Resultats globals: 2 registres trobats en 0.02 segons.
Articles, 2 registres trobats
Articles 2 registres trobats  
1.
10 p, 3.3 MB Hypothalamic loss of Snord116 recapitulates the hyperphagia of Prader-Willi syndrome / Polex-Wolf, Joseph (Medical Research Council (MRC) Metabolic Diseases Unit) ; Lam, Brian Y.H. (Medical Research Council (MRC) Metabolic Diseases Unit, University of Cambridge Metabolic Research Laboratories) ; Larder, Rachel (Medical Research Council (MRC) Metabolic Diseases Unit, University of Cambridge Metabolic Research Laboratories) ; Tadross, John (Medical Research Council (MRC) Metabolic Diseases Unit, University of Cambridge Metabolic Research Laboratories) ; Rimmington, Debra (Medical Research Council (MRC) Metabolic Diseases Unit, University of Cambridge Metabolic Research Laboratories) ; Bosch, Fàtima (Universitat Autònoma de Barcelona. Centre de Biotecnologia Animal i de Teràpia Gènica) ; Bosch i Tubert, Fàtima (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Cenzano, Verónica Jiménez (Universitat Autònoma de Barcelona. Centre de Biotecnologia Animal i de Teràpia Gènica) ; Ayuso, Eduard (Universitat Autònoma de Barcelona. Centre de Biotecnologia Animal i de Teràpia Gènica) ; Ma, Marcella K.L. (Medical Research Council (MRC) Metabolic Diseases Unit, University of Cambridge Metabolic Research Laboratories) ; Rainbow, Kara (Medical Research Council (MRC) Metabolic Diseases Unit, University of Cambridge Metabolic Research Laboratories) ; Coll, Anthony P. (Medical Research Council (MRC) Metabolic Diseases Unit, University of Cambridge Metabolic Research Laboratories) ; O'Rahilly, Stephen (Medical Research Council (MRC) Metabolic Diseases Unit, University of Cambridge Metabolic Research Laboratories) ; Yeo, Giles S.H. (Medical Research Council (MRC) Metabolic Diseases Unit, University of Cambridge Metabolic Research Laboratories)
Profound hyperphagia is a major disabling feature of Prader-Willi syndrome (PWS). Characterization of the mechanisms that underlie PWS-associated hyperphagia has been slowed by the paucity of animal models with increased food intake or obesity. [...]
2018 - 10.1172/JCI97007
The Journal of Clinical Investigation, Vol. 128 (january 2018) , p. 960-969  
2.
8 p, 490.0 KB Hypothalamic-specific manipulation of Fto , the ortholog of the human obesity gene FTO , affects food intake in rats / Tung, Yi-Chun Loraine (University of Cambridge. Metabolic Research Laboratories) ; Ayuso López, Eduard (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ; Shan, Xiaoye (University of Cambridge. Metabolic Research Laboratories) ; Bosch i Tubert, Fàtima (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; O'Rahilly, Stephen (University of Cambridge. Metabolic Research Laboratories) ; Coll, Anthony P. (University of Cambridge. Metabolic Research Laboratories) ; Yeo, Gilles S. H. (University of Cambridge. Metabolic Research Laboratories)
Sequence variants in the first intron of FTO are strongly associated with human obesity and human carriers of the risk alleles show evidence for increased appetite and food intake. Mice globally lacking Fto display a complex phenotype characterised by both increased energy expenditure and increased food intake. [...]
2010 - 10.1371/journal.pone.0008771
PLoS one, Vol. 5, Issue 1 (January 2010) , p. e8771  

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