Mirabel, Clémentine - Search Results - UAB Digital Repository of Documents

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Articles, 4 records found

Articles	4 records found

18 p, 30.1 MB

Preclinical Development of a Therapy for Chronic Traumatic Spinal Cord Injury in Rats Using Human Wharton's Jelly Mesenchymal Stromal Cells : Proof of Concept and Regulatory Compliance / Vives Armengol, Joaquim (Universitat Autònoma de Barcelona. Departament de Medicina) ; Hernández, Joaquim (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Mirabel, Clémentine (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Puigdomenech-poch, Maria (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Romeo-Guitart, David (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Marmolejo Martínez-Artesero, Sara (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Cabrera-Pérez, Raquel (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Jaramillo, Jessica (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Kumru, Hatice (Universitat Autònoma de Barcelona. Departament de Medicina) ; García-lópez, Joan (Universitat Autònoma de Barcelona. Departament de Medicina) ; Vidal-Samsó, Joan (Universitat Autònoma de Barcelona. Departament de Medicina) ; Navarro, X. (Xavier) (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Coll-Bonet, Ruth (Banc de Sang i Teixits)
(1) Background: the use of Mesenchymal Stromal Cells (MSC) in emerging therapies for spinal cord injury (SCI) hold the potential to improve functional recovery. However, the development of cell-based medicines is challenging and preclinical studies addressing quality, safety and efficacy must be conducted prior to clinical testing; (2) Methods: herein we present (i) the characterization of the quality attributes of MSC from the Wharton's jelly (WJ) of the umbilical cord, (ii) safety of intrathecal infusion in a 3-month subchronic toxicity assessment study, and (iii) efficacy in a rat SCI model by controlled impaction (100 kdynes) after single (day 7 post-injury) and repeated dose of 1 × 10 MSC,WJ (days 7 and 14 post-injury) with 70-day monitoring by electrophysiological testing, motor function assessment and histology evaluation; (3) Results: no toxicity associated to MSC,WJ infusion was observed. [...]
2022 - DOI (Digital Object Identifier)

10.3390/cells11142153
Cells, Vol. 11 Núm. 14 (7-2 2022) , p. 2153

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11 p, 682.2 KB

Mesenchymal stem cells for cardiac repair : are the actors ready for the clinical scenario? / Roura, Santiago (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Gálvez-Montón, Carolina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Mirabel, Clémentine (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Vives Armengol, Joaquim (Universitat Autònoma de Barcelona. Departament de Medicina) ; Bayés-Genís, Antoni (Universitat Autònoma de Barcelona. Departament de Medicina)
For years, sufficient progress has been made in treating heart failure following myocardial infarction; however, the social and economic burdens and the costs to world health systems remain high. Moreover, treatment advances have not resolved the underlying problem of functional heart tissue loss. [...]
2017 - DOI (Digital Object Identifier)

10.1186/s13287-017-0695-y
Stem cell research & therapy, Vol. 8 (october 2017)

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10 p, 5.7 MB

Stability enhancement of clinical grade multipotent mesenchymal stromal cell-based products / Mirabel, Clémentine (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Puente-Massaguer, Eduard (Universitat Autònoma de Barcelona. Departament d'Enginyeria Química, Biològica i Ambiental) ; del Mazo-Barbara, Anna (Banc de Sang i Teixits. Servei de Teràpia Cel·lular) ; Reyes, Blanca (Banc de Sang i Teixits. Servei de Teràpia Cel·lular) ; Morton, Philip (Albumedix Ltd (Nottingham)) ; Gòdia, Francesc (Universitat Autònoma de Barcelona. Departament d'Enginyeria Química, Biològica i Ambiental) ; Vives Armengol, Joaquim (Universitat Autònoma de Barcelona. Departament de Medicina)
Successful delivery of cell-based therapeutics into patients is compromised by their short shelf-life upon release from production facilities due to the living nature of the active component that rapidly loses viability, and therefore its properties. [...]
2018 - DOI (Digital Object Identifier)

10.1186/s12967-018-1659-4
Journal of translational medicine, Vol. 16 (october 2018)

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13 p, 3.0 MB

Compliance with good manufacturing practice in the assessment of immunomodulation potential of clinical grade multipotent mesenchymal stromal Cells Derived from Wharton's Jelly / Grau-Vorster, Marta (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Rodríguez, Luciano (Banc de Sang i Teixits) ; del Mazo-Barbara, Anna (Banc de Sang i Teixits) ; Mirabel, Clémentine (Banc de Sang i Teixits) ; Blanco, Margarita (Banc de Sang i Teixits) ; Codinach, Margarita (Banc de Sang i Teixits) ; G. Gómez, Susana (Banc de Sang i Teixits) ; Querol, Sergi (Banc de Sang i Teixits) ; García López, Joan (Banc de Sang i Teixits) ; Vives Armengol, Joaquim (Banc de Sang i Teixits)
The selection of assays suitable for testing the potency of clinical grade multipotent mesenchymal stromal cell (MSC)-based products and its interpretation is a challenge for both developers and regulators. [...]
2019 - DOI (Digital Object Identifier)

10.3390/cells8050484
Cells, Vol. 8 (2019) , p. 1-13

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