Resultats globals: 3 registres trobats en 0.03 segons.
Articles, 3 registres trobats
Articles 3 registres trobats  
1.
8 p, 812.8 KB Tetrasubstituted imidazolium salts as potent antiparasitic agents against African and American trypanosomiases / Ghashghaei, Ouldouz (Universitat de Barcelona. Laboratori de Química Orgànica) ; Kielland, Nicola (Universitat de Barcelona. Laboratori de Química Orgànica) ; Revés, Marc (Universitat de Barcelona. Laboratori de Química Orgànica) ; Taylor, Martin C. (Department of Pathogen Molecular Biology. London School of Hygiene and Tropical Medicine) ; Kelly, John M. (Department of Pathogen Molecular Biology. London School of Hygiene and Tropical Medicine) ; Pietro, Ornella Di (Universitat de Barcelona. Laboratori de Química Farmacèutica) ; Muñoz Torrero, Diego (Universitat de Barcelona. Laboratori de Química Farmacèutica) ; Pérez, Belén. (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Lavilla, Rodolfo (Universitat de Barcelona. Laboratori de Química Orgànica)
Imidazolium salts are privileged compounds in organic chemistry, and have valuable biological properties. Recent studies show that symmetric imidazolium salts with bulky moieties can display antiparasitic activity against T. [...]
2018 - 10.3390/molecules23010177
Molecules, Vol. 23 Núm. 1 (2018) , p. 177  
2.
19 p, 3.9 MB Increasing polarity in tacrine and huprine derivatives : Potent anticholinesterase agents for the treatment of myasthenia gravis / Galdeano, Carles (Universitat de Barcelona. Laboratori de Química Farmaceutica) ; Coquelle, Nicolas (Large-Scale Structures Group. Institut Laue-Langevin) ; Cieslikiewicz-Bouet, Monika (Laboratory COBRA (UMR 6014). Normandie Université. UNIROUEN. Institut National des Sciences Appliquées (INSA) Rouen. CNRS) ; Bartolini, Manuela (Department of Pharmacy and Biotechnology. Alma Mater Studiorum University of Bologna) ; Pérez, Belen (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Clos, Victòria (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Silman, Israel (Department of Neurobiology. Weizmann Institute of Science) ; Jean, Ludovic (Laboratory COBRA (UMR 6014). Normandie Université. UNIROUEN. Institut National des Sciences Appliquées (INSA) Rouen. CNRS) ; Colletier, Jacques Phillippe (Institut de Biologie Structurale. Université Grenoble Alpes. Centre National de la Recherche Scientifique (CNRS). Commissariat à l'Énergie Atomique (CEA) (UMR 5075)) ; Renard, Pierre Yves (Laboratory COBRA (UMR 6014). Normandie Université. UNIROUEN. Institut National des Sciences Appliquées (INSA) Rouen. CNRS) ; Muñoz Torrero, Diego (Universitat de Barcelona. Laboratori de Química Farmaceutica)
Symptomatic treatment of myasthenia gravis is based on the use of peripherally-acting acetylcholinesterase (AChE) inhibitors that, in some cases, must be discontinued due to the occurrence of a number of side-effects. [...]
2018 - 10.3390/molecules23030634
Molecules, Vol. 23 Núm. 3 (2018) , p. 634  
3.
16 p, 3.1 MB Neuroprotective effects of the multitarget agent AVCRI104P3 in brain of middle-aged mice / Relat, J. (Department of Pharmacology. Therapeutic and Toxicology. Autonomous University of Barcelona) ; Come, J. (Department of Pharmacology. Therapeutic and Toxicology. Autonomous University of Barcelona) ; Perez, B. (Department of Pharmacology. Therapeutic and Toxicology. Autonomous University of Barcelona) ; Camps, P. (Laboratory of Pharmaceutical Chemistry (CSIC Associated Unit). Faculty of Pharmacy and Food Sciences. Institute of Biomedicine (IBUB). University of Barcelona) ; Muñoz-Torrero, D. (Laboratory of Pharmaceutical Chemistry (CSIC Associated Unit). Faculty of Pharmacy and Food Sciences. Institute of Biomedicine (IBUB). University of Barcelona) ; Badia Sancho, A. (Albert) (Department of Pharmacology. Therapeutic and Toxicology. Autonomous University of Barcelona) ; Gimenez-Llort, L. (Department of Psychiatry and Forensic Medicine. Autonomous University of Barcelona) ; Clos, M.V. (Department of Pharmacology. Therapeutic and Toxicology. Autonomous University of Barcelona)
Molecular factors involved in neuroprotection are key in the design of novel multitarget drugs in aging and neurodegeneration. AVCRI104P3 is a huprine derivative that exhibits potent inhibitory effects on human AChE, BuChE, and BACE-1 activities, as well as on AChE-induced and self-induced Aβ aggregation. [...]
2018 - 10.3390/ijms19092615
International Journal of Molecular Sciences, Vol. 19 Núm. 9 (april 2018) , p. 2615  

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