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6 p, 731.5 KB |
A metabolite-based machine learning approach to diagnose Alzheimer-type dementia in blood : Results from the European Medical Information Framework for Alzheimer disease biomarker discovery cohort
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Stamate, Daniel (University of London) ;
Kim, Min (Steno Diabetes Center Copenhagen) ;
Proitsi, Petroula (King's College London) ;
Westwood, Sarah (University of Oxford) ;
Baird, Alison (University of Oxford) ;
Nevado-Holgado, Alejo (University of Oxford) ;
Hye, Abdul (King's College London) ;
Bos, Isabelle (Amsterdam UMC) ;
Vos, Stephanie J.B. (Maastricht University) ;
Vandenberghe, Rik (Amsterdam UMC) ;
Teunissen, Charlotte E. (Amsterdam UMC. University Medical Center) ;
Kate, Mara Ten (Amsterdam UMC. University Medical Center) ;
Scheltens, Philip (Vrije Universiteit Amsterdam) ;
Gabel, Silvy (Laboratory for Cognitive Neurology) ;
Meersmans, Karen (Laboratory for Cognitive Neurology) ;
Blin, Olivier (Aix-Marseille Université) ;
Richardson, Jill (GlaxoSmithKline R&D) ;
De Roeck, Ellen (University of Antwerp) ;
Engelborghs, Sebastiaan (Vrije Universiteit Brussel (VUB)) ;
Sleegers, Kristel (Center for Molecular Neurology. VIB) ;
Bordet, Régis (University of Lille) ;
Ramit, Lorena (Hospital Clínic i Provincial de Barcelona) ;
Kettunen, Petronella (Sahlgrenska Academy at University of Gothenburg) ;
Tsolaki, Magda (AHEPA University Hospital (Grècia)) ;
Verhey, Frans (Maastricht University) ;
Alcolea, Daniel (Institut d'Investigació Biomèdica Sant Pau) ;
Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ;
Peyratout, Gwendoline (Lausanne University Hospital) ;
Tainta, Mikel (Fundacion CITA-alzheimer Fundazioa) ;
Johannsen, Peter (Copenhagen University Hospital) ;
Freund-Levi, Yvonne (Karolinska Institutet (Estocolm, Suècia)) ;
Frölich, Lutz (University of Heidelberg) ;
Dobricic, Valerija (University of Lübeck) ;
Frisoni, Giovanni B. (IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli) ;
Molinuevo, José Luis (Universitat Pompeu Fabra) ;
Wallin, Anders (Sahlgrenska Academy at the University of Gothenburg) ;
Popp, Julius (Geneva University Hospitals) ;
Martinez-Lage, Pablo (Fundación CITA-Alzhéimer Fundazioa) ;
Bertram, Lars (University of Oslo) ;
Blennow, Kaj (Sahlgrenska University Hospital (Suècia)) ;
Zetterberg, Henrik (UCL Institute of Neurology (Regne Unit)) ;
Streffer, Johannes (University of Antwerp) ;
Visser, Pieter J. (Amsterdam UMC) ;
Lovestone, Simon (Janssen-Cilag UK Ltd) ;
Legido-Quigley, Cristina (King's College London) ;
Universitat Autònoma de Barcelona
Machine learning (ML) may harbor the potential to capture the metabolic complexity in Alzheimer Disease (AD). Here we set out to test the performance of metabolites in blood to categorize AD when compared to CSF biomarkers. [...]
2019 -  10.1016/j.trci.2019.11.001
Alzheimer's & dementia, Vol. 5 (2019) , p. 933-938
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11 p, 783.1 KB |
Discovery and validation of plasma proteomic biomarkers relating to brain amyloid burden by SOMAscan assay
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Shi, Liu (University of Oxford) ;
Westwood, Sarah (University of Oxford) ;
Baird, Alison L. (University of Oxford) ;
Winchester, Laura (University of Oxford) ;
Dobricic, Valerija (University of Lübeck) ;
Kilpert, Fabian (University of Lübeck) ;
Hong, Shengjun (University of Lübeck) ;
Franke, Andre (Christian-Albrechts-University of Kiel) ;
Hye, Abdul (King's College London) ;
Ashton, Nicholas J. (South London and Maudsley NHS Foundation) ;
Morgan, Angharad R. (Cardiff University) ;
Bos, Isabelle (Maastricht University) ;
Vos, Stephanie J.B. (Amsterdam UMC. University Medical Center) ;
Buckley, Noel J (University of Oxford) ;
Kate, Mara ten (Amsterdam UMC. University Medical Center) ;
Scheltens, Philip (Amsterdam UMC. University Medical Center) ;
Vandenberghe, Rik (University Hospitals Leuven (Bèlgica)) ;
Gabel, Silvy (Laboratory for Cognitive Neurology) ;
Meersmans, Karen (Laboratory for Cognitive Neurology) ;
Engelborghs, Sebastiaan (VUB University Hospital Brussels (UZ Brussel)) ;
De Roeck, Ellen E. (Institute Born-Bunge. University of Antwerp) ;
Sleegers, Kristel (Center for Molecular Neurology. VIB) ;
Frisoni, Giovanni B. (IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli) ;
Blin, Olivier (Aix-Marseille Université) ;
Richardson, Jill C. (GlaxoSmithKline R&D) ;
Bordet, Régis (University of Lille) ;
Molinuevo, José Luis (Hospital Clínic i Provincial de Barcelona) ;
Rami, Lorena (Universitat Pompeu Fabra) ;
Wallin, Anders (Sahlgrenska Academy at University of Gothenburg) ;
Kettunen, Petronella (University of Oxford) ;
Tsolaki, Magda (AHEPA University Hospital (Grècia)) ;
Verhey, Frans (Maastricht University) ;
Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ;
Alcolea, Daniel (Institut d'Investigació Biomèdica Sant Pau) ;
Popp, Julius (Geneva University Hospitals) ;
Peyratout, Gwendoline (Lausanne University Hospital) ;
Martinez-Lage, Pablo (Fundación CITA-Alzhéimer Fundazioa) ;
Tainta, Mikel (CITA-Alzheimer Foundation) ;
Johannsen, Peter Copenhagen University Hospital ;
Teunissen, Charlotte E. (Vrije Universiteit Amsterdam) ;
Freund-Levi, Yvonne (King's College London) ;
Frölich, Lutz (University of Heidelberg) ;
Legido-Quigley, Cristina (Steno Diabetes Center) ;
Barkhof, Frederik (UCL Institutes of Neurology and Healthcare Engineering) ;
Blennow, Kaj (Sahlgrenska University Hospital (Suècia)) ;
Zetterberg, Henrik (UCL Institute of Neurology (Regne Unit)) ;
Baker, Susan (Janssen R&D) ;
Morgan, B.Paul (Cardiff University) ;
Streffer, Johannes (Janssen R&D. LLC) ;
Visser, Pieter Jelle (Karolinska Institutet (Estocolm, Suècia)) ;
Bertram, Lars (University of Oslo) ;
Lovestone, Simon (University of Oxford) ;
Nevado-Holgado, Alejo (University of Oxford) ;
Universitat Autònoma de Barcelona
Plasma proteins have been widely studied as candidate biomarkers to predict brain amyloid deposition to increase recruitment efficiency in secondary prevention clinical trials for Alzheimer's disease. [...]
2019 - 10.1016/j.jalz.2019.06.4951
Alzheimer's & Dementia, Vol. 15 Núm. 11 (november 2019) , p. 1478-1488
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22 p, 986.7 KB |
Primary fatty amides in plasma associated with brain amyloid burden, hippocampal volume, and memory in the European Medical Information Framework for Alzheimer's Disease biomarker discovery cohort
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Kim, Min (Steno Diabetes Center Copenhagen) ;
Snowden, Stuart (University of Cambridge) ;
Suvitaival, Tommi (Steno Diabetes Center Copenhagen) ;
Ali, Ashfaq (Steno Diabetes Center Copenhagen) ;
Merkler, David J. (University of South Florida) ;
Ahmad, Tahmina (King's College London) ;
Westwood, Sarah (University of Oxford) ;
Baird, Alison (University of Oxford) ;
Proitsi, Petroula (King's College London) ;
Nevado-Holgado, Alejo (University of Oxford) ;
Hye, Abdul (Steno Diabetes Center Copenhagen) ;
Bos, Isabelle (Maastricht University) ;
Vos, Stephanie (Maastricht University) ;
Vandenberghe, Rik (University Hospitals Leuven (Bèlgica)) ;
Teunissen, Charlotte (Amsterdam Neuroscience) ;
ten Kate, Mara (Amsterdam Neuroscience) ;
Scheltens, Philip (Amsterdam UMC. University Medical Center) ;
Gabel, Silvy (KU Leuven) ;
Meersmans, Karen (KU Leuven) ;
Blin, Olivier ;
Richardson, Jill (GlaxoSmithKline R&D) ;
De Roeck, Ellen (University of Antwerp) ;
Sleegers, Kristel (VIB) ;
Bordet, Régis (University of Lille) ;
Rami Gonzalez, Lorena (Hospital Clínic i Provincial de Barcelona) ;
Kettunen, Petronella (John Radcliffe Hospital (Oxford, Regne Unit)) ;
Tsolaki, Magda (AHEPA University Hospital (Grècia)) ;
Verhey, Frans (Maastricht University) ;
Sala, Isabel (Institut d'Investigació Biomèdica Sant Pau) ;
Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ;
Peyratout, Gwendoline (Lausanne University Hospital) ;
Tainta, Mikel (CITA-Alzheimer Foundation) ;
Johannsen, Peter (Copenhagen University Hospital) ;
Freund-Levi, Yvonne (Karolinska University Hospital and Karolinska Institutet (Suecia)) ;
Frölich, Lutz (University of Heidelberg) ;
Dobricic, Valerija (University of Lübeck) ;
Engelborghs, Sebastiaan (University Hospital Antwerp (Bèlgica)) ;
Frisoni, Giovanni B. (University of Geneva) ;
Molinuevo, José Luis (Hospital Clínic i Provincial de Barcelona) ;
Wallin, Anders (University of Gothenburg) ;
Popp, Julius (Geneva University Hospitals) ;
Martinez-Lage, Pablo (CITA-Alzheimer Foundation) ;
Bertram, Lars (University of Lübeck) ;
Barkhof, Frederik (Amsterdam Neuroscience) ;
Ashton, Nicholas J (University of Gothenburg) ;
Blennow, Kaj (Sahlgrenska University Hospital (Suècia)) ;
Zetterberg, Henrik (UK Dementia Research Institute) ;
Streffer, Johannes (Janssen Pharmaceutical Companies) ;
Visser, Pieter J. (Amsterdam Neuroscience) ;
Lovestone, Simon (University of Oxford) ;
Legido-Quigley, Cristina (Steno Diabetes Center Copenhagen) ;
Universitat Autònoma de Barcelona
A critical and as-yet unmet need in Alzheimer's disease (AD) is the discovery of peripheral small molecule biomarkers. Given that brain pathology precedes clinical symptom onset, we set out to test whether metabolites in blood associated with pathology as indexed by cerebrospinal fluid (CSF) AD biomarkers. [...]
2019 - 10.1016/j.jalz.2019.03.004
Alzheimer's & Dementia, Vol. 15 Núm. 6 (june 2019) , p. 817-827
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12 p, 1.1 MB |
Inflammatory biomarkers in Alzheimer's disease plasma
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Morgan, Angharad R. (Systems Immunity Research Institute and UK Dementia Research Institute Cardiff, Cardiff University (Regne Unit)) ;
Touchard, Samuel (Systems Immunity Research Institute and UK Dementia Research Institute Cardiff, School of Medicine, Cardiff University (Regne Unit)) ;
Leckey, Claire A. (Cardiff University (Regne Unit)) ;
O'Hagan, Caroline (Cardiff University (Regne Unit)) ;
Nevado-Holgado, Alejo (University of Oxford (Regne Unit)) ;
Barkhof, Frederik (University College London) ;
Bertram, Lars (Max Planck Institute for Molecular Genetics (Alemanya)) ;
Blin, Olivier (Aix-Marseille University (França)) ;
Bos, Isabelle (Maastricht University (Països Baixos)) ;
Dobricic, Valerija (University of Lübeck (Alemanya)) ;
Engelborghs, Sebastiaan (Institute Born-Bunge (Bèlgica)) ;
Frisoni, Giovanni B. (IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli (Brescia, Itàlia)) ;
Froelich, Lutz (University of Heidelberg (Alemanya)) ;
Gabel, Silvy (Laboratory for Cognitive Neurology (Leuven, Bèlgica)) ;
Johannsen, Peter (Karolinska Institutet (Stockholm, Sweden)) ;
Kettunen, Petronella (University of Gothenburg (Gothenburg, Suècia)) ;
Kłoszewska, Iwona (Medical University of Lodz (Lodz, Poland)) ;
Legido-Quigley, Cristina (Imperial College London) ;
Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ;
Martinez-Lage, Pablo (Fundación CITA-Alzheimer Fundazioa (San Sebastian, Spain)) ;
Mecocci, Patrizia (University of Perugia (Itàlia)) ;
Meersmans, Karen (Laboratory for Cognitive Neurology (Bèlgica)) ;
Molinuevo, José Luis (Universitat Pompeu Fabra) ;
Peyratout, Gwendoline (Lausanne University Hospital (Suïssa)) ;
Popp, Julius (Hopitaux Universitaires Geneve and Universite de Geneve (Suïssa)) ;
Richardson, Jill (GlaxoSmithKline R&D (Regne Unit)) ;
Sala, Isabel (Institut d'Investigació Biomèdica Sant Pau) ;
Scheltens, Philip (Vrije Universiteit (Països Baixos)) ;
Streffer, Johannes (University of Antwerp) ;
Soininen, Hikka (University of Eastern Finland) ;
Tainta, Mikel (Fundación CITA Alzheimer (Sant Sebastià, País Basc)) ;
Teunissen, Charlotte E (University Hospitals Leuven (Bèlgica)) ;
Tsolaki, Magda (AHEPA University Hospital (Grècia)) ;
Vandenberghe, Rik (Amsterdam University Medical Centers (Països Baixos)) ;
Visser, Pieter Jelle (Maastricht University (Països Baixos)) ;
Vos, Stephanie (Maastricht University (Països Baixos)) ;
Wahlund, Lars Olof (Karolinska Institutet (Estocolm, Suècia)) ;
Wallin, Anders (University of Gothenburg Sahlgrenska Academy) ;
Westwood, Sarah (University of Oxford (Regne Unit)) ;
Zetterberg, Henrik (UK Dementia Research Institute (Londres, Regne Unit)) ;
Lovestone, Simon (University of Oxford (Regne Unit)) ;
Morgan, B. Paul (Cardiff University (Regne Unit)) ;
Bullmore, Edward (University of Cambridge (Regne Unit)) ;
Bhatti, Junaid (University of Cambridge (Regne Unit)) ;
Chamberlain, Samuel J. (University of Cambridge (Regne Unit)) ;
Correia, Marta Morgado (University of Cambridge (Regne Unit)) ;
Crofts, Anna L. (Université de Sherbrooke (Canadà)) ;
Dickinson, Amber (Addenbroke's Hospital (Cambridge, Regne Unit)) ;
Foster, Andy C. (Cambridgeshire and Peterborough NHS Foundation Trust (Regne Unit)) ;
Kitzbichler, Manfred G. (University of Cambridge (Regne Unit)) ;
Knight, Clare (Cambridgeshire and Peterborough NHS Foundation Trust (Regne Unit)) ;
Lynall, Mary-Ellen (University of Cambridge (Regne Unit)) ;
Maurice, Christina (University of Cambridge (Regne Unit)) ;
O'Donnell, Ciara M. (University College London (Regne Unit)) ;
Pointon, Linda J. (University of Cambridge (Regne Unit)) ;
St George Hyslop, Peter (University of Cambridge (Regne Unit)) ;
Turner, Lorinda (University of Cambridge (Regne Unit)) ;
Vertes, Petra E. (University of Cambridge (Regne Unit)) ;
Widmer, Barry (University of Cambridge (Regne Unit)) ;
Williams, Guy (University of Cambridge (Regne Unit)) ;
Cavanagh, Jonathan T. O. (Karolinska Institutet (Estocolm, Suècia)) ;
Deith, Catherine (Southern General Hospital Glasgow (Escòcia)) ;
Farmer, Scott (Bio Med Sciences Inc.(Galveston, Estats Units)) ;
McClean, John (NHS Greater Glasgow and Clyde (Glasgow, Escòcia)) ;
McColl, Alison (College of Medical, Veterinary & Life Sciences (Glasgow, Escòcia)) ;
McPherson, Andrew (Addenbrooke's Hospital (Cambridge, Regne Unit)) ;
Scouller, Paul (Addenbrooke's Hospital (Cambridge, Regne Unit)) ;
Sutherland, Murray (NHS Greater Glasgow and Clyde (Glasgow, Escòcia)) ;
Boddeke, Erik W.G.M. (Københavns UniversitetThe institution (Copenhaguen, Dinamarca)) ;
Khan, Shahid (GlaxoSmithKline plc. (Regne Unit)) ;
Murphy, Philip Stephen (GlaxoSmithKline plc. (Regne Unit)) ;
Parker, Christine A. (Wellcome Trust (Londres, Regne Unit)) ;
Patel, Jai (GlaxoSmithKline plc. (Regne Unit)) ;
Jones, Declan (Janssen Pharmaceuticals (Titusville, Estats Units)) ;
de Boer, Peter (Janssen Research & Development (Beerse, Bèlgica)) ;
Kemp, John A. (KU Leuven- University Hospital Leuven (Bèlgica)) ;
Drevets, Wayne Curtis (Janssen Research & Development (Beerse, Bèlgica)) ;
Nye, Jeffrey S. (Janssen Research & Development (Beerse, Bèlgica)) ;
Wittenberg, Gayle M. (Janssen Research & Development (Beerse, Bèlgica)) ;
Isaac, John T.R. (Johnson & Johnson (Estats Units)) ;
Bhattacharya, Anindya (Janssen Research & Development (Beerse, Bèlgica)) ;
Carruthers, Niicholas L. (Janssen Research & Development (Beerse, Bèlgica)) ;
Kolb, Hartmuth Christian (Janssen Research & Development (Beerse, Bèlgica)) ;
Pariante, Carmine M. (King's College London (Regne Unit)) ;
Turkheimer, Federico (King's College London (Regne Unit)) ;
Barker, Gareth John (King's College London (Regne Unit)) ;
Byrom, Heidi (King's College London (Regne Unit)) ;
Cash, Diana (King's College London (Regne Unit)) ;
Cattaneo, Annamaria (King's College London (Regne Unit)) ;
Gee, Anthony (King's College London (Regne Unit)) ;
Hastings, Caitlín N.M. (King's College London (Regne Unit)) ;
Mariani, Nicole (King's College London (Regne Unit)) ;
McLaughlin, Anna Patricia (King's College London (Regne Unit)) ;
Mondelli, Valeria (King's College London (Regne Unit)) ;
Nettis, Maria Antonietta (King's College London (Regne Unit)) ;
Nikkheslat, Naghmeh (King's College London (Regne Unit)) ;
Randall, Karen (King's College London (Regne Unit)) ;
Sheridan, Hannah C. (King's College London (Regne Unit)) ;
Simmons, Camilla (King's College London (Regne Unit)) ;
Singh, Nisha (King's College London (Regne Unit)) ;
Van Loo, Victoria (King's College London (Regne Unit)) ;
Vicente-Rodríguez, Marta (King's College London (Regne Unit)) ;
Wood, Tobias (King's College London (Regne Unit)) ;
Worrell, Courtney (King's College London (Regne Unit)) ;
Zajkowska, Zuzanna (King's College London (Regne Unit)) ;
Plath, Niels (H. Lundbeck A/S (Copenhagen, Dinamarca)) ;
Egebjerg, Jan (H. Lundbeck A/S (Copenhagen, Dinamarca)) ;
Eriksson, Hans (H. Lundbeck A/S (Copenhagen, Dinamarca)) ;
Gastambide, Francois (H. Lundbeck A/S (Copenhagen, Dinamarca)) ;
Adams, Karen Husted (H. Lundbeck A/S (Copenhagen, Dinamarca)) ;
Jeggo, Ross D. (H. Lundbeck A/S (Copenhagen, Dinamarca)) ;
Thomsen, Christian (Aalborg Universitetshospital (Aalborg, Dinamarca)) ;
Pederson, Jan Torleif (H. Lundbeck A/S (Copenhagen, Dinamarca)) ;
Campbell, Brian M. (Lundbeck Research USA Inc. (Deerfield, Estats Units)) ;
Möller, Thomas (Lundbeck Research USA Inc. (Deerfield, Estats Units)) ;
Nelson, Bob (H. Lundbeck A/S (Copenhagen, Dinamarca)) ;
Zorn, Stevin H. (Lundbeck Research USA Inc. (Deerfield, Estats Units)) ;
O'Connor, Jason (University of Texas Hlth Sci Ctr San Antonio(Estats Units)) ;
Attenburrow, Mary Jane (Warneford Hospital. NIHR Oxford Cognit Hlth Clin Res Facil (Oxford, Anglaterra)) ;
Baird, Alison (Warneford Hospital. NIHR Oxford Cognit Hlth Clin Res Facil (Oxford, Anglaterra)) ;
Benjamin, Jithen (Warneford Hospital. NIHR Oxford Cognit Hlth Clin Res Facil (Oxford, Anglaterra)) ;
Clare, Stuart (John Radcliffe Hosp, Oxford Ctr Funct MRI Brain (Oxford, Anglaterra)) ;
Cowen, Philip (University of Oxford (Anglaterra)) ;
Huang, I-Shuo Wade (Kennedy Inst Rheumatol (Oxford, Anglaterra)) ;
Hurley, Samuel A. (University of Wisconsin-Madison (Madison, Estats Units)) ;
Jones, Helen (Warneford Hosp, NIHR Oxford Cognit Hlth Clin Res Facil (Oxford, Anglaterra)) ;
Mada, Francisca (Neurosciences & Neurology) ;
Nevado-Holgado, Alejo (University of Oxford (Anglaterra)) ;
Oladejo, Akitayo (Metropolitan Hospital Center (New York, Estats Units)) ;
Ribe, Elena (King's College London (Londres, Anglaterra)) ;
Smith, Katy (Warneford Hospital. NIHR Oxford Cognit Hlth Clin Res Facil (Oxford, Anglaterra)) ;
Vyas, Anviti (University of Oxford (Oxford, Anglaterra)) ;
Hughes, Zoe (Praxis Precision Medicines (Cambridge, Regne Unit)) ;
Balice-Gordon, Rita (Sanofi S.A. (Gentilly, França)) ;
Duerr, James M. (Pfizer Inc.(New York, Estats Units)) ;
Piro, Justin R. (Pfizer Inc.(New York, Estats Units)) ;
Sporn, Jonathan (Gilgamesh Pharmaceut (New York, Estats Units)) ;
Perry, V. Hugh (University of Southampton. Ctr Biol Sci (Hants, Anglaterra)) ;
Cleal, Madeleine (University of Portsmouth (Anglaterra)) ;
Fryatt, Gemma (University of Southampton. Ctr Biol Sci (Hants, Anglaterra)) ;
Gomez-Nicola, Diego (University of Southampton. Ctr Biol Sci (Hants, Anglaterra)) ;
Mancuso, Renzo (University of Southampton (Anglaterra)) ;
Reynolds, Richard (University of Southampton. Ctr Biol Sci (Hants, Anglaterra)) ;
Harrison, Neil (University fo Sussex (Brighton, Anglaterra)) ;
Cercignani, Mara (University fo Sussex (Brighton, Anglaterra)) ;
Clarke, Charlotte L. (University of Sussex (Brighton, Regne Unit)) ;
Hoskins, Elizabeth (Sussex Partnership NHS Foundation Trust (Worthing, Regne Unit)) ;
Kohn, Charmaine (Sussex Partnership NHS Foundation Trust (Worthing, Regne Unit)) ;
Murray, Rosemary (Addenbrooke's Hospital (Cambridge, Regne Unit)) ;
Wilcock, Lauren (Sussex Partnership NHS Fdn Trust (Hove, Anglaterra)) ;
Wlazly, Dominika (Brighton and Sussex University Hospitals NHS Trust (Sussex, Anglaterra)) ;
Mount, Howard T.J. (University of Toronto (Toronto, Canadà)) ;
Universitat Autònoma de Barcelona
Plasma biomarkers for Alzheimer's disease (AD) diagnosis/stratification are a "Holy Grail" of AD research and intensively sought; however, there are no well-established plasma markers. A hypothesis-led plasma biomarker search was conducted in the context of international multicenter studies. [...]
2019 - 10.1016/j.jalz.2019.03.007
Alzheimer's & Dementia, Vol. 15 Núm. 6 (june 2019) , p. 776-787
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13 p, 162.5 KB |
Validation of plasma proteomic biomarkers relating to brain amyloid burden in the EMIF-Alzheimer's disease multimodal biomarker discovery cohort
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Westwood, Sarah (University of Oxford) ;
Baird, Alison L (University of Oxford) ;
Anand, Sneha N. (University of Oxford) ;
Nevado-Holgado, Alejo (University of Oxford) ;
Kormilitzin, Andrey (University of Oxford) ;
Shi, Liu (University of Oxford) ;
Hye, Abdul (King's College London) ;
Ashton, Nicholas J (University of Gothenburg) ;
Morgan, Angharad R. (Cardiff University) ;
Bos, Isabelle (Maastricht University) ;
Vos, Stephanie J.B. (Maastricht University) ;
Baker, Susan (Janssen R and D) ;
Buckley, Noel J (University of Oxford) ;
Ten Kate, Mara (Vrije Universiteit University Medical Center) ;
Scheltens, Philip (Vrije Universiteit University Medical Center) ;
Teunissen, Charlotte E. (Vrije Universiteit University Medical Center) ;
Vandenberghe, Rik (University Hospitals Leuven (Bèlgica)) ;
Gabel, Silvy (Ku Leuven) ;
Meersmans, Karen (Ku Leuven) ;
Engelborghs, Sebastiaan (Vrije Universiteit Brussel (VUB)) ;
De Roeck, Ellen E. (Vrije Universiteit Brussel (VUB)) ;
Sleegers, Kristel (Center for Molecular Neurology) ;
Frisoni, Giovanni B. (Irccs Istituto Centro San Giovanni di Dio Fatebenefratelli) ;
Blin, Olivier (Aix-Marseille Université) ;
Richardson, Jill C. (GlaxoSmithKline R and D) ;
Bordet, Régis (University of Lille) ;
Molinuevo, José Luis (Hospital Clínic i Provincial de Barcelona) ;
Rami, Lorena (Universitat Pompeu Fabra) ;
Wallin, Anders (Sahlgrenska Academy at University of Gothenburg) ;
Kettunen, Petronella (Sahlgrenska Academy at University of Gothenburg) ;
Tsolaki, Magda (AHEPA University Hospital (Grècia)) ;
Verhey, Frans (Maastricht University) ;
Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ;
Sala, Isabel (Institut d'Investigació Biomèdica Sant Pau) ;
Popp, Julius (Geneva University Hospitals) ;
Peyratout, Gwendoline (Lausanne University Hospital) ;
Martinez-Lage, Pablo (Geneva University Hospitals) ;
Tainta, Mikel (CITA-Alzheimer Foundation) ;
Johannsen, Peter (Copenhagen University Hospital) ;
Freund-Levi, Yvonne (Karolinska Institutet (Estocolm, Suècia)) ;
Frölich, Lutz (University of Heidelberg) ;
Dobricic, Valerija (University of Lübeck) ;
Legido-Quigley, Cristina (Steno Diabetes Center) ;
Bertram, Lars (University of Oslo) ;
Barkhof, Frederik (Ucl Institutes of Neurology and Healthcare Engineering) ;
Zetterberg, Henrik (Ucl Institute of Neurology) ;
Morgan, B.Paul (Cardiff University) ;
Streffer, Johannes (Janssen R and D. Llc) ;
Visser, Pieter Jelle (Vu University Medical Center) ;
Lovestone, Simon (Janssen R and D) ;
Universitat Autònoma de Barcelona
We have previously investigated, discovered, and replicated plasma protein biomarkers for use to triage potential trials participants for PET or cerebrospinal fluid measures of Alzheimer's disease (AD) pathology. [...]
2020 - 10.3233/JAD-190434
Journal of Alzheimer's disease, Vol. 74 Núm. 1 (2020) , p. 213-225
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8 p, 1.7 MB |
Plasma Proteomic Biomarkers Relating to Alzheimer's Disease : A Meta-Analysis Based on Our Own Studies
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Shi, L. (Department of Psychiatry. University of Oxford) ;
Buckley, Noel J (Department of Psychiatry. University of Oxford) ;
Bos, Isabelle (Alzheimer Center. VU University Medical Center) ;
Engelborghs, Sebastiaan (Department of Neurology. Universitair Ziekenhuis Brussel. Center for Neurociences (C4N). Vrije Universiteit Brussel) ;
Sleegers, Kristel (Institute Born-Bunge. Department of Biomedical Sciences. University of Antwerp) ;
Frisoni, Giovanni B. (University of Geneva. Department of Psychiatry) ;
Wallin, Anders (Institute of Neuroscience and Physiology. Department of Psychiatry and Neurochemistry. The Sahlgrenska Academy at the University of Gothenburg) ;
Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ;
Popp, J. (Geriatric Psychiatry. Department of Mental Health and Psychiatry. Geneva University Hospitals) ;
Martinez-Lage, P. (CITA-Alzheimer Foundation) ;
Legido-Quigley, Cristina (The Systems Medicine Group. Steno Diabetes Center) ;
Barkhof, Frederik (UCL Institutes of Neurology and Healthcare Engineering) ;
Zetterberg, Henrik (Department of Neurodegenerative Disease. UCL Institute of Neurology) ;
Visser, P.J. (Alzheimer Center. VU University Medical Center) ;
Bertram, Lars (Department of Psychology. University of Oslo) ;
Lovestone, S. ;
Nevado-Holgado, Alejo (Department of Psychiatry. University of Oxford)
Background and Objective: Plasma biomarkers for the diagnosis and stratification of Alzheimer's disease (AD) are intensively sought. However, no plasma markers are well established so far for AD diagnosis. [...]
2021 - 10.3389/fnagi.2021.712545
Frontiers in aging neuroscience, Vol. 13 (July 2021) , p. 712545
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7.
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13 p, 1.8 MB |
Replication study of plasma proteins relating to Alzheimer's pathology
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Shi, Liu (University of Oxford. Department of Psychiatry) ;
Winchester, Laura M. (University of Oxford. Department of Psychiatry) ;
Westwood, Sarah (University of Oxford. Department of Psychiatry) ;
Baird, Alison L (University of Oxford. Department of Psychiatry) ;
Anand, Sneha N (University of Oxford. Department of Psychiatry) ;
Buckley, Noel J. (University of Oxford. Department of Psychiatry) ;
Hye, Abdul (Maurice Wohl Clinical Neuroscience. Institute of Psychiatry. Psychology and Neuroscience. Kings College London) ;
Ashton, Nicholas J. (University of Gothenburg) ;
Bos, Isabelle (Alzheimer Center. VU University Medical Center) ;
Vos, Stephanie J.B. (Maastricht University. School for Mental Health and Neuroscience) ;
Kate, Mara Ten (Amsterdam UMC. University Medical Center) ;
Scheltens, Philip (Amsterdam UMC. University Medical Center) ;
Teunissen, Charlotte E. (Amsterdam University Medical Centers (AUMC)) ;
Vandenberghe, Rik (University Hospitals Leuven (Bèlgica)) ;
Gabel, Silvy (KU Leuven. Laboratory for Cognitive Neurology) ;
Meersmans, Karen (KU Leuven. Laboratory for Cognitive Neurology) ;
Engelborghs, Sebastiaan (Department of Neurology. UZ Brussel and Center for Neurociences (C4N). Vrije Universiteit Brussel) ;
De Roeck, Ellen E (Department of Neurology and Memory Clinic. Hospital Network Antwerp (ZNA) Middelheim and Hoge Beuken) ;
Sleegers, Kristel (University of Antwerp. Institute Born-Bunge) ;
Frisoni, Giovanni B. (IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli) ;
Blin, Olivier (AIX marseille university. INS. Ap-hm) ;
Richardson, Jill C. (Neurosciences Therapeutic Area. GlaxoSmithKline R&D) ;
Bordet, Régis (Inserm. University of Lille. CHU Lille) ;
Molinuevo, José Luis (Barcelonaβeta Brain Research Center (BBRC)) ;
Rami Gonzalez, Lorena (Barcelonaβeta Brain Research Center (BBRC)) ;
Wallin, Anders (Institute of Neuroscience and Physiology. Sahlgrenska Academy at University of Gothenburg) ;
Kettunen, Petronella (Institute of Neuroscience and Physiology. Sahlgrenska Academy at University of Gothenburg) ;
Tsolaki, Magda (AHEPA University Hospital (Grècia)) ;
Verhey, Frans (Maastricht University. School for Mental Health and Neuroscience) ;
Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ;
Sala, Isabel (Institut d'Investigació Biomèdica Sant Pau) ;
Popp, Julius (Geriatric Psychiatry. Department of Mental Health and Psychiatry. Geneva University Hospitals) ;
Peyratout, Gwendoline (Lausanne University Hospital) ;
Martinez-Lage, Pablo (CITA-Alzheimer Foundation) ;
Tainta, Mikel (CITA-Alzheimer Foundation) ;
Johannsen, Peter (Danish Dementia Research Centre. Rigshospitalet. Copenhagen University Hospital) ;
Freund-Levi, Yvonne (Karolinska Institutet Center for Alzheimer Research. Division of Clinical Geriatrics. School of Medical Sciences Örebro University and Department of Neurobiology. Caring Sciences and Society (NVS)) ;
Frölich, Lutz (Department of Geriatric Psychiatry. Zentralinstitut für Seelische Gesundheit. University of Heidelberg) ;
Dobricic, Valerija (Lübeck Interdisciplinary Platform for Genome Analytics. Institutes of Neurogenetics and Cardiogenetics. University of Lübeck) ;
Legido-Quigley, Cristina (The Systems Medicine Group. Steno Diabetes Center) ;
Barkhof, Frederik (UCL Institutes of Neurology and Healthcare Engineering) ;
Andreasson, Ulf (Clinical Sahlgrenska University Hospital) ;
Blennow, Kaj (Sahlgrenska University Hospital (Suècia)) ;
Zetterberg, Henrik (UCL Institute of Neurology (Regne Unit)) ;
Streffer, Johannes (UCB. Braine-l'Alleud. Belgium. formerly Janssen R&D. LLC Beerse) ;
Lill, Christina M. (Ageing Epidemiology Research Unit. School of Public Health. Imperial College) ;
Bertram, Lars (Department of Psychology. University of Oslo) ;
Visser, Pieter Jelle (Alzheimer Center. VU University Medical Center) ;
Kolb, Hartmuth C. (Janssen R&D) ;
Narayan, Vaibhav A. (Janssen R&D) ;
Lovestone, Simon (Janssen R&D) ;
Nevado-Holgado, Alejo (Department of Psychiatry. University of Oxford)
Introduction: This study sought to discover and replicate plasma proteomic biomarkers relating to Alzheimer's disease (AD) including both the "ATN" (amyloid/tau/neurodegeneration) diagnostic framework and clinical diagnosis. [...]
2021 - 10.1002/alz.12322
Alzheimer's & Dementia, Vol. 17 Núm. 9 (september 2021) , p. 1452-1464
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8.
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15 p, 2.1 MB |
Sex-specific metabolic pathways were associated with alzheimer's disease (Ad) endophenotypes in the european medical information framework for ad multimodal biomarker discovery cohort
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Xu, J. (King's College London) ;
Green, R. (King's College London) ;
Kim, M. (Steno Diabetes Center) ;
Lord, J. (King's College London) ;
Ebshiana, A. (King's College London) ;
Westwood, S. (Department of Psychiatry. University of Oxford) ;
Baird, Alison L (Department of Psychiatry. University of Oxford) ;
Nevado-Holgado, Alejo (Department of Psychiatry. University of Oxford) ;
Shi, L. (Department of Psychiatry. University of Oxford) ;
Hye, Abdul (King's College London) ;
Snowden, S. G. (King's College London) ;
Bos, Isabelle (Amsterdam UMC. University Medical Center) ;
Vos, S. J. B. (Maastricht University) ;
Vandenberghe, R. (Alzheimer Center. VU University Medical Center) ;
Teunissen, C. E. (Department of Radiology and Nuclear Medicine. VU University Medical Center) ;
Kate, M. T. (Department of Radiology and Nuclear Medicine. VU University Medical Center) ;
Scheltens, P. (Alzheimer Center. VU University Medical Center) ;
Gabel, Silvy (University Hospitals Leuven (Bèlgica)) ;
Meersmans, K. (University Hospitals Leuven (Bèlgica)) ;
Blin, Olivier (Clinical Pharmacology & Pharmacovigilance Department. Aix-Marseille University-CNRS) ;
Richardson, J. (Neurosciences Therapeutic Area. GlaxoSmithKline R&D) ;
De Roeck, Ellen E (University of Antwerp. Institute Born-Bunge) ;
Engelborghs, Sebastiaan (RUniversity of Antwerp. Institute Born-Bunge) ;
Sleegers, Kristel (Complex Genetics of Alzheimer's Disease Group. VIB Center for Molecular Neurology. VIB) ;
Bordet, Régis (Université de Lille. Department of Medical Pharmacology) ;
Rami Gonzalez, Lorena (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Kettunen, Petronella (University of Gothenburg) ;
Tsolaki, Magda (AHEPA University Hospital (Grècia)) ;
Verhey, F. R. J. (Maastricht University. Alzheimer Centrum Limburg) ;
Alcolea, Daniel (Institut d'Investigació Biomèdica Sant Pau) ;
Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ;
Peyratout, Gwendoline (Lausanne University Hospital) ;
Tainta, Mikel (Fundación CITA-Alzhéimer Fundazioa) ;
Johannsen, Peter (Danish Dementia Research Centre. Rigshospitalet) ;
Freund-Levi, Yvonne (King's College London) ;
Frölich, L. (University of Heidelberg. Department of Geriatric Psychiatry) ;
Dobricic, Valerija (University of Lübeck. Institutes of Neurogenetics and Cardiogenetics) ;
Frisoni, Giovanni B. (IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli) ;
Molinuevo, José Luis (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Wallin, Anders (University of Gothenburg. Sahlgrenska Academy) ;
Popp, J. (University Hospital of Psychiatry Zürich) ;
Martinez-Lage, P. (Center for Research and Advanced Therapies. CITA-Alzheimer Foundation) ;
Bertram, Lars (University of Oslo. Department of Psychology) ;
Blennow, Kaj (Sahlgrenska University Hospital (Suècia)) ;
Zetterberg, Henrik (UCL Institute of Neurology (Regne Unit)) ;
Streffer, J. (Reference Center for Biological Markers of Dementia (BIODEM). Institute Born-Bunge. University of Antwerp) ;
Jelle Visser, P. (Maastricht University. Alzheimer Centrum Limburg) ;
Lovestone, Simon (Janssen-Cilag UK Ltd.) ;
Proitsi, P. (King's College London) ;
Legido-Quigley, Cristina (Steno Diabetes Center) ;
Universitat Autònoma de Barcelona
Background: physiological differences between males and females could contribute to the development of Alzheimer's Disease (AD). Here, we examined metabolic pathways that may lead to precision medicine initiatives. [...]
2021 - 10.3390/biomedicines9111610
Biomedicines, Vol. 9 Núm. 11 (november 2021) , p. 1610
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9.
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16 p, 903.0 KB |
Dickkopf-1 Overexpression in vitro Nominates Candidate Blood Biomarkers Relating to Alzheimer's Disease Pathology
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Shi, Liu (University of Oxford) ;
Winchester, Laura M. (University of Oxford) ;
Liu, Benjamine Y. (University of Oxford) ;
Killick, Richard (Maurice Wohl Institute Clinical Neuroscience Institute) ;
Ribe, Elena M. (University of Oxford) ;
Westwood, Sarah (University of Oxford) ;
Baird, Alison L. (University of Oxford) ;
Buckley, Noel J. (University of Oxford) ;
Hong, Shengjun (University of Lübeck) ;
Dobricic, Valerija (University of Lübeck) ;
Kilpert, Fabian (University of Lübeck) ;
Franke, Andre (Christian-Albrechts-University of Kiel) ;
Kiddle, Steven (King's College London) ;
Sattlecker, Martina (King's College London) ;
Dobson, Richard (University College London) ;
Cuadrado, Antonio ("Victor Babes" National Institute of Pathology) ;
Hye, Abdul (Maurice Wohl Institute Clinical Neuroscience Institute) ;
Ashton, Nicholas J. (University of Gothenburg) ;
Morgan, Angharad R. (Cardiff University) ;
Bos, Isabelle (Amsterdam UMC. University Medical Center) ;
Vos, Stephanie J. B. (Maastricht University) ;
ten Kate, Mara (Amsterdam UMC. University Medical Center) ;
Scheltens, Philip (Amsterdam UMC. University Medical Center) ;
Vandenberghe, Rik (University Hospitals Leuven (Bèlgica)) ;
Gabel, Silvy (Laboratory for Cognitive Neurology) ;
Meersmans, Karen (Laboratory for Cognitive Neurology) ;
Engelborghs, Sebastiaan (Universitair Ziekenhuis Brussel-UZ Brussel. Department of Neurology) ;
De Roeck, Ellen E. (University of Antwerp) ;
Sleegers, Kristel (Center for Molecular Neurology) ;
Frisoni, Giovanni B. (IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli) ;
Blin, Olivier (Aix-Marseille Université) ;
Richardson, Jill C. (GlaxoSmithKline R&D. Neurosciences Therapeutic Area) ;
Bordet, Régis (University of Lille) ;
Molinuevo, José Luis (Barcelonaβeta Brain Research Center (BBRC)) ;
Rami Gonzalez, Lorena (Barcelonaβeta Brain Research Center (BBRC)) ;
Wallin, Anders (Sahlgrenska University Hospital (Suècia)) ;
Kettunen, Petronella (University of Oxford) ;
Tsolaki, Magda (Aristotle University of Thessaloniki) ;
Verhey, Frans (Maastricht University) ;
Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ;
Alcolea, Daniel (Institut d'Investigació Biomèdica Sant Pau) ;
Popp, Julius (University of Geneva) ;
Peyratout, Gwendoline (Lausanne University Hospital) ;
Martinez-Lage, Pablo (CITA-Alzheimer Foundation (San Sebastian)) ;
Tainta, Mikel (Organización Sanitaria Integrada Goierri) ;
Johannsen, Peter (Copenhagen University Hospital) ;
Teunissen, Charlotte E. (Amsterdam UMC. University Medical Center) ;
Freund-Levi, Yvonne (Department of Psychiatry, Örebro Universitetssjukhus) ;
Frölich, Lutz (University of Heidelberg) ;
Legido-Quigley, Cristina (Steno Diabetes Center Copenhagen) ;
Barkhof, Frederik (UCL Institutes of Neurology and Healthcare Engineering) ;
Blennow, Kaj (Sahlgrenska University Hospital (Suècia)) ;
Rasmussen, Katrine Laura (University of Copenhagen) ;
Nordestgaard, Børge Grønne (Copenhagen University Hospital) ;
Frikke-Schmidt, Ruth (University of Copenhagen) ;
Nielsen, Sune Fallgaard (Copenhagen University Hospital) ;
Soininen, Hilkka (University of Eastern Finland) ;
Vellas, Bruno (Univeriste Paul Sabatier) ;
Kloszewska, Iwona (Medical University of Lodz) ;
Mecocci, Patrizia (University of Perugia (Itàlia)) ;
Zetterberg, Henrik (UCL Institute of Neurology (Regne Unit)) ;
Morgan, B. Paul (Cardiff University) ;
Streffer, Johannes (UCB Pharma (Braine-l'Alleud, Bèlgica)) ;
Visser, Pieter Jelle (Karolinska Institutet (Estocolm, Suècia)) ;
Bertram, Lars (University of Oslo) ;
Nevado-Holgado, Alejo (University of Oxford) ;
Lovestone, Simon (University of Oxford) ;
Universitat Autònoma de Barcelona
Previous studies suggest that Dickkopf-1 (DKK1), an inhibitor of Wnt signaling, plays a role in amyloid-induced toxicity and hence Alzheimer's disease (AD). However, the effect of DKK1 expression on protein expression, and whether such proteins are altered in disease, is unknown. [...]
2020 - 10.3233/JAD-200208
Journal of Alzheimer's disease, Vol. 77 (september 2020) , p. 1353-1368
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10.
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15 p, 1.2 MB |
Plasma Protein Biomarkers for the Prediction of CSF Amyloid and Tau and [ 18 F]-Flutemetamol PET Scan Result
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Westwood, Sarah (University of Oxford. Department of Psychiatry) ;
Baird, Alison L. (Department of Psychiatry, University of Oxford) ;
Hye, Abdul (NIHR Biomedical Research Centre for Mental Health (Londres, Regne Unit)) ;
Ashton, Nicholas J. (University of Gothenburg) ;
Nevado-Holgado, Alejo (Department of Psychiatry, University of Oxford) ;
Anand, Sneha N. (Department of Psychiatry, University of Oxford) ;
Liu, Benjamine (Department of Psychiatry, University of Oxford) ;
Newby, Danielle (Department of Psychiatry, University of Oxford) ;
Bazenet, Chantal (King's College London. Institute of Psychiatry, Psychology & Neuroscience) ;
Kiddle, Steven J. (MRC Biostatistics Unit, Cambridge Biomedical Campus, Cambridge Institute of Public Health, University of Cambridge) ;
Ward, Malcolm (King's College London. Institute of Psychiatry, Psychology & Neuroscience) ;
Newton, Ben (GE Healthcare Life Sciences Core Imaging) ;
Desai, Keyur (Biosciences, GE Global Research) ;
Tan Hehir, Cristina (Biosciences, GE Global Research) ;
Zanette, Michelle (GE Healthcare Life Sciences Core Imaging) ;
Galimberti, Daniela (Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico) ;
Parnetti, Lucilla (Center for Memory Disorders and Laboratory of Clinical Neurochemistry, Neurology Clinic, University of Perugia) ;
Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ;
Baker, Susan (Janssen Neuroscience Research & Development) ;
Narayan, Vaibhav A. (Janssen Neuroscience Research & Development) ;
van der Flier, Wiesje M. (Department of Epidemiology and Biostatistics, VU University Medical Center) ;
Scheltens, Philip (Amsterdam Universitair Medische Centra (Amsterdam, Països Baixos)) ;
Teunissen, Charlotte E. (Department of Clinical Chemistry, Neurochemistry Lab and Biobank, Amsterdam Neuroscience, VU University Medical Center) ;
Visser, Pieter Jelle (Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University) ;
Lovestone, Simon (Department of Psychiatry, University of Oxford) ;
Universitat Autònoma de Barcelona
Background: Blood biomarkers may aid in recruitment to clinical trials of Alzheimer's disease (AD) modifying therapeutics by triaging potential trials participants for amyloid positron emission tomography (PET) or cerebrospinal fluid (CSF) Aβ and tau tests. [...]
2018 - 10.3389/fnagi.2018.00409
Frontiers in aging neuroscience, Vol. 10 (december 2018)
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