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Articles, 2 records found
Articles 2 records found  
1.
10 p, 3.4 MB Neuroprotective Effect of Non-viral Gene Therapy Treatment Based on Tetanus Toxin C-fragment in a Severe Mouse Model of Spinal Muscular Atrophy / Oliván, Sara (Universidad de Zaragoza. Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina. Grupo AMB.) ; Calvo, Ana C. (Universidad de Zaragoza. Facultad de Veterinaria. Laboratorio de Genética Bioquímica) ; Rando, Amaya (Universidad de Zaragoza. Facultad de Veterinaria. Laboratorio de Genética Bioquímica) ; Herrando Grabulosa, Mireia (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Manzano, Raquel (University of Oxford. Department of Physiology, Anatomy and Genetics) ; Zaragoza, Pilar (Universidad de Zaragoza. Instituto Agroalimentario de Aragón (IA2)) ; Tizzano, Eduardo F. (Hospital Vall d'Hebron. Àrea de Genètica Clínica i Molecular. Centros de Investigación Biomédica en Red) ; Aguilera Ávila, José (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Osta, Rosario (Universidad de Zaragoza. Centro de Investigación y Tecnología Agroalimentaria de Aragón) ; Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular
Spinal muscular atrophy (SMA) is a hereditary childhood disease that causes paralysis and progressive degeneration of skeletal muscles and spinal motor neurons. SMA is associated with reduced levels of full-length Survival of Motor Neuron (SMN) protein, due to mutations in the Survival of Motor Neuron 1 gene. [...]
2016 - 10.3389/fnmol.2016.00076
Frontiers in Molecular Neuroscience, Vol. 9 (August 2016) , art. 76  
2.
19 p, 3.9 MB Fragment C of Tetanus Toxin : New Insights into Its Neuronal Signaling Pathway / Calvo Royo, Ana Cristina (Universidad de Zaragoza. Facultad de Veterinaria) ; Oliván, Sara (Universidad de Zaragoza. Facultad de Veterinaria) ; Manzano, Raquel (Universidad de Zaragoza. Facultad de Veterinaria) ; Zaragoza Fernández, Pilar (Universidad de Zaragoza. Facultad de Veterinaria) ; Aguilera Ávila, José (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ; Osta, Rosario (Universidad de Zaragoza. Facultad de Veterinaria)
When Clostridium tetani was discovered and identified as a Gram-positive anaerobic bacterium of the genus Clostridium, the possibility of turning its toxin into a valuable biological carrier to ameliorate neurodegenerative processes was inconceivable. [...]
2012 - 10.3390/ijms13066883
International Journal of Molecular Sciences, Vol. 13 (2012) , p. 6883-6901  

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