Resultados globales: 62 registros encontrados en 0.02 segundos.
Artículos, Encontrados 33 registros
Documentos de investigación, Encontrados 29 registros
Artículos Encontrados 33 registros  1 - 10siguientefinal  ir al registro:
1.
13 p, 1.2 MB Peripheral inflammation preceeding ischemia impairs neuronal survival through mechanisms involving miR-127 in aged animals / Loppi, Sanna (University of Arizona) ; Korhonen, Paula (University of Eastern Finland) ; Bouvy-Liivrand, Maria (University of Eastern Finland) ; Caligola, Simone (University of Verona) ; Turunen, Tiia A. (University of Eastern Finland) ; Turunen, Mikko P. (University of Eastern Finland) ; Hernandez de Sande, Ana (University of Eastern Finland) ; Kołosowska, Natalia (University of Eastern Finland) ; Scoyni, Flavia (University of Eastern Finland) ; Rosell Novel, Anna (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; García-Berrocoso, Teresa (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Lemarchant, Sighild (University of Eastern Finland) ; Dhungana, Hiramani (University of Helsinki) ; Montaner, Joan (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Koistinaho, Jari (University of Helsinki) ; Kanninen, Katja M. (University of Eastern Finland) ; Kaikkonen, Minna U. (University of Eastern Finland) ; Giugno, Rosalba (University of Verona) ; Heinäniemi, Merja (University of Eastern Finland) ; Malm, Tarja (University of Eastern Finland) ; Universitat Autònoma de Barcelona
Ischemic stroke, the third leading cause of death in the Western world, affects mainly the elderly and is strongly associated with comorbid conditions such as atherosclerosis or diabetes, which are pathologically characterized by increased inflammation and are known to influence the outcome of stroke. [...]
2020 - 10.1111/acel.13287
Aging Cell, Vol. 20 (december 2020)  
2.
11 p, 1.2 MB Blood Biomarkers to Predict Long-Term Mortality after Ischemic Stroke / Ramiro, Laura (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Abraira, Laura (Universitat Autònoma de Barcelona. Departament de Medicina) ; Quintana, Manuel (Universitat Autònoma de Barcelona. Departament de Medicina) ; García-Rodríguez, Paula (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Santamarina, Estevo (Universitat Autònoma de Barcelona. Departament de Medicina) ; Álvarez-Sabín, José (Universitat Autònoma de Barcelona. Departament de Medicina) ; Zaragoza, Josep (Stroke Unit, Verge de la Cinta University Hospital, 43500 Tortosa, Spain) ; Hernández-Pérez, María (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Ustrell, Xavier (Hospital Universitari Joan XXIII de Tarragona) ; Lara, Blanca (Hospital Universitari de Bellvitge) ; Terceño, Mikel (Stroke Unit, Josep Trueta University Hospital, 17007 Girona, Spain) ; Bustamante, Alejandro (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Montaner, Joan (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Stroke is a major cause of disability and death globally, and prediction of mortality represents a crucial challenge. We aimed to identify blood biomarkers measured during acute ischemic stroke that could predict long-term mortality. [...]
2021 - 10.3390/life11020135
Life, Vol. 11 (february 2021)  
3.
14 p, 488.9 KB Comparison of plasma lipoprotein composition and function in cerebral amyloid angiopathy and Alzheimer's disease / Bonaterra-Pastra, Anna (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Fernández-de-Retana, Sofía (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Rivas-Urbina, Andrea (Institut d'Investigació Biomèdica Sant Pau) ; Puig, Núria (Institut d'Investigació Biomèdica Sant Pau) ; Benitez, Sonia (Institut d'Investigació Biomèdica Sant Pau) ; Pancorbo, Olalla (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Rodriguez-Luna, David (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Pujadas, Francesc (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Freijo, Maria del Mar (Hospital Universitario de Cruces. Departamento de Neurologia) ; Tur, Silvia (Hospital Universitari Son Espases. Departament de Neurologia) ; Martinez Zabaleta, Maite (Hospital Donostia. Departamento de Neurologia) ; Cardona Portela, Pere (Hospital Universitari de Bellvitge) ; Vera, Rocío (Hospital Universitari Ramon y Cajal. Departament de Neurologia) ; Lebrato-Hernández, Lucia (Hospital Universitari Virgen del Rocío. Unitat d'Ictus) ; Arenillas, Juan F (Hospital Clínico Universitario. Departamento de Neurologia) ; Pérez-Sánchez, Soledad (Hospital Universitari Virgen Macarena. Departament de Neurologia) ; Montaner, Joan (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Sanchez-Quesada, Jose Luis (Institut d'Investigació Biomèdica Sant Pau) ; Hernández-Guillamon, Mar (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Universitat Autònoma de Barcelona
Cerebral amyloid angiopathy (CAA) refers to beta-amyloid (Aβ) deposition in brain vessels and is clinically the main cause of lobar intracerebral hemorrhage (ICH). Aβ can also accumulate in brain parenchyma forming neuritic plaques in Alzheimer's disease (AD). [...]
2021 - 10.3390/biomedicines9010072
Biomedicines, Vol. 9 Núm. 1 (2021) , p. 72  
4.
10 p, 736.9 KB Absolute risk and predictors of the growth of acute spontaneous intracerebral haemorrhage : a systematic review and meta-analysis of individual patient data / Al-Shahi Salman, Rustam (Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK) ; Frantzias, Joseph (Department of Neurosurgery, King's College Hospital, London, UK) ; Lee, Robert J (Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK) ; Lyden, Patrick D (Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, California, USA) ; Battey, Thomas W K (Department of Neurology, Massachusetts General Hospital, Boston, MA, USA) ; Ayres, Alison M (Department of Neurology, Massachusetts General Hospital, Boston, MA, USA) ; Goldstein, Joshua N (Department of Emergency Medicine, Massachusetts General Hospital, Boston, MA, USA) ; Mayer, Stephan A (Department of Neurology, Henry Ford Health System, Detroit, MI, USA) ; Steiner, Thorsten (Department of Neurology, Heidelberg University Hospital, Heidelberg, Germany) ; Wang, Xia (The George Institute for Global Health, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia) ; Arima, Hisatomi (The George Institute for Global Health, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia) ; Hasegawa, Hitoshi (Department of Neurosurgery, Brain Research Institute, Niigata University, Niigata, Japan) ; Oishi, Makoto (Department of Neurosurgery, Brain Research Institute, Niigata University, Niigata, Japan) ; Godoy, Daniel A (Intensive Care Unit, Hospital Interzonal de Agudos "San Juan Bautista", Catamarca, Argentina) ; Masotti, Luca (Internal Medicine, Santa Maria Nuova Hospital, Florence, Italy) ; Dowlatshahi, Dar (Department of Medicine (Neurology), University of Ottawa and Ottawa Hospital Research Institute, Ottawa, ON, Canada) ; Rodriguez-Luna, David (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Molina, Carlos A (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Jang, Dong-Kyu (Department of Neurosurgery, Incheon St Mary's Hospital, College of Medicine, The Catholic University of Korea, Incheon, Korea) ; Davalos, Antonio (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Castillo, José (Department of Neurology, University Clinical Hospital of Santiago, Santiago de Compostela, Spain) ; Yao, Xiaoying (Department of Neurology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China) ; Claassen, Jan (Department of Neurology, Columbia University, College of Physicians and Surgeons, New York, NY, USA) ; Volbers, Bastian (Department of Neurology, Inselspital, Bern University Hospital, University of Bern, Switzerland) ; Kazui, Seiji (Kazui Medical Office, Ikeda, Osaka, Japan) ; Okada, Yasushi (Department of Cerebrovascular Medicine and Neurology, National Hospital Organisation Kyushu Medical Centre, Fukuoka, Japan) ; Fujimoto, Shigeru (Division of Neurology, Department of Medicine, Jichi Medical University, Shimotsuke, Tochigi, Japan) ; Toyoda, Kazunori (Department of Cerebrovascular Medicine, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan) ; Li, Qi (Department of Neurology, ThE First Affiliated Hospital of Chongqing Medical University, Chongqing, China) ; Khoury, Jane (University of Cincinnati Medical Centre, Cincinnati, OH, USA) ; Delgado, Pilar (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Sabín, José Álvarez (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Hernández-Guillamon, Mar (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Prats-Sánchez, Luis (Institut d'Investigació Biomèdica Sant Pau) ; Cai, Chunyan (Centre for Clinical and Translational Sciences, McGovern Medical School at the University of Texas Health Science Center, Houston, TX, USA) ; Kate, Mahesh P (Department of Neurology, University of Alberta, Edmonton, AB, Canada) ; McCourt, Rebecca (Department of Neurology, University of Alberta, Edmonton, AB, Canada) ; Venkatasubramanian, Chitra (Division of Stroke and Neurocritical Care, Stanford University, Palo Alto, CA, USA) ; Diringer, Michael N (Department of Neurology and Neurological Surgery, Washington University, St Louis, MO, USA) ; Ikeda, Yukio (Department of Neurosurgery, Tokyo Medical University Hachioji Medical Center, Tokyo, Japan) ; Worthmann, Hans (Department of Neurology, Hannover Medical School, Hannover, Germany) ; Ziai, Wendy C (Johns Hopkins University School of Medicine, Department of Neurology, Anaesthesia and Critical Care Medicine, Division of Neurocritical Care, Baltimore, MD, USA) ; d'Esterre, Christopher D (Department of Radiology, Foothills Medical Centre, University of Calgary, Calgary, AB, Canada) ; Aviv, Richard I (Department of Medical Imaging, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada) ; Raab, Peter (Institute of Diagnostic and Interventional Neuroradiology, Hannover Medical School, Hannover, Germany) ; Murai, Yasuo (Department of Neurological Surgery, Nippon Medical School, Tokyo, Japan) ; Zazulia, Allyson R (Department of Neurology and Neurological Surgery, Washington University, St Louis, MO, USA) ; Butcher, Kenneth S (Department of Neurology, University of Alberta, Edmonton, AB, Canada) ; Seyedsaadat, Seyed Mohammad (Department of Radiology, Mayo Clinic, Rochester, MN, USA) ; Grotta, James C (Memorial Hermann Hospital, Clinical Innovation and Research Institute, Houston, TX, USA) ; Martí-Fàbregas, Joan (Institut d'Investigació Biomèdica Sant Pau) ; Montaner, Joan (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Broderick, Joseph (University of Cincinnati Medical Centre, Cincinnati, OH, USA) ; Yamamoto, Haruko (Center for Advanced Clinical and Translational Sciences, National Cerebral and Cerebrovascular Center, Suita, Osaka, Japan) ; Staykov, Dimitre (Department of Neurology, Hospital of the Brothers of St John, Eisenstadt, Austria) ; Connolly, E Sander (Department of Neurosurgery, Columbia University, College of Physicians and Surgeons, New York, NY, USA) ; Selim, Magdy (Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA, USA) ; Leira, Rogelio (Department of Neurology, University Clinical Hospital of Santiago, Santiago de Compostela, Spain) ; Moon, Byung Hoo (Department of Neurosurgery, Incheon St Mary's Hospital, College of Medicine, The Catholic University of Korea, Incheon, Korea) ; Demchuk, Andrew M (Department of Clinical Neurosciences and Department of Radiology, Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada) ; Di Napoli, Mario (Neurological Service, San Camillo de'Lellis General Hospital, Rieti, Italy) ; Fujii, Yukihiko (Department of Neurosurgery, Brain Research Institute, Niigata University, Niigata, Japan) ; Anderson, Craig S (The George Institute for Global Health, China at Peking University Health Science Center, Beijing, China) ; Rosand, Jonathan (Department of Neurology, Massachusetts General Hospital, Boston, MA, USA) ; Universitat Autònoma de Barcelona
Intracerebral haemorrhage growth is associated with poor clinical outcome and is a therapeutic target for improving outcome. We aimed to determine the absolute risk and predictors of intracerebral haemorrhage growth, develop and validate prediction models, and evaluate the added value of CT angiography. [...]
2018 - 10.1016/S1474-4422(18)30253-9
The Lancet neurology, Vol. 17 (october 2018) , p. 885-894  
5.
24 p, 770.3 KB Inflammatory molecules might become both biomarkers and therapeutic targets for stroke management / Ramiro, Laura (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Simats, Alba ; García-Berrocoso, Teresa (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Montaner, Joan (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Universitat Autònoma de Barcelona
Stroke is the fifth leading cause of death and the most frequent cause of disability worldwide. Currently, stroke diagnosis is based on neuroimaging; therefore, the lack of a rapid tool to diagnose stroke is still a major concern. [...]
2018 - 10.1177/1756286418789340
Therapeutic Advances in Neurological Disorders, Vol. 11 (august 2018)  
6.
8 p, 1.6 MB DNA methylation of MMPs and TIMPs in atherothrombosis process in carotid plaques and blood tissues / Gallego-Fabrega, Cristina (Institut d'Investigació Biomèdica Sant Pau) ; Cullell, Natalia (Institut d'Investigació Biomèdica Sant Pau) ; Soriano-Tárraga, Carolina (Institut Hospital del Mar d'Investigacions Mèdiques) ; Carrera, Caty (Institut d'Investigació Biomèdica Sant Pau) ; Torres-Aguila, Nuria P. (Institut d'Investigació Biomèdica Sant Pau) ; Muiño, Elena (Institut d'Investigació Biomèdica Sant Pau) ; Cárcel-Márquez, Jara (Institut d'Investigació Biomèdica Sant Pau) ; de Moura, Manuel Castro (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Fernández-Sanlés, Alba (Cardiovascular Epidemiology and Genetics Research Group, Hospital del Mar Medical Research Institute, Universitat Pompeu Fabra, Barcelona, Spain) ; Esteller, Manel (Institució Catalana de Recerca i Estudis Avançats (ICREA)) ; Elosua, Roberto (Cardiovascular Epidemiology and Genetics Research Group, Hospital del Mar Medical Research Institute, Universitat Pompeu Fabra, Barcelona, Spain) ; Jiménez-Conde, Jordi (Institut Hospital del Mar d'Investigacions Mèdiques) ; Roquer, Jaume (Institut Hospital del Mar d'Investigacions Mèdiques) ; Montaner, Joan (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Krupinski, Jerzy (* These authors contributed equally to this work) ; Fernandez-Cadenas, Israel (Institut d'Investigació Biomèdica Sant Pau) ; Universitat Autònoma de Barcelona
Background and Purpose: Polymorphisms and serum levels of Matrix Metalloproteinases (MMP) and Tissue Inhibitor of Metalloproteinases (TIMP) have been studied with regard to atheromatous plaques and ischemic stroke, while no studies of DNA methylation (DNAm) patterns of MMP or TIMP have been performed to that end. [...]
2020 - 10.18632/oncotarget.27469
Oncotarget, Vol. 11 (march 2020) , p. 905-912  
7.
14 p, 236.7 KB Clinical Variables and Genetic Risk Factors Associated with the Acute Outcome of Ischemic Stroke : A Systematic Review / Torres-Aguila, Nuria P (Institut d'Investigació Biomèdica Sant Pau) ; Carrera, Caty (Institut d'Investigació Biomèdica Sant Pau) ; Muiño, Elena (Institut d'Investigació Biomèdica Sant Pau) ; Cullell, Natalia (Stroke Pharmacogenomics and Genetics Laboratory, Mutua Terrasa Foundation of Teaching and Research, Mutua Terrassa Hospital, Terrassa) ; Cárcel-Márquez, Jara (Institut d'Investigació Biomèdica Sant Pau) ; Gallego-Fabrega, Cristina (Institut d'Investigació Biomèdica Sant Pau) ; González-Sánchez, Jonathan (Institut d'Investigació Biomèdica Sant Pau) ; Bustamante, Alejandro (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Delgado, Pilar (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Ibañez, Laura (Department of Psychiatry, Washington University School of Medicine, St. Louis, MO) ; Heitsch, Laura (Department of Neurology, Washington University School of Medicine, St. Louis, MO) ; Krupinski, Jerzy (Health Care Science Department, The Manchester Metropolitan University of All Saints, Manchester) ; Montaner, Joan (Department of Neurology, Virgin Rocío and Macarena Hospitals, Institute of Biomedicine of Seville (IBiS), Seville) ; Martí-Fàbregas, Joan (Institut d'Investigació Biomèdica Sant Pau) ; Cruchaga, Carlos (Department of Psychiatry, Washington University School of Medicine, St. Louis, MO) ; Lee, Jin-Moo (Department of Neurology, Washington University School of Medicine, St. Louis, MO) ; Fernandez-Cadenas, Israel (Institut d'Investigació Biomèdica Sant Pau) ; Universitat Autònoma de Barcelona
Stroke is a complex disease and one of the main causes of morbidity and mortality among the adult population. A huge variety of factors is known to influence patient outcome, including demographic variables, comorbidities or genetics. [...]
2019 - 10.5853/jos.2019.01522
Journal of Stroke, Vol. 21 (september 2019) , p. 276-289  
8.
7 p, 289.3 KB Usefulness of TNFR1 as biomarker of intracranial aneurysm in patients with spontaneous subarachnoid hemorrhage / de Torres, Reyes (Neurology Unit, Hospital Virgen Macarena, Seville, Spain) ; Mancha, Fernando (Neurovascular Laboratory, Instituto de Biomedicina de Sevilla, Seville, Spain) ; Bustamante, Alejandro (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Canhao, Patricia (Neuroradiology Department, Centro Hospitalar Lisboa Central, Lisboa, Portugal) ; Fragata, Isabel (Faculdade de Medicina, Instituto de Medicina Molecular, Universidade de Lisboa, Lisboa, Portugal) ; Montaner, Joan (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Universitat Autònoma de Barcelona
To determine the utility of TNF-α receptor (TNFR1) as a biomarker for the presence of aneurysms in patients with acute subarachnoid hemorrhage (SAH). This is a prospective study in patients with acute spontaneous SAH. [...]
2019 - 10.2144/fsoa-2019-0090
Future science OA, Vol. 6 (november 2019)  
9.
12 p, 544.9 KB Association of Apolipoprotein e with Intracerebral Hemorrhage Risk by Race/Ethnicity : A Meta-analysis / Marini, S. (Massachusetts General Hospital) ; Crawford, K. (Massachusetts General Hospital) ; Morotti, A. (Fondazione Mondino IRCCS, Pavia) ; Lee, M.J. (Massachusetts General Hospital) ; Pezzini, A. (Università degli Studi di Brescia) ; Moomaw, C.J. (University of Cincinnati) ; Flaherty, M.L. (University of Cincinnati) ; Montaner, Joan (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Roquer Gonzalez, Jaume (Institut Hospital del Mar d'Investigacions Mèdiques) ; Jimenez Conde, Jordi (Institut Hospital del Mar d'Investigacions Mèdiques) ; Giralt Steinhauer, Eva (Institut Hospital del Mar d'Investigacions Mèdiques) ; Elosua, Roberto (Institut Hospital del Mar d'Investigacions Mèdiques) ; Cuadrado Godia, Elisa (Institut Hospital del Mar d'Investigacions Mèdiques) ; Soriano Tarraga, Carolina (Institut Hospital del Mar d'Investigacions Mèdiques) ; Slowik, A. (Jagiellonian University Medical College, Kraków) ; Jagiella, J.M. (Jagiellonian University Medical College, Kraków) ; Pera, J. (Jagiellonian University Medical College, Kraków) ; Urbanik, A. (Jagiellonian University Medical College, Kraków) ; Pichler, A. (Jagiellonian University Medical College, Kraków) ; Hansen, B.M. (Lund University) ; McCauley, J.L. (John P. Hussman Institute for Human Genomics, Miami) ; Tirschwell, D.L. (University of Washington) ; Selim, M. (Beth Israel Deaconess Medical Center, Boston) ; Brown, D.L. (University of Michigan) ; Silliman, S.L. (University of Florida College of Medicine) ; Worrall, B.B. (University of Virginia Health System) ; Meschia, J.F. (Mayo Clinic, Jacksonville, Florida) ; Kidwell, C.S. (University of Arizona) ; Testai, F.D. (University of Illinois) ; Kittner, S.J. (University of Maryland School of Medicine) ; Schmidt, H. (Medical University of Graz) ; Enzinger, C. (Medical University of Graz) ; Deary, I.J. (University of Edinburgh) ; Rannikmae, K. (University of Edinburgh) ; Samarasekera, N. (University of Edinburgh) ; Salman, R.A.S. (University of Edinburgh) ; Sudlow, C.L. (University of Edinburgh) ; Klijn, C.J.M. (UMC Utrecht Brain Center Rudolf Magnus) ; Van Nieuwenhuizen, K.M. (UMC Utrecht Brain Center Rudolf Magnus) ; Fernandez Cadenas, Israel (Institut d'Investigació Biomèdica Sant Pau) ; Delgado Martínez, María Pilar (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Norrving, B. (Lund University) ; Lindgren, A. (Lund University) ; Goldstein, J.N. (Massachusetts General Hospital) ; Viswanathan, A. (Massachusetts General Hospital) ; Greenberg, S.M. (Massachusetts General Hospital) ; Falcone, G.J. (Yale University) ; Biffi, A. (Massachusetts General Hospital) ; Langefeld, C.D. (Wake Forest University, Winston-Salem, North Carolina) ; Woo, D. (University of Cincinnati College of Medicine) ; Rosand, J. (Massachusetts General Hospital) ; Anderson, C.D. (Massachusetts General Hospital) ; Universitat Autònoma de Barcelona
Importance: Genetic studies of intracerebral hemorrhage (ICH) have focused mainly on white participants, but genetic risk may vary or could be concealed by differing nongenetic coexposures in nonwhite populations. [...]
2019 - 10.1001/jamaneurol.2018.4519
JAMA Neurology, Vol. 76 Núm. 4 (april 2019) , p. 480-491  
10.
17 p, 9.8 MB Peripheral administration of human recombinant ApoJ/clusterin modulates brain beta-amyloid levels in APP23 mice / Fernández de Retana Alda, Sofía (Hospital Universitari Vall d'Hebron) ; Marazuela, Paula (Hospital Universitari Vall d'Hebron) ; Solé Piñol, Montserrat (Hospital Universitari Vall d'Hebron) ; Colell, Guillem (Hospital Universitari Vall d'Hebron) ; Bonaterra, Anna (Hospital Universitari Vall d'Hebron) ; Sánchez Quesada, José Luis (Institut d'Investigació Biomèdica Sant Pau) ; Montaner, Joan (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Maspoch Comamala, Daniel (Institut Català de Nanociència i Nanotecnologia) ; Cano-Sarabia, Mary (Institut Català de Nanociència i Nanotecnologia) ; Hernández Guillamón, María del Mar (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Universitat Autònoma de Barcelona
Background: ApoJ/clusterin is a multifunctional protein highly expressed in the brain. The implication of ApoJ in β-amyloid (Aβ) fibrillization and clearance in the context of Alzheimer's disease has been widely studied, although the source and concentration of ApoJ that promotes or inhibits Aβ cerebral accumulation is not clear yet. [...]
2019 - 10.1186/s13195-019-0498-8
Alzheimer's research & therapy, Vol. 11 (May 2019) , art. 42  

Artículos : Encontrados 33 registros   1 - 10siguientefinal  ir al registro:
Documentos de investigación Encontrados 29 registros  1 - 10siguientefinal  ir al registro:
1.
258 p, 8.7 MB Potencial terapèutic de nous biomarcadors d'isquèmia cerebral / Simats Oriol, Alba ; Montaner, Joan, dir. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; García Berrocoso, Teresa, dir. ; Vila Bover, Miquel, dir. (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular
L'ictus isquèmic és una de les principals causes de mort i discapacitat arreu. Actualment, l'únic tractament efectiu és la teràpia de reperfusió, ja sigui a través del tractament intravenós amb l'activador tissular del plasminogen (rt-PA) o la retirada del clot mitjançant trombectomia mecànica intra-arterial. [...]
Ischemic stroke is one of the leading causes of death and disability worldwide. Currently, the only effective treatments are reperfusion therapies, via the intravenous administration of recombinant tissue plasminogen activator (rt-PA) or the mechanical removal of the thrombus with stent-retriever or aspiration devices. [...]

[Bellaterra] : Universitat Autònoma de Barcelona, 2018.  
2.
212 p, 10.7 MB Estudio de variantes estructurales de ApoA-I y ApoJ recombinantes como aproximación terapéutica en el contexto de la β-amiloidosis cerebral / Fernández de Retana Alda, Sofía ; Hernández Guillamón, María del Mar, dir. ; Cano-Sarabia, Mary, dir. ; Montaner, Joan, dir. ; Universitat Autònoma de Barcelona. Institut de Neurociències
La β-amiloidosis cerebral se caracteriza por la acumulación del péptido β-amiloide (Aβ) en el parénquima y vasos cerebrales siendo la principal característica neuropatológica de la Enfermedad de Alzheimer (EA) y la Angiopatía Amiloide Cerebral (18C). [...]
Cerebral β-amyloidosis is characterized by parenchymal and vascular deposition of Amyloid-β peptide (Aβ), being the main neuropathological hallmark of Alzheimer's Disease and Cerebral Amyloid Angiopathy (CAA). [...]

[Bellaterra] : Universitat Autònoma de Barcelona, 2018.  
3.
366 p, 5.6 MB Genètica aplicada a la clínica neurovascular / Río Espínola, Alberto del ; Fernández Cadenas, Israel, dir. ; Montaner, Joan, dir. ; Álvarez Sabín, J., (José) dir. ; Universitat Autònoma de Barcelona. Departament de Medicina
En aquesta tesi doctoral es descriuen els resultats de l'estudi farmacogenètic Geno-tPA, en el qual es va analitzar el paper de centenars de polimorfismes (SNPs) en la resposta al tractament trombolític de l'ictus isquèmic: recanalització arterial una hora després de la infusió, reoclusión arterial després d'haver recanalitzar, aparició de transformació hemorràgica iatrogènica i mortalitat intrahospitalària. [...]
This thesis describes the results of the Geno-tPA pharmacogenetic study, which analyzed the role of hundreds of polymorphisms (SNPs) in the response to thrombolytic treatmentof ischemic stroke: recanalization one hour after t-PA infusion, arterial reocclusion of the recanalized artery, presence of iatrogenic hemorrhagic transformation and in-hospital mortality. [...]

[Barcelona] : Universitat Autònoma de Barcelona, 2011  
4.
200 p, 5.7 MB Identificación de biomarcadores en el ictus hemorrágico y su estudio funcional en modelos experimentales / Merino Zamorano, Cristina ; Rodríguez Álvarez, José (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Hernández Guillamón, María del Mar, dir. ; Montaner, Joan, dir. ; Universitat Autònoma de Barcelona. Departament de Medicina
La hemorragia intracerebral (HIC) se define como la extravasación de sangre al parénquima encefálico. Aunque la HIC presenta una elevada tasa de mortalidad y discapacidad, muchos de los mecanismos moleculares implicados en esta patología aún se desconocen. [...]
Intracerebral hemorrhage (ICH) is a focal bleeding from a blood vessel in the brain parenchyma. Despite the high ratio of ICH severity and mortality, the molecular mechanisms involved in this disease are still unknown. [...]

[Barcelona] : Universitat Autònoma de Barcelona, 2016  
5.
152 p, 4.4 MB Aplicaciones proteómicas para el descubrimiento de biomarcadores diagnósticos en ictus / Llombart Sebastià, Víctor ; Montaner, Joan, dir. ; Hernández Guillamón, María del Mar, dir. ; Universitat Autònoma de Barcelona. Departament de Medicina
El ictus representa uno de los trastornos neurológicos más severos. En nuestro entorno, esta patología cerebrovascular revela una elevada prevalencia y se sitúa como segunda causa de muerte y primera causa de invalidez y discapacidad, lo que se traduce en un extraordinario impacto a nivel económico, sanitario y social. [...]
Stroke is one of the most severe neurological disorders. In our society, this cerebrovascular disease reveals a high prevalence and represents the second cause of dead and the first cause of disability, with a dramatic impact at the economic, social and health systems. [...]

[Barcelona] : Universitat Autònoma de Barcelona, 2016  
6.
95 p, 2.5 MB Condicionantes pronósticos del ictus isquémico: utilidad de los biomarcadores sanguíneos en su predicción / Bustamante Rangel, Alejandro ; Montaner, Joan, dir. ; Molina Cateriano, Carlos., dir. ; García Dorado, D. ; Universitat Autònoma de Barcelona. Departament de Medicina
El ictus es una de las principales causas de mortalidad y discapacidad en nuestro medio. El pronóstico del ictus depende en gran parte de factores basales no modificables como la edad o la gravedad inicial del mismo, pero también de circunstancias que ocurren durante la historia natural del mismo y conllevan un mal desenlace. [...]
Stroke represents one of the main causes of mortality and disability. Stroke outcome depends mainly on baseline, non-modifiable factors, such as age or stroke severity, but also on several conditions that may occur across the natural history of stroke and leads to a poor outcome. [...]

[Barcelona] : Universitat Autònoma de Barcelona, 2016  
7.
150 p, 21.3 MB Dual role of matrix metalloproteinases in brain injury and neurorepair after cerebral ischemia / Ma, Feifei ; Rosell Novel, Anna, dir. ; Montaner, Joan, dir. ; Rodríguez Álvarez, José (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Universitat Autònoma de Barcelona. Departament de Medicina
L'ictus isquèmic és una de les principals causes de mortalitat, discapacitat de llarg termini i de morbiditat al món. Actualment, els únics tractaments eficaços són el tractament trombolític intravenós amb activador del plasminogen tissular (tPA) i les novedoses trombectomies intra-arterials, que requereixen ser administrades en la fase hiperaguda de la malaltia ( 4,5 hores per al tractament amb tPA i 6 hores per les emergents la teràpies endovasculars). [...]
Ischemic stroke is a leading cause of mortality, long-time disability and morbidity in the world. Currently, the only effective treatments are the intravenous thrombolytic therapy with tissue plasminogen activator (tPA) and the new emerging intra-arterial thrombectomies, which require to be administered in the hyperacute phase of stroke ( 4. [...]

[Barcelona] : Universitat Autònoma de Barcelona, 2015  
8.
138 p, 1.8 MB Prevalencia y determinantes de las lesiones vasculares cerebrales definidas por resonancia magnética y estudio de la función cognitiva en población adulta hipertensa y general / Riba Llena, Yolanda ; Delgado Martínez, Pilar, dir. ; Montaner, Joan, dir. ; Fonollosa Pla, Vicent, tut. (Universitat Autònoma de Barcelona. Departament de Medicina) ; Universitat Autònoma de Barcelona. Departament de Medicina
Las enfermedades cerebrovasculares y la demencia están entre las primeras causas de muerte y discapacidad en el adulto en países desarrollados. Su coste sanitario es muy alto para los sistemas sanitarios de salud pública y su incidencia se espera que siga aumentando con el envejecimiento de la población. [...]
Cerebrovascular disease (stroke) and dementia are first leading causes of death and disability in adults in developed countries. An important amount of public health budgets are spent in those diseases and their incidence is expected to grow with the aging population. [...]

[Barcelona] : Universitat Autònoma de Barcelona, 2015  
9.
186 p, 5.7 MB Eficàcia i seguretat de la simvastatina administrada en la fase aguda de la isquèmia cerebral experimental / Campos Martorell, Mireia ; Hernández Guillamon, Mar, dir. ; Montaner, Joan, dir. ; García-Dorado, David ; Universitat Autònoma de Barcelona. Departament de Medicina
Malgrat tots els esforços realitzats, la realitat és que l'ictus continua sent una de les principals causes de mortalitat i d'incapacitat arreu del món. Actualment, l'únic tractament aprovat per la FDA en la fase aguda de l'ictus isquèmic és el trombolític rt-PA, que tot i haver quedat àmpliament demostrada la seva eficàcia, també se li atribueixen una sèrie d'inconvenients tals com la impossibilitat d'administrar-lo més enllà de les 4. [...]
Despite all the past clinical efforts , stroke remains a major cause of death and disability worldwide. Currently, the only treatment approved by the FDA during the acute phase of ischemic stroke is the thrombolytic rt-PA, which despite its great effectiveness has been widely demostrated, it has also a number of drawbacks such as the impossibility of administrating it beyond 4. [...]

[Barcelona] : Universitat Autònoma de Barcelona, 2015  
10.
116 p, 7.3 MB Factores pronosticos en fase aguda del ictus isquemico en el tratamiento endovascular de reperfusión / Flores Flores, Alan Alberto ; Ribó Jacobi, Marc, dir. ; Montaner, Joan, dir. ; Alvárez Sabín, J, dir. ; Universitat Autònoma de Barcelona. Departament de Medicina
INTRODUCCIÓN: El ictus es la primera causa de discapacidad permanente en la edad adulta, la primera causa de mortalidad en la mujer y la segunda en el hombre. Actualmente, el tratamiento de reperfusión endovascular supone una opción en fase aguda del ictus isquémico debido a una oclusión arterial, sobre todo en casos de refractariedad o pacientes no candidatos a recibir tratamiento fibrínolitico endovenoso. [...]
INTRODUCTION: Stroke is the first cause of permanent disability in adulthood, the first cause of death in women and the second in man. Currently, reperfusion endovascular treatment is an option in acute ischemic stroke due to arterial occlusion, especially in refractory cases or contraindications for intravenous thrombolytic treatment. [...]

[Barcelona] : Universitat Autònoma de Barcelona, 2014  

Documentos de investigación : Encontrados 29 registros   1 - 10siguientefinal  ir al registro:
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