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Articles, 2 records found
Articles 2 records found  
1.
17 p, 1.3 MB Clinical, virological and biochemical evidence supporting the association of HIV-1 reverse transcriptase polymorphism R284K and thymidine analogue resistance mutations M41L, L210W and T215Y in patients failing tenofovir/emtricitabine therapy / Betancor, Gilberto (Centro de Biología Molecular "Severo Ochoa") ; Garriga, César (Instituto de Salud Carlos III. Centro Nacional de Epidemiología) ; Puertas, Maria C. (Hospital Universitari Germans Trias i Pujol. Fundació irsiCaixa) ; Nevot, Maria (Hospital Universitari Germans Trias i Pujol. Fundació irsiCaixa) ; Anta, Lourdes (Hospital Carlos III (Madrid)) ; Blanco, José L. (Hospital Clínic i Provincial de Barcelona) ; Pérez Elías, M. Jesús (Hospital Ramón y Cajal (Madrid)) ; Mendoza, Carmen de (Hospital Carlos III (Madrid)) ; Martínez, Miguel A. (Hospital Universitari Germans Trias i Pujol. Fundació irsiCaixa) ; Martínez Picado, Francisco Javier (Hospital Universitari Germans Trias i Pujol. Fundació irsiCaixa) ; Menéndez-Arias, Luis (Centro de Biología Molecular "Severo Ochoa") ; Spanish AIDS Research Network (ResRIS)
Background: Thymidine analogue resistance mutations (TAMs) selected under treatment with nucleoside analogues generate two distinct genotypic profiles in the HIV-1 reverse transcriptase (RT): (i) TAM1: M41L, L210W and T215Y, and (ii) TAM2: D67N, K70R and K219E/Q, and sometimes T215F. [...]
2012 - 10.1186/1742-4690-9-68
Retrovirology, Vol. 9, N. 68 (13 August 2012) , p. 1-17
2 documents
2.
12 p, 786.4 KB Changes in codon-pair bias of human immunodeficiency virus type 1 have profound effects on virus replication in cell culture / Martrus, Gloria (Hospital Universitari Germans Trias i Pujol. Fundació irsiCaixa) ; Nevot, Maria (Hospital Universitari Germans Trias i Pujol. Fundació irsiCaixa) ; Andrés, Cristina (Hospital Universitari Germans Trias i Pujol. Fundació irsiCaixa) ; Clotet i Sala, Bonaventura (Hospital Universitari Germans Trias i Pujol. Fundació irsiCaixa) ; Martinez, Miguel Ángel (Hospital Universitari Germans Trias i Pujol. Fundació irsiCaixa)
Background: Human immunodeficiency virus type 1 (HIV-1) has a biased nucleotide composition different from human genes. This raises the question of how evolution has chosen the nucleotide sequence of HIV-1 that is observed today, or to what extent the actual encoding contributes to virus replication capacity, evolvability and pathogenesis. [...]
2013 - 10.1186/1742-4690-10-78
Retrovirology, Vol. 10, N. 78 (25 July 2013) , p. 1-12
6 documents

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