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1.
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12 p, 2.6 MB |
Traffic Lights Intervention Reduces Therapeutic Inertia : A Randomized Controlled Trial in Multiple Sclerosis Care
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Saposnik, Gustavo (St. Michael's Hospital, Toronto) ;
Mamdani, Muhammad (Li Ka Shing Centre for Healthcare Analytics Research and Training (LKS-CHART)) ;
Montalban, Xavier (Hospital Universitari Vall d'Hebron) ;
Terzaghi, Maria (St. Michael's Hospital, Toronto) ;
Silva, Berenice (Institute of Neuroscience Buenos Aires (INEBA)) ;
Saladino, Maria Laura (Institute of Neuroscience Buenos Aires (INEBA)) ;
Tobler, Philippe N. (University of Zurich) ;
Caceres, Fernando (Institute of Neuroscience Buenos Aires (INEBA)) ;
Universitat Autònoma de Barcelona.
Departament de Medicina
Background: Therapeutic inertia (TI) is a common phenomenon among physicians who care for patients with chronic conditions. We evaluated the efficacy of the traffic light system (TLS) educational intervention to reduce TI among neurologists with MS expertise. [...]
2019 -  10.1177/2381468319855642
MDM Policy and Practice, Vol. 4 Núm. 1 (2019) , p. 1-12
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2.
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5 p, 336.0 KB |
Does attendance at the ECTRIMS congress impact on therapeutic decisions in multiple sclerosis care?
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Saposnik, Gustavo (University of Zurich) ;
Maurino, Jorge (University of Buenos Aires) ;
Sempere, Angel P. (Hospital General Universitario de Alicante (Alacant, País Valencià)) ;
Terzaghi, Maria A. (St. Michael's Hospital, Toronto) ;
Amato, Maria Pia (University of Florence) ;
Montalban, Xavier (Hospital Universitari Vall d'Hebron) ;
Universitat Autònoma de Barcelona.
Departament de Medicina
Conferences traditionally play an important role in the ongoing medical education of healthcare professionals. We assessed the influence of attending the ECTRIMS congress on therapeutic decision-making in multiple sclerosis (MS) care. [...]
2019 - 10.1177/2055217319835226
Multiple Sclerosis Journal - Experimental, Translational and Clinical, Vol. 5 Núm. 1 (1-3 2019) , p. 205521731983522
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3.
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10 p, 1.1 MB |
The Multiple Sclerosis Care Unit
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Sørensen, Per S (Copenhagen University Hospital) ;
Giovannoni, Gavin (Queen Mary University of London) ;
Montalban, Xavier (Hospital Universitari Vall d'Hebron) ;
Thalheim, Christoph (European Multiple Sclerosis Platform, Brussels) ;
Zaratin, Paola (Multiple Sclerosis International Federation (MSIF)) ;
Comi, Giancarlo (San Raffaele Hospital, Milan) ;
Universitat Autònoma de Barcelona.
Departament de Medicina
Treatment of multiple sclerosis (MS) has become increasingly multifaceted and comprises not only a variety of disease-modifying drugs with different mechanism of action but also a wide range of symptomatic therapies. [...]
2019 - 10.1177/1352458518807082
Multiple sclerosis, Vol. 25 Núm. 5 (april 2019) , p. 627-636
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4.
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11 p, 1.0 MB |
Retinal inner nuclear layer volume reflects inflammatory disease activity in multiple sclerosis; a longitudinal OCT study
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Balk, Lisanne J. (Vrije Universiteit Amsterdam) ;
Coric, Danko (Vrije Universiteit Amsterdam) ;
Knier, Benjamin (Technische Universität München) ;
Zimmermann, Hanna G. (Charité - Universitätsmedizin Berlin) ;
Behbehani, Raed (Ibn Sina Hospital, Kuwait) ;
Alroughani, Raed (Amiri Hospital, Kuwait) ;
Martinez-Lapiscina, Elena H. (Hospital Clínic i Provincial de Barcelona) ;
Brandt, Alexander U. (Charité - Universitätsmedizin Berlin) ;
Sánchez-Dalmau, Bernardo (Hospital Clínic i Provincial de Barcelona) ;
Vidal-Jordana, Angela (Hospital Universitari Vall d'Hebron) ;
Albrecht, Philipp (Heinrich Heine University) ;
Koska, Valeria (Heinrich Heine University) ;
Havla, Joachim (Ludwig-Maximilians Universitaet Muenchen) ;
Pisa, Marco (Vita-Salute San Raffaele University) ;
Nolan, Rachel C. (New York University School of Medicine) ;
Leocani, Letizia (Vita-Salute San Raffaele University) ;
Paul, Friedemann (Max Delbrueck Center for Molecular Medicine and Charité - Universitätsmedizin Berlin) ;
Aktas, Orhan (Heinrich Heine University) ;
Montalban, Xavier (Hospital Universitari Vall d'Hebron) ;
Balcer, Laura J. (New York University School of Medicine) ;
Villoslada, Pablo (Hospital Clínic i Provincial de Barcelona) ;
Outteryck, Olivier (Université Lille) ;
Korn, Thomas (Munich Cluster for Systems Neurology (SyNergy)) ;
Petzold, Axel (Moorfields Eye Hospital & The National Hospital for Neurology and Neurosurgery) ;
Universitat Autònoma de Barcelona.
Departament de Medicina
Background: The association of peripapillary retinal nerve fibre layer (pRNFL) and ganglion cell-inner plexiform layer (GCIPL) thickness with neurodegeneration in multiple sclerosis (MS) is well established. [...]
2019 - 10.1177/2055217319871582
Multiple Sclerosis Journal - Experimental, Translational and Clinical, Vol. 5 Núm. 3 (2019)
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5.
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9 p, 570.9 KB |
Pregnancy Outcomes During the Clinical Development Program of Cladribine in Multiple Sclerosis : An Integrated Analysis of Safety
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Giovannoni, Gavin (Queen Mary University of London) ;
Galazka, Andrew (Merck. Aubonne. Switzerland. a division of Merck KGaA) ;
Schick, Regina (Merck KGaA) ;
Leist, Thomas (Jefferson University) ;
Comi, Giancarlo (Università Vita-Salute San Raffaele. Ospedale San Raffaele) ;
Montalban, Xavier (Hospital Universitari Vall d'Hebron) ;
Damian, Doris (EMD Serono Research and Development Institute. Inc) ;
Dangond, Fernando (EMD Serono Research and Development Institute. Inc) ;
Cook, Stuart (The State University of New Jersey) ;
Universitat Autònoma de Barcelona.
Departament de Medicina
Introduction: Although use of contraception was pre-specified during cladribine clinical trials for multiple sclerosis, some pregnancies did occur. Objective: This analysis reports on pregnancy outcomes in the cladribine clinical development program. [...]
2020 - 10.1007/s40264-020-00948-x
Drug Safety, Vol. 43 Núm. 7 (july 2020) , p. 635-643
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6.
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14 p, 1.0 MB |
Long-term safety and efficacy of daclizumab beta in relapsing-remitting multiple sclerosis : 6-year results from the SELECTED open-label extension study
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Gold, Ralf (Ruhr-University Bochum) ;
Radue, Ernst-Wilhem (University Hospital Basel (Basilea, Suïssa)) ;
Giovannoni, Gavin (Queen Mary University of London) ;
Selmaj, Krzysztof. (University of Warmia and Mazury) ;
Havrdova, Eva Kubala (Charles University) ;
Montalban, Xavier (Hospital Universitari Vall d'Hebron) ;
Stefoski, Dusan (Rush University Medical Center) ;
Sprenger, Till (DKD Helios Klinik Wiesbaden) ;
Robinson, Randy R. (AbbVie Inc.) ;
Fam, Sami (Biogen) ;
Smith, Jonathan (Biogen) ;
Chalkias, Spyros (Biogen) ;
Giannattasio, Giorgio (Biogen) ;
Lima, Gabriel (Biogen) ;
Castro-Borrero, Wanda (Biogen) ;
Universitat Autònoma de Barcelona
Objective: SELECTED, an open-label extension study, evaluated daclizumab beta treatment for up to 6 years in participants with relapsing multiple sclerosis who completed the randomized SELECT/SELECTION studies. [...]
2020 - 10.1007/s00415-020-09835-y
Journal of Neurology, Vol. 267 Núm. 10 (january 2020) , p. 2851-2864
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7.
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11 p, 473.7 KB |
Effectiveness of delayed-release dimethyl fumarate on patient-reported outcomes and clinical measures in patients with relapsing-remitting multiple sclerosis in a real-world clinical setting : PROTEC
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Berger, Thomas (Universitätsklinik für Neurologie) ;
Brochet, B. (Groupe Hospitalier Pellegrin Hôpital Pellegrin) ;
Brambilla, L. (IRCCS Foundation Neurological Institute Carlo Besta) ;
Giacomini, P.S. (Montreal Neurological Institute Hospital) ;
Montalban, Xavier (Hospital Universitari Vall d'Hebron) ;
Vasco Salgado, A (Hospital Professor Doutor Fernando Fonseca) ;
Su, R (Biogen, USA) ;
Bretagne, A (Biogen International GmbH) ;
Universitat Autònoma de Barcelona.
Departament de Medicina
Background: Patient-reported outcomes (PRO) and clinical outcomes give a broad assessment of relapsing-remitting multiple sclerosis (RRMS) disease. Objective: The aim is to evaluate the effectiveness of delayed-release dimethyl fumarate (DMF) on disease activity and PROs in patients with RRMS in the clinic. [...]
2019 - 10.1177/2055217319887191
Multiple Sclerosis Journal - Experimental, Translational and Clinical, Vol. 5 Núm. 4 (2019)
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8.
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11 p, 1.1 MB |
Safety of cladribine tablets in the treatment of patients with multiple sclerosis : An integrated analysis
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Cook, Stuart (Rutgers. The State University of New Jersey) ;
Leist, Thomas (Jefferson University) ;
Comi, Giancarlo (Università Vita-Salute San Raffaele) ;
Montalban, Xavier (Hospital Universitari Vall d'Hebron) ;
Giovannoni, Gavin (Queen Mary University of London) ;
Nolting, Axel (Merck KGaA) ;
Hicking, Christine (Merck KGaA) ;
Galazka, Andrew (Merck. Zone Industrielle de L'Ouriettaz) ;
Sylvester, Elke (Merck KGaA) ;
Universitat Autònoma de Barcelona.
Departament de Medicina
Background: Treating patients with relapsing multiple sclerosis (MS) with cladribine tablets (two times 4 or 5 days of treatment each year for 2 years) results in long-lasting efficacy, with continued stability in many patients for 4 or more years. [...]
2019 - 10.1016/j.msard.2018.11.021
Multiple Sclerosis and Related Disorders, Vol. 29 (april 2019) , p. 157-167
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9.
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17 p, 300.8 KB |
Expert opinion on the use of cladribine tablets in clinical practice
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Sørensen, Per Soelberg (University of Copenhagen) ;
Centonze, Diego (Unit of Neurology and Neurorehabilitation) ;
Giovannoni, Gavin (Queen Mary University of London) ;
Montalban, Xavier (Hospital Universitari Vall d'Hebron) ;
Selchen, Daniel (St. Michael's Hospital, Toronto) ;
Vermersch, Patrick (Univ. Lille) ;
Wiendl, Heinz (University of Münster) ;
Yamout, Bassem (American University of Beirut) ;
Salloukh, Hashem (Ares Trading S.A. Merck Serono S.A) ;
Rieckmann, Peter (University of Erlangen) ;
Universitat Autònoma de Barcelona.
Departament de Medicina
Background: Gaps in current product labels and a lack of detailed clinical guidelines leaves clinicians' questions on the practical management of patients receiving cladribine tablets for the treatment of relapsing multiple sclerosis (MS) unanswered. [...]
2020 - 10.1177/1756286420935019
Therapeutic Advances in Neurological Disorders, Vol. 13 (2020)
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10.
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15 p, 1.4 MB |
Critical role of interleukin (IL)-17 in inflammatory and immune disorders : An updated review of the evidence focusing in controversies
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Ruiz de Morales, José María G. (Universidad de León) ;
Puig, Lluís (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Daudén, Esteban (Hospital Universitario de la Princesa (Madrid)) ;
Cañete, Juan D. (Hospital Clínic i Provincial de Barcelona) ;
Pablos, José Luis (Hospital Universitario 12 de Octubre (Madrid)) ;
Martín, Antonio Oliveira (Hospital Universitario La Paz (Madrid)) ;
Juanatey, Carlos González (Hospital Universitario Lucus Augusti (Lugo)) ;
Adan Civera, Alfredo (Hospital Clínic i Provincial de Barcelona) ;
Montalban, Xavier (Hospital Universitari Vall d'Hebron) ;
Borruel, Natalia (Hospital Universitari Vall d'Hebron) ;
Ortí, Guillermo (Vall d'Hebron Institut d'Oncologia) ;
Holgado-Martín, Esther (Ruber Internacional) ;
Garcia-Vidal, Carolina (Hospital Clínic i Provincial de Barcelona) ;
Vizcaya-Morales, Cynthia (Novartis Pharma) ;
Martín-Vázquez, Víctor (Novartis Farmacéutica) ;
González-Gay, Miguel Ángel (Universidad de Cantabria)
Interleukin 17 (IL-17) is a proinflammatory cytokine that has been the focus of intensive research because of its crucial role in the pathogenesis of different diseases across many medical specialties. [...]
2020 - 10.1016/j.autrev.2019.102429
Autoimmunity Reviews, Vol. 19 Núm. 1 (january 2020) , p. 102429
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