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Articles, 2 records found
Articles 2 records found  
1.
6 p, 558.0 KB Mutations in Escherichia coli aceE and ribB genes allow survival of strains defective in the first step of the isoprenoid biosynthesis pathway / Pérez-Gil, Jordi (Centre de Recerca en Agrigenòmica) ; Uros, Eva Maria (Centre de Recerca en Agrigenòmica) ; Sauret-Güeto, Susanna (Centre de Recerca en Agrigenòmica) ; Lois, L. Maria (Centre de Recerca en Agrigenòmica) ; Kirby, James (Joint BioEnergy Institute) ; Nishimoto, Minobu (Joint BioEnergy Institute) ; Baidoo, Edward E. K. (Joint BioEnergy Institute) ; Keasling, Jay D. (Joint BioEnergy Institute) ; Boronat i Margosa, Albert (Centre de Recerca en Agrigenòmica) ; Rodriguez-Concepción, Manuel (Centre de Recerca en Agrigenòmica)
A functional 2-C-methyl-D-erythritol 4-phosphate (MEP) pathway is required for isoprenoid biosynthesis and hence survival in Escherichia coli and most other bacteria. In the first two steps of the pathway, MEP is produced from the central metabolic intermediates pyruvate and glyceraldehyde 3-phosphate via 1-deoxy-D-xylulose 5-phosphate (DXP) by the activity of the enzymes DXP synthase (DXS) and DXP reductoisomerase (DXR). [...]
2012 - 10.1371/journal.pone.0043775
Plos One, Vol. 7, issue 8 (Aug. 2012) , e43775  
2.
18 p, 2.0 MB Evolutionary diversification and characterization of the eubacterial gene family encoding DXR type II, an alternative isoprenoid biosynthetic enzyme / Carretero-Paulet, Lorenzo (Instituto de Biología Molecular y Celular de Plantas) ; Lipska, Agnieszka (Instituto de Biología Molecular y Celular de Plantas) ; Pérez-Gil, Jordi (Centre de Recerca en Agrigenòmica) ; Sangari, Félix J. (Universidad de Cantabria. Departamento de Biología Molecular) ; Albert, Victor A. (Instituto de Biología Molecular y Celular de Plantas) ; Rodriguez-Concepción, Manuel (Centre de Recerca en Agrigenòmica)
Background: isoprenoids constitute a vast family of natural compounds performing diverse and essential functions in all domains of life. In most eubacteria, isoprenoids are synthesized through the methylerythritol 4-phosphate (MEP) pathway. [...]
2013 - 10.1186/1471-2148-13-180
BMC evolutionary biology, Vol. 13 (2013) , art. 180  

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