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1.
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4 p, 334.8 KB |
Asthma-COPD overlap is not a homogeneous disorder : Further supporting data
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Pérez-de-Llano, Luis (Hospital Universitario Lucus Augusti (Lugo)) ;
Cosio, Borja G. (Centro de Investigación Biomédica en Red de Enfermedades Respiratorias) ;
Iglesias, Amanda (Centro de Investigación Biomédica en Red de Enfermedades Respiratorias) ;
de las Cuevas, Natividad (Hospital 12 de Octubre (Madrid)) ;
Soler-Cataluña, Juan Jose (Hospital Arnau de Vilanova (València)) ;
Izquierdo, Jose Luis (Hospital Universitario de Guadalajara) ;
López-Campos, Jose Luis (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ;
Calero, Carmen (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Plaza, Vicente (Institut d'Investigació Biomèdica Sant Pau) ;
Miravitlles, Marc (Hospital Universitari Vall d'Hebron) ;
Torrego, Alfons (Institut d'Investigació Biomèdica Sant Pau) ;
Moragón, Eva Martínez (Hospital Universitari Doctor Peset (València)) ;
Soriano, Joan B. (Universidad Autónoma de Madrid) ;
Viña, Antolin Lopez (Hospital Puerta de Hierro (Madrid)) ;
Bobolea, Irina (Hospital Clínic i Provincial de Barcelona) ;
Universitat Autònoma de Barcelona
Asthma-COPD ovelap (ACO) is an umbrella term that encompasses patients with COPD and eosinophilic inflammation (e-COPD) and smoking asthmatics with non-fully reversible airflow obstruction (SA). We compared the clinical characteristics and the inflammatory profile of e-COPD and SA. [...]
2017 -  10.1186/s12931-017-0667-x
Respiratory Research, Vol. 18 Núm. 1 (february 2017) , p. 183
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2.
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19 p, 779.0 KB |
Current challenges in chronic bronchial infection in patients with chronic obstructive pulmonary disease
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Lopez-Campos, J.L. (Centro de Investigación Biomédica en Red de Enfermedades Respiratorias) ;
Miravitlles, Marc (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
de la Rosa Carrillo, David (Institut d'Investigació Biomèdica Sant Pau) ;
Cantón, R. (Instituto Ramón y Cajal de Investigación Sanitaria (Madrid)) ;
Soler-Cataluña, J.J. (Hospital Arnau de Villanova-Lliria) ;
Martinez-Garcia, M.A. (Hospital Universitari i Politècnic La Fe (València)) ;
Universitat Autònoma de Barcelona
Currently, chronic obstructive pulmonary disease (COPD) patients and their physicians face a number of significant clinical challenges, one of which is the high degree of uncertainty related to chronic bronchial infection (CBI). [...]
2020 - 10.3390/jcm9061639
Journal of clinical medicine, Vol. 9 Núm. 6 (june 2020) , p. 1639
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3.
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10 p, 1.8 MB |
A proposed approach to chronic airway disease (CAD) using therapeutic goals and treatable traits : A look to the future
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Pérez de Llano, Luis (University Hospital Lucus Augusti (Lugo, Galícia)) ;
Miravitlles, Marc (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Golpe, Rafael (University Hospital Lucus Augusti (Lugo, Galícia)) ;
Alvarez Gutiérrez, Francisco Javier (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ;
Cisneros, Carolina (Hospital Universitario La Princesa (Madrid)) ;
Almonacid, Carlos (Hospital Universitario Ramón y Cajal (Madrid)) ;
Martínez-Moragón, Eva (Hospital Universitari Doctor Peset (València)) ;
González-Barcala, Francisco-Javier (Universidade de Santiago de Compostela) ;
Ramos-Barbón, David (Institut d'Investigació Biomèdica Sant Pau) ;
Plaza, Vicente (Institut d'Investigació Biomèdica Sant Pau) ;
López-Campos, José Luis (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ;
De Torres, Juan Pablo (Queen's University) ;
Casanova Macario, Ciro (Hospital Universitario Nuestra Señora de Candelaria (Santa Cruz de Tenerife)) ;
García-Rivero, J. L. (Hospital de Laredo) ;
Rodriguez Hermosa, Juan Luis (Hospital Clínico San Carlos (Madrid)) ;
Calle Rubio, Myriam (Hospital Clínico San Carlos (Madrid)) ;
Soler-Cataluña, Juan José (Hospital Arnau de Vilanova (València)) ;
Cosio, Borja G (Clínica Quirón-Rotger) ;
Universitat Autònoma de Barcelona
Chronic airflow obstruction affects a wide range of airway diseases, the most frequent of which are asthma, COPD, and bronchiectasis; they are clearly identifiable in their extremes, but quite frequently overlap in some of their pathophysiological and clinical characteristics. [...]
2020 - 10.2147/COPD.S263430
International journal of COPD, Vol. 15 (2020) , p. 2091-2100
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4.
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12 p, 2.1 MB |
Long-Term Risk of Mortality Associated with Isolation of Pseudomonas aeruginosa in COPD : A Systematic Review and Meta-Analysis
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Martinez-García, Miguel Angel (Centro de Investigación Biomédica en Red de Enfermedades Respiratorias) ;
Rigau, David (Institut d'Investigació Biomèdica Sant Pau) ;
Barrecheguren, Miriam (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
García-Ortega, Alberto (Hospital Universitari i Politècnic La Fe (València)) ;
Nuñez, Alexa (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Oscullo Yepez, Grace (Hospital Universitari i Politècnic La Fe (València)) ;
Miravitlles, Marc (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Background: Chronic bronchial infection is frequent in chronic obstructive pulmonary disease (COPD), but the impact of the isolation of pathogenic bacteria, and in particular Pseudomonas aeruginosa (PA) in respiratory samples on the prognosis of COPD is unclear. [...]
2022 - 10.2147/COPD.S346294
International journal of COPD, Vol. 17 (2022) , p. 371-382
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5.
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13 p, 4.1 MB |
New variants of alpha-1-antitrypsin : structural simulations and clinical expression
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Gonzalez, Angel (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Belmonte, Irene (Hospital Universitari Vall d'Hebron) ;
Núñez, Alexa (Hospital Universitari Vall d'Hebron) ;
Farago, Georgina (Hospital Universitari Vall d'Hebron) ;
Barrecheguren, Miriam (Hospital Universitari Vall d'Hebron) ;
Pons Delgado, Mònica (Hospital Universitari Vall d'Hebron) ;
Orriols, Gerard (Hospital Universitari Vall d'Hebron) ;
Gabriel-Medina, Pablo (Hospital Universitari Vall d'Hebron) ;
Rodríguez Frías, Francisco (Hospital Universitari Vall d'Hebron) ;
Miravitlles, Marc (Hospital Universitari Vall d'Hebron) ;
Esquinas, Cristina (Hospital Universitari Vall d'Hebron)
Alpha-1 antitrypsin deficiency (AATD) is characterized by reduced serum levels of the AAT protein and predisposes to liver and lung disease. The characterization at structural level of novel pathogenic SERPINA1 mutants coding for circulating AAT could provide novel insights into the mechanisms of AAT misfolding. [...]
2022 - 10.1186/s12931-022-02271-8
Respiratory Research, Vol. 23 (december 2022)
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6.
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20 p, 2.6 MB |
Exercise capacity and physical activity in COPD patients treated with a LAMA/LABA combination : a systematic review and meta-analysis
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Miravitlles, Marc (Hospital Universitari Vall d'Hebron) ;
García-Rivero, Juan Luís (Hospital Universitario Marqués de Valdecilla (Santander, Cantabria)) ;
Ribera, Xavier (Boehringer Ingelheim España S.A) ;
Galera, Jordi (TFS Health Science) ;
García, Alejandra (Market Access AreaPharmalex Spain) ;
Palomino, Rosa (Market Access AreaPharmalex Spain) ;
Pomares, Xavier (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Universitat Autònoma de Barcelona
Persistent airflow limitation and dyspnoea may reduce chronic obstructive pulmonary disease (COPD) patients exercise capacity and physical activity, undermining their physical status and quality of life. [...]
2022 - 10.1186/s12931-022-02268-3
Respiratory Research, Vol. 23 (december 2022)
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7.
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11 p, 735.0 KB |
Unravelling young COPD and pre-COPD in the general population
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Cosio, Borja G (Universitat de les Illes Balears) ;
Casanova, Ciro (Hospital Universitario Nuestra Señora de Candelaria (Santa Cruz de Tenerife)) ;
Soler-Cataluña, Juan José (Hospital Arnau de Vilanova-Lliria) ;
Soriano, Joan B.. (Hospital Universitario de la Princesa (Madrid)) ;
García-Rio, Francisco (Hospital Universitario La Paz (Madrid)) ;
de Lucas, Pilar (Hospital General Universitario Gregorio Marañón) ;
Alfageme, Inmaculada (Hospital Universitario Virgen de Valme (Sevilla, Andalusia)) ;
Rodríguez González-Moro, José Miguel (Universidad de Alcalá) ;
Sánchez Herrero, María Guadalupe (GSK (Madrid)) ;
Ancochea, Julio (Hospital Universitario de la Princesa (Madrid)) ;
Miravitlles, Marc (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Universitat Autònoma de Barcelona
Chronic obstructive pulmonary disease (COPD) is commonly diagnosed when the airflow limitation is well established and symptomatic. We aimed to identify individuals at risk of developing COPD according to the concept of pre-COPD and compare their clinical characteristics with 1) those who have developed the disease at a young age, and 2) the overall population with and without COPD. [...]
2023 - 10.1183/23120541.00334-2022
ERJ Open Research, Vol. 9 (february 2023)
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8.
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11 p, 746.6 KB |
Prevalence of reduced lung diffusing capacity and CT scan findings in smokers without airflow limitation : a population-based study
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García-Rio, Francisco (Centro de Investigación Biomédica en Red de Enfermedades Respiratorias) ;
Miravitlles, Marc (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Soriano, Joan B. (Hospital Universitario de la Princesa (Madrid)) ;
Cosio, Borja G (Institut d'Investigació Sanitària Illes Balears) ;
Soler-Cataluña, Juan José (Hospital Arnau de Vilanova-Lliria) ;
Casanova, Ciro (Hospital Universitario Nuestra Señora de Candelaria (Santa Cruz de Tenerife)) ;
de Lucas, Pilar (Hospital General Universitario Gregorio Marañón) ;
Alfageme, Inmaculada (Hospital Universitario Virgen de Valme (Sevilla, Andalusia)) ;
Rodríguez González-Moro, José Miguel (Hospital Universitario Príncipe de Asturias (Alcalá de Henares, Madrid)) ;
Sánchez Herrero, María Guadalupe (GSK) ;
Ancochea, Julio (Hospital Universitario de la Princesa (Madrid)) ;
Universitat Autònoma de Barcelona
Population distribution of reduced diffusing capacity of the lungs for carbon monoxide (DLCO) in smokers and main consequences are not properly recognised. The objectives of this study were to describe the prevalence of reduced DLCO in a population-based sample of current and former smoker subjects without airflow limitation and to describe its morphological, functional and clinical implications. [...]
2023 - 10.1136/bmjresp-2022-001468
BMJ Open Respiratory Research, Vol. 10 (january 2023)
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9.
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8 p, 731.6 KB |
COVID-19's impact on care practice for alpha-1-antitrypsin deficiency patients
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Calle Rubio, Myriam (Universidad Complutense de Madrid) ;
López-Campos, José Luis (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ;
Miravitlles, Marc (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Michel de la Rosa, Francisco Javier (Hospital de Donostia (Sant Sebastià, País Basc)) ;
Hernández Pérez, José María (Hospital Universitario Nuestra Señora de Candelaria (Santa Cruz de Tenerife)) ;
Montero Martínez, Carmen (Complejo Hospitalario Universitario de A Coruña) ;
Montoro Ronsano, José Bruno (Hospital Universitari Vall d'Hebron) ;
Casas-Maldonado, Francisco (Universidad de Granada) ;
Rodríguez Hermosa, Juan Luis (Universidad Complutense de Madrid) ;
Tabernero Huguet, Eva María (Hospital Universitario de Cruces (Barakaldo, País Basc)) ;
Martínez Sesmero, José Manuel (Hospital Clínico San Carlos (Madrid)) ;
Martínez Rivera, Carlos (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Callejas González, Francisco Javier (Hospital Complejo Universitario de Albacete) ;
Torres Durán, María (Hospital Álvaro Cunqueiro (Vigo)) ;
Universitat Autònoma de Barcelona
Patients with alpha-1 antitrypsin deficiency (AATD), commonly categorized as a rare disease, have been affected by the changes in healthcare management brought about by COVID-19. This study's aim was to identify the changes that have taken place in AATD patient care as a result of the COVID-19 pandemic in Spain and to propose experts' recommendations aimed at ensuring humanized and quality care for people with AATD in the post-pandemic situation. [...]
2023 - 10.1186/s12913-023-09094-3
BMC health services research, Vol. 23 (january 2023)
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10.
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11 p, 590.5 KB |
Respiratory symptoms and their determinants in the general Spanish population : changes over 20 years
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Miravitlles, Marc (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Soler-Cataluña, Juan José (Hospital Arnau de Vilanova-Lliria) ;
Soriano, Joan B.. (Hospital Universitario de la Princesa (Madrid)) ;
García-Rio, Francisco (Instituto de Investigación Sanitaria del Hospital Universitario La Paz) ;
de Lucas, Pilar (Hospital General Universitario Gregorio Marañón) ;
Alfageme, Inmaculada (Hospital Universitario Virgen de Valme (Sevilla, Andalusia)) ;
Casanova, Ciro (Hospital Universitario Nuestra Señora de Candelaria (Santa Cruz de Tenerife)) ;
Rodríguez González-Moro, José Miguel (Hospital Universitario Príncipe de Asturias (Alcalá de Henares, Madrid)) ;
Sánchez Herrero, María Guadalupe (Departamento Médico (Madrid)) ;
Ancochea, Julio (Hospital Universitario de la Princesa (Madrid)) ;
Cosio, Borja G (Institut d'Investigació Sanitària Illes Balears) ;
Universitat Autònoma de Barcelona
Few large epidemiological studies have analysed the prevalence of respiratory symptoms and their determinants in the general adult population. We investigated the prevalence and determinants of respiratory symptoms and compared their prevalence with that of two previous studies conducted in 1999 and 2009. [...]
2022 - 10.1183/23120541.00067-2022
ERJ Open Research, Vol. 8 (november 2022)
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