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15 p, 2.5 MB Deep tissue translocation of graphene oxide sheets in human glioblastoma 3D spheroids and an orthotopic xenograft model / de Lázaro, Irene (University of Manchester. Nanomedicine Lab) ; Sharp, Paul (University of Manchester. Nanomedicine Lab.) ; Gurcan, Cansu (Ankara University. Department of Biomedical Engineering) ; Ceylan, Ahmed (Ankara University. Faculty of Veterinary Medicine. Department of Histology Embryology) ; Stylianou, Maria (University of Manchester. Nanomedicine Lab.) ; Kisby, Thomas (University of Manchester. Nanomedicine Lab.) ; Chen, Yingxian (University of Manchester. Nanomedicine Lab.) ; Vranic, Sandra (University of Manchester. Nanomedicine Lab.) ; Barr, Katharine (University of Manchester. Nanomedicine Lab.) ; Taheri, Hadiseh (Ankara University. Department of Biomedical Engineering) ; Ozen, Asuman (Ankara University. Faculty of Veterinary Medicine. Department of Histology Embryology) ; Bussy, Cyrill (University of Manchester. Nanomedicine Lab.) ; Yilmazer, Acelya (Ankara University. Department of Biomedical Engineering) ; Kostarelos, Kostas (Institut Català de Nanociència i Nanotecnologia)
Its anatomical localization, a highly heterogeneous and drug-resistant tumor cell population and a "cold" immune microenvironment, all challenge the treatment of glioblastoma. Nanoscale drug delivery systems, including graphene oxide (GO) flakes, may circumvent some of these issues bypassing biological barriers, delivering multiple cargoes to impact several pathways simultaneously, or targeting the immune compartment. [...]
2021 - 10.1002/adtp.202000109
Advanced Therapeutics, Vol. 4, issue 1 (Jan. 2021) , art. 2000109  
Detailed record - Creative Commons

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