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7 p, 525.4 KB Association of variations in HLA class II and other loci with susceptibility to EGFR-mutated lung adenocarcinoma / Shiraishi, Kouya (National Cancer Center Research Institute (Tòquio, Japó)) ; Okada, Yukinori (Tokyo Medical and Dental University) ; Takahashi, Atsushi (RIKEN Center for Integrative Medical Sciences (Yokohama, Japó)) ; Kamatani, Yoichiro (RIKEN Center for Integrative Medical Sciences (Yokohama, Japó)) ; Momozawa, Yukihide (RIKEN Center for Integrative Medical Sciences (Yokohama, Japó)) ; Ashikawa, Kyota (RIKEN Center for Integrative Medical Sciences (Yokohama, Japó)) ; Kunitoh, Hideo (Japanese Red Cross Medical Center (Tòquio, Japó)) ; Matsumoto, Shingo (National Cancer Center Research Institute (Tòquio, Japó)) ; Takano, Atsushi (The University of Tokyo) ; Shimizu, Kimihiro (Gunma University Hospital (Maebashi, Japó)) ; Goto, Akiteru (Akita University (Akita, Japó)) ; Tsuta, Koji (National Cancer Center Hospital (Tòquio, Japó)) ; Watanabe, Shun-ichi (National Cancer Center Hospital (Tòquio, Japó)) ; Ohe, Yuichiro (National Cancer Center Hospital (Tòquio, Japó)) ; Watanabe, Yukio (National Cancer Center Hospital (Tòquio, Japó)) ; Goto, Yasushi (National Cancer Center Hospital (Tòquio, Japó)) ; Nokihara, Hiroshi (National Cancer Center Hospital (Tòquio, Japó)) ; Furuta, Koh (National Cancer Center Hospital (Tòquio, Japó)) ; Yoshida, Akihiko (National Cancer Center Hospital (Tòquio, Japó)) ; Goto, Koichi (National Cancer Center Hospital East (Chiba, Japó)) ; Hishida, Tomoyuki (National Cancer Center Hospital East (Chiba, Japó)) ; Tsuboi, Masahiro (National Cancer Center Hospital East (Chiba, Japó)) ; Tsuchihara, Katsuya (National Cancer Center Research Institute (Tòquio, Japó)) ; Miyagi, Yohei (Kanagawa Cancer Center Research Institute (Yokohama, Japó)) ; Nakayama, Haruhiko (Kanagawa Cancer Center (Yokohama, Japó)) ; Yokose, Tomoyuki (Kanagawa Cancer Center (Yokohama, Japó)) ; Tanaka, Kazumi (Gunma University Hospital (Maebashi, Japó)) ; Nagashima, Toshiteru (Gunma University Hospital (Maebashi, Japó)) ; Ohtaki, Yoichi (Gunma University Hospital (Maebashi, Japó)) ; Maeda, Daichi (Akita University (Akita, Japó)) ; Imai, Kazuhiro (Akita University (Akita, Japó)) ; Minamiya, Yoshihiro (Akita University (Akita, Japó)) ; Sakamoto, Hiromi (National Cancer Center Research Institute (Tòquio, Japó)) ; Saito, Akira (StaGen Co., Ltd. (Tòquio, Japó)) ; Shimada, Yoko (National Cancer Center Research Institute (Tòquio, Japó)) ; Sunami, Kuniko (National Cancer Center Research Institute (Tòquio, Japó)) ; Saito, Motonobu (National Cancer Center Research Institute (Tòquio, Japó)) ; Inazawa, Johji (Tokyo Medical and Dental University) ; Nakamura, Yusuke (University of Chicago) ; Yoshida, Teruhiko (National Cancer Center Research Institute (Tòquio, Japó)) ; Yokota, Jun (Institut Germans Trias i Pujol. Institut de Medicina Predictiva i Personalitzada del Càncer) ; Matsuda, Fumihiko (Kyoto University) ; Matsuo, Keitaro (Aichi Cancer Center Research Institute (Nagoya, Japó)) ; Daigo, Yataro (The University of Tokyo) ; Kubo, Michiaki (RIKEN Center for Integrative Medical Sciences (Yokohama, Japó)) ; Kohno, Takashi (National Cancer Center Research Institute (Tòquio, Japó))
Lung adenocarcinoma driven by somatic EGFR mutations is more prevalent in East Asians (30-50%) than in European/Americans (10-20%). Here we investigate genetic factors underlying the risk of this disease by conducting a genome-wide association study, followed by two validation studies, in 3,173 Japanese patients with EGFR mutation-positive lung adenocarcinoma and 15,158 controls. [...]
2016 - 10.1038/ncomms12451
Nature communications, Vol. 7 (August 2016) , art. 12451  

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