Resultats globals: 7 registres trobats en 0.04 segons.
Articles, 7 registres trobats
Articles 7 registres trobats  
1.
17 p, 6.0 MB A new mouse model to study restoration of interleukin-6 (IL-6) expression in a Cre-dependent manner : microglial IL-6 regulation of experimental autoimmune encephalomyelitis / Sanchis, Paula (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Fernandez-Gayol, Olaya (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Comes, Gemma (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Aguilar Ludwig, Kevin (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Escrig, Anna (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Giralt, Mercedes (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Palmiter, Richard D. (University of Washington. Department of Biochemistry) ; Hidalgo Pareja, Juan (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
Interleukin-6 (IL-6) is a pleiotropic cytokine that controls numerous physiological processes both in basal and neuroinflammatory conditions, including the inflammatory response to experimental autoimmune encephalomyelitis (EAE). [...]
2020 - 10.1186/s12974-020-01969-0
Journal of neuroinflammation, Vol. 17 (October 2020) , art. 304  
2.
18 p, 4.4 MB Interleukin-6 Derived from the Central Nervous System May Influence the Pathogenesis of Experimental Autoimmune Encephalomyelitis in a Cell-Dependent Manner / Sanchis, Paula (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Fernandez-Gayol, Olaya (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Comes, Gemma (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Escrig, Anna (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Giralt, Mercedes (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Palmiter, Richard D. (Department of Biochemistry, Genome Sciences, and Howard Hughes Medical Institute, University of Washington) ; Hidalgo Pareja, Juan (Universitat Autònoma de Barcelona. Institut de Neurociències)
BACKGROUND: Interleukin-6 (IL-6) is a pleiotropic and multifunctional cytokine that plays a critical role in induction of experimental autoimmune encephalomyelitis (EAE), a mouse model of multiple sclerosis (MS). [...]
2020 - 10.3390/cells9020330
Cells, Vol. 9 Núm. 2 (2 2020)  
3.
17 p, 2.6 MB Succination is increased on select proteins in the brainstem of the NADH dehydrogenase (ubiquinone) Fe-S protein 4 (Ndufs4) Knockout Mouse, a Model of Leigh Syndrome / Piroli, G. G. (Department of Pharmacology. Physiology and Neuroscience. University of South Carolina) ; Manuel, A. M. (Department of Pharmacology. Physiology and Neuroscience. University of South Carolina) ; Clapper, A. C. (Department of Pharmacology. Physiology and Neuroscience. University of South Carolina) ; Walla, M. D. (Mass Spectrometry Center. Department of Chemistry and Biochemistry. University of South Carolina) ; Baatz, J. E. (Department of Pharmacology. Physiology and Neuroscience. University of South Carolina) ; Palmiter, Richard D (Howard Hughes Medical Institute and Department of Biochemistry. University of Washington) ; Quintana Puebla, Alberto (Seattle Children's Research Institute) ; Frizzell, N. (Department of Pharmacology. Physiology and Neuroscience. University of South Carolina)
Elevated fumarate concentrations as a result of Krebs cycle inhibition lead to increases in protein succination, an irreversible post-Translational modification that occurs when fumarate reacts with cysteine residues to generate S-(2-succino)cysteine (2SC). [...]
2016 - 10.1074/mcp.M115.051516
Molecular and Cellular Proteomics, Vol. 15 Núm. 2 (february 2016) , p. 445-461  
4.
9 p, 846.3 KB Striatal GPR88 modulates foraging efficiency / Rainwater, Aundrea (Howard Hughes Medical Institute (Maryland, Estats Units d'Amèrica)) ; Sanz Iglesias, Elisenda (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Palmiter, Richard D. (Howard Hughes Medical Institute (Maryland, Estats Units d'Amèrica)) ; Quintana Romero, Albert (Universitat Autònoma de Barcelona. Institut de Neurociències)
The striatum is anatomically and behaviorally implicated in behaviors that promote efficient foraging. To investigate this function, we studied instrumental choice behavior in mice lacking GPR88, a striatum-enriched orphan G-protein-coupled receptor that modulates striatal medium spiny neuron excitability. [...]
2017 - 10.1523/JNEUROSCI.2439-16.2017
The Journal of neuroscience, Vol. 37, Núm. 33 (August 2017) , p. 7939-7947  
5.
8 p, 2.2 MB Loss of mitochondrial Ndufs4 in striatal medium spiny neurons mediates progressive motor impairment in a mouse model of leigh syndrome / Chen, Byron (University of Washington. Howard Hughes Medical Institute) ; Hui, Jessica (Seattle Children's Research Institute (Seattle, Estats Units d'Amèrica)) ; Montgomery, Kelsey S. (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Gella, Alejandro (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Bolea Tomás, Irene (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Sanz Iglesias, Elisenda (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Palmiter, Richard D. (Howard Hughes Medical Institute (Maryland, Estats Units d'Amèrica)) ; Quintana Romero, Albert (Universitat Autònoma de Barcelona. Institut de Neurociències)
Inability of mitochondria to generate energy leads to severe and often fatal myoencephalopathies. Among these, Leigh syndrome (LS) is one of the most common childhood mitochondrial diseases; it is characterized by hypotonia, failure to thrive, respiratory insufficiency and progressive mental and motor dysfunction, leading to early death. [...]
2017 - 10.3389/fnmol.2017.00265
Frontiers in molecular neuroscience, Vol. 10 (August 2017) , article 265  
6.
9 p, 1.4 MB Severely impaired learning and altered neuronal morphology in mice lacking NMDA receptors in medium spiny neurons / Beutler, Lisa R. (University of Washington. Department of Genome Sciences) ; Eldred, Kiara C. (Howard Hughes Medical Institute (Estats Units d'Amèrica)) ; Quintana Romero, Albert (University of Washington. Department of Biochemistry) ; Keene, C. Dirk (University of Washington. Department of Pathology) ; Rose, Shannon E. (University of Washington. Department of Pathology) ; Postupna, Nadia (University of Washington. Department of Pathology) ; Montine, Thomas J. (University of Washington. Department of Pathology) ; Palmiter, Richard D. (University of Washington. Department of Genome Sciences)
The striatum is composed predominantly of medium spiny neurons (MSNs) that integrate excitatory, glutamatergic inputs from the cortex and thalamus, and modulatory dopaminergic inputs from the ventral midbrain to influence behavior. [...]
2011 - 10.1371/journal.pone.0028168
PloS one, Vol. 6 Num. 11 (November 2011) , p. e28168  
7.
28 p, 14.2 MB Agouti-related peptide neural circuits mediate adaptive behaviors in the starved state / Padilla, Stephanie L. (Howard Hughes Medical Institute (Maryland, Estats Units d'Amèrica)) ; Qiu, Jian (Oregon Health and Science University (Oregon, Estats Units d'Amèrica)) ; Soden, Marta E. (University of Washington (Seattle, Estats Units d'Amèrica)) ; Sanz Iglesias, Elisenda (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Nestor, Casey C. (Oregon Health and Science University (Oregon, Estats Units d'Amèrica)) ; Barker, Forrest D. (Howard Hughes Medical Institute (Maryland, Estats Units d'Amèrica)) ; Quintana Romero, Albert (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Zweifel, Larry S. (University of Washington (Seattle, Estats Units d'Amèrica)) ; Rønnekleiv, Oline K. (Oregon Health and Science University (Oregon, Estats Units d'Amèrica)) ; Kelly, Martin J. (Oregon Health and Science University (Oregon, Estats Units d'Amèrica)) ; Palmiter, Richard D. (Howard Hughes Medical Institute (Maryland, Estats Units d'Amèrica))
In the face of starvation, animals will engage in high-risk behaviors that would normally be considered maladaptive. Starving rodents, for example, will forage in areas that are more susceptible to predators and will also modulate aggressive behavior within a territory of limited or depleted nutrients. [...]
2016 - 10.1038/nn.4274
Nature neuroscience, Vol. 19, Num. 5 (May 2016) , p. 734-741  

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