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1.
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13 p, 828.8 KB |
Prospective detection of mutations in cerebrospinal fluid, pleural effusion, and ascites of advanced cancer patients to guide treatment decisions
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Villatoro, Sergi (Grup Quirónsalud (Barcelona, Catalunya)) ;
Mayo-de-las-Casas, Clara (Grup Quirónsalud (Barcelona, Catalunya)) ;
Jordana-Ariza, Núria (Grup Quirónsalud (Barcelona, Catalunya)) ;
Viteri-Ramírez, Santiago (Grup Quirónsalud (Barcelona, Catalunya)) ;
Garzón-Ibañez, Mónica (Grup Quirónsalud (Barcelona, Catalunya)) ;
Moya-Horno, Irene (Hospital General de Catalunya) ;
García-Peláez, Beatrtiz (Grup Quirónsalud (Barcelona, Catalunya)) ;
González-Cao, María (Grup Quirónsalud (Barcelona, Catalunya)) ;
Malapelle, Umberto (University of Naples Federico II) ;
Balada-Bel, Ariadna (Grup Quirónsalud (Barcelona, Catalunya)) ;
Martínez-Bueno, Alejandro (Grup Quirónsalud (Barcelona, Catalunya)) ;
Campos, Raquel (Grup Quirónsalud (Barcelona, Catalunya)) ;
Reguart, Noemi (Hospital Clínic i Provincial de Barcelona) ;
Majem, Margarita (Institut d'Investigació Biomèdica Sant Pau) ;
Blanco, Remei (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya)) ;
Blasco, Ana (Hospital General Universitari de València) ;
Catalán, María J. (Grup Quirónsalud (Barcelona, Catalunya)) ;
González, Xavier (Hospital General de Catalunya) ;
Troncone, Giancarlo (University of Naples Federico II) ;
Karachaliou, Niki (Hospital del Sagrat Cor (Barcelona, Catalunya)) ;
Rosell, Rafael (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Molina-Vila, Miguel Ángel (Grup Quirónsalud (Barcelona, Catalunya)) ;
Universitat Autònoma de Barcelona
Many advanced cases of cancer show central nervous system, pleural, or peritoneal involvement. In this study, we prospectively analyzed if cerebrospinal fluid (CSF), pleural effusion (PE), and/or ascites (ASC) can be used to detect driver mutations and guide treatment decisions. [...]
2019 -  10.1002/1878-0261.12574
Molecular Oncology, Vol. 13 Núm. 12 (january 2019) , p. 2633-2645
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2.
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14 p, 1.8 MB |
Usefulness of two independent DNA and rna tissue-based multiplex assays for the routine care of advanced NSCLC patients
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Marin, Elba (Hospital Clínic i Provincial de Barcelona) ;
Teixidó, Cristina (Hospital Clínic i Provincial de Barcelona) ;
Carmona Rocha, Elena (Hospital Clínic i Provincial de Barcelona) ;
Reyes, Roxana (Hospital Clínic i Provincial de Barcelona) ;
Arcocha, Ainara (Hospital Clínic i Provincial de Barcelona) ;
Viñolas, Nuria (Hospital Clínic i Provincial de Barcelona) ;
Rodríguez-Mues, M Carmen (Hospital Clínic i Provincial de Barcelona) ;
Cabrera, Carlos (Instituto Oncologico Dr. Rosell) ;
Sánchez, Marcelo (Hospital Clínic i Provincial de Barcelona) ;
Vollmer, Ivan G. (Hospital Clínic i Provincial de Barcelona) ;
Castillo, Sergi (Hospital General de Granollers) ;
Muñoz, Silvia (Hospital General de Granollers) ;
Sullivan, Ivana (Institut d'Investigació Biomèdica Sant Pau) ;
Rodríguez, Adela (Hospital Clínic i Provincial de Barcelona) ;
Garcia, Mireia (Hospital Clínic i Provincial de Barcelona) ;
Alos, Silvia (Hospital Clínic i Provincial de Barcelona) ;
Jares, Pedro (Hospital Clínic i Provincial de Barcelona) ;
Martinez, Antonio (Hospital Clínic i Provincial de Barcelona) ;
Prat, Aleix (Hospital Clínic i Provincial de Barcelona) ;
Molina-Vila, Miguel Ángel (Quirón Dexeus University Hospital) ;
Reguart, Noemi (Hospital Clínic i Provincial de Barcelona) ;
Universitat Autònoma de Barcelona
Personalized medicine is nowadays a paradigm in lung cancer management, offering important benefits to patients. This study aimed to test the feasibility and utility of embedding two multiplexed genomic platforms as the routine workup of advanced non-squamous non-small cell lung cancer (NSCLC) patients. [...]
2020 - 10.3390/cancers12051124
Cancers, Vol. 12 Núm. 5 (may 2020) , p. 1124
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3.
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17 p, 2.3 MB |
Combinatorial Blood Platelets-Derived circRNA and mRNA Signature for Early-Stage Lung Cancer Detection
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D'Ambrosi, Silvia (Amsterdam UMC. University Medical Center) ;
Giannoukakos, Stavros (Centro de Investigación Biomédica de la Universidad de Granada) ;
Antunes-Ferreira, Mafalda (Amsterdam UMC. University Medical Center) ;
Pedraz-Valdunciel, Carlos (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Bracht, Jillian (Hospital Universitari Dexeus - Grup Quirónsalud) ;
Potie, Nicolas (Centro de Investigación Biomédica de la Universidad de Granada) ;
Giménez-Capitán, Ana (Hospital Universitari Dexeus - Grup Quirónsalud) ;
Hackenberg, Michael (Centro de Investigación Biomédica de la Universidad de Granada) ;
Fernandez Hilario, Alberto (Universidad de Granada) ;
Molina-Vila, Miguel Ángel (Hospital Universitari Dexeus - Grup Quirónsalud) ;
Rosell, Rafael (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Würdinger, Thomas (Amsterdam UMC. University Medical Center) ;
Koppers-Lalic, Danijela (Leiden University) ;
Universitat Autònoma de Barcelona
Despite the diversity of liquid biopsy transcriptomic repertoire, numerous studies often exploit only a single RNA type signature for diagnostic biomarker potential. This frequently results in insufficient sensitivity and specificity necessary to reach diagnostic utility. [...]
2023 - 10.3390/ijms24054881
International journal of molecular sciences, Vol. 24 (march 2023)
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4.
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14 p, 586.6 KB |
Comprehensive cross-platform comparison of methods for non-invasive EGFR mutation testing : results of the RING observational trial
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Romero, Atocha (Hospital Universitario Puerta de Hierro Majadahonda (Madrid)) ;
Jantus-Lewintre, Eloisa (Universitat Politècnica de València) ;
García-Peláez, Beatriz (Hospital Universitari Dexeus (Barcelona, Catalunya)) ;
Royuela, Ana (Hospital Universitario Puerta de Hierro Majadahonda (Madrid)) ;
Insa, Amelia (Hospital Clínic Universitari (València)) ;
Cruz Castellanos, Patricia (Hospital Universitario La Paz (Madrid)) ;
Collazo-Lorduy, Ana (Hospital Universitario HM Sanchinarro (Madrid)) ;
Pérez Altozano, Javier (Hospital Virgen de los Lirios) ;
Vidal, Oscar Juan (Hospital Universitari i Politècnic La Fe (València)) ;
Diz Taín, P (Complejo Asistencial Universitario de León) ;
Cobo, Manuel (Hospital Regional Universitario de Málaga) ;
Hernández, Berta (Complejo Hospitalario de Navarra) ;
Vázquez Estevez, Sergio (Hospital Universitario Lucus Augusti (Lugo)) ;
Benítez, Gretel (Complejo Hospitalario Universitario Insular de Gran Canaria) ;
Guirado, Maria (Hospital General Universitario de Elche) ;
Majem, Margarita (Institut d'Investigació Biomèdica Sant Pau) ;
Bernabé, Reyes (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ;
Ortega Granados, Ana Laura (Complejo Hospitalario de Jaén) ;
Blasco, Ana (Centro de Investigación Biomédica en Red de Cáncer) ;
Bosch-Barrera, J (Institut d'Investigació Biomèdica de Girona) ;
Jurado, Jose M. (Hospital Universitario San Cecilio (Granada)) ;
García González, Jorge (Hospital Clínico Universitario (Santiago de Compostela, Galícia)) ;
Viteri, Santiago (Instituto Oncológico Dr. Rosell. Hospital Universitario Dexeus. Grupo Quiron Salud) ;
Garcia Giron, Carlos (Hospital Universitario de Burgos) ;
Massuti, Bartomeu (Hospital General Universitario de Alicante (Alacant, País Valencià)) ;
Lopez Martín, Ana (Hospital Universitario Severo Ochoa) ;
Rodriguez-Festa, Alejandro (Fundación de Investigación Biomédica del H.U. Puerta de Hierro Majadahonda) ;
Calabuig-Fariñas, Silvia (Universitat de València. Departament de Patologia) ;
Molina-Vila, Miguel Ángel (Hospital Universitari Dexeus (Barcelona, Catalunya)) ;
Provencio, Mariano (Hospital Universitario Puerta de Hierro Majadahonda (Madrid))
Several platforms for noninvasive EGFR testing are currently used in the clinical setting with sensitivities ranging from 30% to 100%. Prospective studies evaluating agreement and sources for discordant results remain lacking. [...]
2021 - 10.1002/1878-0261.12832
Molecular Oncology, Vol. 15 Núm. 1 (january 2021) , p. 43-56
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5.
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10 p, 654.4 KB |
Multiplex Detection of Clinically Relevant Mutations in Liquid Biopsies of Cancer Patients Using a Hybridization-Based Platform
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Giménez-Capitán, Ana (Grup Quirónsalud (Barcelona, Catalunya)) ;
Bracht, Jillian (Universitat Autònoma de Barcelona) ;
García Mosquera, Juan José (Grup Quirónsalud (Barcelona, Catalunya)) ;
Jordana-Ariza, Núria (Grup Quirónsalud (Barcelona, Catalunya)) ;
García, Beatriz (Grup Quirónsalud (Barcelona, Catalunya)) ;
Garzón Ibáñez, Mónica (Grup Quirónsalud (Barcelona, Catalunya)) ;
Mayo-De-Las-Casas, Clara (Grup Quirónsalud (Barcelona, Catalunya)) ;
Viteri, Santiago (Grup Quirónsalud (Barcelona, Catalunya)) ;
Martínez-Bueno, Alejandro (Grup Quirónsalud (Barcelona, Catalunya)) ;
Aguilar-Hernández, Andrés (Grup Quirónsalud (Barcelona, Catalunya)) ;
Sullivan, Ivana (Institut d'Investigació Biomèdica Sant Pau) ;
Johnson, Eric (NanoString Technologies) ;
Huang, Chun-Ying (NanoString Technologies) ;
Gerlach, Jay L. (NanoString Technologies) ;
Warren, Sarah (NanoString Technologies) ;
Beechem, Joseph M. (NanoString Technologies) ;
Teixidó, Cristina (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Rosell, Rafael (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Reguart, Noemi (Hospital Clínic i Provincial de Barcelona) ;
Molina-Vila, Miguel Ángel. (Grup Quirónsalud (Barcelona, Catalunya))
BACKGROUND: With the advent of precision oncology, liquid biopsies are quickly gaining acceptance in the clinical setting. However, in some cases, the amount of DNA isolated is insufficient for Next-Generation Sequencing (NGS) analysis. [...]
2021 - 10.1093/clinchem/hvaa248
Clinical Chemistry, Vol. 67 Núm. 3 (january 2021) , p. 554-563
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6.
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12 p, 4.7 MB |
Analysis of extracellular vesicle mRNA derived from plasma using the nCounter platform
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Bracht, Jillian (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Giménez-Capitán, Ana (Quirón Dexeus University Hospital. Pangaea Oncology, Laboratory of Oncology) ;
Huang, Chung-Ying (NanoString Technologies, Seattle, WA USA) ;
Potie, Nicolas (Biotechnology Institute, Centro de Investigacion Biomedica, PTS. Bioinformatics Laboratory) ;
Pedraz-Valdunciel, Carlos (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Warren, Sarah (NanoString Technologies, Seattle, WA USA) ;
Rosell, Rafael (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Molina-Vila, Miguel Ángel (Quirón Dexeus University Hospital. Pangaea Oncology, Laboratory of Oncology)
Extracellular vesicles (EVs) are double-layered phospholipid membrane vesicles that are released by most cells and can mediate intercellular communication through their RNA cargo. In this study, we tested if the NanoString nCounter platform can be used for the analysis of EV-mRNA. [...]
2021 - 10.1038/s41598-021-83132-0
Scientific reports, Vol. 11 (february 2021)
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7.
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11 p, 2.1 MB |
Src-Homology 2 Domain-Containing Phosphatase 2 in Resected EGFR Mutation-Positive Lung Adenocarcinoma
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Ito, Masaoki (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Codony-Servat, Jordi (Institut Universitari Dexeus) ;
Giménez-Capitán, Ana (Institut Universitari Dexeus) ;
Serra-Mitjans, Mireia (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya)) ;
Pérez-Ochoa, Francisco (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya)) ;
Llige, David (Institut Germans Trias i Pujol) ;
Chaib, Imane (Institut Germans Trias i Pujol) ;
Rami-Porta, Ramon (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya)) ;
Obiols, Carme (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya)) ;
Call, Sergi (Universitat Autònoma de Barcelona. Departament de Ciències Morfològiques) ;
Iglesias, Manuela (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya)) ;
Belda, José (Belda Sanchis) (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya)) ;
Tarroch-Sarasa, Xavier (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya)) ;
Karachaliou, Niki (Institut Universitari Dexeus) ;
Molina-Vila, Miguel Ángel (Institut Universitari Dexeus) ;
Okada, Morihito (Hiroshima University. Department of Surgical Oncology) ;
Rosell, Rafael (Institut Germans Trias i Pujol)
EGFR mutation-positive lung adenocarcinoma (LUAD) displays impaired phosphorylation of ERK and Src-homology 2 domain-containing phosphatase 2 (SHP2) in comparison with EGFR wild-type LUADs. We hypothesize that SHP2 expression could be predictive in patients positive with resected EGFR mutation versus patients with EGFR wild-type LUAD. [...]
2020 - 10.1016/j.jtocrr.2020.100084
JTO Clinical and Research Reports, Vol. 1 Núm. 4 (august 2020)
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8.
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14 p, 2.2 MB |
Multiplex RNA-based detection of clinically relevant MET alterations in advanced non-small cell lung cancer
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Aguado, Cristina (Quirón Dexeus University Hospital) ;
Teixidó, Cristina (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Román, Ruth (Quirón Dexeus University Hospital) ;
Reyes, Roxana (Hospital Clínic i Provincial de Barcelona) ;
Giménez-Capitán, Ana (Quirón Dexeus University Hospital) ;
Marin, Elba (Hospital Clínic i Provincial de Barcelona) ;
Cabrera, Carlos (Grup Quirónsalud (Barcelona, Catalunya)) ;
Viñolas, Nuria (Hospital Clínic i Provincial de Barcelona) ;
Castillo, Sergi (Hospital General de Granollers) ;
Muñoz, Silvia (Hospital General de Granollers) ;
Arcocha, Ainara (Hospital Clínic i Provincial de Barcelona) ;
López Vilaró, Laura (Institut d'Investigació Biomèdica Sant Pau) ;
Sullivan, Ivana (Institut d'Investigació Biomèdica Sant Pau) ;
Aldeguer, Erika (Quirón Dexeus University Hospital) ;
Rodríguez, Sonia (Quirón Dexeus University Hospital) ;
Moya, Irene (Grup Quirónsalud (Barcelona, Catalunya)) ;
Viteri, Santiago (Quiron Salud Group) ;
Cardona Zorrilla, Andrés Felipe (Clínica del Country) ;
Palmero, Ramon (L'Hospitalet) ;
Sainz, Cristina (Centro de Investigación Biomédica en Red de Cáncer) ;
Mesa-Guzmán, Miguel (Universidad Pública de Navarra) ;
Lozano, Maria D. (Universidad Pública de Navarra) ;
Aguilar-Hernández, Andrés (Grup Quirónsalud (Barcelona, Catalunya)) ;
Martínez-Bueno, Alejandro (Grup Quirónsalud (Barcelona, Catalunya)) ;
González-Cao, María (Grup Quirónsalud (Barcelona, Catalunya)) ;
Gonzalvo, Elena (Hospital Clínic i Provincial de Barcelona) ;
Leenders, William P. J. (Radboud Institute for Molecular Life Sciences) ;
Rosell, Rafael (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Montuenga, Luis M. (Universidad Pública de Navarra) ;
Prat, Aleix (Hospital Clínic i Provincial de Barcelona) ;
Molina-Vila, Miguel Ángel (Quirón Dexeus University Hospital) ;
Reguart, Noemi (Hospital Clínic i Provincial de Barcelona)
We studied MET alterations in 474 advanced non-small-cell lung cancer (NSCLC) patients by nCounter, an RNA-based technique. We identified 3% with MET Δex14 mRNA and 3. 5% with very-high MET mRNA expression, a surrogate of MET amplification. [...]
2020 - 10.1002/1878-0261.12861
Molecular Oncology, Vol. 15 (december 2020) , p. 350-363
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9.
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13 p, 2.9 MB |
BRAF mutations classes I, II, and III in NSCLC patients included in the SLLIP trial : The need for a new pre-clinical treatment rationale
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Bracht, Jillian (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Karachaliou, Niki (Hospital Universitari Sagrat Cor. Institut Oncològic Rosell) ;
Bivona, Trever (University of California. Department of Medicine) ;
Lanman, Richard B. (Guardant Health) ;
Faull, Iris (Guardant Health) ;
Nagy, Rebecca J. (Guardant Health) ;
Drozdowskyj, Ana (PIVOTAL SL) ;
Berenguer, Jordi (Institut Universitari Quirón-Dexeus. Laboratori de Biologia Molecular) ;
Fernandez-Bruno, Manuel (Hospital Universitario Sagrat Cor. Institut Oncològic Rosell) ;
Molina-Vila, Miguel Ángel (Institut Universitari Quirón-Dexeus. Laboratori de Biologia Molecular) ;
Rosell, Rafael (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
BRAF V600 mutations have been found in 1-2% of non-small-cell lung cancer (NSCLC) patients, with Food and Drug Administration (FDA) approved treatment of dabrafenib plus trametinib and progression free survival (PFS) of 10. [...]
2019 - 10.3390/cancers11091381
Cancers, Vol. 11, Issue 9 (September 2019) , art. 1381
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10.
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12 p, 1.4 MB |
Co-activation of STAT3 and YES-Associated Protein 1 (YAP1) Pathway in EGFR-Mutant NSCLC
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Chaib, Imane (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Karachaliou, Niki (Instituto Oncológico Dr. Rosell, Institut Universitari Quirón-Dexeus) ;
Pilotto, Sara (Medical Oncology, Azienda Ospedaliera Universitaria Integrata, University of Verona) ;
Codony-Servat, Jordi (Pangaea Biotech, Laboratory of Molecular Biology) ;
Cai, Xueting (Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine) ;
Li, Xuefei (Shangai Pulmonary Hospital, Tongji University School of Medicine, Shangai) ;
Drozdowskyj, Ana (Pivotal, Madrid) ;
Codony Servat, Carles (Pangaea Biotech, Laboratory of Molecular Biology) ;
Yang, Jie (Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine) ;
Hu, Chunping (Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine) ;
Cardona Zorrilla, Andrés Felipe (Clinica del Country, Bogotá) ;
Lopez Vivanco, Guillermo (Hospital Universitario de Cruces (Barakaldo, País Basc)) ;
Vergnenegre, Alain (Service de Pathologie Respiratoire et d'Allergologie, CHU, Limoges France) ;
Sanchez, Jose Miguel (Hospital Universitario de la Princesa (Madrid)) ;
Provencio, Mariano (Hospital Universitario Puerta de Hierro Majadahonda (Madrid)) ;
Marinis, Filippo de (Hospital Universitario de Cruces (Barakaldo, País Basc)) ;
Passaro, Antonio (Hospital Universitario de Cruces (Barakaldo, País Basc)) ;
Carcereny, Enric (Service de Pathologie Respiratoire et d'Allergologie, CHU, Limoges France) ;
Reguart, Noemi (Hospital Clínic i Provincial de Barcelona) ;
Garcia Campelo, Charo (Hospital Universitario de la Princesa (Madrid)) ;
Teixidó, Cristina (Pangaea Biotech, Laboratory of Molecular Biology) ;
Sperduti, Isabella (Hospital Universitario Puerta de Hierro Majadahonda (Madrid)) ;
Rodriguez, Sonia (Pangaea Biotech, Laboratory of Molecular Biology) ;
Lavazzi, Chiara (Hospital Universitario de Cruces (Barakaldo, País Basc)) ;
Verlicchi, Alberto (Hospital Clínic i Provincial de Barcelona) ;
Aguirre, Itziar de (Institut Germans Trias i Pujol) ;
Queralt, C (Institut Germans Trias i Pujol) ;
Wei, Jia (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Estrada-Tejedor, Roger (WVU Cancer Institute, West Virginia University, Morgantown, WV, USA) ;
Puig de la Bellacasa, Raimon (WVU Cancer Institute, West Virginia University, Morgantown, WV, USA) ;
Ramirez, Jose Luis (Institut Germans Trias i Pujol) ;
Jacobson, Kirstine (WV Clinical and Translational Science Institute, Morgantown, WV, USA) ;
Ditzel, Henrik J. (WV Clinical and Translational Science Institute, Morgantown, WV, USA) ;
Santarpia, Mariacarmela (UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, CA, USA) ;
Viteri, Santiago (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Molina, Miguel Angel (Pangaea Biotech, Laboratory of Molecular Biology) ;
Zhou, Caicun (Shangai Pulmonary Hospital, Tongji University School of Medicine, Shangai) ;
Cao, Peng (Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, China) ;
Ma, Patrick C. (WVU Cancer Institute, West Virginia University, Morgantown, WV, USA) ;
Bivona, Trever (UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, CA, USA) ;
Rosell, Rafael (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Background: The efficacy of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) in EGFR-mutant non- small cell lung cancer (NSCLC) is limited by adaptive activation of cell survival signals. [...]
2017
Journal of the National Cancer Institute, Vol. 109 (september 2017) , p. 1-12
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