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1.
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33 p, 20.4 MB |
Hyaluronic acid-GPRC5C signalling promotes dormancy in haematopoietic stem cells
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Zhang, Yu Wei (University of Freiburg, Germany) ;
Mess, Julian (University of Freiburg, Germany) ;
Aizarani, Nadim (University of Freiburg, Germany) ;
Mishra, Pankaj (University of Freiburg, Germany) ;
Johnson, Carys (University of Cambridge, UK) ;
Romero-Mulero, Mari Carmen (University of Freiburg, Germany) ;
Rettkowski, Jasmin (University of Freiburg, Germany) ;
Schönberger, Katharina (University of Freiburg, Germany) ;
Obier, Nadine (Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany) ;
Jäcklein, Karin (Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany) ;
Woessner, Nadine M. (University of Freiburg, Germany) ;
Lalioti, Maria Eleni (Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany) ;
Velasco-Hernandez, Talia (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Sikora, Katarzyna (Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany) ;
Wäsch, Ralph (University of Freiburg, Germany) ;
Lehnertz, Bernhard (University of Montreal, Canada) ;
Sauvageau, Guy (University of Montreal, Canada) ;
Manke, Thomas (Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany) ;
Menendez, Pablo (Institució Catalana de Recerca i Estudis Avançats) ;
Walter, Sebastian Gottfried (University Hospital of Cologne, Germany) ;
Minguet, Susana (University of Freiburg, Germany) ;
Laurenti, Elisa (University of Cambridge, UK) ;
Günther, Stefan (University of Freiburg, Germany) ;
Grün, Dominic (Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany) ;
Cabezas-Wallscheid, Nina (Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany)
Bone marrow haematopoietic stem cells (HSCs) are vital for lifelong maintenance of healthy haematopoiesis. In inbred mice housed in gnotobiotic facilities, the top of the haematopoietic hierarchy is occupied by dormant HSCs, which reversibly exit quiescence during stress. [...]
2022 -  10.1038/s41556-022-00931-x
Nature Cell Biology, Vol. 24 Núm. 7 (july 2022) , p. 1038-1048
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2.
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15 p, 2.7 MB |
ALPL-1 is a target for chimeric antigen receptor therapy in osteosarcoma
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Mensali, Nadia (Department of Cellular Therapy. Oslo University Hospital) ;
Köksal, Hakan (Oslo University Hospital) ;
Joaquina, Sandy (Oslo University Hospital) ;
Wernhoff, Patrick (Oslo University Hospital) ;
Casey, Nicholas P. (Oslo University Hospital) ;
Romecín, Paola Alejandra (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Panisello, Carla (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Rodríguez, René (Instituto de Salud Carlos III) ;
Vimeux, Lene (Université de Paris) ;
Juzeniene, Asta (Oslo University Hospital) ;
Myhre, Marit R. (Oslo University Hospital) ;
Fåne, Anne (Oslo University Hospital) ;
Castilla Ramírez, Caroline (Virgen del Rocio University Hospital) ;
Maggadottir, Solrun Melkork (Oslo University Hospital) ;
Duru, Adil Doganay (Nova Southeastern University) ;
Georgoudaki, Anna-Maria (Department of Oncology-Pathology. Karolinska Institutet) ;
Grad, Iwona (Oslo University Hospital) ;
Maturana, Andrés Daniel (Nagoya University) ;
Gaudernack, Gustav (Department of Cancer Immunology. Oslo University Hospital) ;
Kvalheim, Gunnar (Department of Cellular Therapy. Oslo University Hospital) ;
Carcaboso, Angel M. (Institut de Recerca Sant Joan de Déu) ;
De Álava, Enrique (Universidad de Sevilla) ;
Donnadieu, Emma (Université de Paris) ;
Bruland, Øyvind S (University of Oslo) ;
Menendez, Pablo (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Inderberg, Else Marit (Oslo University Hospital) ;
Wälchli, Sébastien (Oslo University Hospital)
Osteosarcoma (OS) remains a dismal malignancy in children and young adults, with poor outcome for metastatic and recurrent disease. Immunotherapies in OS are not as promising as in some other cancer types due to intra-tumor heterogeneity and considerable off-target expression of the potentially targetable proteins. [...]
2023 - 10.1038/s41467-023-39097-x
Nature communications, Vol. 14 Núm. 1 (december 2023) , p. 3375
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3.
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4.
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16 p, 3.4 MB |
Low input capture Hi-C (liCHi-C) identifies promoter-enhancer interactions at high-resolution
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Tomás Daza, Laureano (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Rovirosa, Llorenç (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
López-Martí, Paula (Barcelona Supercomputing Center) ;
Nieto-Aliseda, Andrea (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Serra, François (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Planas-Riverola, Ainhoa (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Molina, Oscar (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
McDonald, Rebecca (Wellcome-MRC Cambridge Stem Cell Institute) ;
Ghevaert, Cedric (NHS Blood and Transplant) ;
Cuatrecasas, Esther (Hospital Sant Joan de Déu (Manresa)) ;
Costa, Dolors (Cancer Network Biomedical Research Center) ;
Camós, Mireia (Instituto de Salud Carlos III) ;
Bueno, Clara (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Menéndez, Pablo (Institució Catalana de Recerca i Estudis Avançats) ;
Valencia, Alonso (Institució Catalana de Recerca i Estudis Avançats) ;
Javierre, B. M (Institut Germans Trias i Pujol)
Long-range interactions between regulatory elements and promoters are key in gene transcriptional control; however, their study requires large amounts of starting material, which is not compatible with clinical scenarios nor the study of rare cell populations. [...]
2023 - 10.1038/s41467-023-35911-8
Nature communications, Vol. 14 Núm. 1 (december 2023) , p. 268
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5.
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9 p, 686.2 KB |
The relapsed acute lymphoblastic leukemia network (ReALLNet) : a multidisciplinary project from the spanish society of pediatric hematology and oncology (SEHOP)
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Velasco, Pablo (Hospital Universitari Vall d'Hebron) ;
Bautista, Francisco (Princess Máxima Center for Pediatric Oncology, Utrecht, Netherlands) ;
Rubio, Alba (Hospital Infantil Universitario Niño Jesús) ;
Aguilar, Yurena (Hospital Miguel Servet Hospital) ;
Rives, Susana (Hospital Sant Joan de Déu (Barcelona, Catalunya)) ;
Dapena, Jose L (Hospital Sant Joan de Déu (Barcelona, Catalunya)) ;
Pérez, Antonio (Universidad Autónoma de Madrid) ;
Ramirez, Manuel (Fundación Para La Investigación Biomédica Hospital Infantil Universitario Niño Jesús) ;
Saiz-Ladera, Cristina (Fundación Para La Investigación Biomédica Hospital Infantil Universitario Niño Jesús) ;
Izquierdo, Elisa (La Paz University Hospital) ;
Escudero, Adela (La Paz University Hospital) ;
Camós, Mireia (Hospital Sant Joan de Déu (Barcelona, Catalunya)) ;
Vega-García, Nerea (Hospital Sant Joan de Déu (Barcelona, Catalunya)) ;
Ortega, Margarita (Vall d'Hebron Institut d'Oncologia) ;
Hidalgo-Gómez, Gloria (Vall d'Hebron Institut d'Oncologia) ;
Palacio, Carlos (Vall d'Hebron Institut d'Oncologia) ;
Menéndez, Pablo (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Bueno, Clara (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Montero, Joan (Universitat de Barcelona) ;
Romecín, Paola A. (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Zazo, Santiago (Universidad Politécnica de Madrid) ;
Alvarez, Federico (Universidad Politécnica de Madrid) ;
Parras, Juan (Universidad Politécnica de Madrid) ;
Ortega-Sabater, Carmen (University of Castilla-La Mancha) ;
Chulián, Salvador (Universidad de Cádiz) ;
Rosa, María (Universidad de Cádiz) ;
Cirillo, Davide (Barcelona Supercomputing Center) ;
García, Elena (Fundación Para La Investigación Biomédica Hospital Infantil Universitario Niño Jesús) ;
García, Jorge (Fundación Para La Investigación Biomédica Hospital Infantil Universitario Niño Jesús) ;
Manzano-Muñoz, Albert (Universitat de Barcelona) ;
Minguela, Alfredo (Instituto Murciano de Investigación Biosanitaria) ;
Fuster, Jose L. (Instituto Murciano de Investigación Biosanitaria)
Acute lymphoblastic leukemia (ALL) is the most common pediatric cancer, with survival rates exceeding 85%. However, 15% of patients will relapse; consequently, their survival rates decrease to below 50%. [...]
2023 - 10.3389/fped.2023.1269560
Frontiers in Pediatrics, Vol. 11 (september 2023)
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6.
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7 p, 1.1 MB |
Epigenome profiling reveals aberrant DNA methylation signature in GATA2 deficiency
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Marin-Bejar, Oskar (Institut d'Investigació Biomèdica de Bellvitge) ;
Romero-Moya, Damia (Institut d'Investigació Biomèdica de Bellvitge) ;
Rodriguez-Ubreva, Javier (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Distefano, Maximiliano (Hospital Sant Joan de Déu (Manresa)) ;
Lessi, Francesca (Fondazione Pisana Per la Scienza ONLUS (FPS)) ;
Aretini, Paolo (Fondazione Pisana Per la Scienza ONLUS (FPS)) ;
Liquori, Alessandro (Instituto de Salud Carlos III) ;
Castaño, Julio (Banc de Sang i Teixits) ;
Kozyra, Emilia (University of Freiburg) ;
Kotmayer, Lili (Semmelweis University. Budapest, Hungary) ;
Bueno, Clara (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Cervera, José (Hospital Universitari i Politècnic La Fe (València)) ;
Rodriguez-Gallego, José Carlos (University of Las Palmas de Gran Canaria) ;
Nomdedeu, Josep Francisco (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Murillo- Sanjuán, Laura (Vall d'Hebron Institut d'Oncologia) ;
de Heredia, Cristina Díaz (Vall d'Hebron Institut d'Oncologia) ;
Pérez-Martinez, Antonio (Universidad Autónoma de Madrid) ;
López-Cadenas, Félix (Instituto Biosanitario de Salamanca (IBSAL)) ;
Martínez-Laperche, Carolina (Hospital Gregorio Marañón. Instituto de Investigación Sanitaria) ;
Dorado-Herrero, Nieves (Hospital Gregorio Marañón. Instituto de Investigación Sanitaria) ;
Marco, Francisco M. (Institute for Health and Biomedical Research (ISABIAL)) ;
Prósper, Felipe (Instituto de Salud Carlos III) ;
Menendez, Pablo (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Valcárcel, David (Vall d'Hebron Institut d'Oncologia) ;
Ballestar, Esteban (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Bödör, Csaba (Semmelweis University. Budapest, Hungary) ;
Bigas Salvans, Anna (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Catalá, Albert (Centro de Investigación Biomédica en Red de Enfermedades Raras) ;
Wlodarski, Marcin W. (St. Jude Children's Research Hospital, Memphis, TN) ;
Giorgetti, Alessandra (Institut d'Investigació Biomèdica de Bellvitge) ;
Universitat Autònoma de Barcelona.
Departament de Medicina
2023 - 10.3324/haematol.2022.282305
Haematologica, Vol. 108 Núm. 9 (september 2023) , p. 2551-2557
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7.
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29 p, 5.2 MB |
Chromosomal instability in aneuploid acute lymphoblastic leukemia associates with disease progression
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Molina, Oscar (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Ortega-Sabater, C. (Mathematical Oncology Laboratory. Department of Mathematics & amp; Institute of Applied Mathematics in Science and Engineering. Universidad de Castilla-La Mancha) ;
Thampi, Namitha (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Fernández Fuentes, Narcís (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Guerrero Murillo, Mercedes (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Martínez Moreno, Alba (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Vinyoles, Meritxell (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Velasco-Hernández, Talia (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Bueno, Clara (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Trincado Alonso, Juan Luis, 1987- (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Granada, Isabel (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Campos, Diana (DiNA Science. S.A) ;
Giménez, Carles (DiNA Science. S.A) ;
Boer, Judith M. (Princess Maxima Center for Pediatric Oncology) ;
den Boer, Monique L. (Department of Pediatric Oncology and Hematology. Erasmus Medical Center - Sophia Children's Hospital) ;
Calvo, Gabriel F. (Mathematical Oncology Laboratory. Department of Mathematics & amp; Institute of Applied Mathematics in Science and Engineering. Universidad de Castilla-La Mancha) ;
Camós, Mireia (Centro de Investigación Biomédica en Red de Enfermedades Raras) ;
Fuster, José Luis (Pediatric Hematology and Oncology Department. Hospital Clínico Universitario Virgen de la Arrixaca. Instituto Murciano de Investigación Biosanitaria (IMIB)) ;
Velasco, P. (Hospital Universitari Vall d'Hebron) ;
Ballerini, Paola (AP-HP. Service of Pediatric Hematology. Hopital Armand Trousseau) ;
Locatelli, Franco (Bambino Gesù Children's Hospital. Catholic University of Sacred Heart) ;
Mullighan, Charles G. (Department of Pathology. St. Jude Children's Research Hospital) ;
Spierings, Diana C.J. (European Research Institute for the Biology of Aging (ERIBA). University of Groningen. University Medical Center Groningen) ;
Foijer, Floris (European Research Institute for the Biology of Aging (ERIBA). University of Groningen. University Medical Center Groningen) ;
Pérez-García, Víctor M. (Mathematical Oncology Laboratory. Department of Mathematics & amp; Institute of Applied Mathematics in Science and Engineering. Universidad de Castilla-La Mancha) ;
Menéndez Bujan, Pablo (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Chromosomal instability (CIN) lies at the core of cancer development leading to aneuploidy, chromosomal copy-number heterogeneity (chr-CNH) and ultimately, unfavorable clinical outcomes. Despite its ubiquity in cancer, the presence of CIN in childhood B-cell acute lymphoblastic leukemia (cB-ALL), the most frequent pediatric cancer showing high frequencies of aneuploidy, remains unknown. [...]
2024 - 10.1038/s44321-023-00006-w
EMBO Molecular Medicine, Vol. 16 Núm. 1 (16 2024) , p. 64-92
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8.
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14 p, 1.6 MB |
Overcoming CAR-Mediated CD19 Downmodulation and Leukemia Relapse with T Lymphocytes Secreting Anti-CD19 T-cell Engagers
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Blanco, Belén (Red Española de Terapias Avanzadas (TERAV)) ;
Ramírez-Fernández, Ángel (Immuno-Oncology and Immunotherapy Group. Instituto de Investigación Sanitaria 12 de Octubre (imas12)) ;
Bueno, Clara (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Argemí-Muntadas, Lidia (Aarhus University, Denmark) ;
Fuentes, Patricia (Centro de Biología Molecular Severo Ochoa CSIC-UAM) ;
Aguilar-Sopeña, Óscar (Instituto de Investigación Sanitaria 12 de Octubre (imas12)) ;
Gutierrez-Agüera, Francisco (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Zanetti, Samanta Romina (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Tapia-Galisteo, Antonio (Hospital Universitario Puerta de Hierro Majadahonda (Madrid)) ;
Díez-Alonso, Laura (Instituto de Investigación Sanitaria 12 de Octubre (imas12)) ;
Segura-Tudela, Alejandro (Instituto de Investigación Sanitaria 12 de Octubre (imas12)) ;
Castellá, Maria (Hospital Clínic i Provincial de Barcelona) ;
Marzal, Berta (Hospital Clínic i Provincial de Barcelona) ;
Betriu-Méndez, Sergi (Hospital Clínic i Provincial de Barcelona) ;
Harwood, Seandean L. (Aarhus University, Denmark) ;
Compte, Marta (Hospital Universitario Puerta de Hierro Majadahonda (Madrid)) ;
Lykkemark, Simon (Aarhus University, Denmark) ;
Erce-Llamazares, Ainhoa (Instituto de Investigación Sanitaria 12 de Octubre (imas12)) ;
Rubio-Pérez, Laura (Universidad Francisco de Vitoria (UFV). Pozuelo de Alarcón) ;
Jiménez-Reinoso, Anaïs (Instituto de Investigación Sanitaria 12 de Octubre (imas12)) ;
Domínguez-Alonso, Carmen (Instituto de Investigación Sanitaria 12 de Octubre (imas12)) ;
Neves, Maria (Centro de Biología Molecular Severo Ochoa CSIC-UAM) ;
Morales, Pablo (Hospital 12 de Octubre (Madrid)) ;
Paz-Artal, Estela (Department of Immunology Ophthalmology and ENT. School of Medicine. Universidad Complutense) ;
Guedan, Sonia (Hospital Clínic i Provincial de Barcelona) ;
Sanz, Laura (Hospital Universitario Puerta de Hierro Majadahonda (Madrid)) ;
Toribio, Maria L. (Centro de Biología Molecular Severo Ochoa CSIC-UAM) ;
Roda-Navarro, Pedro (Instituto de Investigación Sanitaria 12 de Octubre (imas12)) ;
Juan, Manel (Hospital Clínic i Provincial de Barcelona) ;
Menéndez Bujan, Pablo (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Álvarez-Vallina, Luis (Hospital 12 de Octubre (Madrid))
Chimeric antigen receptor (CAR)-modified T cells have revolutionized the treatment of CD19-positive hematologic malignancies. Although anti-CD19 CAR-engineered autologous T cells can induce remission in patients with B-cell acute lymphoblastic leukemia, a large subset relapse, most of them with CD19-positive disease. [...]
2022 - 10.1158/2326-6066.CIR-21-0853
Cancer Immunology Research, Vol. 10 Núm. 4 (april 2022) , p. 498-511
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9.
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6 p, 9.9 MB |
Comprehensive characterization of a novel, oncogenic and targetable SEPTIN6::ABL2 fusion in T-ALL
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Lahera, Antonio (Area of Genetics and Genomics. IIS Fundación Jiménez Díaz) ;
Vela Martín, Laura (Area of Genetics and Genomics. IIS Fundación Jiménez Díaz) ;
López Nieva, Pilar (Institute for Molecular Biology-IUBM. Universidad Autónoma de Madrid) ;
Salgado Sánchez, Rocío Nieves (Cytogenetics Service. Hospital Universitario Fundación Jiménez Díaz) ;
Rodriguez-Perales, Sandra (Molecular Cytogenetics & Genome Editing Unit. Human Cancer Genetics Program. Centro Nacional de Investigaciones Oncologicas) ;
Torres-Ruiz, Rocío (Advanced Therapy Unit. Instituto de Investigación Sanitaria Fundación Jiménez Díaz) ;
López Lorenzo, José L. (Hospital Universitario Fundación Jiménez Díaz) ;
Cornago, Javier (Division of Hematology and Hemotherapy. IIS Fundación Jiménez Díaz) ;
Llamas, Pilar (Division of Hematology and Hemotherapy. IIS Fundación Jiménez Díaz) ;
Fernández Navarro, Pablo (Networking Biomedical Research Centre of Epidemiology and Public Health) ;
Sánchez Domínguez, Rebeca (Networking Biomedical Research Centre of Rare Diseases) ;
Segovia, José C. (Networking Biomedical Research Centre of Rare Diseases) ;
Sastre, Isabel (Department of Genome Dynamics and Function. Centro de Biología Molecular Severo Ochoa. Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid) ;
Cobos Fernández, María Á. (Medical Oncology Department. Hospital Universitario 12 de Octubre) ;
Menéndez Bujan, Pablo (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Santos Hernández, Javier (Institute for Molecular Biology-IUBM. Universidad Autónoma de Madrid) ;
Fernández Piqueras, José (Institute for Molecular Biology-IUBM. Universidad Autónoma de Madrid) ;
Villa Morales, María (Institute for Molecular Biology-IUBM. Universidad Autónoma de Madrid)
2023 - 10.1111/bjh.18901
British Journal of Haematology, Vol. 202 Núm. 3 (august 2023) , p. 693-698
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10.
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14 p, 2.7 MB |
GPRC5C drives branched-chain amino acid metabolism in leukemogenesis
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Zhang, Yu Wei (Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany) ;
Velasco-Hernández, Talia (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Mess, Julian (University of Freiburg) ;
Lalioti, Maria Eleni (Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany) ;
Romero-Mulero, Mari Carmen (University of Freiburg, Germany) ;
Obier, Nadine (Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany) ;
Karantzelis, Nikolaos (University Medical Center Freiburg, Germany) ;
Rettkowski, Jasmin (University of Freiburg, Germany) ;
Schönberger, Katharina (Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany) ;
Karabacz, Noemie (Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany) ;
Jäcklein, Karin (Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany) ;
Morishima, Tatsuya (Kumamoto University, Japan) ;
Trincado Alonso, Juan Luis, 1987- (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Romecin, Paola (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Martinez, Alba (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Takizawa, Hitoshi (Kumamoto University, Japan) ;
Shoumariyeh, Khalid (University of Freiburg, Germany) ;
Renders, Simon (Heidelberg University Hospital (Alemanya)) ;
Zeiser, Robert (University of Freiburg, Germany) ;
Pahl, Heike L. (University Medical Center Freiburg, Germany) ;
Béliveau, François (Quebec leukemia cell bank. Hopital Maisonneuve-Rosemont, Montreal, Canada) ;
Hébert, Josee (Quebec leukemia cell bank. Hopital Maisonneuve-Rosemont, Montreal, Canada) ;
Lehnertz, Bernhard (University of Montreal, Canada) ;
Sauvageau, Guy (University of Montreal, Canada) ;
Menendez, Pablo (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Cabezas-Wallscheid, Nina (Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany)
Leukemia stem cells (LSCs) share numerous features with healthy hematopoietic stem cells (HSCs). G-protein coupled receptor family C group 5 member C (GPRC5C) is a regulator of HSC dormancy. However, GPRC5C functionality in acute myeloid leukemia (AML) is yet to be determined. [...]
2023 - 10.1182/bloodadvances.2023010460
Blood advances, Vol. 7 Núm. 24 (december 2023) , p. 7525-7538
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