|
1.
|
|
13 p, 1.9 MB |
Genetic characterization of the ALFA study : Uncovering genetic profiles in the Alzheimer's continuum
/
Vilor-Tejedor, Natalia (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Genius, Patricia (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Rodríguez-Fernández, Blanca (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Minguillón, Carolina (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Sadeghi, Iman (Centre de Regulació Genòmica) ;
González-Escalante, Armand (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Crous-Bou, Marta (Hospital Universitari de Bellvitge) ;
Suárez-Calvet, Marc (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Grau-Rivera, Oriol (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Brugulat-Serrat, Anna (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Sánchez-Benavides, Gonzalo (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Esteller, M (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Fauria, Karine (Pasqual Maragall Foundation) ;
Molinuevo, José Luis (Pasqual Maragall Foundation) ;
Navarro, Arcadi 1969- (Universitat Pompeu Fabra) ;
Gispert, Juan Domingo (Institut Hospital del Mar d'Investigacions Mèdiques)
INTRODUCTION: In 2013, the ALzheimer's and FAmilies (ALFA) project was established to investigate pathophysiological changes in preclinical Alzheimer's disease (AD), and to foster research on early detection and preventive interventions. [...]
2023 -  10.1002/alz.13537
Alzheimer's & Dementia, 2023
|
|
|
2.
|
|
21 p, 11.5 MB |
Identification of constrained sequence elements across 239 primate genomes
/
Kuderna, Lukas F. K. (Illumina. Co. Illumina Artificial Intelligence Laboratory (San Diego, Estats Units)) ;
Ulirsch, Jacob C. (Illumina. Co. Illumina Artificial Intelligence Laboratory (San Diego, Estats Units)) ;
Rashid, Sabrina (Illumina. Co. Illumina Artificial Intelligence Laboratory (San Diego, Estats Units)) ;
Ameen, Mohamed (Illumina. Co. Illumina Artificial Intelligence Laboratory (San Diego, Estats Units)) ;
Sundaram, Laksshman (Illumina. Co. Illumina Artificial Intelligence Laboratory (San Diego, Estats Units)) ;
Hickey, Glenn (University of California. Santa Cruz Genomics Institute) ;
Cox, Anthony J. (Illumina. Co. Illumina Artificial Intelligence Laboratory (San Diego, Estats Units)) ;
Gao, Hong (Illumina. Co. Illumina Artificial Intelligence Laboratory (San Diego, Estats Units)) ;
Kumar, Arvind (Illumina. Co. Illumina Artificial Intelligence Laboratory (San Diego, Estats Units)) ;
Aguet, Francois (Illumina. Co. Illumina Artificial Intelligence Laboratory (San Diego, Estats Units)) ;
Christmas, Matthew J. (Uppsala University. Department of Medical Biochemistry and Microbiology) ;
Clawson, Hiram (University of California. Santa Cruz Genomics Institute) ;
Haeussler, Maximilian (University of California. Santa Cruz Genomics Institu) ;
Janiak, Mareike C. (University of Salford. School of Science, Engineering and Environment) ;
Kuhlwilm, Martin (University of Vienna. Department of Evolutionary Anthropology) ;
Orkin, Joseph D. (Université de Montréal. Département d'Anthropologie) ;
Bataillon, Thomas (Aarhus University. Bioinformatics Research Centre) ;
Shivakumara Manu (Academy of Scientific and Innovative Research (Ghaziabad, Índia)) ;
Valenzuela, Alejandro (Institut de Biologia Evolutiva (Barcelona)) ;
Bergman, Juraj (Aarhus University. Bioinformatics Research Centre) ;
Rouselle, Marjolaine (Aarhus University. Bioinformatics Research Centre) ;
Silva, Felipe Ennes (Mamirauá Institute for Sustainable Development) ;
Agueda Calpena, Lidia (Centre Nacional d'Anàlisi Genòmica (CNAG)) ;
Blanc, Julie (Centre Nacional d'Anàlisi Genòmica (CNAG)) ;
Gut, Marta (Centre Nacional d'Anàlisi Genòmica (CNAG)) ;
de Vries, Dorien (University of Salford. School of Science, Engineering and Environment) ;
Goodhead, Ian (University of Salford. School of Science, Engineering and Environment) ;
Harris, R. Alan (Baylor College of Medicine. Department of Molecular and Human Genetics) ;
Raveendran, Muthuswamy (Baylor College of Medicine. Department of Molecular and Human Genetics) ;
Jensen, Axel (Uppsala University. Department of Ecology and Genetics) ;
Chuma, Idriss S. (Tanzania National Parks) ;
Horvath, Julie E. (University of North Carolina at Chapel Hill. Renaissance Computing Institute) ;
Hvilsom, Christina (Copenhagen Zoo) ;
Juan, David (Institut de Biologia Evolutiva (Barcelona)) ;
Frandsen, Peter (Copenhagen Zoo) ;
Schraiber, Joshua G. (Illumina. Co. Illumina Artificial Intelligence Laboratory (San Diego, Estats Units)) ;
de Melo, Fabiano R. (Universidade Federal de Viçosa) ;
Bertuol, Fabrício (Universidade Federal do Amazonas. Departamento de Genética) ;
Byrne, Hazel (University of Utah. Department of Anthropology) ;
Sampaio, Iracilda (Universidade Federal do Pará (Brasil)) ;
Pires Farias, Izeni (Universidade Federal do Amazonas. Departamento de Genética) ;
Valsecchi, João (Comunidad de Manejo de Fauna Silvestre en la Amazonía y en Latinoamérica-ComFauna) ;
Messias, Malu (Universidade Federal de Rondônia) ;
da Silva, Maria N. F. (Instituto Nacional de Pesquisas da Amazônia) ;
Trivedi, Mihir (Centre for Cellular and Molecular Biology (Hyderabad, Índia)) ;
Rossi, Rogerio (Universidade Federal do Mato Grosso. Instituto de Biociências) ;
Hrbek, Tomas (Trinity University. Department of Biology) ;
Andriaholinirina, Nicole (University of Mahajanga. Faculty of Science, Technology and Environment) ;
Rabarivola, Clément J. (University of Mahajanga. Faculty of Science, Technology and Environment) ;
Zaramody, Alphonse (University of Mahajanga. Faculty of Science, Technology and Environment) ;
Jolly, Clifford J. (New York University .Department of Anthropology) ;
Phillips-Conroy, Jane (Washington University School of Medicine in St Louis. Department of Neuroscience) ;
Wilkerson, Gregory (MD Anderson Cancer Center. Keeling Center for Comparative Medicine and Research) ;
Abbee, C. (MD Anderson Cancer Center. Keeling Center for Comparative Medicine and Research) ;
Simmons, Joe H. (MD Anderson Cancer Center. Keeling Center for Comparative Medicine and Research) ;
Fernandez-Duque, Eduardo (Yale University. Department of Anthropology) ;
Kanthaswamy, Sree (University of California. California National Primate Research Center) ;
Shiferaw, Fekadu (The Carter Center Ethiopia) ;
Wu, Dong-Dong (Chinese Academy of Sciences. Kunming Institute of Zoology. State Key Laboratory of Genetic Resources and Evolution) ;
Zhou, Long (Zhejiang University School of Medicine. Center for Evolutionary and Organismal Biology) ;
Shao, Yong (Chinese Academy of Sciences. Kunming Institute of Zoology. State Key Laboratory of Genetic Resources and Evolution) ;
Zhang, Guojie (Zhejiang University Medical Center) ;
Keyyu, Julius D. (Tanzania Wildlife Research Institute) ;
Knauf, Sascha (Justus Liebig University. Faculty of Veterinary Medicine) ;
Le, Minh D. (Vietnam National University. Department of Environmental Ecology) ;
Lizano, Esther (Institut Català de Paleontologia Miquel Crusafont) ;
Merker, Stefan epartment of Environmental Ecology (State Museum of Natural History Stuttgart. Department of Zoology) ;
Navarro, Arcadi, 1969- (Institut de Biologia Evolutiva (Barcelona)) ;
Nadler, Tilo (Cuc Phuong Commune) ;
Khor, Chiea Chuen (Genome Institute of Singapore) ;
Lee, Jessica (Mandai Nature) ;
Tan, Patrick (Duke-NUS Medical School) ;
Lim, Weng Khong (SingHealth Duke-NUS Genomic Medicine Centre) ;
Kitchener, Andrew C. (School of Geosciences) ;
Zinner, Dietmar (Leibniz ScienceCampus Primate Cognition) ;
Gut, Ivo (Centre Nacional d'Anàlisi Genòmica (CNAG)) ;
Melin, Amanda D. (University of Calgary. Alberta Children's Hospital Research Institute) ;
Guschanski, Katerina (University of Edinburgh. School of Biological Sciences) ;
Schierup, Mikkel Heide (Aarhus University. Bioinformatics Research Centre) ;
Beck, Robin (University of Salford. School of Science, Engineering and Environment) ;
Karakikes, Ioannis (Stanford University. Department of Cardiothoracic Surgery) ;
Wang, Kevin C. (Veterans Affairs Palo Alto Healthcare System) ;
Umapathy, Govindhaswamy (Centre for Cellular and Molecular Biology (Hyderabad, Índia)) ;
Roos, Christian (Leibniz Institute for Primate Research. German Primate Center) ;
Boubli, Jean (University of Salford. School of Science, Engineering and Environment) ;
Siepel, Adam (Simons Center for Quantitative Biology. Cold Spring Harbor Laboratory) ;
Kundaje, Anshul (Stanford University. Department of Genetics) ;
Paten, Benedict (University of California. Santa Cruz Genomics Institute) ;
Lindblad-Toh, Kerstin (Uppsala University. Department of Medical Biochemistry and Microbiology) ;
Rogers, Jeffrey (Baylor College of Medicine. Department of Molecular and Human Genetics) ;
Marques-Bonet, Tomas 1975- (Institut Català de Paleontologia Miquel Crusafont) ;
Farh, Kyle Kai-How (Illumina. Co. Illumina Artificial Intelligence Laboratory (San Diego, Estats Units))
Noncoding DNA is central to our understanding of human gene regulation and complex diseases and measuring the evolutionary sequence constraint can establish the functional relevance of putative regulatory elements in the human genome. [...]
2023 - 10.1038/s41586-023-06798-8
Nature, Published online nov. 2023
|
|
|
3.
|
|
9 p, 404.0 KB |
Identification of a functional variant in the KIF5A-CYP27B1-METTL1-FAM119B locus associated with multiple sclerosis
/
Alcina, Antonio (Instituto de Parasitología y Biomedicina "López-Neyra") ;
Fedetz, Maria (Instituto de Parasitología y Biomedicina "López-Neyra") ;
Fernández, Óscar (Hospital Regional Universitario Carlos Haya (Málaga)) ;
Saiz, Albert (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Izquierdo, Guillermo (Hospital Universitario Virgen Macarena (Sevilla, Andalusia)) ;
Lucas, Miguel (Hospital Universitario Virgen Macarena (Sevilla, Andalusia)) ;
Leyva, Laura (Hospital Regional Universitario Carlos Haya (Málaga)) ;
García-León, Juan Antonio (Hospital Regional Universitario Carlos Haya (Málaga)) ;
Abad-Grau, María del Mar (Universidad de Granada) ;
Alloza, Iraide (Universidad del País Vasco) ;
Antigüedad, Alfredo (Hospital de Basurto (Bilbao, Biscaia)) ;
Garcia-Barcina, María J. (Hospital de Basurto (Bilbao, Biscaia)) ;
Vandenbroeck, Koen (Universidad del País Vasco) ;
Varadé, Jezabel (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos) ;
de la Hera, Belén (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos) ;
Arroyo, Rafael (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos) ;
Comabella, Manuel (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Montalban, Xavier (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Petit-Marty, Natalia (Institut de Biologia Evolutiva (UPF-CSIC) (Barcelona)) ;
Navarro, Arcadi 1969- (Institut de Biologia Evolutiva (UPF-CSIC) (Barcelona)) ;
Otaegui, David (Biodonostia Osasun Ikerketako Institutura (País Basc)) ;
Olascoaga, Javier (Hospital Universitario Donosti) ;
Blanco, Yolanda (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Urcelay, Elena (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos) ;
Matesanz, Fuencisla (Instituto de Parasitología y Biomedicina "López-Neyra")
Background and aim: Several studies have highlighted the association of the 12q13. 3-12q14. 1 region with coeliac disease, type 1 diabetes, rheumatoid arthritis and multiple sclerosis (MS); however, the causal variants underlying diseases are still unclear. [...]
2013 - 10.1136/jmedgenet-2012-101085
Journal of medical genetics, Vol. 50, Issue 1 (May 2013) , p. 25-33
|
|
|
4.
|
|
36 p, 6.3 MB |
Look-alike humans identified by facial recognition algorithms show genetic similarities
/
Joshi, Ricky S. (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Rigau, M. (Barcelona Supercomputing Center) ;
García-Prieto, Carlos A (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Castro de Moura, Manuel (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Piñeyro, David (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Moran, S (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Davalos, Veronica (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Carrión, P. (Institut de Biologia Evolutiva (UPF-CSIC) (Barcelona)) ;
Ferrando-Bernal, Manuel (Institut de Biologia Evolutiva (UPF-CSIC) (Barcelona)) ;
Olalde, I. (Institut de Biologia Evolutiva (UPF-CSIC) (Barcelona)) ;
Lalueza-Fox, Carles (Institut de Biologia Evolutiva (UPF-CSIC) (Barcelona)) ;
Navarro, Arcadi 1969- (Institució Catalana de Recerca i Estudis Avançats) ;
Fernández-Tena, C. (Herta Security. S.L.) ;
Aspandi, D. (Universitat Pompeu Fabra. Departament de Tecnologies de la Informació i les Comunicacions) ;
Sukno, F.M. (Universitat Pompeu Fabra. Departament de Tecnologies de la Informació i les Comunicacions) ;
Binefa i Valls, Xavier (Universitat Pompeu Fabra. Departament de Tecnologies de la Informació i les Comunicacions) ;
Valencia, A. (Institució Catalana de Recerca i Estudis Avançats) ;
Esteller, M (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
The human face is one of the most visible features of our unique identity as individuals. Interestingly, monozygotic twins share almost identical facial traits and the same DNA sequence but could exhibit differences in other biometrical parameters. [...]
2022 - 10.1016/j.celrep.2022.111257
Cell reports, Vol. 40 Núm. 8 (23 2022) , p. 111257
|
|
|
5.
|
|
11 p, 1001.7 KB |
Genetic predisposition to alzheimer's disease is associated with enlargement of perivascular spaces in centrum semiovale region
/
Ciampa, Iacopo (Hospital del Sagrat Cor (Barcelona, Catalunya)) ;
Operto, Grégory (Centro de Investigación Biomédica en Red sobre Fragilidad y Envejecimiento Saludable) ;
Falcon, Carles (Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina) ;
Minguillon, Carolina (Centro de Investigación Biomédica en Red sobre Fragilidad y Envejecimiento Saludable) ;
Castro de Moura, Manuel (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Piñeyro, David (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Esteller, M (Universitat de Barcelona) ;
Molinuevo, José Luis (Universitat Pompeu Fabra) ;
Guigó, Roderic (Barcelona Institute of Science and Technology (BIST)) ;
Navarro, Arcadi 1969- (Universitat Pompeu Fabra) ;
Gispert, Juan Domingo (Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina) ;
Vilor-Tejedor, Natalia (Erasmus University Medical Center Rotterdam) ;
Universitat Autònoma de Barcelona
This study investigated whether genetic factors involved in Alzheimer's disease (AD) are associated with enlargement of Perivascular Spaces (ePVS) in the brain. A total of 680 participants with T2-weighted MRI scans and genetic information were acquired from the ALFA study. [...]
2021 - 10.3390/genes12060825
Genes, Vol. 12 Núm. 6 (june 2021) , p. 825
|
|
|
6.
|
|
6 p, 201.9 KB |
Pharmacogenomic study in patients with multiple sclerosis
/
Bustamante, Marta F. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Morcillo-Suarez, Carlos (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Malhotra, Sunny (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Rio, Jordi (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Leyva, Laura (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Fernández, Oscar (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Zettl, Uwe K. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Killestein, Joep (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Brassat, David (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
García-Merino, Juan Antonio (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Sánchez, Antonio J. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Urcelay, Elena (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Alvarez-Lafuente, Roberto (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Villar, Lusia M. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Alvarez-Cermeño, José C (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Farré, Xavier (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Lechner-Scott, Jeannette (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Vandenbroeck, Koen (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Rodríguez-Antigüedad, Alfredo (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Martinelli Boneschi, Filippo (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Chan, Andrew (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Oksenberg, Jorge (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Navarro, Arcadi, 1969- (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Montalban, Xavier (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Comabella, Manuel (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Universitat Autònoma de Barcelona
We aimed to investigate the association between polymorphisms located in type I interferon (IFN)-induced genes, genes belonging to the toll-like receptor (TLR) pathway, and genes encoding neurotransmitter receptors and the response to IFN-β treatment in patients with multiple sclerosis (MS). [...]
2015 - 10.1212/NXI.0000000000000154
Neurology® neuroimmunology & neuroinflammation, Vol. 2 (september 2015)
|
|
|
7.
|
|
20 p, 2.8 MB |
Functional Implications of Human-Specific Changes in Great Ape microRNAs
/
Gallego, Alicia (Universitat Pompeu Fabra. Departament de Ciències Experimentals i de la Salut) ;
Melé, Marta (Centre de Regulació Genòmica) ;
Balcells Ortega, Ingrid (University of Helsinki. Department of Biosciences) ;
García-Ramallo, Eva (Universitat Pompeu Fabra. Departament de Ciències Experimentals i de la Salut) ;
Torruella-Loran, Ignasi (Universitat Pompeu Fabra. Departament de Ciències Experimentals i de la Salut) ;
Fernández-Bellon, Hugo (Universitat Autònoma de Barcelona) ;
Abello, Teresa (Zoo de Barcelona) ;
Kondova, Ivanela (Biomedical Primate Research Centre) ;
Bontrop, Ronald (Biomedical Primate Research Centre) ;
Hvilsom, Christina (Copenhagen Zoo) ;
Navarro, Arcadi, 1969- (Institució Catalana de Recerca i Estudis Avançats) ;
Marquès-Bonet, Tomàs (Centro Nacional de Análisis Genómico) ;
Espinosa-Parrilla, Yolanda (University of Magallanes. School of Medicine)
microRNAs are crucial post-transcriptional regulators of gene expression involved in a wide range of biological processes. Although microRNAs are highly conserved among species, the functional implications of existing lineage-specific changes and their role in determining differences between humans and other great apes have not been specifically addressed. [...]
2016 - 10.1371/journal.pone.0154194
PloS one, Vol. 11, Issue 4 (April 2016) , art. e0154194
|
|
|
8.
|
|
22 p, 1.5 MB |
A New Risk Variant for Multiple Sclerosis at 11q23.3 Locus Is Associated with Expansion of CXCR5+ Circulating Regulatory T Cells
/
Gil Varea, Elia (Hospital Universitari Vall d'Hebron) ;
Fedetz, Maria (Instituto de Parasitología y Biomedicina "López-Neyra") ;
Eixarch, Herena (Hospital Universitari Vall d'Hebron) ;
Spataro, Nino (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Villar, Luisa M (Instituto Ramón y Cajal de Investigación Sanitaria (Madrid)) ;
Urcelay, Elena (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos) ;
Saiz, Albert (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Fernández, Óscar (Instituto de Investigación Biomédica de Málaga) ;
Leyva, Laura (Instituto de Investigación Biomédica de Málaga) ;
Ramió-Torrentà, Lluís (Universitat de Girona) ;
Vandenbroeck, Koen (IKERBASQUE (Bilbao)) ;
Otaegui, David (Biodonostia Osasun Ikerketako Institutura (País Basc)) ;
Castillo-Triviño, Tamara (Hospital Universitario de Donostia (Sant Sebastià, País Basc)) ;
Izquierdo, Guillermo (Hospital Universitario Virgen Macarena (Sevilla, Andalusia)) ;
Malhotra, Sunny (Hospital Universitari Vall d'Hebron) ;
Bosch, Elena (Centro de Investigación Biomédica en Red de Salud Mental) ;
Navarro, Arcadi, 1969- (Institució Catalana de Recerca i Estudis Avançats) ;
Alcina, Antonio (Instituto de Parasitología y Biomedicina "López-Neyra") ;
Montalban, Xavier (University of Toronto) ;
Matesanz, Fuencisla (Instituto de Parasitología y Biomedicina "López-Neyra") ;
Comabella, Manuel (Hospital Universitari Vall d'Hebron) ;
Universitat Autònoma de Barcelona
Genome-wide association studies and meta-analysis have contributed to the identification of more than 200 loci associated with multiple sclerosis (MS). However, a proportion of MS heritability remains unknown. [...]
2020 - 10.3390/jcm9030625
Journal of clinical medicine, Vol. 9 (february 2020)
|
|
|
9.
|
|
12 p, 1.3 MB |
The genetic impact of an Ebola outbreak on a wild gorilla population
/
Fontsere, Claudia (Institut de Biologia Evolutiva (UPF-CSIC) (Barcelona)) ;
Frandsen, Peter (University of Copenhagen. Department of Biology. Section for Computational and RNA Biology) ;
Hernandez Rodriguez, Jessica (Institut de Biologia Evolutiva (UPF-CSIC) (Barcelona)) ;
Niemann, Jonas (University of Copenhagen. Center for Evolutionary Hologenomics. The GLOBE Institute) ;
Hjorth Scharff-Olsen, Camilla (University of Copenhagen. Center for Evolutionary Hologenomics. The GLOBE Institute) ;
Vallet, Dominique (Centre National de la Recherche Scientifique. University of Rennes. ECOBIO: Ecosystems, Biodiversity, Evolution) ;
Le Gouar, Pascaline (Centre National de la Recherche Scientifique. University of Rennes. ECOBIO: Ecosystems, Biodiversity, Evolution) ;
Ménard, Nelly (Centre National de la Recherche Scientifique. University of Rennes. ECOBIO: Ecosystems, Biodiversity, Evolution) ;
Navarro, Arcadi, 1969- (Institut de Biologia Evolutiva (UPF-CSIC) (Barcelona)) ;
Siegismund, Hans R. (University of Copenhagen. Department of Biology. Section for Computational and RNA Biology) ;
Hvilsom, Christina (Copenhagen Zoo. Research and Conservation) ;
Gilbert, M. Thomas P. (University of Copenhagen. Center for Evolutionary Hologenomics. The GLOBE Institute) ;
Kuhlwilm, Martin (Institut de Biologia Evolutiva (UPF-CSIC) (Barcelona)) ;
Hughes, David (Institut de Biologia Evolutiva (UPF-CSIC) (Barcelona)) ;
Marques-Bonet, Tomas 1975- (Institut Català de Paleontologia Miquel Crusafont)
Background: Numerous Ebola virus outbreaks have occurred in Equatorial Africa over the past decades. Besides human fatalities, gorillas and chimpanzees have also succumbed to the fatal virus. The 2004 outbreak at the Odzala-Kokoua National Park (Republic of Congo) alone caused a severe decline in the resident western lowland gorilla (Gorilla gorilla gorilla) population, with a 95% mortality rate. [...]
2021 - 10.1186/s12864-021-08025-y
BMC genomics, Vol. 22 (October 2021) , art. 735
|
|
|
10.
|
|
17 p, 2.4 MB |
Epigenomic profiling of primate lymphoblastoid cell lines reveals the evolutionary patterns of epigenetic activities in gene regulatory architectures
/
García Perez, Raquel (Institut de Biologia Evolutiva (UPF-CSIC) (Barcelona)) ;
Esteller-Cucala, Paula (Institut de Biologia Evolutiva (UPF-CSIC) (Barcelona)) ;
Mas, Glòria (Centre de Regulació Genòmica) ;
Lobón, Irene (Institut de Biologia Evolutiva (UPF-CSIC) (Barcelona)) ;
Di Carlo, Valerio (Centre de Regulació Genòmica) ;
Riera, Meritxell (Institut de Biologia Evolutiva (UPF-CSIC) (Barcelona)) ;
Kuhlwilm, Martin (Institut de Biologia Evolutiva (UPF-CSIC) (Barcelona)) ;
Navarro, Arcadi, 1969- (Institut de Biologia Evolutiva (UPF-CSIC) (Barcelona)) ;
Blancher, Antoine (Centre de Physiopathologie Toulouse-Purpan) ;
Di Croce, Luciano (Centre de Regulació Genòmica) ;
Gomez-Skarmeta, José Luis (Centro Andaluz de Biología del Desarrollo) ;
Juan, David (Institut de Biologia Evolutiva (UPF-CSIC) (Barcelona)) ;
Marques-Bonet, Tomas 1975- (Institut Català de Paleontologia Miquel Crusafont)
Changes in the epigenetic regulation of gene expression have a central role in evolution. Here, we extensively profiled a panel of human, chimpanzee, gorilla, orangutan, and macaque lymphoblastoid cell lines (LCLs), using ChIP-seq for five histone marks, ATAC-seq and RNA-seq, further complemented with whole genome sequencing (WGS) and whole genome bisulfite sequencing (WGBS). [...]
2021 - 10.1038/s41467-021-23397-1
Nature communications, Vol. 12 (May 2021) , art. 3116
|
|
visitant ::
identificació
alerta personal via correu electrònic o subscribiu-vos al 
canal RSS.
