Pardo Fernández, Luis - Search Results - UAB Digital Repository of Documents

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Articles, 2 records found Research literature, 1 records found

Articles	2 records found

14 p, 6.3 MB

CREB Regulates Distinct Adaptive Transcriptional Programs in Astrocytes and Neurons / Pardo Fernández, Luis (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Valor, Luis Miguel (Hospital Universitario Puerta del Mar (Cadis, Andalusia)) ; Eraso-Pichot, Abel (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Barco, Ángel (Universidad Miguel Hernández de Elche. Instituto de Neurociencias) ; Golbano Rodríguez, Arantxa (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Hardingham, Giles E. (University of Edinburgh. Dementia Research Institute) ; Masgrau Juanola, Roser (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Galea, Elena (Universitat Autònoma de Barcelona. Institut de Neurociències)
The cyclic AMP response element binding protein (CREB) is a primary hub of a activity-driven genetic programs in neurons controlling plasticity, neurogenesis and survival. By contrast, the gene networks coordinated by CREB in astrocytes are Unknown despite the fact that the astrocytic CREB is a also activity-driven and neuroprotective. [...]
2017 - DOI (Digital Object Identifier)

10.1038/s41598-017-06231-x
Scientific reports, Vol. 7(2017) , art. 6390

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26 p, 3.6 MB

CREB decreases astrocytic excitability by modifying subcellular calcium fluxes via the sigma-1 receptor / Eraso-Pichot, Abel (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Larramona Arcas, Raquel (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Vicario-Orri, E. (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Villalonga, R. (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Pardo Fernández, Luis (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Galea, Elena (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Masgrau Juanola, Roser (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Astrocytic excitability relies on cytosolic calcium increases as a key mechanism, whereby astrocytes contribute to synaptic transmission and hence learning and memory. While it is a cornerstone of neurosciences that experiences are remembered, because transmitters activate gene expression in neurons, long-term adaptive astrocyte plasticity has not been described. [...]
2016 - DOI (Digital Object Identifier)

10.1007/s00018-016-2397-5
Cellular and Molecular Life Sciences, Vol. 74, no. 5 (March 2017) , p. 937-950

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Research literature	1 records found

257 p, 4.8 MB

CREB-dependent transcription in astrocytes : signalling pathways, gene profiles and neuroprotective role in brain injury / Pardo Fernández, Luis ; Galea, Elena, dir. ; Masgrau Juanola, Roser, dir. (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular
El estudio de los astrocitos se ha vuelto muy relevante en el ámbito de las neurociencias desde el descubrimiento, a principios de los años 90, de que aquellas "células de soporte" podían responder a la actividad sináptica. [...]
The study of astrocytes has become highly relevant in the realm of neurosciences since the discovery in the early 90's that those "supportive cells" can respond to synaptic activity. Nowadays, it is accepted that astrocytes have the ability to modulate synaptic transmission through the release of molecules that act at both pre-synaptic and post-synaptic sites, the so-called gliotransmitters. [...]
Bellaterra : Universitat Autònoma de Barcelona, 2015

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