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47 p, 816.8 KB Highly versatile polyelectrolyte complexes for improving the enzyme replacement therapy of lysosomal storage disorders. / Giannotti, MI (Universitat de Barcelona. Departament de Química física) ; Abasolo, Ibane (Universitat Autònoma de Barcelona. Vall d'Hebron Institut de Recerca) ; Oliva, Mireia (Universitat de Barcelona. Departament de Farmàcia i Tecnologia Farmacèutica, i Fisicoquímica) ; Andrade, Fernanda (Universitat de Barcelona. Departament de Farmàcia i Tecnologia Farmacèutica, i Fisicoquímica) ; García-Aranda, Natalia (Universitat Autònoma de Barcelona. Vall d'Hebron Institut de Recerca) ; Melgarejo, Marta (Combinatorial Chemistry Unit, Barcelona Science Park (Baldiri Reixac)) ; Pulido, Daniel (Combinatorial Chemistry Unit, Barcelona Science Park (Baldiri Reixac)) ; Corchero Nieto, José Luis (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Fernández, Yolanda (Universitat Autònoma de Barcelona. Vall d'Hebron Institut de Recerca) ; Villaverde Corrales, Antonio (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Royo, Miriam (Combinatorial Chemistry Unit, Barcelona Science Park (Baldiri Reixac)) ; Garcia-Parajo, Maria F. (Institut de Ciencies Fotoniques, The Barcelona Institute of Science and Technology) ; Sanz, Fausto (Combinatorial Chemistry Unit, Barcelona Science Park (Baldiri Reixac)) ; Simó Schwartz Jr (Universitat Autònoma de Barcelona. Vall d'Hebron Institut de Recerca)
Lysosomal storage disorders are currently treated by enzyme replacement therapy (ERT) through the direct administration of the unprotected recombinant protein to the patients. Herein we present an ionically crosslinked polyelectrolyte complex (PEC) composed of trimethyl chitosan (TMC) and -galactosidase A (GLA), the defective enzyme in Fabry disease, with the capability of directly targeting endothelial cells by incorporating peptide ligands containing the RGD sequence. [...]
2016 - 10.1021/acsami.6b08356
ACS applied materials & interfaces, Vol. 8 Núm 39 (Octubre 2016) , p. 25741-25752  

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