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13 p, 1.3 MB |
Amerindian Ancestry Influences Genetic Susceptibility to Chronic Obstructive Pulmonary Disease
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Díaz-Peña, Roberto (Liquid Biopsy Analysis Unit, Oncomet, Health Research Institute of Santiago (IDIS), 15706 Santiago de Compostela, Spain) ;
Boekstegers, Felix (Statistical Genetics Group, Institute of Medical Biometry and Informatics, University of Heidelberg) ;
Silva, Rafael S. (Unidad Respiratorio, Centro de Diagnóstico Terapéutico, Hospital Regional de Talca) ;
Jaime, Sergio (Unidad Respiratorio, Centro de Diagnóstico Terapéutico, Hospital Regional de Talca) ;
Hosgood, H. Dean (Department of Epidemiology and Population Health, Albert Einstein College of Medicine) ;
Miravitlles, Marc (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Agustí, Àlvar (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Lorenzo Bermejo, Justo (Statistical Genetics Group, Institute of Medical Biometry and Informatics, University of Heidelberg) ;
Olloquequi, Jordi (Universidad Autónoma de Chile. Instituto de Ciencias Biomédicas) ;
Universitat Autònoma de Barcelona
The contribution of genetic ancestry on chronic obstructive pulmonary disease (COPD) predisposition remains unclear. To explore this relationship, we analyzed the associations between 754,159 single nucleotide polymorphisms (SNPs) and risk of COPD (n = 214 cases, 193 healthy controls) in Talca, Chile, considering the genetic ancestry and established risk factors. [...]
2020 -  10.3390/jpm10030093
Journal of Personalized Medicine, Vol. 10 (august 2020)
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14 p, 1.0 MB |
Withdrawal of inhaled corticosteroids in COPD patients : Rationale and algorithms
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Avdeev, S. (Clinical Department. Federal Pulmonology Research Institute. Federal Medical and Biological Agency of Russia) ;
Aisanov, Z. (Department of Pulmonology. N.I. Pirogov Russian State National Research Medical University) ;
Arkhipov, V. (Department of Clinical Pharmacology and Therapy. Russian Medical Academy of Continuous Professional Education) ;
Belevskiy, A. (Department of Pulmonology. N.I. Pirogov Russian State National Research Medical University) ;
Leshchenko, I. (Department of Phthisiology. Pulmonology and Thoracic Surgery. Ural State Medical University) ;
Ovcharenko, S. (Department of Internal Diseases No.1. I.M. Sechenov First Moscow State Medical University) ;
Shmelev, E. (Department of Differential Diagnostics. Federal Central Research Institute of Tuberculosis) ;
Miravitlles, Marc. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Universitat Autònoma de Barcelona
Observational studies indicate that overutilization of inhaled corticosteroids (ICS) is common in patients with chronic obstructive pulmonary disease (COPD). Overprescription and the high risk of serious ICS-related adverse events make withdrawal of this treatment necessary in patients for whom the treatment-related risks outweigh the expected benefits. [...]
2019 - 10.2147/COPD.S207775
International journal of COPD, Vol. 14 (2019) , p. 1267-1280
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6 p, 3.0 MB |
Time to revise COPD treatment algorithm
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Matsunaga, Kazuto (Department of Respiratory Medicine and Infectious Disease. Graduate School of Medicine. Yamaguchi University) ;
Oishi, K. (Department of Medicine and Clinical Science. Graduate School of Medicine. Yamaguchi University) ;
Miravitlles, Marc. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Anzueto, A. (Pulmonary Diseases Section. Audie L. Murphy Memorial VA Hospital. South Texas Veterans Health Care System) ;
Universitat Autònoma de Barcelona
In 2017, a new two-step algorithm for the treatment of COPD was proposed. This algorithm was based on the severity of symptoms and phenotypes or treatable traits, and patient-specialised assessment targeting eosinophilic inflammation, chronic bronchitis, and frequent infections is recommended after exacerbation occurs despite maximal bronchodilation therapy. [...]
2019 - 10.2147/COPD.S219051
International journal of COPD, Vol. 14 (2019) , p. 2229-2234
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11 p, 1.3 MB |
Mixed Th2 and non-Th2 inflammatory pattern in the asthma-COPD overlap : a network approach
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de Llano, Luis Pérez (Department of Respiratory Medicine. Hospital Lucus Augusti) ;
Cosío, Borja G (Centro de Investigación Biomédica en Red de Enfermedades Respiratorias) ;
Iglesias, Amanda (Centro de Investigación Biomédica en Red de Enfermedades Respiratorias) ;
de las Cuevas, Natividad (Hospital Universitario 12 de Octubre (Madrid)) ;
Soler-Cataluña, Juan Jose (Department of Respiratory Medicine, Hospital Arnau de Vilanova, Valencia, Spain) ;
Izquierdo, Jose Luis (Department of Respiratory Medicine, Hospital Universitario de Guadalajara, Guadalajara, Spain) ;
López-Campos, Jose Luis (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ;
Calero, Carmen (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ;
Plaza, Vicente (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Miravitlles, Marc (Hospital Universitari Vall d'Hebron) ;
Torrego, Alfons (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Martinez-Moragon, Eva (Hospital Universitari Doctor Peset (València)) ;
Soriano, Joan B (Instituto de Investigación Hospital Universitario de la Princesa) ;
Viña, Antolin Lopez (Hospital Puerta de Hierro (Madrid)) ;
Bobolea, Irina (Hospital Clinic, CIBERehd. Department of Pathology)
The asthma-chronic obstructive pulmonary disease (COPD) overlap (ACO) is a clinical condition that combines features of those two diseases, and that is difficult to define due to the lack of understanding of the underlying mechanisms. [...]
2018 - 10.2147/COPD.S153694
International journal of COPD, Vol. 13 (february 2018) , p. 591-601
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11 p, 4.8 MB |
Geographical distribution of COPD prevalence in Europe, estimated by an inverse distance weighting interpolation technique
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Blanco, Ignacio (Sociedad Española de Neumología y Cirugía Torácica) ;
Diego, Isidro (Universidad de Oviedo) ;
Bueno, Patricia (Hospital de Jarrio, Asturias) ;
Fernández, Eloy (Hospital Universitario de Cabueñes) ;
Casas-Maldonado, Francisco (Hospital Universitario San Cecilio (Granada)) ;
Esquinas, Cristina (Hospital Universitari Vall d'Hebron) ;
Soriano, Joan B (Hospital Universitario de la Princesa) ;
Miravitlles, Marc (Hospital Universitari Vall d'Hebron) ;
Universitat Autònoma de Barcelona
Existing data on COPD prevalence are limited or totally lacking in many regions of Europe. The geographic information system inverse distance weighted (IDW) interpolation technique has proved to be an effective tool in spatial distribution estimation of epidemiological variables, when real data are few and widely separated. [...]
2017 - 10.2147/COPD.S150853
International journal of COPD, Vol. 13 (december 2017) , p. 57-67
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9 p, 678.3 KB |
Palliative care and prognosis in COPD : a systematic review with a validation cohort
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Almagro, Pere (Universitat de Barcelona. Hospital Mútua de Terrassa) ;
Yun, Sergi (Universitat de Barcelona. Hospital Mútua de Terrassa) ;
Sangil, Ana (Universitat de Barcelona. Hospital Mútua de Terrassa) ;
Rodríguez-Carballeira, Mónica (Universitat de Barcelona. Hospital Mútua de Terrassa) ;
Marine, Meritxell (Universitat de Barcelona. Hospital Mútua de Terrassa) ;
Landete, Pedro (Instituto de Investigación Hospital Universitario de la Princesa) ;
Soler-Cataluña, Juan José (Hospital Arnau de Vilanova (València)) ;
Soriano, Joan B (Universidad Autónoma de Madrid. Hospital Universitario de la Princesa) ;
Miravitlles, Marc (Hospital Universitari Vall d'Hebron) ;
Universitat Autònoma de Barcelona
Current recommendations to consider initiation of palliative care (PC) in COPD patients are often based on an expected poor prognosis. However, this approach is not evidence-based, and which and when COPD patients should start PC is controversial. [...]
2017 - 10.2147/COPD.S135657
International journal of COPD, Vol. 12 (june 2017) , p. 1721-1729
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9 p, 577.2 KB |
Self-reported daily walking time in COPD : relationship with relevant clinical and functional characteristics
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Ramon, Maria A (Hospital Universitari Vall d'Hebron) ;
Esquinas, Cristina (Hospital Universitari Vall d'Hebron) ;
Barrecheguren Fernández, Miriam (Hospital Universitari Vall d'Hebron) ;
Pleguezuelos, Eulogio (Hospital de Mataró) ;
Molina, Jesús (Centro de Salud Francia, Madrid) ;
Quintano, José A (Centro de Salud de Lucena I, Córdoba) ;
Roman-Rodríguez, Miguel (Centre de Salut de Son Pisà, Palma de Mallorca) ;
Naberan, Karlos (Centro de Salud Campo de Belchite, Zaragoza) ;
Llor, Carl (EAP Via Roma, Barcelona) ;
Roncero, Carlos (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
Miravitlles, Marc (Hospital Universitari Vall d'Hebron)
Quantifying physical activity in chronic obstructive pulmonary disease (COPD) is important as physical inactivity is related to poor health outcomes. This study analyzed the relationship between patients' self-reported daily walking time and relevant characteristics related to COPD severity. [...]
2017 - 10.2147/COPD.S128234
International journal of COPD, Vol. 12 (april 2017) , p. 1173-1181
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7 p, 339.5 KB |
Application of a diagnostic algorithm for the rare deficient variant Mmalton of alpha-1-antitrypsin deficiency : a new approach
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Belmonte, Irene (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Barrecheguren Fernández, Miriam (Hospital Universitari Vall d'Hebron) ;
López-Martínez, Rosa M (Hospital Universitari Vall d'Hebron) ;
Esquinas, Cristina (Hospital Universitari Vall d'Hebron) ;
Rodríguez, Esther (Centro de Investigación Biomédica en Red de Enfermedades Respiratorias) ;
Miravitlles, Marc (Centro de Investigación Biomédica en Red de Enfermedades Respiratorias) ;
Rodriguez-Frias, Francisco (CIBER of Liver and Digestive Diseases. Instituto Nacional de Salud Carlos III) ;
Universitat Autònoma de Barcelona
Alpha-1-antitrypsin deficiency (AATD) is associated with a high risk for the development of early-onset emphysema and liver disease. A large majority of subjects with severe AATD carry the ZZ genotype, which can be easily detected. [...]
2016 - 10.2147/COPD.S115940
International journal of COPD, Vol. 11, Num. 1 (October 2016) , p. 2535-2541
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