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Articles, 18 records found
Research literature, 20 records found
Articles 18 records found  1 - 10next  jump to record:
1.
9 p, 239.4 KB Optic Nerve Topography in Multiple Sclerosis Diagnosis / Vidal-Jordana, Angela (Hospital Universitari Vall d'Hebron) ; Rovira, Alex (Hospital Universitari Vall d'Hebron) ; Arrambide, Georgina (Hospital Universitari Vall d'Hebron) ; Otero-Romero, Susana (Hospital Universitari Vall d'Hebron) ; Río, Jordi (Hospital Universitari Vall d'Hebron) ; Comabella, Manuel (Hospital Universitari Vall d'Hebron) ; Nos, Carlos (Hospital Universitari Vall d'Hebron) ; Castilló, Joaquin (Hospital Universitari Vall d'Hebron) ; Galan, Ingrid (Hospital Universitari Vall d'Hebron) ; Cabello, Sergio (Hospital Universitari Vall d'Hebron) ; Moncho, Dulce (Hospital Universitari Vall d'Hebron) ; Rahnama, Kimia (Hospital Universitari Vall d'Hebron) ; Thonon, Vanessa (Hospital Universitari Vall d'Hebron) ; Rodríguez-Acevedo, Breogan (Hospital Universitari Vall d'Hebron) ; Zabalza, Ana (Hospital Universitari Vall d'Hebron) ; Midaglia, Luciana (Hospital Universitari Vall d'Hebron) ; Auger, Cristina (Hospital Universitari Vall d'Hebron) ; Sastre-Garriga, Jaume (Hospital Universitari Vall d'Hebron) ; Montalban, Xavier (Hospital Universitari Vall d'Hebron) ; Tintoré, Mar (Hospital Universitari Vall d'Hebron) ; Universitat Autònoma de Barcelona
To assess the added value of the optic nerve region (by using visual evoked potentials [VEPs]) to the current diagnostic criteria. From the Barcelona clinically isolated syndrome (CIS) cohort, patients with complete information to assess dissemination in space (DIS), the optic nerve region, and dissemination in time at baseline (n = 388) were selected. [...]
2021 - 10.1212/WNL.0000000000011339
Neurology, Vol. 96 (january 2021) , p. e482-e490  
2.
12 p, 2.1 MB The long-term outcomes of CIS patients in the Barcelona inception cohort : Looking back to recognize aggressive MS / Tintoré, Mar (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Arrambide, Georgina (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Otero-Romero, Susana (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Carbonell-Mirabent, Pere (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Río, Jordi (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Tur, Carmen (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Comabella, Manuel (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Nos, Carlos (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Arévalo, María Jesús (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Anglada, Elisenda (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Menendez, Rebeca (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Midaglia, Luciana (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Galán, Ingrid (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Vidal-Jordana, Angela (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Castilló, Joaquin (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Mulero, P (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Zabalza, Ana (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Rodríguez-Acevedo, Breogan (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Rodriguez, Marta (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Espejo, Carmen (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Sequeira, Joao (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Mitjana, Raquel (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; de Barros, Andrea (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Pareto, Deborah (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Auger, Cristina (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Pérez-Hoyos, Santiago (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Sastre-Garriga, Jaume (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Rovira, Alex (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Montalban, Xavier (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Universitat Autònoma de Barcelona
To explore the long-term outcomes of patients with clinically isolated syndromes from the Barcelona cohort. We selected patients with a follow-up longer than 10 years to (1) estimate the risks of multiple sclerosis (MS) and disability accumulation according to the baseline number of T2 lesions and to compare treated versus untreated patients and early versus delayed treatment, and (2) to study baseline features of patients with aggressive MS (Expanded Disability Status Scale (EDSS) ⩾6. [...]
2019 - 10.1177/1352458519877810
Multiple sclerosis, Vol. 26 (october 2019) , p. 1658-1669  
3.
9 p, 776.0 KB Multiple sclerosis management during the COVID-19 pandemic / Moss, Brandon P ; Mahajan, Kedar R ; Bermel, Robert A ; Hellisz, Kelsey ; Hua, Le H ; Hudec, Timothy ; Husak, Scott ; McGinley, Marisa P ; Ontaneda, Daniel ; Wang, Zhini ; Weber, Malory ; Tagliani, Paula (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Cárdenas-Robledo, Simón (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Zabalza, Ana (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Arrambide, Georgina (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Carbonell-Mirabent, Pere (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Rodríguez-Barranco, Marta (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Sastre-Garriga, Jaume (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Tintoré, Mar (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Montalban, Xavier (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Douglas, Morgan ; Ogbuokiri, Esther ; Aravidis, Berna ; Cohen, Jeffrey A ; Mowry, Ellen M ; Fitzgerald, Kathryn C ; Universitat Autònoma de Barcelona
People with multiple sclerosis (MS) may be at higher risk for complications from the 2019 coronavirus (COVID-19) pandemic due to use of immunomodulatory disease modifying therapies (DMTs) and greater need for medical services. [...]
2020 - 10.1177/1352458520948231
Multiple sclerosis, august 2020  
4.
10 p, 1.6 MB Exome sequencing study in patients with multiple sclerosis reveals variants associated with disease course / Gil-Varea, Elia (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Urcelay, Elena (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC)) ; Vilariño-Güell, Carles (University of British Columbia. Department of Medical Genetics) ; Costa, Carme (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Midaglia, Luciana (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Matesanz, Fuencisla (Instituto de Parasitología y Biomedicina "López-Neyra") ; Rodríguez-Antigüedad, Alfredo (Hospital Universitario Basurto-Osakidetza. Servicio de Neurología) ; Oksenberg, Jorge (University of California. Department of Neurology) ; Espino-Paisan, Laura (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC)) ; Dessa Sadovnick, A. (University of British Columbia. Department of Medical Genetics) ; Saiz, Albert (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Villar, Luisa M. (Instituto Ramón y Cajal de Investigación Sanitaria (Madrid)) ; García-Merino, Juan Antonio (Hospital Universitario Puerta de Hierro Majadahonda (Madrid)) ; Ramió-Torrentà, Lluís (Hospital Universitari de Girona Doctor Josep Trueta) ; Triviño, Juan Carlos (Genomic Systems, Valencia, Spain) ; Quintana, Ester (Hospital Universitari de Girona Doctor Josep Trueta) ; Robles, René (Hospital Universitari de Girona Doctor Josep Trueta) ; Sánchez-López, Antonio (Hospital Universitario Puerta de Hierro Majadahonda (Madrid)) ; Arroyo, Rafael (Hospital Universitario Quirón Salud. Servicio de Neurología) ; Alvarez-Cermeño, Jose C. (Instituto Ramón y Cajal de Investigación Sanitaria (Madrid)) ; Vidal-Jordana, Angela (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Malhotra, Sunny (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Fissolo, Nicolas (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Montalban, Xavier (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Comabella, Manuel (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Universitat Autònoma de Barcelona
It remains unclear whether disease course in multiple sclerosis (MS) is influenced by genetic polymorphisms. Here, we aimed to identify genetic variants associated with benign and aggressive disease courses in MS patients. [...]
2018 - 10.1186/s12974-018-1307-1
Journal of neuroinflammation, Vol. 15 (september 2018)  
5.
8 p, 976.6 KB Efficacy and safety of ozanimod in multiple sclerosis : Dose-blinded extension of a randomized phase II study / Cohen, Jeffrey A ; Comi, Giancarlo ; Arnold, Douglas L ; Bar-Or, Amit ; Selmaj, Krzysztof W ; Steinman, Lawrence ; Havrdová, Eva K ; Cree, Bruce AC ; Montalbán, Xavier (Universitat Autònoma de Barcelona. Departament de Medicina) ; Hartung, Hans-Peter ; Huang, Vivian ; Frohna, Paul ; Skolnick, Brett E ; Kappos, Ludwig
Ozanimod, an oral immunomodulator, selectively targets sphingosine 1-phosphate receptors 1 and 5. Evaluate efficacy, safety, and tolerability of ozanimod in relapsing multiple sclerosis. In the RADIANCE Part A phase II study (NCT01628393), participants with relapsing multiple sclerosis were randomized (1:1:1) to once-daily ozanimod hydrochloride (0. [...]
2018 - 10.1177/1352458518789884
Multiple sclerosis, Vol. 25 (july 2018) , p. 1255-1262  
6.
12 p, 1.5 MB MAGNIMS consensus recommendations on the use of brain and spinal cord atrophy measures in clinical practice / Sastre-Garriga, Jaume (Centre d'Esclerosi Mútiple de Catalunya (Cemcat)) ; Pareto, Deborah (Hospital Universitari Vall d'Hebron) ; Battaglini, Marco (University of Siena. Department of Medicine, Surgery and Neuroscience) ; Rocca, Maria A. (IRCCS San Raffaele Scientific Institute (Milà, Itàlia). Institute of Experimental Neurology) ; Ciccarelli, Olga (University College London Hospitals. National Institute for Health Research Biomedical Research Centre) ; Enzinger, Christian (Medical University of Graz. Department of Neurology and Division of Neuroradiology, Vascular and Interventional Radiology, Department of Radiology) ; Wuerfel, Jens (University of Basel. Medical Image Analysis Center (MIAC AG) and Department of Biomedical Engineering) ; Sormani, Maria P. (IRCCS, Ospedale Policlinico San Martino, Genoa) ; Barkhof, Frederik (University College London. Institutes of Neurology and Healthcare Engineering) ; Yousry, Tarek A. (University College London Hospitals National Hospital for Neurology and Neurosurgery, University College London Institute of Neurology. Lysholm Department of Neuroradiology) ; De Stefano, Nicola (University of Siena. Department of Medicine, Surgery and Neuroscience) ; Tintoré, Mar (Centre d'Esclerosi Mútiple de Catalunya (Cemcat)) ; Filippi, Massimo (Vita-Salute San Raffaele University) ; Gasperini, Claudio (San Camillo-Forlanini Hospital. Multiple Sclerosis Center, Department of Neurosciences) ; Kappos, Ludwig (Neurologic Clinic and Policlinic, Departments of Medicine, Clinical Research and Biomedical Engineering, University Hospital, University of Basel) ; Río, Jordi (Universitat Autònoma de Barcelona) ; Frederiksen, Jette (University of Copenhagen) ; Palace, Jackie (University of Oxford. Nuffield Department of Clinical Neurosciences) ; Vrenken, Hugo (Amsterdam Neuroscience, MS Center Amsterdam, Department of Radiology and Nuclear Medicine, Amsterdam UMC) ; Montalban, Xavier (University of Toronto. Division of Neurology, St Michael's Hospital) ; Rovira, Alex (Hospital Universitari Vall d'Hebron) ; Universitat Autònoma de Barcelona ; Hospital Universitari Vall d'Hebron ; Centre d'Esclerosi Mútiple de Catalunya (Cemcat)
Early evaluation of treatment response and prediction of disease evolution are key issues in the management of people with multiple sclerosis (MS). In the past 20 years, MRI has become the most useful paraclinical tool in both situations and is used clinically to assess the inflammatory component of the disease, particularly the presence and evolution of focal lesions - the pathological hallmark of MS. [...]
2020 - 10.1038/s41582-020-0314-x
Nature Reviews. Neurology, Vol. 16 (february 2020) , p. 171-182  
7.
10 p, 331.3 KB Menarche, pregnancies, and breastfeeding do not modify long-term prognosis in multiple sclerosis / Zuluaga, M.I. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Otero-Romero, Susana (Hospital Universitari Vall d'Hebron) ; Rovira, Alex (Hospital Universitari Vall d'Hebron) ; Pérez-Hoyos, Santiago (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Arrambide, Georgina (Hospital Universitari Vall d'Hebron) ; Negrotto, L. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Galán, Infrid (Hospital Universitari Vall d'Hebron) ; Río, Jordi (Hospital Universitari Vall d'Hebron) ; Comabella, Manuel (Hospital Universitari Vall d'Hebron) ; Nos, Carlos. (Hospital Universitari Vall d'Hebron) ; Arévalo, María Jesús (Hospital Universitari Vall d'Hebron) ; Vidal-Jordana, Angela (Hospital Universitari Vall d'Hebron) ; Castilló, Joaquín (Hospital Universitari Vall d'Hebron) ; Rodríguez Acevedo, Breogán (Hospital Universitari Vall d'Hebron) ; Midaglia, Luciana (Hospital Universitari Vall d'Hebron) ; Mulero, P. (Hospital Universitari Vall d'Hebron) ; Mitjana, Raquel (Hospital Universitari Vall d'Hebron) ; Auger, Cristina (Hospital Universitari Vall d'Hebron) ; Sastre-Garriga, Jaume (Hospital Universitari Vall d'Hebron) ; Montalban, Xavier (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Tintoré, Mar (Division of Neurology. St. Michael's Hospital. University of Toronto) ; Universitat Autònoma de Barcelona
ObjectiveTo investigate the effect of menarche, pregnancies, and breastfeeding on the risk of developing multiple sclerosis (MS) and disability accrual using a multivariate approach based on a large prospective cohort of patients with clinically isolated syndrome (CIS). [...]
2019 - 10.1212/WNL.0000000000007178
Neurology, Vol. 92 Núm. 13 (26 2019) , p. E1507-E1516  
8.
12 p, 8.9 MB Expression of Bone Morphogenetic Proteins in Multiple Sclerosis Lesions / Costa, Carme (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Eixarch, Herena (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Martinez-Saez, Elena (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Calvo-Barreiro, Laura (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Calucho, Maite (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Castro, Zoraida (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Ortega-Aznar, Arantxa (Hospital Universitari Vall d'Hebron) ; Ramón y Cajal, Santiago (Hospital Universitari Vall d'Hebron) ; Montalban, Xavier (University of Toronto) ; Espejo, Carmen (Hospital Universitari Vall d'Hebron) ; Universitat Autònoma de Barcelona
Bone morphogenetic proteins (BMPs) are secreted proteins that belong to the transforming growth factor-β superfamily. In the adult brain, they modulate neurogenesis, favor astrogliogenesis, and inhibit oligodendrogenesis. [...]
2019 - 10.1016/j.ajpath.2018.11.007
American Journal of Pathology, Vol. 189 Núm. 3 (march 2019) , p. 665-676  
9.
15 p, 948.8 KB Adherence and satisfaction of smartphone- And smartwatch-based remote active testing and passive monitoring in people with multiple sclerosis : Nonrandomized interventional feasibility study / Midaglia, Luciana. (Universitat Autònoma de Barcelona. Departament de Medicina) ; Mulero, P. (Hospital Universitari Vall d'Hebron. Centre d'Esclerosi Mútiple de Catalunya) ; Montalban, Xavier (University of Toronto) ; Graves, Jennifer (Department of Neurology. University of California) ; Hauser, Stephen L. (Department of Neurology. University of California) ; Julian, Laura (Genentech Inc) ; Baker, Michael (F Hoffmann-La Roche Ltd) ; Schadrack, Jan (F Hoffmann-La Roche Ltd) ; Gossens, Christian (F Hoffmann-La Roche Ltd) ; Scotland, Alf (F Hoffmann-La Roche Ltd) ; Lipsmeier, Florian (F Hoffmann-La Roche Ltd) ; Van Beek, Johan (F Hoffmann-La Roche Ltd) ; Bernasconi, Corrado (F Hoffmann-La Roche Ltd) ; Belachew, Shibeshih (F Hoffmann-La Roche Ltd) ; Lindemann, Michael (Department of Economics. Baden-Wuerttemberg Cooperative State University)
Background: Current clinical assessments of people with multiple sclerosis are episodic and may miss critical features of functional fluctuations between visits. Objective: The goal of the research was to assess the feasibility of remote active testing and passive monitoring using smartphones and smartwatch technology in people with multiple sclerosis with respect to adherence and satisfaction with the FLOODLIGHT test battery. [...]
2019 - 10.2196/14863
Journal of medical Internet research, Vol. 21 Núm. 8 (2019) , p. e14863  
10.
10 p, 237.0 KB Native ancestry is associated with optic neuritis and age of onset in hispanics with multiple sclerosis / Amezcua, Lilyana (University of Southern California) ; Beecham, Ashley H. (University of Miami. Miller School of Medicine) ; Delgado, Silvia R. (University of Miami. Miller School of Medicine) ; Chinea, Angel (San Juan Multiple Sclerosis Center (Puerto Rico)) ; Burnett, Margaret (University of Southern California) ; Manrique, Clara Patricia (University of Miami. Miller School of Medicine) ; Gomez, Refujia (University of Southern California) ; Comabella, Manuel (University of San Francisco School of Medicine) ; Montalban, Xavier (University of San Francisco School of Medicine) ; Ortega, Melissa (University of Miami. Miller School of Medicine) ; Tornes, Leticia (University of Miami. Miller School of Medicine) ; Lund, Brett T. (University of Southern California) ; Islam, Talat (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Conti, David (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Oksenberg, Jorge R. (University of Southern California) ; McCauley, Jacob L. (University of Miami. Miller School of Medicine) ; Universitat Autònoma de Barcelona
Hispanics with multiple sclerosis (MS) present younger and more often with optic neuritis (ON) as compared to Whites in the western United States. Regional differences related to Hispanic genetic admixture could be responsible. [...]
2018 - 10.1002/acn3.646
Annals of Clinical and Translational Neurology, Vol. 5, Issue 11 (November 2018) , p. 1362-1371  

Articles : 18 records found   1 - 10next  jump to record:
Research literature 20 records found  1 - 10next  jump to record:
1.
209 p, 29.1 MB The gut microbiota as a therapeutic target in multiple sclerosis / Calvo Barreiro, Laura ; Espejo, Carmen, dir. ; Eixarch Ahufinger, Herena, dir. ; Montalbán Gairín, Xavier, dir. ; Fonollosa Pla, Vicent, dir.
L'esclerosi múltiple (EM) és una malaltia crònica i degenerativa, i el trastorn inflamatori desmielinitzant del sistema nerviós central (SNC) més comú arreu del món. Tot i que la seva etiologia autoimmune encara es desconeix, en la seva patogènia participen tant la resposta immune innata com l'adaptativa. [...]
La esclerosis múltiple (EM) es una enfermedad crónica y degenerativa y el trastorno inflamatorio desmielinizante del sistema nervioso central (SNC) más común en todo el mundo. Aunque su etiología autoinmune todavía no está clara, en su patogenia participan tanto la respuesta inmune innata como la adaptativa. [...]
Multiple sclerosis (MS) is a chronic and degenerative disease and the most common inflammatory demyelinating disorder of the central nervous system (CNS) worldwide. Although its autoimmune aetiology is still unclear, both innate and adaptive immune responses participate in MS pathogenesis. [...]

2020  
2.
244 p, 4.1 MB Búsqueda de variantes genéticas causales y estudio de sus implicaciones funcionales en pacientes con esclerosis múltiple / Gil Varea, Elia ; Comabella, Manuel, dir. ; Malhotra, Sunny, 1984-, dir. ; Montalbán Gairín, Xavier, dir. ; Selva O'Callaghan, Albert, dir. ; Universitat Autònoma de Barcelona. Departament de Medicina
Varios estudios de asociación del genoma completo (GWAS) han contribuido a la caracterización del componente genético de la esclerosis múltiple (EM). Estos estudios examinan cientos de miles o millones de polimorfismos de un solo nucleótido (SNPs) distribuidos por todo el genoma. [...]
Several genome-wide association studies (GWAS) have contributed to the characterization of the genetic component of multiple sclerosis (MS). These studies examine hundreds of thousands or millions of single nucleotide polymorphisms (SNPs) distributed throughout the whole genome. [...]

[Barcelona] : Universitat Autònoma de Barcelona, 2019.  
3.
87 p, 1.1 MB Indicadores precoces de respuesta al tratamiento con interferón en pacientes con esclerosis múltiple / Castilló Justribó, Joaquín ; Montalban Gairin, Xavier, dir. ; Río Izquierdo, Jordi, dir. ; Fonollosa Pla, Vicent, dir. ; Universitat Autònoma de Barcelona. Departament de Medicina
Introducción: el tratamiento con interferón β sigue siendo la terapia inmunomoduladora más extendida en el tratamiento de la esclerosis múltiple remitente-recurrente si bien su eficacia es parcial. [...]
Introduction: treatment with interferon β remains the most widespread immunomodulatory therapy in the treatment of relapsing-remitting multiple sclerosis, although its efficacy is partial. In the absence of a specific biomarker of response, early identification of patients with treatment failure or a partial response is critical to defining therapeutic strategies. [...]

[Barcelona] : Universitat Autònoma de Barcelona, 2016  
4.
258 p, 3.6 MB Estudio del papel de los genes perforin 1 (PRF1), caspase 8 (CASP8) y B-cell translocation gene 1 (BTG1) en esclerosis múltiple / Camiña Tato, Montserrat ; Montalban Gairín, Xavier, dir. ; Comabella López, Manuel, dir. ; Vilardell Tarrés, Miquel, dir. ; Universitat Autònoma de Barcelona. Departament de Medicina
El estudio de las bases genéticas de las enfermedades es clave para un diagnóstico mejor y más rápido de las patologías así como, para su mejor tratamiento. En los últimos años se han descubierto un gran número de genes que pueden generar susceptibilidad a la EM, sin embargo, hay muchos que aún están pendientes de replicación en otras poblaciones. [...]
The study of the genetic basis of the diseases is key not only for a better and fast diagnostic of the diseases, but also for a better treatment. In recent years, many genes that confer susceptibility to MS have been discovered; however, many remain yet to be replicated in other populations. [...]

[Barcelona] : Universitat Autònoma de Barcelona, 2016  
5.
154 p, 2.5 MB Estudio del efecto de pseudoatrofia cerebral en pacientes con esclerosis múltiple remitente-recurrente / Vidal Jordana, Ángela ; Montalban Gairín, Xavier, dir. ; Sastre Garriga, Jaume, dir. ; Universitat Autònoma de Barcelona. Departament de Medicina
La esclerosis múltiple (EM) es una enfermedad crónica, inmunomediada y degenerativa que afecta principalmente a adulto jóvenes, siendo la segunda causa de discapacidad neurológica en esas edades. [...]
Multiple sclerosis (MS) is a chronic, immune-mediated and degenerative disease that primarily affects young adults. It is the second cause of neurological disability in this age group. Brain volume (BV) loss is known to occur since very early stages of the disease and it has been related to relevant clinical outcomes such as neurological disability. [...]

[Barcelona] : Universitat Autònoma de Barcelona, 2016  
6.
194 p, 1.2 MB Factores pronósticos no radiológicos de conversión a esclerosis múltiple y discapacidad de los síndromes clínicamente aislados / Pelayo Vergara, Raúl ; Tintoré Subirana, María del Mar, dir. ; Montalbán Gairín, Xavier, dir. ; Universitat Autònoma de Barcelona. Departament de Medicina
La resonancia magnética (RM) se ha convertido en la herramienta básica para el diagnóstico de la esclerosis múltiple (EM) y establecer el riesgo de conversión a la misma y de discapacidad de los síndromes clínicamente aislados (SCA). [...]
Magnetic resonance imaging (MRI) has become the basic tool for the diagnosis of multiple sclerosis (MS) and to establish the risk of conversion to MS and disability of the clinically isolated syndromes (CIS). [...]

[Barcelona] : Universitat Autònoma de Barcelona, 2016  
7.
249 p, 6.5 MB Study of diagnostic and prognostic clinical, biological, and magnetic resonance imaging markers at the time of a clinically isolated syndrome / Arrambide, Georgina ; Montalban Gairín, Xavier, dir. (Universitat Autònoma de Barcelona. Departament de Medicina) ; Tintoré Subirana, María del Mar, dir. ; Espejo, Carmen, dir. (Hospital Universitari Vall d'Hebron) ; Universitat Autònoma de Barcelona. Departament de Medicina
En este trabajo estudiamos marcadores con valor diagnóstico o pronóstico en el momento de presentar un síndrome clínico aislado (CIS, del inglés clinically isolated syndrome). Dado que presentar un CIS representa un riesgo para desarrollar esclerosis múltiple (EM), se considera crucial identificar qué pacientes tendrán un segundo brote y determinar el grado de acumulación de discapacidad a medio y largo plazo. [...]
The present work is concerned with finding diagnostic and prognostic markers at the time of a clinically isolated syndrome (CIS). Given that presenting a CIS indicates the possibility of developing multiple sclerosis (MS), it is considered crucial to identify which patients will present a second attack and to determine the degree of disability accumulation over the medium to long-term. [...]

[Barcelona] : Universitat Autònoma de Barcelona, 2016  
8.
220 p, 12.6 MB Epidemiología de la esclerosis múltiple en Catalunya / Otero Romero, Susana ; Vaqué Rafart, Josep, dir. ; Montalban Gairín, Xavier, dir. ; Sastre Garriga, Jaume, dir. ; Universitat Autònoma de Barcelona. Departament de Pediatria, d'Obstetrícia i Ginecologia i de Medicina Preventiva
Els estudis epidemiològics d'Esclerosi Múltiple (EM) a nivell mundial mostren un augment generalitzat en la prevalença i un increment en la incidència, fonamentalment en les latituds més baixes, considerades inicialment zones de baix risc. [...]
Los estudios epidemiológicos de Esclerosis Múltiple (EM) a nivel mundial muestran un aumento generalizado en la prevalencia y un incremento en la incidencia, fundamentalmente en las latitudes más bajas, consideradas inicialmente zonas de bajo riesgo. [...]
Epidemiological studies on multiple sclerosis (MS) show a global increase in the prevalence worldwide and increased incidence, mainly in the lower latitudes, initially considered low risk areas. Therefore, southern Europe becomes a key area for the study of current epidemiological trends of MS. [...]

[Barcelona] : Universitat Autònoma de Barcelona, 2015  
9.
186 p, 4.0 MB Utilidad de las medidas de atrofia cerebral en el diagnóstico y seguimiento de la esclerosis múltiple / Pérez Miralles, Francisco Carlos ; Montalban Gairin, Xavier, dir. ; Sastre Garriga, Jaume, dir. ; Universitat Autònoma de Barcelona. Departament de Medicina
La esclerosis múltiple (EM) es una enfermedad inflamatoria desmielinizante del sistema nervioso central. Su evolución es muy variable entre individuos, como también lo es la respuesta de éstos al tratamiento. [...]
Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system. Its evolution varies widely among individuals, and so is their response to treatment. Measures of MS clinical activity are only partially useful to predict changes in the evolution of the disease. [...]

[Barcelona] : Universitat Autònoma de Barcelona, 2016  
10.
122 p, 5.3 MB Estudio clínico y de resonancia magnética orientado al conocimiento del sustrato patológico de la discapacidad en la esclerosis múltiple primariamente progresiva / Tur Gómez, Carmen ; Montalban Gairín, Xavier, dir. ; Fonollosa Pla, Vicenç ; Universitat Autònoma de Barcelona. Departament d'Antropologia Social i Cultural
Con el objetivo de contribuir al estudio de los mecanismos que subyacen al aumento de la discapacidad en la esclerosis múltiple primariamente progresiva (EMPP), fijamos tres objetivos principales. Asimismo, nos propusimos hacer una revisión de la literatura sobre EMPP publicada hasta el momento actual, utilizando la web www. [...]
In order to contribute to the study of mechanisms that underlie clinical progression in primary progressive multiple sclerosis (PPMS), three objectives were established. Besides, as an introduction to the main studies of the thesis, we also decided to review the literature about PPMS. [...]

[Barcelona] : Universitat Autònoma de Barcelona, 2015
2 documents

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3 Montalban, X
3 Montalban, X
2 Montalban, X.
1 Montalban, Xavier,
2 Montalbán, X.
23 Montalbán, Xavier
1 Montalbán, Xavier,
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