Resultats globals: 4 registres trobats en 0.02 segons.
Articles, 3 registres trobats
Documents de recerca, 1 registres trobats
Articles 3 registres trobats  
1.
10 p, 929.1 KB antibacTR : dynamic antibacterial-drug-target ranking integrating comparative genomics, structural analysis and experimental annotation / Panjkovich, Alejandro (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Gibert, Isidre (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Daura i Ribera, Xavier (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
Background : development of novel antibacterial drugs is both an urgent healthcare necessity and a partially neglected field. The last decades have seen a substantial decrease in the discovery of novel antibiotics, which combined with the recent thrive of multi-drug-resistant pathogens have generated a scenario of general concern. [...]
2014 - 10.1186/1471-2164-15-36
PLoS one, Vol. 15, No. 36 (2014)  
2.
12 p, 1.2 MB Exploiting protein flexibility to predict the location of allosteric sites / Panjkovich, Alejandro (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Daura i Ribera, Xavier (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Background: Allostery is one of the most powerful and common ways of regulation of protein activity. However, for most allosteric proteins identified to date the mechanistic details of allosteric modulation are not yet well understood. [...]
2012 - 10.1186/1471-2105-13-273
BMC Bioinformatics, Vol. 13, N. 273 (October 2012) , p. 1-12  
3.
14 p, 1.9 MB Assessing the structural conservation of protein pockets to study functional and allosteric sites: implications for drug discovery / Panjkovich, Alejandro (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Daura i Ribera, Xavier (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Background: With the classical, active-site oriented drug-development approach reaching its limits, protein ligand-binding sites in general and allosteric sites in particular are increasingly attracting the interest of medicinal chemists in the search for new types of targets and strategies to drug development. [...]
2010 - 10.1186/1472-6807-10-9
BMC Structural biology, Vol. 10, Núm. 9 (March 2010) , p. 9-9  

Documents de recerca 1 registres trobats  
1.
93 p, 2.4 MB Structure and evolution of protein allosteric sites / Panjkovich, Alejandro ; Daura i Ribera, Xavier, dir. (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí"
La presente tesis estudia los sitios alostéricos desde una perspectiva estructural y evolutiva. La regulación alostérica es un aspecto fundamental de la vida a nivel molecular, ya que es el mecanismo más potente y frecuente en la regulación de la actividad proteica: mediante la unión de un ligando a un sitio que no es el sitio activo. [...]
This thesis studies protein allosteric sites from a structural and evolutionary perspective. Allostery is a fundamental aspect of life at the molecular level, the most common and powerful mechanism of protein activity regulation: through binding of a ligand to a site which is not the active site. [...]

[Barcelona] : Universitat Autònoma de Barcelona, 2014  

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