunya (UVic-UCC), Vic, Spain) ;
Martínez Picado, Francisco Javier (Institució Catalana de Recerca i Estudis Avançats (ICREA))
In most patients, current antiretroviral therapy (ART) regimens can rapidly reduce plasma viral load. However, even after years of effective treatment, a significant proportion of patients show residual plasma viremia below the clinical detection limit. [...]
2016 - 10.1186/s12977-016-0282-9
Retrovirology, Vol. 13 (august 2016)
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7.
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11 p, 635.6 KB |
P-glycoprotein (ABCB1) activity decreases raltegravir disposition in primary CD4+P-gp high cells and correlates with HIV-1 viral load
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Minuesa Dinarés, Gerard (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Arimany-Nardi, Cristina (National Biomedical Research Institute on Liver and Gastrointestinal Diseases (CIBER EHD), Instituto de Salud Carlos III) ;
Erkizia, Itziar (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Cedeño, Samandhy (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Moltó Marhuenda, José (Institut Germans Trias i Pujol. Fundació de Lluita contra la Sida) ;
Clotet, Bonaventura (Institució Catalana de Recerca i Estudis Avançats (ICREA)) ;
Pastor-Anglada, Marçal (National Biomedical Research Institute on Liver and Gastrointestinal Diseases (CIBER EHD), Instituto de Salud Carlos III) ;
Martínez Picado, Francisco Javier (Universitat de Vic, Universitat Central de Catalunya (UVic-UCC))
To evaluate the role of P-glycoprotein (P-gp) and multidrug-resistant-protein 1 (MRP1) on raltegravir intracellular drug disposition in CD4+ T cells, investigate the effect of HIV-1 infection on P-gp expression and correlate HIV-1 viraemia with P-gp activity in primary CD4+ T cell subsets. [...]
2016 - 10.1093/jac/dkw215
Journal of Antimicrobial Chemotherapy, Vol. 71 (june 2016) , p. 2782-2792
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8.
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7 p, 702.8 KB |
Persistent HIV-1 replication during antiretroviral therapy
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Martinez-Picado, Javier (Institut de recerca Sida IrsiCaixa, Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol (IGTP), Badalona) ;
Deeks, Steven G. (Department of Medicine, University of California, San Francisco, California, USA) ;
Universitat Autònoma de Barcelona
The present review will highlight some of the recent findings regarding the capacity of HIV-1 to replicate during antiretroviral therapy (ART). Although ART is highly effective at inhibiting HIV replication, it is not curative. [...]
2016 - 10.1097/COH.0000000000000287
Current Opinion in HIV and AIDS, Vol. 11 (april 2016) , p. 417-423
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9.
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11 p, 679.0 KB |
Does rapid HIV disease progression prior to combination antiretroviral therapy hinder optimal CD4 + T-cell recovery once HIV-1 suppression is achieved?
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Jarrin, Inma (Instituto de Salud Carlos III, Madrid, Spain) ;
Pantazis, Nikos (Athens University Medical School, Athens, Greece) ;
Dalmau, Judith (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Phillips, Andrew N. (Research Department of Infection and Population Health) ;
Olson, Ashley (Medical Research Council Clinical Trials Unit, University College London, London, UK) ;
Mussini, Cristina (Institute of Infectious Diseases, University of Modena and Reggio Emilia, Modena, Italy) ;
Boufassa, Faroudy (Univ Paris-Sud, Le Kremlim Bicetre) ;
Costagliola, Dominique (INSERM, Paris, France) ;
Porter, Kholoud (Medical Research Council Clinical Trials Unit, University College London, London, UK) ;
Blanco, Juliá (Universitat de Vic-Central de Catalunya, UVIC-UCC, Vic) ;
Del Amo, Julia (Instituto de Salud Carlos III, Madrid, Spain) ;
Martínez Picado, Francisco Javier (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
This article compares trends in CD4 + T-cell recovery and proportions achieving optimal restoration (≥500 cells/μl) after viral suppression following combination antiretroviral therapy (cART) initiation between rapid and nonrapid progressors. [...]
2015 - 10.1097/QAD.0000000000000805
AIDS (London, England), Vol. 29 (october 2015) , p. 2323-2333
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10.
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10 p, 473.8 KB |
Establishment and Replenishment of the Viral Reservoir in Perinatally HIV-1-infected Children Initiating Very Early Antiretroviral Therapy
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Martínez-Bonet, Marta (Hospital General Universitario Gregorio Marañón) ;
Puertas, Maria Carmen (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Fortuny, Claudia (Hospital Sant Joan de Déu) ;
Ouchi, Dan (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Mellado, Maria José (Hospital Universitario Infantil LA PAZ) ;
Rojo, Pablo (Servicio de Pediatría. Hospital 12 de Octubre) ;
Noguera-Julian, Antoni (Hospital Sant Joan de Déu) ;
Muñoz-Fernández, Ma Angeles (Hospital General Universitario Gregorio Marañón) ;
Martinez-Picado, Javier (Institució Catalana de Recerca i Estudis Avançats) ;
Universitat Autònoma de Barcelona
Initiation of combined antiretroviral therapy within the first 12 weeks of life in vertically human immunodeficiency virus type 1-infected children favors the establishment of low-level proviral reservoirs. [...]
2015 - 10.1093/cid/civ456
Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America, Vol. 61 (june 2015) , p. 1169-1178
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