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1.
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27 p, 6.2 MB |
Immunoregulatory Biomarkers of the Remission Phase in Type 1 Diabetes : miR-30d-5p Modulates PD-1 Expression and Regulatory T Cell Expansion
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Gómez Muñoz, Laia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Perna-Barrull, David (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Murillo-Vallés, Marta (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Armengol, Maria Pilar (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Alcalde, Marta (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Català, Martí (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Rodríguez-Fernández, Silvia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Sunye, Sergi (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Valls, Aina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Pérez Sánchez, Jacobo (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Corripio, Raquel (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Vives Pi, Marta (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Universitat Autònoma de Barcelona
The partial remission (PR) phase of type 1 diabetes (T1D) is an underexplored period characterized by endogenous insulin production and downmodulated autoimmunity. To comprehend the mechanisms behind this transitory phase and develop precision medicine strategies, biomarker discovery and patient stratification are unmet needs. [...]
2023 -  10.3390/ncrna9020017
Non-Coding RNA, Vol. 9 (february 2023)
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2.
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8 p, 1.3 MB |
Impact of COVID19 pandemic on patients with rare diseases in Spain, with a special focus on inherited metabolic diseases
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Rovira-Remisa, M. Mar (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Moreira, Mónica (Universitat Autònoma de Barcelona) ;
Ventura-Wichner, Paula S (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Gonzalez-Alvarez, Pablo (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Mestres, Núria (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Graterol Torres, Fredzzia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Joaquín, Clara (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Rodríguez-Palmero, Agustí (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Martínez-Colls, Maria del Mar (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Roche, Ana (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Ibáñez-Micó, Salvador (Hospital Universitario Virgen de la Arrixaca (Múrcia)) ;
López-Laso, Eduardo (Instituto Maimónides de Investigación Biomédica de Córdoba) ;
Méndez-Hernández, María Jesús (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Murillo-Vallés, Marta (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Monlleó-Neila, Laura (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Maqueda-Castellote, Elena (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Del Toro, Mireia (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Felipe-Rucián, Ana (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Giralt López, Maria (Universitat Autònoma de Barcelona) ;
Cortès-Saladelafont, Elisenda (Universitat Autònoma de Barcelona)
The Covid-19 pandemic soon became an international health emergency raising concern about its impact not only on physical health but also on quality of life and mental health. Rare diseases are chronically debilitating conditions with challenging patient care needs. [...]
2023 - 10.1016/j.ymgmr.2023.100962
Molecular Genetics and Metabolism Reports, Vol. 35 (march 2023) , p. 100962
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3.
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23 p, 12.1 MB |
Candidate Biomarkers for the Prediction and Monitoring of Partial Remission in Pediatric Type 1 Diabetes
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Gómez Muñoz, Laia (Institut Germans Trias i Pujol) ;
Perna-Barrull, David (Institut Germans Trias i Pujol) ;
Caroz-Armayones, Josep M. (The Johns Hopkins University - Pompeu Fabra University Public Policy Center) ;
Murillo-Vallés, Marta (Institut Germans Trias i Pujol) ;
Rodríguez-Fernández, Silvia (Institut Germans Trias i Pujol) ;
Valls, Aina (Institut Germans Trias i Pujol) ;
Vázquez, Federico (Institut Germans Trias i Pujol) ;
Pérez Sánchez, Jacobo (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Corripio, Raquel (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Castaño, Luis (Instituto de Investigación Sanitaria Biocruces Bizkaia) ;
Bel, Joan (Institut Germans Trias i Pujol) ;
Vives Pi, Marta (Institut Germans Trias i Pujol)
The partial remission (PR) phase, a period experienced by most patients with type 1 diabetes (T1D) soon after diagnosis, is characterized by low insulin requirements and improved glycemic control. Given the great potential of this phase as a therapeutic window for immunotherapies because of its association with immunoregulatory mechanisms and β-cell protection, our objective was to find peripheral immunological biomarkers for its better characterization, monitoring, and prediction. [...]
2022 - 10.3389/fimmu.2022.825426
Frontiers in immunology, Vol. 13 (february 2022)
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4.
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8 p, 689.8 KB |
Prenatal Betamethasone Exposure and its Impact on Pediatric Type 1 Diabetes Mellitus : A Preliminary Study in a Spanish Cohort
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Perna-Barrull, David (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Murillo-Vallés, Marta (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Real, Nati (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Gómez Muñoz, Laia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Rodríguez-Fernández, Silvia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Bel, Joan (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Puig Domingo, Manuel (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Vives Pi, Marta (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Universitat Autònoma de Barcelona
Betamethasone, a glucocorticoid used to induce lung maturation when there is a risk of preterm delivery, can affect the immune system maturation and type 1 diabetes (T1D) incidence in the progeny. It has been described that prenatal betamethasone protects offspring from experimental T1D development. [...]
2022 - 10.1155/2022/6598600
Journal of Diabetes Research, Vol. 2022 (march 2022)
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5.
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14 p, 1.8 MB |
NK Cell Subsets Changes in Partial Remission and Early Stages of Pediatric Type 1 Diabetes
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Gómez Muñoz, Laia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Perna-Barrull, David (Institut Germans Trias i Pujol) ;
Villalba Felipe, Adrián (Institut Germans Trias i Pujol) ;
Rodríguez-Fernández, Silvia (Institut Germans Trias i Pujol) ;
Ampudia Carrasco, Rosa María (Institut Germans Trias i Pujol) ;
Teniente Serra, Aina (Institut Germans Trias i Pujol) ;
Vázquez, Federico (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Murillo-Vallés, Marta (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Pérez Sánchez, Jacobo (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Corripio, Raquel (Universitat Autònoma de Barcelona. Departament de Pediatria, Obstetrícia i Ginecologia i Medicina Preventiva i Salut Pública) ;
Bel, Joan (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Vives Pi, Marta (Institut Germans Trias i Pujol)
Type 1 diabetes (T1D) is a chronic metabolic disease characterized by the autoimmune destruction of β-cells in the pancreatic islets. T1D is preceded by islet-specific inflammation led by several immune cells. [...]
2021 - 10.3389/fimmu.2020.611522
Frontiers in immunology, Vol. 11, art. 611522 (january 2021)
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6.
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2 p, 318.1 KB |
Dendritic cells from paediatric patients with type 1 diabetes show altered phagocytosis capacity correlating with disease evolution
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Rodríguez-Fernández, Silvia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Murillo-Vallés, Marta (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Perna-Barrull, David (Institut Germans Trias i Pujol) ;
Villalba Felipe, Adrián (Institut Germans Trias i Pujol) ;
Maspoch Comamala, Daniel (Institut Català de Nanociència i Nanotecnologia) ;
Bel, Joan (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Vives Pi, Marta (Institut Germans Trias i Pujol)
Autoimmunity against β-cells in type 1 diabetes (T1D) is prompted by defective immunological tolerance, an event in which dendritic cells (DCs) play a crucial role as orchestrators of the immune response. [...]
2019 - 10.1007/s00125-019-4946-6
Diabetologia, Vol. 62, supl. 1 (Set. 2019) , art. S224
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7.
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14 p, 127.3 KB |
Measurement properties of the online EuroQol-5D-youth instrument in children and adolescents with type 1 diabetes mellitus : Questionnaire study
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Mayoral, K.. (Universitat Autònoma de Barcelona. Departament de Pediatria, Obstetrícia i Ginecologia i Medicina Preventiva i Salut Pública) ;
Rajmil, Luis (Agència de Qualitat i Avaluació Sanitàries de Catalunya) ;
Murillo-Vallés, Marta (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Garin, Olatz (Universitat Pompeu Fabra. Departament de Ciències Experimentals i de la Salut) ;
Pont, A. (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública) ;
Alonso, Jordi (Universitat Pompeu Fabra. Departament de Ciències Experimentals i de la Salut) ;
Bel, Joan (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Pérez Sánchez, Jacobo (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Corripio, Raquel (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Carreras, Gemma (Institut d'Investigació Biomèdica Sant Pau) ;
Herrero Espinet, Francisco Javier (Corporació de Salut del Maresme i la Selva. Hospital de Calella) ;
Mengibar, J. M. (Corporació de Salut del Maresme i la Selva. Hospital de Blanes) ;
Rodríguez Arjona, Dolors (Agència de Qualitat i Avaluació Sanitàries de Catalunya) ;
Ravens-Sieberer, Ulrike (Department of Child and Adolescent Psychiatry. Psychotherapy. and Psychosomatics. University Medical Center Hamburg - Eppendorf) ;
Raat, Hein (Department of Public Health. Erasmus University Medical Center Rotterdam) ;
Serra-Sutton, V. (Agència de Qualitat i Avaluació Sanitàries de Catalunya) ;
Ferrer, M. (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública)
Background: The lack of continuity between health-related quality of life (HRQoL) instruments designed for children and adults hinders change analysis with a life course approach. To resolve this gap, EuroQol (EQ) developed the EQ-5D-Youth (EQ-5D-Y), derived from the EQ-5D for adults. [...]
2019 - 10.2196/14947
Journal of medical Internet research, Vol. 21 Núm. 11 (2019) , p. e14947
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18 p, 2.6 MB |
Partial remission and early stages of pediatric type 1 diabetes display immunoregulatory changes. A pilot study
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Villalba Felipe, Adrián (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Fonolleda, Mireia (Institut Germans Trias i Pujol) ;
Murillo-Vallés, Marta (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Rodríguez-Fernández, Silvia (Institut Germans Trias i Pujol) ;
Ampudia Carrasco, Rosa María (Institut Germans Trias i Pujol) ;
Perna-Barrull, David (Institut Germans Trias i Pujol) ;
Raina, María Belén (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Quirant, Bibiana (Institut Germans Trias i Pujol) ;
Planas, Raquel (Institut Germans Trias i Pujol) ;
Teniente Serra, Aina (Institut Germans Trias i Pujol) ;
Bel, Joan (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Vives Pi, Marta (Institut Germans Trias i Pujol) ;
Universitat Autònoma de Barcelona
Type 1 diabetes (T1D) is a chronic metabolic disease of unknown etiology that results from β-cell destruction. The onset of the disease, which arises after a long asymptomatic period of autoimmune attack, may be followed by a relapsing and remitting progression, a phenomenon that is most evident during the partial remission phase (PR). [...]
2019 - 10.1016/j.trsl.2019.03.002
Translational Research, Vol. 210 (august 2019) , p. 8-25
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10.
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8 p, 1.2 MB |
Differential association between S100A4 levels and insulin resistance in prepubertal children and adult subjects with clinically severe obesity
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Taxerås, Siri D. (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Galán, María (Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares) ;
Campderrós, Laura (Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición) ;
Piquer García, Irene (Institut Germans Trias i Pujol) ;
Pellitero, Silvia (Institut Germans Trias i Pujol) ;
Martínez, Eva (Institut Germans Trias i Pujol) ;
Puig, Rocío (Institut Germans Trias i Pujol) ;
Lucena, Icíar (v) ;
Tarascó, Jordi (Institut Germans Trias i Pujol) ;
Moreno, Pau (Institut Germans Trias i Pujol) ;
Balibrea Del Castillo, José María (Hospital Universitari Vall d'Hebron) ;
Bel, Joan (Institut Germans Trias i Pujol) ;
Murillo-Vallés, Marta (Institut Germans Trias i Pujol) ;
Martínez, María (Institut Germans Trias i Pujol) ;
Ramon-Krauel, Marta (Hospital Sant Joan de Déu (Manresa)) ;
Puig Domingo, Manuel (Institut Germans Trias i Pujol) ;
Villarroya, Francesc (Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición) ;
Lerin, Carles (Hospital Sant Joan de Déu (Manresa)) ;
Sánchez-Infantes, David (Institut Germans Trias i Pujol) ;
Universitat Autònoma de Barcelona
Objectives: S100A4 has been recently identified as an adipokine associated with insulin resistance (IR) in adult subjects with obesity. However, no data about its levels in children with obesity and only a few approaches regarding its potential mechanism of action have been reported. [...]
2020 - 10.1002/osp4.381
Obesity Science and Practice, Vol. 6 Núm. 1 (january 2020) , p. 99-106
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