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12 p, 786.4 KB Changes in codon-pair bias of human immunodeficiency virus type 1 have profound effects on virus replication in cell culture / Martrus, Gloria (Hospital Universitari Germans Trias i Pujol. Fundació irsiCaixa) ; Nevot, Maria (Hospital Universitari Germans Trias i Pujol. Fundació irsiCaixa) ; Andrés, Cristina (Hospital Universitari Germans Trias i Pujol. Fundació irsiCaixa) ; Clotet i Sala, Bonaventura (Hospital Universitari Germans Trias i Pujol. Fundació irsiCaixa) ; Martinez, Miguel Ángel (Hospital Universitari Germans Trias i Pujol. Fundació irsiCaixa)
Background: Human immunodeficiency virus type 1 (HIV-1) has a biased nucleotide composition different from human genes. This raises the question of how evolution has chosen the nucleotide sequence of HIV-1 that is observed today, or to what extent the actual encoding contributes to virus replication capacity, evolvability and pathogenesis. [...]
2013 - 10.1186/1742-4690-10-78
Retrovirology, Vol. 10, N. 78 (25 July 2013) , p. 1-12
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