Resultados globales: 2 registros encontrados en 0.01 segundos.
Artículos, Encontrados 1 registros
Documentos de investigación, Encontrados 1 registros
Artículos Encontrados 1 registros  
14 p, 2.3 MB SUMO-2 and PIAS1 modulate insoluble mutant huntingtin protein accumulation / O'Rourke, Jacqueline Gire (University of California) ; Gareau, Jaclyn R. (Sloan-Kettering Institute) ; Ochaba, Joseph (University of California) ; Song, Wan (University of California) ; Raskó, Tamás (Max-Delbrueck-Center for Molecular Medicine) ; Reverter i Cendrós, David (Sloan-Kettering Institute) ; Lee, John (University of Iowa) ; Mas Monteys, Alexandre (University of Iowa) ; Pallos, Judit (University of California) ; Mee, Lisa (University of California) ; Vashishtha, Malini (University of California) ; Apostol, Barbara L. (University of California) ; Nicholson, Thomas Peter (Enzo Life Sciences Ltd.) ; Illes, Katalin (University of California) ; Zhu, Ya-Zhen (University of California) ; Dasso, Mary (National Institute of Child Health and Development) ; Bates, Gillian P. (King's College London School of Medicine) ; Difiglia, Marian (Massachusetts General Hospital and Harvard Medical School) ; Davidson, Beverly (University of Iowa) ; Wanker, Erich E. (Max-Delbrueck-Center for Molecular Medicine) ; Marsh, J. Lawrence (University of California) ; Lima, Christopher D. (Sloan-Kettering Institute) ; Steffan, Joan S. (University of California) ; Thompson, Leslie M. (University of California.)
A key feature in Huntington disease (HD) is the accumulation of mutant Huntingtin (HTT) protein, which may be regulated by posttranslational modifications. Here, we define the primary sites of SUMOmodification in the amino-terminal domain of HTT, show modification downstream of this domain, and demonstrate that HTT is modified by the stress-inducible SUMO-2. [...]
2013 - 10.1016/j.celrep.2013.06.034
Cell Reports, Vol. 4, Issue 2 (July 2013) , p. 362-375  

Documentos de investigación Encontrados 1 registros  
138 p, 858.7 KB Aproximacions de teràpia gènica per a la diabetis mellitus centrades en la manipulació genètica del múscul esquelètic / Mas Monteys, Alexandre ; Bosch i Tubert, Fàtima (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular)
En la present tesi es desenvolupa una nova aproximació de teràpia gènica a fí de proporcionar un nou tractament per a la diabetis mellitus de tipus 1 que millori les teràpies actuals per aquesta malaltia. [...]
In this work we developed a new gene therapy approach for the treatment of type 1 diabetes. This approach is focused on the genetic manipulation of skeletal muscle to express insulin and glucokinase genes in order to obtain a constitutive production of the hormone and to increase the glucose uptake. [...]

Bellaterra : Universitat Autònoma de Barcelona, 2004  

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