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Low-frequency drug-resistant HIV-1 and risk of virological failure to first-line NNRTI-based ART : a multicohort European case-control study using centralized ultrasensitive 454 pyrosequencing / Cozzi-Lepri, Alessandro (University College London) ; Noguera-Julian, Marc (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Di Giallonardo, Francesca (University Hospital Zurich (Suïssa)) ; Schuurman, Rob (Department of Virology. University Medical Centre, Utrecht) ; Däumer, Martin (Institut für Immunologie und Genetik, Kaiserslautern, Germany) ; Aitken, Sue (Department of Virology. University Medical Centre, Utrecht) ; Ceccherini-Silberstein, Francesca (Department of Experimental Medicine and Surgery, University of Rome Tor Vergata) ; D'Arminio Monforte, Antonella (Clinic of Infectious Diseases, 'San Paolo' Hospital) ; Geretti, Anna Maria (Institute of Infection & Global Health, University of Liverpool) ; Booth, Clare L. (Department of Virology, Royal Free London NHS Foundation Trust) ; Kaiser, Rolf (Institute of Virology, University of Cologne) ; Michalik, Claudia (Competence Network for HIV/AIDS, Bochum, Germany) ; Jansen, Klaus (Competence Network for HIV/AIDS, Bochum, Germany) ; Masquelier, Bernard (Université Bordeaux 2) ; Bellecave, Pantxika (Université Bordeaux 2) ; Kouyos, Roger D. (University Hospital Zurich (Suïssa)) ; Castro, Erika (Centre Hospitalier Universitaire Vaudois (Lausanne, Suïssa). Service of Community Psychiatry) ; Furrer, Hansjakob (Bern University Hospital) ; Schultze, Anna (University College London) ; Günthard, Huldrych F. (University Hospital Zurich (Suïssa)) ; Brun-Vezinet, Francoise (Department of Virology, Bichat University Hospital, Paris) ; Paredes, Roger (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Metzner, Karin J. (University Hospital Zurich (Suïssa)) ; CHAIN Minority HIV-1 Variants Working Group
It is still debated if pre-existing minority drug-resistant HIV-1 variants (MVs) affect the virological outcomes of first-line NNRTI-containing ART. This Europe-wide case-control study included ART-naive subjects infected with drug-susceptible HIV-1 as revealed by population sequencing, who achieved virological suppression on first-line ART including one NNRTI. [...]
2014 - DOI (Digital Object Identifier)

10.1093/jac/dku426
Journal of antimicrobial chemotherapy, Vol. 70 (october 2014) , p. 930-940

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