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15 p, 703.1 KB Ultra-Deep Pyrosequencing Detects Conserved Genomic Sites and Quantifies Linkage of Drug-Resistant Amino Acid Changes in the Hepatitis B Virus Genome / Rodríguez Frías, Francisco (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Tabernero, David (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Quer, Josep 1963- (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Esteban Mur, Juan Ignacio (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Ortega, Israel (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Domingo, Esteban (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Cubero, María Dolores (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Camós Anguila, Sílvia (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Ferrer, Carles (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Sánchez, Alex (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Jardí, Rosendo (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Schaper, Melanie (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Homs, Maria (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Garcia-Cehic, D. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Guardia Massó, Jaume (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Esteban, Rafael (Esteban Mur) (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Buti, Maria (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Universitat Autònoma de Barcelona
Selection of amino acid substitutions associated with resistance to nucleos(t)ide-analog (NA) therapy in the hepatitis B virus (HBV) reverse transcriptase (RT) and their combination in a single viral genome complicates treatment of chronic HBV infection and may affect the overlapping surface coding region. [...]
2012 - 10.1371/journal.pone.0037874
PloS one, Vol. 7 (may 2012)  
Detailed record - Creative Commons

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