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Resultats globals: 2 registres trobats en 0.03 segons.
Articles, 2 registres trobats
Articles 2 registres trobats  
1.
17 p, 3.3 MB A Molecular Basis for Selective Antagonist Destabilization of Dopamine D Receptor Quaternary Organization / Marsango, Sara (University of Glasgow) ; Caltabiano, Gianluigi 1978- (Universitat Autònoma de Barcelona. Laboratori de Medicina Computacional) ; Jiménez-Rosés, Mireia (Universitat Autònoma de Barcelona. Laboratori de Medicina Computacional) ; Millan, Mark J. (Institut de Recherches Servier, France) ; Pediani, John D. (University of Glasgow) ; Ward, Richard J. (University of Glasgow) ; Milligan, Graeme (University of Glasgow)
The dopamine D receptor (DR) is a molecular target for both first-generation and several recently-developed antipsychotic agents. Following stable expression of this mEGFP-tagged receptor, Spatial Intensity Distribution Analysis indicated that a substantial proportion of the receptor was present within dimeric/oligomeric complexes and that increased expression levels of the receptor favored a greater dimer to monomer ratio. [...]
2017 - 10.1038/s41598-017-02249-3
Scientific reports, Vol. 7 (may 2017)  
Registre complet - Creative Commons
2.
17 p, 2.9 MB Analysis of Human Dopamine D Receptor Quaternary Structure / Marsango, Sara (University of Glasgow) ; Caltabiano, Gianluigi 1978- (Universitat Autònoma de Barcelona. Laboratori de Medicina Computacional) ; Pou, Chantevy (University of Glasgow) ; Varela Liste, María José (University of Glasgow) ; Milligan, Graeme (University of Glasgow)
Background: The dopamine D receptor can form dimers/oligomers, but the molecular basis for this is poorly defined. Results: Molecular modeling, mutagenesis, and analysis of inactive state receptor crystal structures allowed assessment of models of receptor organization. [...]
2015 - 10.1074/jbc.M114.630681
Journal of biological chemistry, Vol. 290 (april 2015) , p. 15146-15162  
Registre complet - Creative Commons

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