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11 p, 673.6 KB |
DLST mutations in pheochromocytoma and paraganglioma cause proteome hyposuccinylation and metabolic remodeling
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Mellid, Sara (Hereditary Endocrine Cancer Group. Spanish National Cancer Research Centre) ;
García, Fernando (Proteomics Unit. Spanish National Cancer Research Centre) ;
Leandro-García, Luís Javier (Hereditary Endocrine Cancer Group. Spanish National Cancer Research Centre) ;
Díaz-Talavera, Alberto (Centro de Investigación Biomédica en Red de Enfermedades Raras) ;
Martínez-Montes, Ángel Mario (Hereditary Endocrine Cancer Group. Spanish National Cancer Research Centre) ;
Gil, Eduardo (Hereditary Endocrine Cancer Group. Spanish National Cancer Research Centre) ;
Calsina, Bruna (Hereditary Endocrine Cancer Group. Spanish National Cancer Research Centre) ;
Monteagudo, María (Hereditary Endocrine Cancer Group. Spanish National Cancer Research Centre) ;
Letón, Rocío (Hereditary Endocrine Cancer Group. Spanish National Cancer Research Centre) ;
Roldán-Romero, Juan María (Hereditary Endocrine Cancer Group. Spanish National Cancer Research Centre) ;
Santos, María (Hereditary Endocrine Cancer Group. Spanish National Cancer Research Centre) ;
Lanillos, Javier (Hereditary Endocrine Cancer Group. Spanish National Cancer Research Centre) ;
Valdivia, Carlos (Hereditary Endocrine Cancer Group. Spanish National Cancer Research Centre) ;
Martínez-Puente, Natalia (Centro de Investigación Biomédica en Red de Enfermedades Raras) ;
de Nicolás-Hernández, Javier (Hereditary Endocrine Cancer Group. Spanish National Cancer Research Centre) ;
Jiménez,Scherezade (Monoclonal Antibodies Core Unit. Spanish National Cancer Research Centre) ;
Pérez-Martínez, Manuel (Confocal Microscopy Core Unit. Spanish National Cancer Research Centre) ;
Honrado, Emiliano (Anatomical Pathology Service. Hospital of León) ;
Coloma, Javier (Structural Biology Programme. Spanish National Cancer Research Centre) ;
Cerezo, Ana (CNIO-Lilly Cell Signalling and Immunometabolism Section. Spanish National Cancer Research Centre) ;
Santiveri, Clara María (Spectroscopy and Nuclear Magnetic Resonance Unit. Spanish National Cancer Research Centre) ;
Esteller, M (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Campos-Olivas, Ramón (Spectroscopy and Nuclear Magnetic Resonance Unit. Spanish National Cancer Research Centre) ;
Caleiras, Eduardo (Histopathology Core Unit. Spanish National Cancer Research Centre) ;
Montero-Conde, Cristina (Hereditary Endocrine Cancer Group. Spanish National Cancer Research Centre) ;
Rodríguez-Antona, Cristina (Hereditary Endocrine Cancer Group. Spanish National Cancer Research Centre) ;
Muñoz, Javier (Ikerbasque. Basque Foundation for Science) ;
Robledo, Mercedes (Centro de Investigación Biomédica en Red de Enfermedades Raras) ;
Cascón, Alberto (Centro de Investigación Biomédica en Red de Enfermedades Raras)
2023 -  10.1002/cac2.12427
Cancer Communications, Vol. 43 Núm. 7 (july 2023) , p. 838-843
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22 p, 8.7 MB |
pTINCR microprotein promotes epithelial differentiation and suppresses tumor growth through CDC42 SUMOylation and activation
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Boix, Olga (Vall d'Hebron Institut d'Oncologia) ;
Martínez, Marion (Vall d'Hebron Institut d'Oncologia) ;
Vidal, Santiago (Universidade de Santiago de Compostela) ;
Giménez-Alejandre, Marta (Vall d'Hebron Institut d'Oncologia) ;
Palenzuela, Lluís (Vall d'Hebron Institut d'Oncologia) ;
Lorenzo-Sanz, Laura (Institut d'Investigació Biomèdica de Bellvitge) ;
Quevedo, Laura (Universidad de Cantabria) ;
Moscoso, Olivier (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Ruiz-Orera, Jorge (Max Delbrück Center for Molecular Medicine in the Helmholtz Association) ;
Ximénez-Embún, Pilar (Centro Nacional de Investigaciones Oncológicas) ;
Ciriaco, Nikaoly (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Nuciforo, Paolo (Vall d'Hebron Institut d'Oncologia) ;
Stephan-Otto Attolini, Camille (Institute for Research in Biomedicine (IRB Barcelona)) ;
Albà, M. Mar (Institució Catalana de Recerca i Estudis Avançats) ;
Muñoz, Javier (Centro Nacional de Investigaciones Oncológicas) ;
Tian, Tian V. (Vall d'Hebron Institut d'Oncologia) ;
Varela, Ignacio (Universidad de Cantabria) ;
Vivancos, Ana (Vall d'Hebron Institut d'Oncologia) ;
Ramón y Cajal, Santiago (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Muñoz, Purificación (Institut d'Investigació Biomèdica de Bellvitge) ;
Rivas Vázquez, Carmen (Centro Nacional de Biotecnología (Madrid)) ;
Abad, María (Vall d'Hebron Institut d'Oncologia) ;
Universitat Autònoma de Barcelona
The human transcriptome contains thousands of small open reading frames (sORFs) that encode microproteins whose functions remain largely unexplored. Here, we show that TINCR lncRNA encodes pTINCR, an evolutionary conserved ubiquitin-like protein (UBL) expressed in many epithelia and upregulated upon differentiation and under cellular stress. [...]
2022 - 10.1038/s41467-022-34529-6
Nature communications, Vol. 13 (november 2022)
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11 p, 1.3 MB |
Rapid detection of Legionella pneumophila in drinking water, based on filter immunoassay and chronoamperometric measurement
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J. Ezenarro, Josune (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Párraga-Niño, Noemí (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Sabriá-Leal, M (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
del Campo, F. Javier (Institut de Microelectrònica de Barcelona) ;
Muñoz Pascual, Francisco Javier (Institut de Microelectrònica de Barcelona) ;
Jordi Mas, Jordi (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Uría Moltó, Naroa (Institut de Microelectrònica de Barcelona)
Legionella is a pathogenic bacterium, ubiquitous in freshwater environments and able to colonise man-made water systems from which it can be transmitted to humans during outbreaks. The prevention of such outbreaks requires a fast, low cost, automated and often portable detection system. [...]
2020 - 10.3390/bios10090102
Biosensors, Vol. 10, Núm. 9 (September 2020) , art. 102
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11 p, 3.0 MB |
Comparison of four UAV georeferencing methods for environmental monitoring purposes focusing on the combined use with airborne and satellite remote sensing platforms
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Padró Garcia, Joan-Cristian (Universitat Autònoma de Barcelona. Departament de Geografia) ;
Muñoz, Francisco-Javier (HEMAV S.L.) ;
Planas, Jordi 1950- (Universitat Autònoma de Barcelona. Departament de Geografia) ;
Pons, Xavier (Universitat Autònoma de Barcelona. Departament de Geografia)
This work is aimed at the environmental remote sensing community that uses UAV optical frame imagery in combination with airborne and satellite data. Taking into account the economic costs involved and the time investment, we evaluated the fit-for-purpose accuracy of four positioning methods of UAV-acquired imagery: 1) direct georeferencing using the onboard raw GNSS (GNSSNAV) data, 2) direct georeferencing using Post-Processed Kinematic single-frequency carrier-phase without in situ ground support (PPK1), 3) direct georeferencing using Post-Processed Kinematic double-frequency carrier-phase GNSS data with in situ ground support (PPK2), and 4) indirect georeferencing using Ground Control Points (GCP). [...]
2019 - 10.1016/j.jag.2018.10.018
International journal of applied earth observation and geoinformation, Vol. 75 (March 2019) , p. 130-140
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39 p, 4.7 MB |
mTORC1-dependent AMD1 regulation sustains polyamine metabolism in prostate cancer
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Zabala-Letona, Amaia (Centro de Investigación Biomédica en Red de Cáncer) ;
Arruabarrena-Aristorena, Amaia (CIC bioGUNE) ;
Martín Martín, Natalia (Centro de Investigación Biomédica en Red de Cáncer) ;
Fernández Ruiz, Sonia (Centro de Investigación Biomédica en Red de Cáncer) ;
Sutherland, James D. (CIC bioGUNE) ;
Clasquin, Michelle (AGIOS Pharmaceuticals) ;
Tomás Cortázar, Julen (CIC bioGUNE) ;
Jiménez, José (Hospital Universitari Vall d'Hebron) ;
Torres Ramírez, Inés Ma. de (Hospital Universitari Vall d'Hebron) ;
Quang, Phong (AGIOS Pharmaceuticals) ;
Ximénez-Embún, Pilar (Centro Nacional de Investigaciones Oncológicas) ;
Bago, Ruzica (MRC Protein Phosphorylation and Ubiquitylation Unit) ;
Ugalde Olano, Aitziber (Hospital de Basurto (Bilbao, Biscaia)) ;
Loizaga Iriarte, Ana (Hospital de Basurto (Bilbao, Biscaia)) ;
Lacasa Viscasillas, Isabel (Hospital de Basurto (Bilbao, Biscaia)) ;
Unda, Miguel (Hospital de Basurto (Bilbao, Biscaia)) ;
Torrano, Verónica (Centro de Investigación Biomédica en Red de Cáncer) ;
Cabrera, Diana (CIC bioGUNE) ;
van Liempd, Sebastiaan M. (CIC bioGUNE) ;
Cendon, Ylenia (Universidad Autónoma de Madrid) ;
Castro, Elena (Centro Nacional de Investigaciones Oncológicas) ;
Murray, Stuart (AGIOS Pharmaceuticals) ;
Revandkar, Ajinkya (University of Lausanne) ;
Alimonti, Andrea (University of Lausanne) ;
Zhang, Yinan (Harvard School of Public Health) ;
Barnett, Amelia (AGIOS Pharmaceuticals) ;
Lein, Gina (AGIOS Pharmaceuticals) ;
Pirman, David (AGIOS Pharmaceuticals) ;
Cortazar, Ana Rosa (CIC bioGUNE) ;
Arreal, Leire (CIC bioGUNE) ;
Prudkin, Ludmila (Hospital Universitari Vall d'Hebron) ;
Astobiza, Ianire (CIC bioGUNE) ;
Valcárcel Jiménez, Lorea (CIC bioGUNE) ;
Zúñiga-García, Patricia (CIC bioGUNE) ;
Fernández Domínguez, Itziar (CIC bioGUNE) ;
Piva, Marco (CIC bioGUNE) ;
Caro-Maldonado, Alfredo (CIC bioGUNE) ;
Sánchez Mosquera, Pilar (CIC bioGUNE) ;
Castillo Martín, Mireia (Fundação Champalimaud) ;
Serra, Violeta (Hospital Universitari Vall d'Hebron) ;
Beraza, Naiara (CIC bioGUNE) ;
Gentilella, Antonio (Institut Català d'Oncologia) ;
Thomas, George (Institut Català d'Oncologia) ;
Azkargorta, Mikel (Carlos III Networked Proteomics Platform) ;
Elortza, Felix (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ;
Farràs, Rosa (Centro de Investigación Príncipe Felipe (València)) ;
Olmos, David (Hospital Universitario Virgen de la Victoria (Màlaga, Andalusia)) ;
Efeyan, Alejo (Centro Nacional de Investigaciones Oncológicas) ;
Anguita, Juan (Ikerbasque) ;
Muñoz, Javier (Carlos III Networked Proteomics Platform) ;
Falcón Pérez, Juan M. (Ikerbasque) ;
Barrio, Rosa (CIC bioGUNE) ;
Macarulla Mercadé, Teresa (Hospital Universitari Vall d'Hebron) ;
Mato, José M. (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ;
Martínez Chantar, Maria L. (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ;
Cordon Cardo, Carlos (Icahn School of Medicine at Mount Sinai) ;
Aransay, Ana M. (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ;
Marks, Kevin (AGIOS Pharmaceuticals) ;
Baselga Torres, Josep, 1959-2021, (Memorial Sloan Kettering Cancer Center) ;
Tabernero, Josep (Hospital Universitari Vall d'Hebron) ;
Nuciforo, Paolo (Hospital Universitari Vall d'Hebron) ;
Manning, Brendan D. (Harvard School of Public Health) ;
Marjon, Katya (AGIOS Pharmaceuticals) ;
Carracedo, Arkaitz (University of the Basque Country) ;
Universitat Autònoma de Barcelona
Activation of the PTEN-PI3K-mTORC1 pathway consolidates metabolic programs that sustain cancer cell growth and proliferation,. Here we show that mTORC1 regulates polyamine dynamics, a metabolic route that is essential for oncogenicity. [...]
2017 - 10.1038/nature22964
Nature, Vol. 547 (July 2017) , p. 109-113
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10 p, 687.1 KB |
A framework for genomic biomarker actionability and its use in clinical decision making
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Vidwans, Smruti J. (CollabRx Inc. (USA)) ;
Turski, Michelle L. (CollabRx Inc. (USA)) ;
Janku, Filip (University of Texas. MD Anderson Cancer Center (USA)) ;
Garrido-Laguna, Ignacio (University of Utah. Huntsman Cancer Institute (USA)) ;
Munoz, Javier (Banner MD Anderson Cancer Center (USA)) ;
Schwab, Richard (University of California. Moores Cancer Center (USA)) ;
Subbiah, Vivek (University of Texas. MD Anderson Cancer Center (USA)) ;
Rodón Ahnert, Jordi (Vall d'Hebron Institut d'Oncologia) ;
Kurzrock, Razelle (University of California. Moores Cancer Center (USA)) ;
Universitat Autònoma de Barcelona
The increasing scope and availability of genetic testing options for patients suffering from cancer has raised questions about how to use results of molecular diagnostics to inform patient care. For some biomarkers (e. [...]
2014 - 10.18632/oncoscience.90
Oncoscience, Vol. 1, Núm. 10 (October 2014) , p. 614-623
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34 p, 458.7 KB |
La comunicación audiovisual como herramienta para la apropiación social de la ciencia y temas urbanos : un estudio de caso en la ciudad de Popayán, Colombia
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Córdoba Calvo, Andrés Alejandro (Institución Universitaria Colegio Mayor del Cauca) ;
Muñoz Hoyos, Javier Ancisar (Colegio Mayor del Cauca)
Los medios de comunicación ya no solo tienen la tarea y el poder de informar. Pueden ir más allá y hacer grandes contribuciones en las distintas áreas del conocimiento. El audiovisual, uno de ellos y a través del cual se buscará reflexionar sobre su papel en distintos escenarios, desde los informativos, pasando por los grupos científicos hasta los temas de ciudad.
Els mitjans de comunicació ja no només tenen la tasca i el poder d'informar. Poden anar més enllà i fer grans contribucions en les diferents àrees del coneixement. L'audiovisual, és un d'ells mitjançant el qual es buscarà reflexionar sobre el seu paper en diferents escenaris, des dels informatius, passant pels grups científics fins als temes de ciutat.
The media no longer only have the task and the power to inform. They can go further and make great contributions in different areas of knowledge. The audiovisual is one of them, through which it is sought to reflect on its role in various scenarios, from news, including scientific groups and even city issues.
2016
Ruta comunicación, Núm. 7 (2016) , p. 24-57 (Artículos)
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