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11 p, 4.2 MB Time series modeling of cell cycle exit identifies Brd4 dependent regulation of cerebellar neurogenesis / Penas Pérez, Clara (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Maloof, M. E. (University of Miami Miller School of Medicine. Center for Therapeutic Innovation. Department of Psychiatry and Behavioral Sciences) ; Stathias, V. (University of Miami Miller School of Medicine. Center for Therapeutic Innovation. Department of Psychiatry and Behavioral Sciences) ; Long, J. (University of Miami Miller School of Medicine. Department of Surgery) ; Tan, S. K. (University of Miami Miller School of Medicine. Department of Psychiatry and Behavioral Sciences) ; Mier, J. (University of Miami Miller School of Medicine. Department of Neurosurgery. Miami Project to Cure Paralysis) ; Fang, Y. (The Rockefeller University. Laboratory of Development Neurobiology) ; Valdes, C. (Florida International University. Computing and Information Sciences) ; Rodriguez-Blanco, J. (University of Miami Miller School of Medicine. Department of Surgery) ; Chiang, C. M. (University of Texas Southwestern Medical Center. Simmons Comprehensive Cancer Center. Department of Biochemistry and Department of Pharmacology) ; Robbins, D. J. (University of Miami Miller School of Medicine. Department of Surgery) ; Liebl, D. J. (University of Miami Miller School of Medicine. Department of Surgery) ; Lee, J. K. (University of Miami Miller School of Medicine. Department of Neurosurgery. Miami Project to Cure Paralysis) ; Hatten, M. E. (The Rockefeller University. Laboratory of Development Neurobiology) ; Clarke, J. (University of Nebraska. Department of Statistics) ; Ayad, N. G. (University of Miami Miller School of Medicine. Department of Psychiatry and Behavioral Sciences. Center for Therapeutic Innovation. Sylvester Comprehensive Cancer Center. Miami Project to Cure Paralysis)
Cerebellar neuronal progenitors undergo a series of divisions before irreversibly exiting the cell cycle and differentiating into neurons. Dysfunction of this process underlies many neurological diseases including ataxia and the most common pediatric brain tumor, medulloblastoma. [...]
2019 - 10.1038/s41467-019-10799-5
Nature communications, Vol. 10 Núm. 1 (january 2019) , p. 3028  
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