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6 p, 251.2 KB |
How reliably can algorithms identify eosinophilic asthma phenotypes using non-invasive biomarkers?
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Betancor, Diana (Hospital Universitario Fundación Jiménez Díaz) ;
Olaguibel, José María (Centro de Investigación Biomédica en Red de Enfermedades Respiratorias) ;
Rodrigo-Muñoz, José Manuel (Hospital Universitario Fundación Jiménez Díaz) ;
Arismendi, Ebymar (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Barranco, Pilar (Hospital Universitario La Paz (Madrid)) ;
Barroso, Blanca (Hospital Universitario Fundación Jiménez Díaz) ;
Bobolea, Irina (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Cárdaba, Blanca (Hospital Universitario Fundación Jiménez Díaz) ;
Cruz, María Jesús (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Curto Sánchez, Elena (Institut d'Investigació Biomèdica Sant Pau) ;
Del Pozo, Victoria (Hospital Universitario Fundación Jiménez Díaz) ;
González-Barcala, Francisco-Javier (Complejo Hospitalario Universitario de Santiago de Compostela) ;
Martínez Rivera, Carlos (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Mullol, Joaquim (Universitat de Barcelona) ;
Muñoz Gall, Xavier (Hospital Universitari Vall d'Hebron) ;
Picado, Cesar (Universitat de Barcelona) ;
Plaza, Vicente (Institut d'Investigació Biomèdica Sant Pau) ;
Quirce Gancedo, Santiago (Hospital Universitario La Paz (Madrid)) ;
Rial, Manuel Jorge (Complejo Hospitalario Universitario de A Coruña) ;
Soto-Retes, Lorena (Institut d'Investigació Biomèdica Sant Pau) ;
Valero, Antonio (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Valverde-Monge, Marcela (Centro de Investigación Biomédica en Red de Enfermedades Respiratorias) ;
Sastre, Joaquin (Centro de Investigación Biomédica en Red de Enfermedades Respiratorias)
Asthma is a heterogeneous respiratory disease that encompasses different inflammatory and functional endophenotypes. Many non-invasive biomarkers has been investigated to its pathobiology. Heany et al proposed a clinical algorithm that classifies severe asthmatic patients into likely-eosinophilic phenotypes, based on accessible biomarkers: PBE, current treatment, FeNO, presence of nasal polyps (NP) and age of onset. [...]
2022 -  10.1002/clt2.12182
Clinical and translational allergy, Vol. 12, Issue 8 (August 2022) , art. e12182
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17 p, 1.5 MB |
Multi-ancestry genome-wide association study of asthma exacerbations
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Herrera-Luis, Esther (Universidad de La Laguna. Departamento de Bioquímica, Microbiología, Biología Celular y Genética) ;
Ortega, Victor E. (División de Medicina Respiratoria. Departamento de Medicina Interna. Mayo Clinic) ;
Ampleford, Elizabeth J. (Department of Internal Medicine. Center for Precision Medicine. Wake Forest School of Medicine) ;
Sio, Yang Yie (Department of Biological Sciences. National University of Singapore) ;
Granell, Raquel (MRC Integrative Epidemiology Unit (IEU). Population Health Sciences. Bristol Medical School. University of Bristol) ;
de Roos, Emmely (Department of Respiratory Medicine. Ghent University Hospital) ;
Terzikhan, Natalie (Department of Respiratory Medicine. Ghent University Hospital) ;
Vergara, Ernesto Elorduy (Institute of Computation Biology. Helmholtz Zentrum München. German Research Center for Environmental Health) ;
Hernandez-Pacheco, Natalia (Centro de Investigación Biomédica en Red de Enfermedades Respiratorias) ;
Perez-Garcia, Javier (Universidad de La Laguna. Departamento de Bioquímica, Microbiología, Biología Celular y Genética) ;
Martin-Gonzalez, Elena (Universidad de La Laguna. Departamento de Bioquímica, Microbiología, Biología Celular y Genética) ;
Lorenzo-Diaz, Fabian (Instituto Universitario de Enfermedades Tropicales y Salud Pública de Canarias. Universidad de La Laguna) ;
Hashimoto, Simone (Department of Respiratory Medicine. Amsterdam University Medical Center. University of Amsterdam) ;
Brinkman, Paul (Department of Respiratory Medicine. Amsterdam University Medical Center. University of Amsterdam) ;
Jorgensen, Andrea L. (Department of Health Data Science. Institute of Population Health. University of Liverpool) ;
Yan, Qi (Department of Obstetrics and Gynecology. Columbia University Irving Medical Center) ;
Forno, Erick (Division of Pediatric Pulmonary Medicine. UPMC Children's Hospital of Pittsburgh. University of Pittsburgh) ;
Vijverberg, Susanne J. (Department of Paediatric Respiratory Medicine and Allergy. Emma's Children Hospital. Amsterdam UMC. University of Amsterdam) ;
Lethem, Ryan (MRC Integrative Epidemiology Unit (IEU). Population Health Sciences. Bristol Medical School. University of Bristol) ;
Espuela-Ortiz, Antonio (Universidad de La Laguna. Departamento de Bioquímica, Microbiología, Biología Celular y Genética) ;
Gorenjak, Mario (Center for Human Molecular Genetics and Pharmacogenomics. Faculty of Medicine. University of Maribor) ;
Eng, Celeste (Department of Medicine. University of California San Francisco) ;
González-Pérez, Ruperto (Unidad de Asma Grave. Servicio de Alergología. Hospital Universitario de Canarias.) ;
Hernández-Pérez, José M. (Hospital General de La Palma. Servicio de Neumología) ;
Poza-Guedes, Paloma (Hospital Universitario de Canarias. Unidad de Asma Grave. Servicio de Alergología) ;
Sardón, Olaia (Universidad del País Vasco. Departamento de Pediatría) ;
Corcuera, Paula (Hospital Universitario Donostia. Division of Pediatric Respiratory Medicine) ;
Hawkins, Greg A. (Department of Biochemistry. Wake Forest School of Medicine) ;
Marsico, Annalisa (Computational Health Center. Helmholtz Zentrum München. German Research Center for Environmental Health) ;
Bahmer, Thomas (Airway Research Center North (ARCN). Members of the Germany Center for Lung Research (DZL)) ;
Rabe, Klaus F. (Airway Research Center North (ARCN). Members of the Germany Center for Lung Research (DZL)) ;
Hansen, Gesine (Department of Pediatric Pneumology. Allergology and Neonatology. Hannover Medical School) ;
Kopp, Matthias V. (Department of Paediatric Respiratory Medicine. Inselspital. University Children's Hospital of Bern. University of Bern) ;
Rios, Raimon (Programa de Pós Graduação em Imunologia (PPGIm). Instituto de Ciências da Saúde. Universidade Federal da Bahia (UFBA)) ;
Cruz, Maria Jesús (Hospital Universitari Vall d'Hebron) ;
González-Barcala, Francisco Javier (Complejo Hospitalario Universitario de Santiago de Compostela. Servicio de Neumología) ;
Olaguibel, José María (Complejo Hospitalario de Navarra) ;
Plaza, Vicente (Institut d'Investigació Biomèdica Sant Pau) ;
Quirce Gancedo, Santiago (Hospital Universitario La Paz. Instituto de Investigación Hospital Universitario La Paz. Servicio de Alergología) ;
Canino, Glorisa (Behavioral Sciences Research Institute. University of Puerto Rico) ;
Cloutier, Michelle (Department of Pediatrics. University of Connecticut) ;
Del Pozo, Victoria (Instituto de Investigación Sanitaria Hospital Universitario Fundación Jiménez Díaz. Servicio de Inmunología) ;
Rodriguez-Santana, Jose R. (Centro de Neumología Pediátrica) ;
Korta-Murua, Javier (Universidad del País Vasco. Departamento de Pediatría) ;
Villar, Jesús (Hospital Universitario de Gran Canaria Doctor Negrín. Multidisciplinary Organ Dysfunction Evaluation Research Network. Research Unit) ;
Potočnik, Uros (Laboratory for Biochemistry. Molecular Biology and Genomics. Faculty for Chemistry and Chemical Engineering. University of Maribor) ;
Figueiredo, Camila (Instituto de Ciências da Saúde. Universidade Federal da Bahia) ;
Kabesch, Michael (Department of Paediatric Pneumology and Allergy. University Children's Hospital Regensburg (KUNO)) ;
Mukhopadhyay, Somnath (Population Pharmacogenetics Group. Biomedical Research Institute. Ninewells Hospital and Medical School. University of Dundee) ;
Pirmohamed, Munir (Department of Pharmacology and Therapeutics. Institute of Systems. Molecular and Integrative Biology. University of Liverpool) ;
Hawcutt, Daniel (NIHR Alder Hey Clinical Research Facility. Alder Hey Children's Hospital) ;
Melén, Erik (Sachs' Children's Hospital. South General Hospital) ;
Palmer, Colin (Population Pharmacogenetics Group. Biomedical Research Institute. Ninewells Hospital and Medical School. University of Dundee) ;
Turner, Steve (Child Health. University of Aberdeen) ;
Maitland-van der Zee, Anke H. (Department of Paediatric Respiratory Medicine and Allergy. Emma's Children Hospital. Amsterdam UMC. University of Amsterdam) ;
von Mutius, Erika (Comprehensive Pneumology Center Munich (CPC-M). Member of the German Center for Lung Research) ;
Celedón, Juan C. (Division of Pediatric Pulmonary Medicine. UPMC Children's Hospital of Pittsburgh. University of Pittsburgh) ;
Brusselle, Guy (Department of Respiratory Medicine. Erasmus University Medical Center) ;
Chew, Fook Tim (Department of Biological Sciences. National University of Singapore) ;
Bleecker, Eugene (Division of Genetics. Genomics. and Precision Medicine. Department of Internal Medicine. University of Arizona College of Medicine) ;
Meyers, Deborah (Division of Genetics. Genomics. and Precision Medicine. Department of Internal Medicine. University of Arizona College of Medicine) ;
Burchard, Esteban G. (Department of Bioengineering and Therapeutic Sciences. University of California San Francisco) ;
Pino-Yanes, Maria (Universidad de la Laguna. Instituto de Tecnologías Biomédicas)
Background: Asthma exacerbations are a serious public health concern due to high healthcare resource utilization, work/school productivity loss, impact on quality of life, and risk of mortality. The genetic basis of asthma exacerbations has been studied in several populations, but no prior study has performed a multi-ancestry meta-analysis of genome-wide association studies (meta-GWAS) for this trait. [...]
2022 - 10.1111/pai.13802
Pediatric Allergy and Immunology, Vol. 33 Núm. 6 (june 2022) , p. e13802
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14 p, 2.6 MB |
Analysis of Differentially Expressed MicroRNAs in Serum and Lung Tissues from Individuals with Severe Asthma Treated with Oral Glucocorticoids
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Gil-Martínez, Marta (Centro de Investigación Biomédica en Red de Enfermedades Respiratorias) ;
Lorente-Sorolla, Clara (Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz) ;
Rodrigo-Muñoz, José M. (Instituto de Salud Carlos III) ;
Lendínez, Miguel Ángel (Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz) ;
Núñez-Moreno, Gonzalo (Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz) ;
de la Fuente, Lorena (Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz) ;
Mínguez, Pablo (Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz) ;
Mahíllo-Fernández, Ignacio (Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz) ;
Sastre, Joaquin (Hospital Universitario Fundación Jiménez Díaz) ;
Valverde-Monge, Marcela (Hospital Universitario Fundación Jiménez Díaz) ;
Quirce Gancedo, Santiago (Hospital Universitario La Paz (Madrid)) ;
Caballero, María L. (Hospital Universitario La Paz (Madrid)) ;
González-Barcala, Francisco J. (Complejo Hospitalario Universitario de Santiago de Compostela) ;
Arismendi, Ebymar (Hospital Clínic i Provincial de Barcelona) ;
Bobolea, Irina (Hospital Clínic i Provincial de Barcelona) ;
Valero, Antonio (Hospital Clínic i Provincial de Barcelona) ;
Muñoz Gall, Xavier (Hospital Universitari Vall d'Hebron) ;
Cruz, María Jesús (Hospital Universitari Vall d'Hebron) ;
Martínez Rivera, Carlos (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Plaza, Vicente (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Olaguibel, José M. (Complejo Hospitalario de Navarra) ;
Del Pozo, Victoria (Universidad Autónoma de Madrid) ;
Universitat Autònoma de Barcelona
Nowadays, microRNAs (miRNAs) are increasingly used as biomarkers due to their potential contribution to the diagnosis and targeted treatment of a range of diseases. The aim of the study was to analyze the miRNA expression profiles in serum and lung tissue from patients with severe asthma treated with oral corticosteroids (OCS) and those without OCS treatment. [...]
2023 - 10.3390/ijms24021611
International journal of molecular sciences, Vol. 24 (january 2023)
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4.
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10 p, 933.3 KB |
Clinical and inflammatory characteristics of patients with asthma in the Spanish MEGA project cohort
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Rial, Manuel J. (Hospital Universitario Fundación Jiménez Díaz) ;
Álvarez-Puebla, Maria J. (Complejo Hospitalario de Navarra) ;
Arismendi, Ebymar (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Caballero, María L. (Hospital Universitario La Paz (Madrid)) ;
Cañas, José A. (Centro de Investigación Biomédica en Red de Enfermedades Respiratorias) ;
Cruz Carmona, María Jesús (Hospital Universitari Vall d'Hebron) ;
González-Barcala, Francisco-Javier (Hospital Clínico Universitario (Santiago de Compostela, Galícia)) ;
Luna-Porta, Juan-Alberto (Instituto de Investigación Sanitaria del Hospital Universitario La Paz) ;
Martínez Rivera, Carlos (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Mullol, Joaquim (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Muñoz Gall, Xavier (Hospital Universitari Vall d'Hebron) ;
Olaguibel, José M. (Centro de Investigación Biomédica en Red de Enfermedades Respiratorias) ;
Picado, César (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Plaza, Vicente (Institut d'Investigació Biomèdica Sant Pau) ;
Quirce Gancedo, Santiago (Hospital Universitario La Paz (Madrid)) ;
Romero-Mesones, Christian (Hospital Universitari Vall d'Hebron) ;
Salgado, Francisco-Javier (Universidade de Santiago de Compostela) ;
Sastre, Beatriz (Centro de Investigación Biomédica en Red de Enfermedades Respiratorias) ;
Soto-Retes, Lorena (Institut d'Investigació Biomèdica Sant Pau) ;
Valero, Antonio (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Valverde, Marcela (Hospital Universitario Fundación Jiménez Díaz) ;
Sastre, Joaquin (Centro de Investigación Biomédica en Red de Enfermedades Respiratorias) ;
Del Pozo, Victoria (Centro de Investigación Biomédica en Red de Enfermedades Respiratorias) ;
Universitat Autònoma de Barcelona
The MEGA (MEchanism underlying the Genesis and evolution of Asthma) project is a multicenter cohort study carried out in eight Spanish hospitals, gathering clinical, physiological, and molecular data from patients with asthma and multimorbidities in order to gain insight into the different physiopathological mechanisms involved in this disorder. [...]
2021 - 10.1002/clt2.12001
Clinical and translational allergy, Vol. 11 (march 2021)
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