Home > Search Results: Pascual-Reguant, L.
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43 p, 3.9 MB LOXL2-mediated H3K4 oxidation reduces chromatin accessibility in triple-negative breast cancer cells / Cebrià Costa, Joan Pau (Vall d'Hebron Institut d'Oncologia) ; Pascual Reguant, Laura (Vall d'Hebron Institut d'Oncologia) ; Gonzalez-Perez, Abel (Institute for Research in Biomedicine (IRB Barcelona)) ; Serra-Bardenys, Gemma (Vall d'Hebron Institut d'Oncologia) ; Querol, Jessica (Vall d'Hebron Institut d'Oncologia) ; Cosín Tomás, Marc (Vall d'Hebron Institut d'Oncologia) ; Verde, Gaetano (Universitat Internacional de Catalunya. Facultat de Ciències de la Salut) ; Aiese Cigliano, Riccardo (Sequentia Biotech SL) ; Sanseverino, Walter. (Sequentia Biotech SL) ; Segura-Bayona, Sandra (Institute for Research in Biomedicine (IRB Barcelona)) ; Iturbide, Ane (Institute of Epigenetics and Stem Cells) ; Andreu Martínez, David (Universitat Pompeu Fabra. Departament de Ciències Experimentals i de la Salut) ; Nuciforo, Paolo. (Vall d'Hebron Institut d'Oncologia) ; Bernadó Morales, Cristina (Centro de Investigación Biomédica en Red de Cáncer) ; Rodilla, Verónica (Vall d'Hebron Institut d'Oncologia) ; Arribas, Joaquín V (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Yélamos, José (Institut Hospital del Mar d'Investigacions Mèdiques) ; Garcia de Herreros, Antonio (Institut Hospital del Mar d'Investigacions Mèdiques) ; Stracker, Travis H. (Institute for Research in Biomedicine (IRB Barcelona)) ; Peiró, Sandra (Vall d'Hebron Institut d'Oncologia)
Oxidation of H3 at lysine 4 (H3K4ox) by lysyl oxidase-like 2 (LOXL2) generates an H3 modification with an unknown physiological function. We find that LOXL2 and H3K4ox are higher in triple-negative breast cancer (TNBC) cell lines and patient-derived xenografts (PDXs) than those from other breast cancer subtypes. [...]
2020 - 10.1038/s41388-019-0969-1
Oncogene, Vol. 39 (2020) , p. 79-121  
Detailed record - Creative Commons

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