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13 p, 2.2 MB CSF1R blockade slows the progression of amyotrophic lateral sclerosis by reducing microgliosis and invasion of macrophages into peripheral nerves / Martínez Muriana, Anna (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Mancuso, Renzo (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Francos Quijorna, Isaac (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Olmos Alonso, Adrian (University of Southampton. Centre for Biological Sciences) ; Osta, Rosario (Universidad de Zaragoza) ; Perry, V. Hugh (University of Southampton. Centre for Biological Sciences) ; Navarro, X. (Xavier) (Xavier) (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Gomez-Nicola, Diego (University of Southampton. Centre for Biological Sciences) ; López Vales, Rubén (Universitat Autònoma de Barcelona. Institut de Neurociències)
Inflammation is a common neuropathological feature in several neurological disorders, including amyotrophic lateral sclerosis (ALS). We have studied the contribution of CSF1R signalling to inflammation in ALS, as a pathway previously reported to control the expansion and activation of microglial cells. [...]
2016 - 10.1038/srep25663
Scientific reports, Vol. 6 (May 2016) , article 25663  

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