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14 p, 6.9 MB |
Gasdermin B expression predicts poor clinical outcome in HER2-positive breast cancer
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Hergueta-Redondo, Marta (Biochemistry Department, Universidad Autónoma de Madrid (UAM), Instituto de Investigaciones Biomédicas "Alberto Sols" (CSIC-UAM), IdiPAZ, Madrid, Spain) ;
Sarrio, David (Biochemistry Department, Universidad Autónoma de Madrid (UAM), Instituto de Investigaciones Biomédicas "Alberto Sols" (CSIC-UAM), IdiPAZ, Madrid, Spain) ;
Molina-Crespo, Ángela (Biochemistry Department, Universidad Autónoma de Madrid (UAM), Instituto de Investigaciones Biomédicas "Alberto Sols" (CSIC-UAM), IdiPAZ, Madrid, Spain) ;
Vicario, Rocío (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Bernadó-Morales, Cristina (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Martínez, Lidia (Biochemistry Department, Universidad Autónoma de Madrid (UAM), Instituto de Investigaciones Biomédicas "Alberto Sols" (CSIC-UAM), IdiPAZ, Madrid, Spain) ;
Rojo-Sebastián, Alejandro (Pathology Department, MD Anderson Cancer Center, Madrid, Spain) ;
Serra-Musach, Jordi (Breast Cancer and Systems Biology Unit, ProCURE, Catalan Institute of Oncology, IDIBELL, L'Hospitalet del Llobregat, Barcelona, Spain) ;
Mota, Alba (Translational Research Laboratory, MD Anderson Internacional Foundation, Madrid, Spain) ;
Martínez-Ramírez, Ángel (Cytogenetics Department, MD Anderson Cancer Center, Madrid, Spain) ;
Castilla, Maria Ángeles (Pathology Department, Hospital Universitario Virgen del Rocío, Sevilla, Spain) ;
González-Martin, Antonio (Oncology Department, MD Anderson Cancer Center, Madrid, Spain) ;
Pernas, Sonia (Breast Cancer and Systems Biology Unit, ProCURE, Catalan Institute of Oncology, IDIBELL, L'Hospitalet del Llobregat, Barcelona, Spain) ;
Cano, Amparo (Biochemistry Department, Universidad Autónoma de Madrid (UAM), Instituto de Investigaciones Biomédicas "Alberto Sols" (CSIC-UAM), IdiPAZ, Madrid, Spain) ;
Cortes, Javier (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Nuciforo, Paolo. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Peg, Vicente (Hospital Universitari Vall d'Hebron) ;
Palacios, José (Pathology Department, Hospital Universitario Ramón y Cajal, Madrid, Spain) ;
Pujana, Miguel Ángel (Breast Cancer and Systems Biology Unit, ProCURE, Catalan Institute of Oncology, IDIBELL, L'Hospitalet del Llobregat, Barcelona, Spain) ;
Arribas, Joaquín (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Moreno-Bueno, Gema (Translational Research Laboratory, MD Anderson Internacional Foundation, Madrid, Spain) ;
Universitat Autònoma de Barcelona
Around, 30-40% of HER2-positive breast cancers do not show substantial clinical benefit from the targeted therapy and, thus, the mechanisms underlying resistance remain partially unknown. Interestingly, ERBB2 is frequently co-amplified and co-expressed with neighbour genes that may play a relevant role in this cancer subtype. [...]
2016 -  10.18632/oncotarget.10787
Oncotarget, Vol. 7 (july 2016) , p. 56295-56308
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13 p, 2.3 MB |
The NER-related gene GTF2H5 predicts survival in high-grade serous ovarian cancer patients
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Gayarre, Javier (Human Genetics Group, Spanish National Cancer Research Center (CNIO)) ;
Kamieniak, Marta M. (Human Genetics Group, Spanish National Cancer Research Center (CNIO)) ;
Cazorla-Jiménez, Alicia (Department of Pathology, Fundación Jiménez Díaz-IDC Salud) ;
Muñoz-Repeto, Ivan (Human Genetics Group, Spanish National Cancer Research Center (CNIO)) ;
Borrego, Salud (Biomedical Network Research Centre on Rare Diseases (CIBERER)) ;
García-Donas, Jesús (Medical Oncology Service, Oncologic Center Clara Campal) ;
Hernando, Susana (Department of Oncology, Fundación Hospital Alcorcón) ;
Robles-Díaz, Luis (Familial Cancer Unit and Medical Oncology Department, Hospital 12 de Octubre) ;
García-Bueno, José M. (Department of Oncology, Hospital General de Albacete) ;
Ramón y Cajal, Teresa (Institut d'Investigació Biomèdica Sant Pau) ;
Hernández-Agudo, Elena (Breast Cancer Clinical Research Unit, Spanish National Cancer Research Center (CNIO)) ;
Heredia Soto, Victoria (Pathology and Translational Oncology Research Laboratories, Hospital La Paz Institute for Health Research (IdiPAZ)) ;
Márquez-Rodas, Ivan (Medical Oncology Service, Instituto de Investigación Sanitaria Gregorio Marañón, Universidad Complutense) ;
Echarri, María José (Medical Oncology Service, Hospital Severo Ochoa) ;
Lacambra-Calvet, Carmen (Department of Internal Medicine, Hospital Severo Ochoa) ;
Sáez, Raquel (Laboratory of Genetics, Hospital Donostia) ;
Cusidó, Maite (Department of Obstetrics and Gynecology, Hospital Universitario Quirón-Dexeus) ;
Redondo, Andrés (Department of Medical Oncology, Hospital La Paz IdiPAZ, Madrid) ;
Paz-Ares, Luis (Medical Oncology Service, Hospital 12 de Octubre) ;
Hardisson, David (Pathology Research Laboratory, Department of Pathology, Hospital La Paz IdiPAZ, and Facultad de Medicina, Universidad Autónoma de Madrid) ;
Mendiola, Marta (Pathology and Translational Oncology Research Laboratories, Hospital La Paz Institute for Health Research (IdiPAZ)) ;
Palacios, José (Department of Pathology, Hospital Universitario Ramón y Cajal) ;
Benítez, Javier (Biomedical Network Research Centre on Rare Diseases (CIBERER)) ;
García, María José (Biomedical Network Research Centre on Rare Diseases (CIBERER)) ;
Universitat Autònoma de Barcelona.
Departament de Medicina
We aimed to evaluate the prognostic and predictive value of the nucleotide excision repair-related gene GTF2H5, which is localized at the 6q24. 2-26 deletion previously reported by our group to predict longer survival of high-grade serous ovarian cancer patients. [...]
2015 - 10.3802/jgo.2016.27.e7
Journal of Gynecologic Oncology, Vol. 27 (november 2015)
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14 p, 707.2 KB |
Las bóvedas de crucería del manuscrito «Llibre de trasas de viax y muntea», de Joseph Ribes
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Tellia, Fabio (Universidad Politécnica de Madrid) ;
Palacios, José Carlos (Universidad Politécnica de Madrid)
El manuscrito de Joseph Ribes, Llibre de trasas de viax y muntea (1708), es un auténtico tratado de cantería en el que aparece una extensa colección de trazas de montea de todo tipo. El libro, carente de texto, contiene trazas que van desde la cantería medieval hasta la estereotomía clásica. [...]
El manuscrit de Joseph Ribes, Llibre de trasas de viax y muntea (1708), és un autèntic tractat de picapedreria en què apareix una extensa col·lecció de traces de sagita de tot tipus. El llibre, mancat de text, conté traces que van des de la picapedreria medieval fins a l'estereotomia clàssica. [...]
The manuscript of Joseph Ribes, the Llibre de Trasas de viax and muntea (1708), is an authentic treatise on stone cutting in which an extensive collection of tracings of all types appears. The book, devoid of text, contains traces ranging from medieval stonework to classical stereotomy. [...]
2015 - 10.5565/rev/locus.235
Locus amoenus, Núm. 13 (2015) , p. 29-41 (Articles)
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4 p, 327.5 KB |
Theoretical evidence for the kick-out mechanism for B diffusion in SiC
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Rurali, Riccardo (Centro Nacional de Microelectrónica) ;
Godignon, Philippe (Centro Nacional de Microelectrónica) ;
Rebollo Palacios, José Andrés (Centro Nacional de Microelectrónica) ;
Ordejon, Pablo (Institut de Ciència de Materials de Barcelona) ;
Hernández, Eduardo R. (Institut de Ciència de Materials de Barcelona) ;
American Physical Society
In this letter, we analyze by means of first-principles electronic structure calculations the diffusion of B impurities in 3C-SiC. We find, through molecular dynamics, that substitutional B at a Si lattice site is readily displaced by a nearby Si interstitial by the process known as a kick-out mechanism, in agreement with recent experimental results. [...]
2002 - 10.1063/1.1515369
Applied physics letters, Vol. 81, Issue 16 (October 2002) , p. 2989-2991
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4 p, 272.4 KB |
First-principles study of n-type dopants and their clustering in SiC
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Rurali, Riccardo (Centro Nacional de Microelectrónica) ;
Godignon, Philippe (Centro Nacional de Microelectrónica) ;
Rebollo Palacios, José Andrés (Centro Nacional de Microelectrónica) ;
Hernández, Eduardo R. (Institut de Ciència de Materials de Barcelona) ;
Ordejon, Pablo (Institut de Ciència de Materials de Barcelona) ;
American Physical Society
We report the results of an ab initio study of N and P dopants in SiC. We find that while N substitutes most favorably at a C lattice site, P does so preferably at a Si site, except in n-doping and Si-rich 3C-SiC. [...]
2003 - 10.1063/1.1583870
Applied physics letters, Vol. 82, Issue 24 (June 2003) , p. 4298-4300
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12 p, 915.6 KB |
PAM50 breast cancer subtyping by RT-qPCR and concordance with standard clinical molecular markers
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Bastien, Roy R. L. (The ARUP Institute for Clinical and Experimental Pathology (Salt Lake City, Estats Units d'Amèrica)) ;
Rodríguez-Lescure, Álvaro (Hospital Universitario de Elche (Elx, País Valencià)) ;
Ebbert, Mark T.W. (The ARUP Institute for Clinical and Experimental Pathology (Salt Lake City, Estats Units d'Amèrica)) ;
Prat, Aleix (Universitat Autónoma de Barcelona. Departament de Medicina) ;
Munárriz, Blanca (Hospital Universitario La Fe (València, País Valencià)) ;
Rowe, Leslie (The ARUP Institute for Clinical and Experimental Pathology (Salt Lake City, Estats Units d'Amèrica)) ;
Miller, Patricia (The ARUP Institute for Clinical and Experimental Pathology (Salt Lake City, Estats Units d'Amèrica)) ;
Ruiz Borrego, Manuel (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ;
Anderson, Daniel (The ARUP Institute for Clinical and Experimental Pathology (Salt Lake City, Estats Units d'Amèrica)) ;
Lyons, Bradley (The ARUP Institute for Clinical and Experimental Pathology (Salt Lake City, Estats Units d'Amèrica)) ;
Álvarez, Isabel (Hospital de Donostia (Sant Sebastià, País Basc)) ;
Dowell, Tracy (The ARUP Institute for Clinical and Experimental Pathology (Salt Lake City, Estats Units d'Amèrica)) ;
Wall, David (The ARUP Institute for Clinical and Experimental Pathology (Salt Lake City, Estats Units d'Amèrica)) ;
Seguí, Miguel Ángel (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Barley, Lee (The ARUP Institute for Clinical and Experimental Pathology (Salt Lake City, Estats Units d'Amèrica)) ;
Boucher, Kenneth M. (Huntsman Cancer Institute (Salt Lake City, Estats Units d'Amèrica)) ;
Alba, Emilio (Hospital Universitario Virgen de la Victoria (Màlaga, Andalusia)) ;
Pappas, Lisa (Huntsman Cancer Institute (Salt Lake City, Estats Units d'Amèrica)) ;
Davis, Carole A. (Huntsman Cancer Institute (Salt Lake City, Estats Units d'Amèrica)) ;
Aranda, Ignacio (Hospital General Universitario de Alicante (Alacant, País Valencià)) ;
Fauron, Christiane (The ARUP Institute for Clinical and Experimental Pathology (Salt Lake City, Estats Units d'Amèrica)) ;
Stijleman, Inge J. (Huntsman Cancer Institute (Salt Lake City, Estats Units d'Amèrica)) ;
Palacios, José (Hospital Virgen del Rocio (Sevilla, Andalusia)) ;
Antón, Antonio (Hospital Universitario Miguel Servet (Saragossa, Aragó)) ;
Carrasco, Eva (GEICAM. Spanish Breast Cancer Research Group (Madrid)) ;
Caballero, Rosalía (GEICAM. Spanish Breast Cancer Research Group (Madrid)) ;
Ellis, Matthew J. (Washington University. Department of Oncology (St. Louis, Estats Units d'Amèrica)) ;
Nielsen, Torsten O. (University of British Columbia. Department of Anatomical Pathology (Vancouver, Canadà)) ;
Perou, Charles M. (University of North Carolina at Chapel Hill. Lineberger Comprehensive Cancer Center (Chapel Hill, Estats Units d'Amèrica)) ;
Astill, Mark (The ARUP Institute for Clinical and Experimental Pathology (Salt Lake City, Estats Units d'Amèrica)) ;
Bernard, Philip S. (Huntsman Cancer Institute (Salt Lake City, Estats Units d'Amèrica)) ;
Martín, Miguel (Universidad Complutense de Madrid. Hospital General Universitario Gregorio Marañón)
Background: Many methodologies have been used in research to identify the "intrinsic" subtypes of breast cancer commonly known as Luminal A, Luminal B, HER2-Enriched (HER2-E) and Basal-like. The PAM50 gene set is often used for gene expression-based subtyping; however, surrogate subtyping using panels of immunohistochemical (IHC) markers are still widely used clinically. [...]
2012 - 10.1186/1755-8794-5-44
BMC medical genomics, Vol. 15, N. 44 (October 2012) , p. 1-9
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