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First-in-human PeriCord cardiac bioimplant : Scalability and GMP manufacturing of an allogeneic engineered tissue graft
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Prat-Vidal, Cristina (Institut d'Investigació Biomèdica de Bellvitge - IDIBELL, L'Hospitalet de Llobregat, Spain) ;
Rodríguez-Gómez, Luciano (Cell Therapy Service, Banc de Sang i Teixits, Edifici Dr. Frederic Duran i Jordà, Passeig Taulat, 116, 08005 Barcelona, Spain) ;
Aylagas, Miriam (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Nieto-Nicolau, Nuria (Barcelona Tissue Bank (BTB), Banc de Sang i Teixits (BST), Barcelona, Spain) ;
Gastelurrutia, Paloma (Institut d'Investigació Biomèdica de Bellvitge - IDIBELL, L'Hospitalet de Llobregat, Spain) ;
Agustí, Elba (Barcelona Tissue Bank (BTB), Banc de Sang i Teixits (BST), Barcelona, Spain) ;
Gálvez-Montón, Carolina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Jorba, Ignasi (Institute for Bioengineering of Catalonia (IBEC), The Barcelona Institute of Science and Technology, CIBERES, University of Barcelona, Barcelona, Spain) ;
Teis, Albert (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Monguió-Tortajada, Marta (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Roura, Santiago (CIBER Cardiovascular, Instituto de Salud Carlos III, Madrid, Spain) ;
Vives Armengol, Joaquim (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Torrents-Zapata, Silvia (Cell Therapy Service, Banc de Sang i Teixits, Edifici Dr. Frederic Duran i Jordà, Passeig Taulat, 116, 08005 Barcelona, Spain) ;
Coca, María Isabel (Cell Therapy Service, Banc de Sang i Teixits, Edifici Dr. Frederic Duran i Jordà, Passeig Taulat, 116, 08005 Barcelona, Spain) ;
Reales, Laura (Cell Therapy Service, Banc de Sang i Teixits, Edifici Dr. Frederic Duran i Jordà, Passeig Taulat, 116, 08005 Barcelona, Spain) ;
Cámara-Rosell, María Luisa (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Cediel, Germán (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Coll, Ruth (Research and Education. Banc de Sang i Teixits, Edifici Dr. Frederic Duran i Jordà, Passeig Taulat, 116, 08005 Barcelona, Spain) ;
Farré, Ramon (Unit of Biophysics and Bioengineering, School of Medicine and Health Sciences, University of Barcelona-IDIBAPS-CIBERES, Barcelona, Spain) ;
Navajas, Daniel (Institute for Bioengineering of Catalonia (IBEC), The Barcelona Institute of Science and Technology, CIBERES, University of Barcelona, Barcelona, Spain) ;
Vilarrodona, Anna (Barcelona Tissue Bank (BTB), Banc de Sang i Teixits (BST), Barcelona, Spain) ;
García-López, Joan (Research and Education. Banc de Sang i Teixits, Edifici Dr. Frederic Duran i Jordà, Passeig Taulat, 116, 08005 Barcelona, Spain) ;
Muñoz-Guijosa, Christian (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Querol, Sergi (Transfusional Medicine Group, Vall d'Hebron Research Institute, Autonomous University of Barcelona, Barcelona, Spain) ;
Bayes-Genis, Antoni (Universitat Autònoma de Barcelona. Departament de Medicina)
Small cardiac tissue engineering constructs show promise for limiting post-infarct sequelae in animal models. This study sought to scale-up a 2-cm 2 preclinical construct into a human-size advanced therapy medicinal product (ATMP; PeriCord), and to test it in a first-in-human implantation. [...]
2020 -  10.1016/j.ebiom.2020.102729
EBioMedicine, Vol. 54 (april 2020)
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