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18 p, 3.4 MB |
Single-cell multi-omics analysis of COVID-19 patients with pre-existing autoimmune diseases shows aberrant immune responses to infection
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Barmada, Anis (Department of Medical Genetics. University of Cambridge) ;
Handfield, Louis-François (Wellcome Sanger Institute (Regne Unit)) ;
Godoy-Tena, Gerard (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
de la Calle-Fabregat, Carlos (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Ciudad, Laura (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Arutyunyan, Anna (Wellcome Sanger Institute (Regne Unit)) ;
Andrés-León, Eduardo (Instituto de Parasitología y Biomedicina "López-Neyra") ;
Hoo, Regina (Wellcome Sanger Institute (Regne Unit)) ;
Porter, Tarryn (Wellcome Sanger Institute (Regne Unit)) ;
Oszlanczi, Agnes (Wellcome Sanger Institute (Regne Unit)) ;
Richardson, Laura (Wellcome Sanger Institute (Regne Unit)) ;
Calero-Nieto, Fernando (Department of Haematology and Wellcome & MRC Cambridge Stem Cell Institute. University of Cambridge) ;
Wilson, Nicola K. (Department of Haematology and Wellcome & MRC Cambridge Stem Cell Institute. University of Cambridge) ;
Marchese, Domenica (Centre de Regulació Genòmica) ;
Sancho-Serra, Carmen (Wellcome Sanger Institute. Wellcome Genome Campus) ;
Carrillo, Jorge (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Presas-Rodríguez, Silvia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Ramo-Tello, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Ruiz-Sanmartin, Adolfo (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Ferrer, Ricard (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Ruiz-Rodriguez, Juan Carlos (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Martínez Gallo, Mónica (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Munera-Campos, Mónica (Institut Germans Trias i Pujol) ;
Carrascosa, José Manuel (Institut Germans Trias i Pujol) ;
Göttgens, Berthold (Department of Haematology and Wellcome & MRC Cambridge Stem Cell Institute. University of Cambridge) ;
Heyn, Holger (Universitat Pompeu Fabra) ;
Prigmore, Elena (Wellcome Sanger Institute (Regne Unit)) ;
Casafont-Solé, Ivette (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Solanich, Xavier (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Sánchez-Cerrillo, Idelfonso (Department of Immunology. Hospital Universitario La Princesa) ;
González-Álvaro, Isidoro (Rheumatology Service. Hospital Universitario La Princesa) ;
Raimondo, Maria Gabriella (Deutsches Zentrum Immuntherapie. Friedrich-Alexander-University Erlangen-Nürnberg and Universitätsklinikum Erlangen) ;
Ramming, Andreas (Deutsches Zentrum Immuntherapie. Friedrich-Alexander-University Erlangen-Nürnberg and Universitätsklinikum Erlangen) ;
Martin, Javier (Instituto de Parasitología y Biomedicina "López-Neyra") ;
Martínez Cáceres, Eva María (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Ballestar, Esteban (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Vento-Tormo1, Roser (Wellcome Sanger Institute. Wellcome Genome Campus) ;
Rodríguez-Ubreva, Javier (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
In COVID-19, hyperinflammatory and dysregulated immune responses contribute to severity. Patients with pre-existing autoimmune conditions can therefore be at increased risk of severe COVID-19 and/or associated sequelae, yet SARS-CoV-2 infection in this group has been little studied. [...]
2024 -  10.1002/eji.202350633
European Journal of Immunology, Vol. 54 Núm. 1 (january 2024) , p. 2350633
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15 p, 4.2 MB |
GATA2 Promotes Hematopoietic Development and Represses Cardiac Differentiation of Human Mesoderm
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Castaño Cardoso, Julio (Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina) ;
Aranda, Sergi (Universitat Pompeu Fabra. Centre de Regulació Genòmica (CRG-UPF)) ;
Bueno, Clara (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Calero-Nieto, Fernando (Department of Hematology. Wellcome and MRC Cambridge Stem Cell Institute and Cambridge Institute for Medical Research. University of Cambridge) ;
Mejia-Ramirez, Eva (Centro de Medicina Regenerativa de Barcelona) ;
Mosquera, José Luis (Institut d'Investigació Biomèdica de Bellvitge) ;
Blanco, Enrique (Universitat Pompeu Fabra. Centre de Regulació Genòmica (CRG-UPF)) ;
Wang, Xiaonan (Wellcome and MRC Cambridge Stem Cell Institute and Cambridge Institute for Medical Research. University of Cambridge) ;
Prieto, Cristina (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Zabaleta, Lorea (Laboratory of Hematological Diseases. Fundación Inbiomed) ;
Mereu, Elisabetta (Centre de Regulació Genòmica) ;
Rovira, Meritxell (Centro de Medicina Regenerativa de Barcelona) ;
Jiménez-Delgado, Senda (Centro de Medicina Regenerativa de Barcelona) ;
Matson, Daniel Rusch (Department of Cell and Regenerative Biology. UW-Madison Blood Research Program. Carbone Cancer Center. University of Wisconsin School of Medicine and Public Health) ;
Heyn, Holger (Universitat Pompeu Fabra) ;
Bresnick, Emery H. (Department of Cell and Regenerative Biology. UW-Madison Blood Research Program. Carbone Cancer Center. University of Wisconsin School of Medicine and Public Health) ;
Göttgens, Berthold (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Di Croce, Luciano (Institució Catalana de Recerca i Estudis Avançats) ;
Menéndez Bujan, Pablo (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Raya, Ángel (Institució Catalana de Recerca i Estudis Avançats) ;
Giorgetti, Alessandra (Centro de Medicina Regenerativa de Barcelona) ;
Universitat Autònoma de Barcelona
In vertebrates, GATA2 is a master regulator of hematopoiesis and is expressed throughout embryo development and in adult life. Although the essential role of GATA2 in mouse hematopoiesis is well established, its involvement during early human hematopoietic development is not clear. [...]
2019 - 10.1016/j.stemcr.2019.07.009
Stem cell reports, Vol. 13 Núm. 3 (october 2019) , p. 515-529
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13 p, 3.9 MB |
Enhanced hemato-endothelial specification during human embryonic differentiation through developmental cooperation between AF4-MLL and MLL-AF4 fusions
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Bueno, Clara (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Calero-Nieto, Fernando (Department of Hematology. Cambridge Institute for Medical Research and Wellcome Trust-Medical Research Council Cambridge Stem Cell Institute. University of Cambridge) ;
Wang, X. (Department of Hematology. Cambridge Institute for Medical Research and Wellcome Trust-Medical Research Council Cambridge Stem Cell Institute. University of Cambridge) ;
Valdés-Mas, Rafael (Dreamgenics S.L. Oviedo) ;
Gutiérrez-Agüera, Francisco (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Roca Ho, Heleia (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Ayllon, Veronica (Centro Pfizer - Universidad de Granada - Junta de Andalucía de Genómica e Investigación Oncológica) ;
Real, P. J. (Centro Pfizer - Universidad de Granada - Junta de Andalucía de Genómica e Investigación Oncológica) ;
Arambilet Mobilla, David (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Espinosa, Lluís (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Torres, Raul (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Agraz-Doblás, Antonio (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Varela, Ignacio (Universidad de Cantabria. Departamento de Biología Molecular) ;
De Boer, J. (University College London Great Ormond Street Institute of Child Health. Cancer Section) ;
Bigas Salvans, Anna (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Gottgens, B. (Department of Hematology. Cambridge Institute for Medical Research and Wellcome Trust-Medical Research Council Cambridge Stem Cell Institute. University of Cambridge) ;
Marschalek, Rolf (Institute of Pharmaceutical Biology. Goethe-University) ;
Menéndez Bujan, Pablo (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Universitat Autònoma de Barcelona
The t(4;11)(q21;q23) translocation is associated with high-risk infant pro-B-cell acute lymphoblastic leukemia and arises prenatally during embryonic/fetal hematopoiesis. The developmental/pathogenic contribution of the t(4;11)-resulting MLL-AF4 (MA4) and AF4-MLL (A4M) fusions remains unclear; MA4 is always expressed in patients with t(4;11)+ B-cell acute lymphoblastic leukemia, but the reciprocal fusion A4M is expressed in only half of the patients. [...]
2019 - 10.3324/haematol.2018.202044
Haematologica, Vol. 104 Núm. 6 (2019) , p. 1189-1201
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9 p, 584.8 KB |
The role of H3O+ in the crystal structure of illite
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Nieto, Fernando (Universidad de Granada. Departamento de Mineralogía y Petrología) ;
Mellini, Marcello (Universita di Siena. Dipartimento di Scienze della Terra) ;
Abad, Isabel (Universidad de Jaén. Departamento de Geología)
In spite of decades of research on the subject, the crystal structure of illite is still poorly understood. The purpose of this study was to address this problem by investigating the nature of the interlayer content in illite IMt-2 from Silver Hill, Montana, using analytical transmission electron microscopy (ATEM), thermogravimetry (TG), and X-ray powder diffraction (XRPD) analyses. [...]
2010 - 10.1346/CCMN.2010.0580208
Clays and Clay Minerals, Vol. 58, Núm. 2 (2010) , p. 238-246
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18 p, 1.7 MB |
Smectite formation in submarine hydrothermal sediments : Samples from the HMS Challenger expedition (1872-1876)
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Cuadros, Javier (Natural History Museum. Department of Mineralogy) ;
Dekov, Vesselin M. (University of Sofia. Department of Geology and Paleontology) ;
Arroyo, Xabier (Universidad de Granada. Departamento de Mineralogía y Petrología) ;
Nieto, Fernando (Universidad de Granada. Departamento de Mineralogía y Petrología)
Clay processes, mineral reactions, and element budgets in oceans continue to be important topics for scientific investigation, particularly with respect to understanding better the roles of chemistry, formation mechanism, and input from hydrothermal fluids, seawater, and non-hydrothermal mineral phases. [...]
2011 - 10.1346/CCMN.2011.0590204
Clays and Clay Minerals, Vol. 59, Núm. 2 (2011) , p. 147-164
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