1.
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14 p, 2.0 MB |
Effect of tumor burden and radical surgery on survival difference between upfront, early interval or delayed cytoreductive surgery in ovarian cancer
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Angeles, Martina Aida (Institut Universitaire du Cancer de Toulouse Oncopole) ;
Cabarrou, Bastien (Institut Universitaire du Cancer de Toulouse Oncopole) ;
Gil-Moreno, Antonio 1965- (Vall d'Hebron Institut d'Oncologia) ;
Pérez-Benavente, Assumpció (Vall d'Hebron Institut d'Oncologia) ;
Spagnolo, Emanuela (Hospital Universitario La Paz (Madrid)) ;
Rychlik, Agnieszka (Department of Gynaecologic Oncology, Maria Skłodowska-Curie National Research Institute of Oncology) ;
Martínez-Gómez, Carlos (INSERM CRCT 1 (França)) ;
Guyon, Frédéric (Department of Surgical Oncology, Institut Bergonié (França)) ;
Zapardiel, Ignacio (Hospital Universitario La Paz (Madrid)) ;
Querleu, Denis (Honorary Professor of the University of Toulouse) ;
Illac, Claire (Institut Universitaire du Cancer de Toulouse Oncopole) ;
Migliorelli, Federico (Department of Gynaecology and Obstetrics, Centre Hospitalier Intercommunal des Vallées de l'Ariège (França)) ;
Bétrian, Sarah (Institut Universitaire du Cancer de Toulouse Oncopole) ;
Ferron, Gwénaël (INSERM CRCT 19 (França)) ;
Hernández Gutierrez, Alicia (Instituto de Investigación Sanitaria del Hospital Universitario La Paz) ;
Martinez, Alejandra (INSERM CRCT 19 (França)) ;
Universitat Autònoma de Barcelona
We sought to evaluate the impact on survival of tumor burden and surgical complexity in relation to the number of cycles of neoadjuvant chemotherapy (NACT) in patients with advanced ovarian cancer (OC) with minimal (CC-1) or no residual disease (CC-0). [...]
2021 - 10.3802/jgo.2021.32.e78
Journal of Gynecologic Oncology, Vol. 32 (august 2021)
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2.
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13 p, 1.7 MB |
A combination of molecular and clinical parameters provides a new strategy for high-grade serous ovarian cancer patient management
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Bradbury, Melissa (Hospital Universitari Vall d'Hebron) ;
Borràs, Eva (Universitat Pompeu Fabra) ;
Vilar, Marta (Hospital Universitari Vall d'Hebron) ;
Castellvi, Josep (Hospital Universitari Vall d'Hebron) ;
Sanchez Iglesias, Jose Luis (Hospital Universitari Vall d'Hebron) ;
Pérez-Benavente, Assumpció (Hospital Universitari Vall d'Hebron) ;
Gil-Moreno, Antonio 1965- (Hospital Universitari Vall d'Hebron) ;
Fàbrega-Santamaria, Anna (Hospital Universitari Vall d'Hebron) ;
Sabidó, Eduard (Universitat Pompeu Fabra) ;
Universitat Autònoma de Barcelona
High-grade serous carcinoma (HGSC) is the most common and deadly subtype of ovarian cancer. Although most patients will initially respond to first-line treatment with a combination of surgery and platinum-based chemotherapy, up to a quarter will be resistant to treatment. [...]
2022 - 10.1186/s12967-022-03816-7
Journal of translational medicine, Vol. 20 (december 2022)
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3.
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16 p, 4.6 MB |
BRCA1 mutations in high-grade serous ovarian cancer are associated with proteomic changes in DNA repair, splicing, transcription regulation and signaling
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Bradbury, Melissa (Centre de Regulació Genòmica) ;
Castellvi, Josep (Hospital Universitari Vall d'Hebron) ;
Méndez Fernández, Olga (Hospital Universitari Vall d'Hebron) ;
Sanchez Iglesias, Jose Luis (Hospital Universitari Vall d'Hebron) ;
Pérez-Benavente, Assumpció (Hospital Universitari Vall d'Hebron) ;
Gil-Moreno, Antonio 1965- (Centro de Investigación Biomédica en Red de Cáncer) ;
Sabidó, Eduard (Centre de Regulació Genòmica) ;
Santamaría, Anna (Hospital Universitari Vall d'Hebron) ;
Borràs, Eva (Centre de Regulació Genòmica) ;
Vall d'Hebron Institut de Recerca (VHIR)
Despite recent advances in the management of BRCA1 mutated high-grade serous ovarian cancer (HGSC), the physiology of these tumors remains poorly understood. Here we provide a comprehensive molecular understanding of the signaling processes that drive HGSC pathogenesis with the addition of valuable ubiquitination profiling, and their dependency on BRCA1 mutation-state directly in patient-derived tissues. [...]
2022 - 10.1038/s41598-022-08461-0
Scientific reports, Vol. 12 (march 2022)
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4.
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5.
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25 p, 12.2 MB |
Aurora Borealis (Bora), Which Promotes Plk1 Activation by Aurora A, Has an Oncogenic Role in Ovarian Cancer
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Parrilla, Alfonso (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Barber, Marta (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Majem Cavaller, Blanca (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Castellvi, Josep (Hospital Universitari Vall d'Hebron) ;
Morote Robles, Juan (Hospital Universitari Vall d'Hebron) ;
Sánchez, José Luis (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Pérez-Benavente, Assumpció (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Segura, Miguel F. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Gil-Moreno, Antonio 1965- (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Santamaría, Anna (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Universitat Autònoma de Barcelona
Identifying novel actionable factors that critically contribute to tumorigenesis is essential in ovarian cancer, an aggressive and disseminative tumor, with limited therapeutic options available. Here we show that Aurora Borealis (BORA), a mitotic protein that plays a key role in activating the master mitotic kinase polo-like kinase 1 (PLK1), has an oncogenic role in ovarian cancer. [...]
2020 - 10.3390/cancers12040886
Cancers, Vol. 12 (april 2020)
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6.
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11 p, 3.2 MB |
Nerve-sparing versus non-nerve-sparing radical hysterectomy : surgical and long-term oncological outcomes
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Gil-Moreno, Antonio 1965- (Hospital Universitari Vall d'Hebron) ;
Carbonell-Socias, Melchor (Hospital Universitari Vall d'Hebron) ;
Salicrú, Sabina (Hospital Universitari Vall d'Hebron) ;
Bradbury, Melissa (Hospital Universitari Vall d'Hebron) ;
García, Ángel (Hospital Universitari Vall d'Hebron) ;
Vergés, Ramona (Hospital Universitari Vall d'Hebron) ;
Puig, Oriol Puig (Hospital Universitari Vall d'Hebron) ;
Sánchez-Iglesias, José Luís (Hospital Universitari Vall d'Hebron) ;
Cabrera Díaz, Silvia (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
de la Torre, Javier (Hospital Universitari Vall d'Hebron) ;
Gómez-Hidalgo, Natalia R. (Hospital Universitari Vall d'Hebron) ;
Pérez-Benavente, Assumpció (Hospital Universitari Vall d'Hebron) ;
Díaz-Feijoo, Berta (Hospital Universitari Vall d'Hebron) ;
Universitat Autònoma de Barcelona
There are controversies regarding the long-term oncological safety of preservation of pelvic innervation during radical hysterectomy (RH). This study aimed to analyze the feasibility and safety of nerve-sparing radical hysterectomy (NSRH) for cervical cancer compared with non-NSRH following 17 years of experience in a tertiary cancer referral center. [...]
2019 - 10.18632/oncotarget.27078
Oncotarget, Vol. 10 (july 2019) , p. 4598-4608
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7.
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12 p, 3.0 MB |
Exosome-like vesicles in uterine aspirates : a comparison of ultracentrifugation-based isolation protocols
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Campoy Moncayo, Irene (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Lanau Angulo, Lucia (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Altadill, Tatiana (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Sequeiros, Tamara (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Cabrera Díaz, Silvia (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Cubo-Abert, Montserrat (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Pérez-Benavente, Assumpció (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Garcia, Angel (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Borrós, Salvador (Universitat Ramon Llull. Institut Químic de Sarrià-IQS) ;
Santamaría, Anna (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Ponce, Jordi (Hospital Universitari de Bellvitge) ;
Matias-Guiu, Xavier (Institut de Recerca Biomèdica de Lleida) ;
Reventós, Jaume (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Gil-Moreno, Antonio 1965- (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Rigau, Marina (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Colás Ortega, Eva (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Universitat Autònoma de Barcelona
Uterine aspirates are used in the diagnostic process of endometrial disorders, yet further applications could emerge if its complex milieu was simplified. Exosome-like vesicles isolated from uterine aspirates could become an attractive source of biomarkers, but there is a need to standardize isolation protocols. [...]
2016 - 10.1186/s12967-016-0935-4
Journal of translational medicine, Vol. 14 (june 2016)
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