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20 p, 11.4 MB |
Disruption of the HLA-E/NKG2X axis is associated with uncontrolled HIV infections
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Romero-Martín, Luis (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Duran-Castells, Clara (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Olivella, Mireia (Universitat de Vic - Universitat Central de Catalunya) ;
Rosás-Umbert, Miriam (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Ruiz Riol, Marta (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Sanchez, Jorge (Impacta) ;
Hartigan-O'Connor, Dennis (University of California) ;
Mothe, Beatriz (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Olvera, Alex (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Brander, Christian (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Universitat Autònoma de Barcelona
The contribution of the HLA-E/NKG2X axis in NK-mediated control of HIV infection remains unclear. We have studied the relationship between HLA-E expression and phenotypical as well as functional characteristics of NK cells, in the context of chronic HIV infection and in an in vitro model of acute infection. [...]
2022 -  10.3389/fimmu.2022.1027855
Frontiers in immunology, Vol. 13 (november 2022)
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2.
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9 p, 1.6 MB |
Vaccination with an HIV T-cell immunogen induces alterations in the mouse gut microbiota
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Borgognone, Alessandra (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Elizalde-Torrent, Aleix (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Casadellà, Maria (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Romero, Luis (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Escribà, Tuixent (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Parera, Mariona (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Català-Moll, Francesc (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Noguera-Julian, Marc (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Brander, Christian (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Olvera, Alex (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Paredes, Roger (Universitat Autònoma de Barcelona. Departament de Medicina)
The gut microbiota is emerging as a crucial factor modulating vaccine responses; however, few studies have investigated if vaccines, in turn, can alter the microbiota and to what extent such changes may improve vaccine efficacy. [...]
2022 - 10.1038/s41522-022-00368-y
npj biofilms and microbiomes, Vol. 8 (december 2022)
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8 p, 959.2 KB |
Revisiting the taxonomical classification of Porcine Circovirus type 2 (PCV2) : still a real challenge
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Franzo, Giovanni (University of Padua. Department of Animal Medicine, Production and Health) ;
Cortey, Martí (The Pirbright Institute (Regne Unit)) ;
Olvera, Alex (IrsiCaixa - HIVACAT) ;
Novosel, Dinko (Croatian Veterinary Institute. Department of Pathology) ;
De Castro, Alessandra Marnie Martins Gomes (University of Sao Paulo. Department of Preventive Veterinary Medicine and Animal Health) ;
Biagini, Philippe (Unité de Virologie Moléculaire, Emergence et Co-évolution Virale) ;
Segalés Coma, Joaquim (Universitat Autònoma de Barcelona. Departament de Sanitat i d'Anatomia Animals) ;
Drigo, Michele (University of Padua. Department of Animal Medicine, Production and Health)
PCV2 has emerged as one of the most devastating viral infections of swine farming, causing a relevant economic impact due to direct losses and control strategies expenses. Epidemiological and experimental studies have evidenced that genetic diversity is potentially affecting the virulence of PVC2. [...]
2015 - 10.1186/s12985-015-0361-x
Virology Journal, Vol. 12 (august 2015)
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5.
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12 p, 2.3 MB |
Benzyl-2-Acetamido-2-Deoxy-α--Galactopyranoside Increases Human Immunodeficiency Virus Replication and Viral Outgrowth Efficacy In Vitro
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Olvera, Alex (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Martinez, Javier P. (Universitat Pompeu Fabra. Departament de Ciències Experimentals i de la Salut) ;
Casadellà, Maria (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Llano Montero, Anuska (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Rosás, Míriam (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Mothe, Beatriz (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Ruiz-Riol, Marta (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Arsequell, Gemma (Institut de Química Avançada de Catalunya) ;
Valencia, Gregorio (Institut de Química Avançada de Catalunya) ;
Noguera-Julian, Marc (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Paredes, Roger (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Meyerhans, Andreas (Institució Catalana de Recerca i Estudis Avançats) ;
Brander, Christian (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa)
Glycosylation of host and viral proteins is an important posttranslational modification needed to ensure correct function of glycoproteins. For this reason, we asked whether inhibition of O-glycosylation during human immunodeficiency virus (HIV) in vitro replication could affect HIV infectivity and replication rates. [...]
2018 - 10.3389/fimmu.2017.02010
Frontiers in immunology, Vol. 8 (january 2018)
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19 p, 3.7 MB |
Recombinant BCG expressing HTI prime and recombinant ChAdOx1 boost is safe and elicits HIV-1-specific T-cell responses in BALB/c mice
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Kilpeläinen, Athina (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Saubi, Narcis (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Guitart, Núria (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Olvera, Alex (Universitat de Vic - Universitat Central de Catalunya) ;
Hanke, Tomáš (Kumamoto University. International Research Center of Medical Sciences (IRCMS)) ;
Brander, Christian. (AELIX Therapeutics) ;
Joseph, Joan (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Universitat Autònoma de Barcelona
Despite the availability of anti-retroviral therapy, HIV-1 infection remains a massive burden on healthcare systems. Bacillus Calmette-Guérin (BCG), the only licensed vaccine against tuberculosis, confers protection against meningitis and miliary tuberculosis in infants. [...]
2019 - 10.3390/vaccines7030078
Vaccines (Basel), Vol. 7 Núm. 3 (september 2019) , p. 78
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15 p, 676.0 KB |
Mechanisms of abrupt loss of virus control in a cohort of previous HIV controllers
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Rosás Umbert, Miriam (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Llano Montero, Anuska (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Bellido, Rocío (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Olvera, Alex (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Ruiz-Riol, Marta (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Rocafort, Muntsa (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Fernández, Marco A. (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Cobarsi, Patricia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Crespo Casal, Manuel (Complexo Hospitalario Universitario de Vigo) ;
Dorrell, Lucy (Nuffield Department of Medicine, University of Oxford) ;
Del Romero, Jorge (Centro Sanitario Sandoval, Madrid) ;
Alcami, Jose (Instituto de Salud Carlos III) ;
Paredes, Roger (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Brander, Christian (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Mothe, Beatriz (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa)
A few individuals can control HIV infection without the need for antiretroviral treatment and are referred to as HIV controllers. We have studied HIV controllers who suddenly lose this ability and present with high in vivo viral replication and decays in their CD4 + T-cell counts to identify potential immune and virological factors that were responsible for initial virus control. [...]
2019 - 10.1128/JVI.01436-18
Journal of Virology, Vol. 93 (february 2019)
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13 p, 2.5 MB |
Identification of Interleukin-27 (IL-27)/IL-27 Receptor Subunit Alpha as a Critical Immune Axis for In Vivo HIV Control
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Ruiz-Riol, M. (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Berdnik, D. ;
Llano Montero, Anuska (Institut Germans Trias i Pujol) ;
Mothe, Beatriz. (Institut Germans Trias i Pujol) ;
Gálvez, Cristina (Institut Germans Trias i Pujol) ;
Pérez-Álvarez, Susana (Institut Germans Trias i Pujol) ;
Oriol-Tordera, B. (Institut Germans Trias i Pujol) ;
Olvera, A. (Institut Germans Trias i Pujol) ;
Silva-Arrieta, S. (Institut Germans Trias i Pujol) ;
Meulbroek, M. (Institut Germans Trias i Pujol) ;
Pujol Vila, Ferran (Projecte dels NOMS-HISPANOSIDA) ;
Coll, Josep (Institut Germans Trias i Pujol) ;
Martinez-Picado, J. (Institut Germans Trias i Pujol) ;
Ganoza, C. ;
Sanchez, J. ;
Gómez, G. ;
Wyss-Coray, T. ;
Brander, Christian. (Institut Germans Trias i Pujol)
Intact and broad immune cell effector functions and specific individual cytokines have been linked to HIV disease outcome, but their relative contribution to HIV control remains unclear. We asked whether the proteome of secreted cytokines and signaling factors in peripheral blood can be used to discover specific pathways critical for host viral control. [...]
2017 - 10.1128/JVI.00441-17
Journal of Virology, Vol. 91 (july 2017)
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12 p, 1.2 MB |
Lymphocyte Activation Dynamics Is Shaped by Hereditary Components at Chromosome Region 17q12-q21
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Carreras Sureda, Amado, 1986- (Universitat Pompeu Fabra. Departament de Ciències Experimentals i de la Salut) ;
Rubio Moscardo, Fanny (Universitat Pompeu Fabra. Departament de Ciències Experimentals i de la Salut) ;
Olvera, Alex (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Argilaguet, Jordi 1977- (Universitat Pompeu Fabra. Departament de Ciències Experimentals i de la Salut) ;
Kiefer, Kerstin (Universitat Pompeu Fabra. Departament de Ciències Experimentals i de la Salut) ;
Mothe, Beatriz (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Meyerhans, Andreas (Universitat Pompeu Fabra. Departament de Ciències Experimentals i de la Salut) ;
Brander, Christian (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Vicente, Rubén (Universitat Pompeu Fabra. Departament de Ciències Experimentals i de la Salut)
Single nucleotide polymorphisms (SNPs) located in the chromosome region 17q12-q21 are risk factors for asthma. Particularly, there are cis-regulatory haplotypes within this region that regulate differentially the expression levels of ORMDL3, GSDMB and ZPBP2 genes. [...]
2016 - 10.1371/journal.pone.0166414
PloS one, Vol. 11 Núm. 11 (November 2016)
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