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1.
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17 p, 9.8 MB |
Peripheral administration of human recombinant ApoJ/clusterin modulates brain beta-amyloid levels in APP23 mice
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Fernández de Retana Alda, Sofía (Hospital Universitari Vall d'Hebron) ;
Marazuela, Paula (Hospital Universitari Vall d'Hebron) ;
Solé Piñol, Montserrat (Hospital Universitari Vall d'Hebron) ;
Colell, Guillem (Hospital Universitari Vall d'Hebron) ;
Bonaterra, Anna (Hospital Universitari Vall d'Hebron) ;
Sánchez Quesada, José Luis (Hospital de la Santa Creu i Sant Pau) ;
Montaner, Joan (Vall d'Hebron Institut de Recerca) ;
Maspoch Comamala, Daniel (Institut Català de Nanociència i Nanotecnologia) ;
Cano Sarabia, Antonia María (Institut Català de Nanociència i Nanotecnologia) ;
Hernández Guillamón, María del Mar (Vall d'Hebron Institut de Recerca)
Background: ApoJ/clusterin is a multifunctional protein highly expressed in the brain. The implication of ApoJ in β-amyloid (Aβ) fibrillization and clearance in the context of Alzheimer's disease has been widely studied, although the source and concentration of ApoJ that promotes or inhibits Aβ cerebral accumulation is not clear yet. [...]
2019 -  10.1186/s13195-019-0498-8
Alzheimer's research and therapy, Vol. 11 (May 2019) , art. 42
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2.
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13 p, 3.3 MB |
Characterization of ApoJ-reconstituted high-density lipoprotein (rHDL) nanodisc for the potential treatment of cerebral β-amyloidosis
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Fernández de Retana Alda, Sofía (Vall d'Hebron Institut de Recerca) ;
Cano Sarabia, Antonia María (Institut Català de Nanociència i Nanotecnologia) ;
Marazuela, Paula (Hospital Universitari Vall d'Hebron) ;
Sánchez Quesada, José Luis (Hospital de la Santa Creu i Sant Pau) ;
García León, Annabel (Institut d'Investigacions Biomèdiques Sant Pau) ;
Montañola, Alex (Vall d'Hebron Institut de Recerca) ;
Montaner, Joan (Vall d'Hebron Institut de Recerca) ;
Maspoch Comamala, Daniel (Institut Català de Nanociència i Nanotecnologia) ;
Hernández Guillamón, María del Mar (Vall d'Hebron Institut de Recerca)
Cerebral β-amyloidosis is a major feature of Alzheimer's disease (AD), characterized by the accumulation of β-amyloid protein (Aβ) in the brain. Several studies have implicated lipid/lipoprotein metabolism in the regulation of β-amyloidosis. [...]
2017 - 10.1038/s41598-017-15215-w
Scientific reports, Vol. 7 (November 2017) , art. 14637
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3.
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12 p, 1.3 MB |
Early measurement of interleukin-10 predicts the absence of CT scan lesions in mild traumatic brain injury
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Lagerstedt,Linnéa (University of Geneva. Department of Human Protein Sciences) ;
Egea Guerrero, Juan José (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ;
Rodríguez Rodríguez, Ana (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ;
Bustamante Rangel, Alejandro (Vall d'Hebron Institut de Recerca) ;
Montaner, Joan (Vall d'Hebron Institut de Recerca) ;
El Rahal, Amir (Geneva University Hospitals. Department of Clinical Neurosciences.) ;
Andereggen, Elisabeth (Geneva University Hospitals. Emergency Center) ;
Rinaldi, Lara (Geneva University Hospitals. Department of Surgery) ;
Sarrafzadeh, Asita (Geneva University Hospitals. Department of Clinical Neurosciences) ;
Schaller, Karl (Geneva University Hospitals. Department of Clinical Neurosciences) ;
Sanchez, Jean-Charles (University of Geneva. Department of Human Protein Sciences)
Traumatic brain injury is a common event where 70%-90% will be classified as mild TBI (mTBI). Among these, only 10% will have a brain lesion visible via CT scan. A triage biomarker would help clinicians to identify patients with mTBI who are at risk of developing a brain lesion and require a CT scan. [...]
2019 - 10.1371/journal.pone.0193278
PloS one, Vol. 13 Núm. 2 (2019) , p. e0193278
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4.
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13 p, 3.4 MB |
Combining H-FABP and GFAP increases the capacity to differentiate between CT-positive and CT-negative patients with mild traumatic brain injury
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Lagerstedt, Linnéa (University of Geneva. Department of Specialities of Internal Medicine) ;
Egea Guerrero, Juan José (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ;
Bustamante rangel, Alejandro (Vall d'Hebron Institut de Recerca) ;
Rodríguez Rodríguez, Ana (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ;
Quintana, Manuel (Hospital Universitario La Paz (Madrid)) ;
García Armengol, Roser (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Prica, Carmen Melinda (Hospital de Tortosa Verge de la Cinta) ;
Andereggen, Elisabeth (Geneva University Hospitals. Emergency Center) ;
Rinaldi, Lara (Geneva University Hospitals. Department of Surgery) ;
Sarrafzadeh, Asita (Geneva University Hospitals. Department of Clinical Neurosciences) ;
Schaller, Karl (Geneva University Hospitals. Department of Clinical Neurosciences) ;
Montaner, Joan (Vall d'Hebron Institut de Recerca) ;
Sanchez, Jean-Charles (University of Geneva. Department of Specialities of Internal Medicine)
Mild traumatic brain injury (mTBI) patients may have trauma-induced brain lesions detectable using CT scans. However, most patients will be CT-negative. There is thus a need for an additional tool to detect patients at risk. [...]
2017 - 10.1371/journal.pone.0200394
PloS one, Vol. 12 Núm. 9 (2017) , p. e0185072
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5.
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15 p, 517.3 KB |
GRECOS project (Genotyping Recurrence Risk of Stroke). The use of genetics to predict the vascular recurrence after stroke
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Fernández Cadenas, Israel (Hospital Vall d'Hebron. Departament de Neurologia) ;
Mendióroz, Maite (Hospital Vall d'Hebron. Departament de Neurologia) ;
Giralt, Dolors (Hospital Vall d'Hebron. Departament de Neurologia) ;
Nafria, Cristina (Hospital Vall d'Hebron. Departament de Neurologia) ;
Garcia, Elena (Fundació Docència i Recerca Mutua Terrassa) ;
Carrera, Caty (Hospital Vall d'Hebron Departament de Neurologia) ;
Gallego-Fabrega, Cristina (Fundació Docència i Recerca Mutua Terrassa) ;
Domingues-Montanari, Sophie (Hospital Vall d'Hebron. Departament de Neurologia) ;
Delgado, Pilar (Hospital Vall d'Hebron. Departament de Neurologia) ;
Ribó, Marc (Hospital Vall d'Hebron. Departament de Neurologia) ;
Castellanos, Mar (Hospital Universitari Dr. Josep Trueta. Departament de Neurologia) ;
Martínez, Sergi (Institut d'Investigació Biomèdica Sant Pau) ;
Freijo, Mari Mar (Hospital de Basurto. Departamento de Neurologia) ;
Jiménez-Conde, Jordi (Hospital del Mar. Departament de Neurologia) ;
Rubiera, Marta (Hospital Vall d'Hebron. Departament de Neurologia) ;
Alvarez Sabín, José (Hospital Vall d'Hebron. Departament de Neurologia) ;
Molina, Carlos A. (Hospital Vall d'Hebron. Departament de Neurologia) ;
Font, Maria Angels (Hospital de Bellvitge. Departament de Neurologia) ;
Grau Olivares, Marta (Hospital Universitari Sagrat Cor. Departament de Neurologia) ;
Palomeras, Ernest (Hospital de Mataró. Departament de Neurologia) ;
Perez de la Ossa, Natalia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Martinez Zabaleta, Maite (Hospital Donostia. Departamento de Neurologia) ;
Masjuan, Jaime (Hospital Ramon y Cajal. Departamento de Neurologia) ;
Moniche, Francisco (Hospital Universitario Virgen del Rocío. Departamento de Neurologia) ;
Canovas, David (Corporació Sanitària Parc Taulí. Departament de Neurologia) ;
Piñana, Carlos (Hospital Universitario Virgen de las Nieves. Departamento de Neurologia) ;
Purroy, Francisco (Hospital Universitari Arnau de Vilanova. Departament de Neurologia) ;
Cocho, Dolores (Hospital de Granollers. Departament de Neurologia) ;
Navas, Inma (Hospital Mútua de Terrassa. Departament de Neurologia) ;
Tejero, Carlos (Hospital Clínico Universitario Lozano Blesa. Departamento de Neurologia) ;
Aymerich, Nuria (Hospital de Navarra. Departamento de Neurologia) ;
Cullell, Natalia (Fundació Docència i Recerca Mutua Terrassa) ;
Muiño, Elena (Fundació Docència i Recerca Mutua Terrassa) ;
Serena, Joaquín (Hospital Universitari Dr. Josep Trueta. Departament de Neurologia) ;
Rubio, Francisco (Hospital de Bellvitge. Departament de Neurologia) ;
Davalos, Antoni (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Roquer González, Jaume (Hospital del Mar. Departament de Neurologia) ;
Arenillas Lara, Juan Francisco (Hospital Clínico Universitario de Valladolid. Departamento de Neurologia) ;
Martí Fábregas, Joan (Institut d'Investigació Biomèdica Sant Pau) ;
Keene, Keith (Center for Health Disparities. East Carolina University) ;
Chen, Wei-Min (Department of Public Health Sciences; Center for Public Health Genomics, University of Virginia) ;
Worrall, Bradford (Department of Neurology; Department of Public Health Sciences, University of Virginia) ;
Sale, Michele (Center for Public Health Genomics, University of Virginia) ;
Arboix, Adrià (Hospital Universitari Sagrat Cor. Departament de Neurologia) ;
Krupinski, Jerzy (Hospital Mútua de Terrassa. Departament de Neurologia) ;
Montaner, Joan (Hospital Vall d'Hebron. Departament de Neurologia) ;
GRECOSstudy group ;
Universitat Autònoma de Barcelona
Background and Purpose—Vascular recurrence occurs in 11% of patients during the first year after ischemic stroke (IS) or transient ischemic attack (TIA). Clinical scores do not predict the whole vascular recurrence risk, therefore we aimed to find genetic variants associated with recurrence that might improve the clinical predictive mode is in IS. [...]
2017 - 10.1161/STROKEAHA.116.014322
Stroke, Vol. 48 Núm. 5 (2017) , p. 1147-1153
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6.
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11 p, 899.4 KB |
H-FABP: A new biomarker to differentiate between CT-positive and CT-negative patients with mild traumatic brain injury
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Lagerstedt,Linnéa (University of Geneva. Department of Human Protein Sciences) ;
Egea Guerrero, Juan José (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ;
Bustamante Rangel, Alejandro (Vall d'Hebron Institut de Recerca) ;
Montaner, Joan (Vall d'Hebron Institut de Recerca) ;
Rodríguez Rodríguez, Ana (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ;
El Rahal, Amir (Geneva University Hospitals. Department of Clinical Neurosciences) ;
Turck, Natacha (University of Geneva. Department of Human Protein Sciences) ;
Quintana, Manuel (Hospital Universitario La Paz (Madrid)) ;
García Armengol, Roser (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Prica, Carmen Melinda (Hospital de Tortosa Verge de la Cinta) ;
Andereggen, Elisabeth (Geneva University Hospitals. Emergency Center) ;
Rinaldi, Lara (Geneva University Hospitals. Department of Surgery) ;
Sarrafzadeh, Asita (University Hospital Heidelberg. Department of Neurosurgery) ;
Schaller, Karl (Geneva University Hospitals. Department of Clinical Neurosciences) ;
Sanchez, Jean-Charles (University of Geneva. Department of Human Protein Sciences)
The majority of patients with mild traumatic brain injury (mTBI) will have normal Glasgow coma scale (GCS) of 15. Furthermore, only 5%±8% of them will be CT-positive for an mTBI. Having a useful biomarker would help clinicians evaluate a patient's risk of developing intracranial lesions. [...]
2017 - 10.1371/journal.pone.0175572
PloS one, Vol. 12 Núm. 4 (2017) , p. 1-11
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7.
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11 p, 168.8 KB |
Genetic variants in CETP increase risk of intracerebral hemorrhage
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Anderson, Christopher D. (Program in Medical and Population Genetics, Broad Institute) ;
Falcone, Guido J. (Departments of Epidemiology and Biostatistics, Harvard T. H. Chan School of Public Health) ;
Phuah, Chia-Ling (Program in Medical and Population Genetics, Broad Institute) ;
Radmanesh, Farid (Program in Medical and Population Genetics, Broad Institute) ;
Brouwers, H. Bart (Program in Medical and Population Genetics, Broad Institute) ;
Battey, Thomas W. K. (Program in Medical and Population Genetics, Broad Institute) ;
Biffi, Alessandro (Division of Psychiatry, Department of Psychiatry, MGH) ;
Peloso, Gina M. (Program in Medical and Population Genetics, Broad Institute) ;
Liu, Dajiang J. (Institute of Personalized Medicine, Penn State College of Medicine) ;
Ayres, Alison M. (J. Philip Kistler Stroke Research Center, Department of Neurology, MGH) ;
Goldstein, Joshua N. (Department of Emergency Medicine, MGH) ;
Viswanathan, Anand (J. Philip Kistler Stroke Research Center, Department of Neurology, MGH) ;
Greenberg, Steven M. (J. Philip Kistler Stroke Research Center, Department of Neurology, MGH) ;
Selim, Magdy (Beth Israel Deaconess Medical Center) ;
Meschia, James F. (Mayo Clinic) ;
Brown, Devin L. (University of Michigan Health System) ;
Worrall, Bradford B. (University of Virginia Health System) ;
Silliman, Scott L. (University of Florida College of Medicine) ;
Tirschwell, David L. (University of Washington) ;
Flaherty, Matthew L. (University of Cincinnati College of Medicine) ;
Kraft, Peter (Departments of Epidemiology and Biostatistics, Harvard T. H. Chan School of Public Health) ;
Jagiella, Jeremiasz M. (Jagiellonian University Medical College) ;
Schmidt, Helena (Medical University Graz) ;
Hansen, Björn M. (Skåne University Hospital) ;
Jimenez-Conde, Jordi (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Giralt-Steinhauer, Eva (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Elosua Llanos, Roberto (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Cuadrado-Godia, Elisa (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Soriano Tàrraga, Carolina (Institut Hospital del Mar d'Investigacions Mèdiques) ;
van Nieuwenhuizen, Koen M. (University Medical Center Utrecht) ;
Klijn, Catharina J. M. (Donders Institute for Brain, Cognition, and Behavior, Radboud University Medical Center) ;
Rannikmae, Kristiina (University of Edinburgh) ;
Samarasekera, Neshika (University of Edinburgh) ;
Salman, Rustam Al-Shahi (University of Edinburgh) ;
Sudlow, Catherine L. (University of Edinburgh) ;
Deary, Ian J. (University of Edinburgh) ;
Morotti, Andrea (Neurology Clinic, University of Brescia) ;
Pezzini, Alessandro (Neurology Clinic, University of Brescia) ;
Pera, Joanna (Jagiellonian University Medical College) ;
Urbanik, Andrzej (Jagiellonian University Medical College) ;
Pichler, Alexander (Medical University of Graz) ;
Enzinger, Christian (Medical University of Graz) ;
Norrving, Bo (Skåne University Hospital) ;
Montaner, Joan (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Fernandez-Cadenas, Israel (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Delgado Martínez, Pilar (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Roquer González, Jaume (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Lindgren, Arne (Skåne University Hospital) ;
Slowik, Agnieszka (Jagiellonian University Medical College) ;
Schmidt, Reinhold (Medical University of Graz) ;
Kidwell, Chelsea S. (University of Arizona) ;
Kittner, Steven J. (Baltimore Veterans Administration Medical Center and University of Maryland School of Medicine) ;
Waddy, Salina P. (National Institutes of Health) ;
Langefeld, Carl D. (Wake Forest University) ;
Abecasis, Goncalo (University of Michigan School of Public Health) ;
Willer, Cristen J. (University of Michigan Medical School) ;
Kathiresan, Sekar (Cardiovascular Disease Prevention Center, MGH) ;
Woo, Daniel (University of Cincinnati College of Medicine) ;
Rosand, Jonathan (Program in Medical and Population Genetics, Broad Institute) ;
Universitat Autònoma de Barcelona.
Departament de Neurologia
In observational epidemiologic studies, higher plasma high-density lipoprotein cholesterol (HDL-C) has been associated with increased risk of intracerebral hemorrhage (ICH). DNA sequence variants that decrease cholesteryl ester transfer protein (CETP) gene activity increase plasma HDL-C; as such, medicines that inhibit CETP and raise HDL-C are in clinical development. [...]
2016 - 10.1002/ana.24780
Annals of Neurology, Vol. 80 (october 2016) , p. 730-740
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14 p, 2.2 MB |
Charge effect of a liposomal delivery system encapsulating simvastatin to treat experimental ischemic stroke in rats
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Campos Martorell, Mireia (Vall d'Hebron Institut de Recerca) ;
Cano Sarabia, Antonia María (Institut Català de Nanociència i Nanotecnologia) ;
Simats, Alba (Vall d'Hebron Institut de Recerca) ;
Hernández Guillamón, María del Mar (Vall d'Hebron Institut de Recerca) ;
Rosell, Anna (Vall d'Hebron Institut de Recerca) ;
Maspoch Comamala, Daniel (Institut Català de Nanociència i Nanotecnologia) ;
Montaner, Joan (Hospital Vall d'Hebron. Departament de Neurologia) ;
Universitat Autònoma de Barcelona
Although the beneficial effects of statins on stroke have been widely demonstrated both in experimental studies and in clinical trials, the aim of this study is to prepare and characterize a new liposomal delivery system that encapsulates simvastatin to improve its delivery into the brain. [...]
2016 - 10.2147/IJN.S107292
International Journal of Nanomedicine, Vol. 11 (June 2016) , p. 3035-3048
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9 p, 447.1 KB |
N-glycome Profile Levels Relate to Silent Brain Infarcts in a Cohort of Hypertensives
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Vilar Bergua, Andrea (Vall d'Hebron Institut de Recerca) ;
Riba Llena, Iolanda (Vall d'Hebron Institut de Recerca) ;
Vanhooren, Valerie (Rijksuniversiteit te Gent) ;
Dewaele, Sylviane (Rijksuniversiteit te Gent) ;
Libert, Claude (Rijksuniversiteit te Gent) ;
Penalba, Anna (Vall d'Hebron Institut de Recerca) ;
Montaner, Joan (Vall d'Hebron Institut de Recerca) ;
Delgado, Pilar (Universitat Autònoma de Barcelona. Departament de Medicina)
Silent brain infarcts (s) are highly prevalent in the aged population and relate to the occurrence of further stroke and dementia. Serum N-glycome levels have been previously associated with aging and they might be related as well to the presence of s and age-related white matter hyperintensities. [...]
2015 - 10.1161/JAHA.115.002669
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol. 4, issue 11 (Oct. 2015)
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11 p, 542.3 KB |
Cerebral ischaemia and matrix metalloproteinase-9 modulate the angiogenic function of early and late outgrowth endothelial progenitor cells
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Morancho, Anna (Vall d'Hebron Institut de Recerca) ;
Hernández-Guillamon, Mar (Vall d'Hebron Institut de Recerca) ;
Boada, Cristina (Vall d'Hebron Institut de Recerca) ;
Barceló, Verónica (Vall d'Hebron Institut de Recerca) ;
Giralt, Dolors (Vall d'Hebron Institut de Recerca) ;
Ortega, Laura (Vall d'Hebron Institut de Recerca) ;
Montaner, Joan (Vall d'Hebron Institut de Recerca) ;
Rosell, Anna (Vall d'Hebron Institut de Recerca) ;
Universitat Autònoma de Barcelona
The enhancement of endogenous angiogenesis after stroke will be critical in neurorepair therapies where endothelial progenitor cells (EPCs) might be key players. Our aim was to determine the influence of cerebral ischaemia and the role of matrix metalloproteinase-9 (MMP-9) on the angiogenic function of EPCs. [...]
2013 - 10.1111/jcmm.12116
Journal of Cellular and Molecular Medicine, Vol. 17 (august 2013) , p. 1543-1553
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