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1.
13 p, 471.4 KB Overall Survival with Daratumumab, Lenalidomide, and Dexamethasone in Previously Treated Multiple Myeloma (POLLUX) : A Randomized, Open-Label, Phase III Trial / Dimopoulos, Meletios (National and Kapodistrian University of Athens) ; Oriol, Albert (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Nahi, Hareth (Department of Medicine. Karolinska University) ; San-Miguel, J (Clínica Universidad de Navarra) ; Bahlis, Nizar J. (University of Calgary) ; Usmani, S. Z (Memorial Sloan Kettering Cancer Center) ; Rabin, Neil (Department of Haematology. University College London Hospitals NHS Trust) ; Orlowski, Robert Z. (Department of Lymphoma and Myeloma. The University of Texas) ; Suzuki, Kenshi (Department of Hematology. Japanese Red Cross Medical Center) ; Plesner, Torben (University of Southern Denmark) ; Yoon, Sung Soo (Department of Internal Medicine. Seoul National University) ; Ben Yehuda, Dina (Hematology Department. Hebrew University) ; Richardson, Paul G. (Dana-Farber Cancer Institute (Estats Units d'Amèrica)) ; Goldschmidt, Hartmut (Heidelberg University Hospital (Alemanya)) ; Reece, Donna (Department of Medical Oncology and Hematology. Princess Margaret Cancer Centre) ; Ahmadi, Tahamtan (Genmab US (Estats Units d'Amèrica)) ; Qin, Xiang (Janssen Research & Development (Xina)) ; Garvin Mayo, Wendy (Janssen Research & Development (Estats Units d'Amèrica)) ; Gai, Xue (Janssen Research & Development (Estats Units d'Amèrica)) ; Carey, Jodi (Janssen Research & Development (Estats Units d'Amèrica)) ; Carson, Robin (Janssen Research & Development (Estats Units d'Amèrica)) ; Moreau, Philippe (Hematology Department. University Hospital Hôtel-Dieu)
PURPOSEWith the initial analysis of POLLUX at a median follow-up of 13. 5 months, daratumumab in combination with lenalidomide and dexamethasone (D-Rd) significantly prolonged progression-free survival versus lenalidomide and dexamethasone (Rd) alone in patients with relapsed or refractory multiple myeloma (RRMM). [...]
2023 - 10.1200/JCO.22.00940
Journal of Clinical Oncology, Vol. 41 Núm. 8 (october 2023) , p. 1590-1599  
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2.
10 p, 1.8 MB Carfilzomib-Dexamethasone Versus Bortezomib-Dexamethasone in Relapsed or Refractory Multiple Myeloma : Updated Overall Survival, Safety, and Subgroups / Orlowski, Robert Z. (Department of Lymphoma and Myeloma. The University of Texas M.D. Anderson Cancer Center) ; Moreau, Philippe (Department of Hematology. University Hospital Hotel-Dieu) ; Niesvizky, Ruben (Department of Medical Oncology. Myeloma Center. New York Presbyterian Hospital-Weill Cornell Medical Center) ; Ludwig, Heinz (Wilhelminen Cancer Research Institute (Viena, Àustria)) ; Oriol, Albert (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Chng, Wee Joo (Department of Hematology Oncology. National University of Singapore) ; Goldschmidt, Hartmut (Department of Hematology Oncology. Heidelberg University Clinic and the National Center of Tumor Diseases) ; Yang, Zhao (Department of Biostatistics. Amgen. Inc) ; Kimball, Amy S. (Department of Clinical Research. Amgen. Inc) ; Dimopoulos, Meletios (Department of Clinical Therapeutics. University Athens School of Medicine) ; Universitat Autònoma de Barcelona
Introduction: The phase III RandomizEd, OpeN Label, Phase 3 Study of Carfilzomib Plus DExamethAsone Vs Bortezomib Plus DexamethasOne in Patients With Relapsed Multiple Myeloma (ENDEAVOR) trial showed significantly improved progression-free survival and overall survival (OS) with carfilzomib (56 mg/m) and dexamethasone (Kd56) versus bortezomib and Kd56 (Vd) in patients with relapsed or refractory multiple myeloma (RRMM). [...]
2019 - 10.1016/j.clml.2019.04.018
Clinical Lymphoma, Myeloma & Leukemia, Vol. 19 Núm. 8 (august 2019) , p. 522-530.e1  
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2 Orlowski, Robert Z.
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