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Narcolepsy and adjuvanted pandemic influenza A (H1N1) 2009 vaccines - Multi-country assessment
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Weibel, Daniel (Medical Informatics Department, Erasmus Medical Center, Rotterdam, The Netherlands) ;
Sturkenboom, Miriam (Julius Global Health, University Utrecht Medical Center, Utrecht, The Netherlands) ;
Black, Steven (Cincinnati Children's Hospital, Cincinnati, OH, USA) ;
de Ridder, Maria (Medical Informatics Department, Erasmus Medical Center, Rotterdam, The Netherlands) ;
Dodd, Caitlin (Medical Informatics Department, Erasmus Medical Center, Rotterdam, The Netherlands) ;
Bonhoeffer, Jan (Brighton Collaboration Foundation, Basel, Switzerland) ;
Vanrolleghem, Ann (Medical Informatics Department, Erasmus Medical Center, Rotterdam, The Netherlands) ;
van der Maas, Nicoline (Dept. Epidemiology and Surveillance, National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands) ;
Lammers, Gert Jan (Sleep-Wake Center SEIN, Heemstede, The Netherlands) ;
Overeem, Sebastiaan (Sleep Medicine Centre Kempenhaeghe, Heeze, The Netherlands) ;
Gentile, Angela (Hospital de Niños Ricardo Gutiérrez, Ciudad Autónoma de Buenos Aires, Argentina) ;
Giglio, Norberto (Hospital de Niños Ricardo Gutiérrez, Ciudad Autónoma de Buenos Aires, Argentina) ;
Castellano, Vanesa (Hospital de Niños Ricardo Gutiérrez, Ciudad Autónoma de Buenos Aires, Argentina) ;
Kwong, Jeffrey C. (Institute for Clinical Evaluative Sciences (ICES), Ontario, Canada) ;
Murray, Brian J. (Division of Neurology, Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto, Canada) ;
Cauch-Dudek, Karen (Institute for Clinical Evaluative Sciences (ICES), Ontario, Canada) ;
Juhasz, Diana (Institute for Clinical Evaluative Sciences (ICES), Ontario, Canada) ;
Campitelli, Michael (Institute for Clinical Evaluative Sciences (ICES), Ontario, Canada) ;
Datta, Alexandre N. (University Hospital Basel, Basel, Switzerland) ;
Kallweit, Ulf (Witten/Herdecke University, Department of Rehabilitation, Witten/Herdecke, Germany) ;
Huang, Wan-Ting (Taiwan Centers for Disease Control, Taipei, Taiwan) ;
Huang, Yu-Shu (Department of Child Psychiatry and Sleep Center, Chang Gung Memorial Hospital and University, Taoyuan, Taiwan) ;
Hsu, Chung-Yao (Department of Neurology and Sleep Disorders Center, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan) ;
Chen, Hsi-Chung (Department of Psychiatry and Center of Sleep Disorders, National Taiwan University Hospital, Taipei, Taiwan) ;
Giner Soriano, Maria (Institut Universitari d'Investigació en Atenció Primària Jordi Gol) ;
Morros, Rosa (Institut Universitari d'Investigació en Atenció Primària Jordi Gol) ;
Gaig, Carles (Neurology Service and Multidisciplinary Sleep Disorders Unit, Hospital Clinic of Barcelona, Barcelona, Spain) ;
Tió, Ester (Althaia Xarxa Assistencial Universitària de Manresa, Neurology Service, Manresa, Barcelona, Spain) ;
Perez-Vilar, Silvia (Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat (FISABIO), Vaccine Research, Valencia, Spain) ;
Diez-Domingo, Javier (Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat (FISABIO), Vaccine Research, Valencia, Spain) ;
Puertas, Francisco Javier (Servicio de Neurofisiologia, Hospital Universitari de la Ribera, Valencia, Spain) ;
Svenson, Lawrence W. (Division of Preventive Medicine, University of Alberta, Alberta, Canada) ;
Mahmud, Salaheddin M. (Vaccine and Drug Evaluation Centre, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Manitoba, Canada) ;
Carleton, Bruce (Faculty of Medicine, University of British Columbia, British Columbia, Canada) ;
Naus, Monika (Faculty of Medicine, University of British Columbia, British Columbia, Canada) ;
Arnheim-Dahlström, Lisen (Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden) ;
Pedersen, Lars (Clinical Medicine/Epidemiology, Aarhus University, Aarhus, Denmark) ;
DeStefano, Frank (Centers for Disease Control and Prevention (CDC), Immunization Safety Office, Atlanta, USA) ;
Shimabukuro, Tom T. (Centers for Disease Control and Prevention (CDC), Immunization Safety Office, Atlanta, USA) ;
Universitat Autònoma de Barcelona
In 2010, a safety signal was detected for narcolepsy following vaccination with Pandemrix, an AS03-adjuvanted monovalent pandemic H1N1 influenza (pH1N1) vaccine. To further assess a possible association and inform policy on future use of adjuvants, we conducted a multi-country study of narcolepsy and adjuvanted pH1N1 vaccines. [...]
2018 -  10.1016/j.vaccine.2018.08.008
Vaccine, Vol. 36 (august 2018) , p. 6202-6211
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