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1.
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10 p, 9.2 MB |
Hazard assessment of different-sized polystyrene nanoplastics in hematopoietic human cell lines
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Tavakolpournegari, Alireza (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Annangi, Balasubramanyam (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Villacorta, Aliro (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Banaei, Gooya (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Martin, Joan (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Pastor Benito, Susana (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Marcos Dauder, Ricardo (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Hernández Bonilla, Alba (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
The environmental presence of micro/nanoplastics (MNPLs) is an environmental and human health concern. Such MNPLs can result from the physicochemical/biological degradation of plastic goods (secondary MNPLs) or can result from industrial production at that size, for different commercial purposes (primary MNPLs). [...]
2023 -  10.1016/j.chemosphere.2023.138360
Chemosphere, Vol. 325 (June 2023) , art. 138360
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2.
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26 p, 3.6 MB |
In vitro approaches to determine the potential carcinogenic risk of environmental pollutants
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Barguilla, Irene (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Maguer-Satta, Veronique (Centre de Recherche en Cancérologie de Lyon) ;
Guyot, Boris (Centre de Recherche en Cancérologie de Lyon) ;
Pastor Benito, Susana (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Marcos Dauder, Ricardo (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Hernández Bonilla, Alba (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
One important environmental/health challenge is to determine, in a feasible way, the potential carcinogenic risk associated with environmental agents/exposures. Since a significant proportion of tumors have an environmental origin, detecting the potential carcinogenic risk of environmental agents is mandatory, as regulated by national and international agencies. [...]
2023 - 10.3390/ijms24097851
International journal of molecular sciences, Vol. 24, Issue 9 (April 2023) , art. 7851
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3.
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2 p, 739.5 KB |
Author Correction : DNA damage in circulating leukocytes measured with the comet assay may predict the risk of death
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Bonassi, Stefano (San Raffaele University) ;
Ceppi, Marcello (San Martino Policlinic Hospital) ;
Møller, Peter (University of Copenhagen) ;
Azqueta, Amaya (Universidad de Navarra) ;
Milić, Mirta (Institute for Medical Research and Occupational Health) ;
Neri, Monica (IRCCS San Raffaele Roma) ;
Brunborg, Gunnar (Norwegian Institute of Public Health) ;
Godschalk, Roger (University of Maastricht. Department of Pharmacology and Toxicology) ;
Koppen, Gudrun (Flemish Institute of Technological Research) ;
Langie, Sabine (University of Maastricht. Department of Pharmacology and Toxicology) ;
Teixeira, João Paulo (Instituto de Saúde Pública, Universidade Do Porto) ;
Bruzzone, Marco (San Martino Policlinic Hospital) ;
Da Silva, Juliana (Lutheran University of Brazil) ;
Benedetti, Danieli (Lutheran University of Brazil) ;
Cavallo, Delia (Department of Occupational and Environmental Medicine, Epidemiology and Hygiene) ;
Ursini, Cinzia Lucia (Department of Occupational and Environmental Medicine, Epidemiology and Hygiene) ;
Giovannelli, Lisa (University of Florence. Department NEUROFARBA) ;
Moretti, Silvia (University of Florence. Department of Health Sciences) ;
Riso, Patrizia (University of Milan. Department of Food, Environmental and Nutritional Sciences) ;
Del Bo', Cristian (University of Milan. Department of Food, Environmental and Nutritional Sciences) ;
Russo, Patrizia (San Raffaele University) ;
Dobrzyńska, Malgorzata (National Institute of Public Health NIH) ;
Goroshinskaya, Irina A. (National Medical Research Center for Oncology) ;
Surikova, Ekaterina I. (National Medical Research Center for Oncology) ;
Staruchova, Marta (Slovak Medical University) ;
Barančoková, Magdalena (Slovak Medical University) ;
Volkovova, Katarina (Slovak Medical University) ;
Kažimirova, Alena (Slovak Medical University) ;
Smolkova, Bozena (Slovak Academy of Sciences) ;
Laffon, Blanca (Instituto de Investigación Biomédica de A Coruña) ;
Valdiglesias, Vanessa (Universidade da Coruña) ;
Pastor Benito, Susana (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Marcos Dauder, Ricardo (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Hernández Bonilla, Alba (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Gajski, Goran (Institute for Medical Research and Occupational Health) ;
Spremo-Potparević, Biljana (University of Belgrade) ;
Živković, Lada (University of Belgrade) ;
Boutet-Robinet, Elisa (Université de Toulouse) ;
Perdry, Hervé (Univ Paris-Saclay) ;
Lebailly, Pierre (Centre François Baclesse (Caen, França)) ;
Perez, Carlos L. (Universidad de Ciencias Médicas de La Habana) ;
Basaran, Nursen (Hacettepe University. Department of Pharmaceutical Toxicology) ;
Nemeth, Zsuzsanna (National Public Health Center) ;
Safar, Anna (National Public Health Center) ;
Dusinska, Maria (Health Effects Laboratory) ;
Collins, Andrew R (University of Oslo. Department of Nutrition)
2021 - 10.1038/s41598-021-98620-6
Scientific reports, Vol. 11 (September 2021) , art. 19043
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4.
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11 p, 1.1 MB |
DNA damage in circulating leukocytes measured with the comet assay may predict the risk of death
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Bonassi, Stefano (San Raffaele University) ;
Ceppi, Marcello (San Martino Policlinic Hospital) ;
Møller, Peter (University of Copenhagen) ;
Azqueta, Amaya (Universidad de Navarra) ;
Milić, Mirta (Institute for Medical Research and Occupational Health) ;
Neri, Monica (IRCCS San Raffaele Roma) ;
Brunborg, Gunnar (Norwegian Institute of Public Health) ;
Godschalk, Roger (University of Maastricht. Department of Pharmacology and Toxicology) ;
Koppen, Gudrun (Flemish Institute of Technological Research) ;
Langie, Sabine (University of Maastricht. Department of Pharmacology and Toxicology) ;
Teixeira, João Paulo (Instituto de Saúde Pública, Universidade Do Porto) ;
Bruzzone, Marco (San Martino Policlinic Hospital) ;
Da Silva, Juliana (Lutheran University of Brazil) ;
Benedetti, Danieli (Lutheran University of Brazil) ;
Cavallo, Delia (Department of Occupational and Environmental Medicine, Epidemiology and Hygiene) ;
Ursini, Cinzia Lucia (Department of Occupational and Environmental Medicine, Epidemiology and Hygiene) ;
Giovannelli, Lisa (University of Florence. Department NEUROFARBA) ;
Moretti, Silvia (University of Florence. Department of Health Sciences) ;
Riso, Patrizia (University of Milan. Department of Food, Environmental and Nutritional Sciences) ;
Del Bo', Cristian (University of Milan. Department of Food, Environmental and Nutritional Sciences) ;
Russo, Patrizia (San Raffaele University) ;
Dobrzyńska, Malgorzata (National Institute of Public Health NIH) ;
Goroshinskaya, Irina A. (National Medical Research Center for Oncology) ;
Surikova, Ekaterina I. (National Medical Research Center for Oncology) ;
Staruchova, Marta (Slovak Medical University) ;
Barančoková, Magdalena (Slovak Medical University) ;
Volkovova, Katarina (Slovak Medical University) ;
Kažimirova, Alena (Slovak Medical University) ;
Smolkova, Bozena (Slovak Academy of Sciences) ;
Laffon, Blanca (Instituto de Investigación Biomédica de A Coruña) ;
Valdiglesias, Vanessa (Universidade da Coruña) ;
Pastor Benito, Susana (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Marcos Dauder, Ricardo (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Hernández Bonilla, Alba (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Gajski, Goran (Institute for Medical Research and Occupational Health) ;
Spremo-Potparević, Biljana (University of Belgrade) ;
Živković, Lada (University of Belgrade) ;
Boutet-Robinet, Elisa (Université de Toulouse) ;
Perdry, Hervé (Univ Paris-Saclay) ;
Lebailly, Pierre (Centre François Baclesse (Caen, França)) ;
Perez, Carlos L. (Universidad de Ciencias Médicas de La Habana) ;
Basaran, Nursen (Hacettepe University. Department of Pharmaceutical Toxicology) ;
Nemeth, Zsuzsanna (National Public Health Center) ;
Safar, Anna (National Public Health Center) ;
Dusinska, Maria (Health Effects Laboratory) ;
Collins, Andrew R (University of Oslo. Department of Nutrition)
The comet assay or single cell gel electrophoresis, is the most common method used to measure strand breaks and a variety of other DNA lesions in human populations. To estimate the risk of overall mortality, mortality by cause, and cancer incidence associated to DNA damage, a cohort of 2,403 healthy individuals (25,978 person-years) screened in 16 laboratories using the comet assay between 1996 and 2016 was followed-up. [...]
2021 - 10.1038/s41598-021-95976-7
Scientific reports, Vol. 11 (August 2021) , art. 16793
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5.
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14 p, 3.2 MB |
Micrornas as a suitable biomarker to detect the effects of long-term exposures to nanomaterials. Studies on tio2np and mwcnt
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Ballesteros Ribera, Sandra (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Vales, Gerard (Finnish Institute of Occupational Health) ;
Velázquez Henar, Antonia (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Pastor Benito, Susana (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Alaraby, Mohamed (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Marcos Dauder, Ricardo (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Hernández Bonilla, Alba (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
The presence of nanomaterials (NMs) in the environment may represent a serious risk to human health, especially in a scenario of chronic exposure. To evaluate the potential relationship between NM-induced epigenetic alterations and carcinogenesis, the present study analyzed a panel of 33 miRNAs related to the cell transformation process in BEAS-2B cells transformed by TiO2NP and long-term MWCNT exposure. [...]
2021 - 10.3390/nano11123458
Nanomaterials, Vol. 11, Issue 12 (December 2021) , art. 3458
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6.
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16 p, 2.8 MB |
Long-term effects of polystyrene nanoplastics in human intestinal Caco-2 cells
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Domenech, Josefa (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Britto, Mariana de (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Velázquez Henar, Antonia (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Pastor Benito, Susana (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Hernández Bonilla, Alba (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Marcos Dauder, Ricardo (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Cortes Crignola, Constanza (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
The increasing presence of micro- and nanoplastics (MNPLs) in the environment, and their consequent accumulation in trophic niches, could pose a potential health threat to humans, especially due to their chronic ingestion. [...]
2021 - 10.3390/biom11101442
Biomolecules, Vol. 11, issue 10 (Oct. 2021) , art. 1444
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7.
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11 p, 680.8 KB |
Exposure to disinfection by-products in swimming pools and biomarkers of genotoxicity and respiratory damage - The PISCINA2 Study
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Font-Ribera, Laia 1982- (Institut de Salut Global de Barcelona) ;
Marco, Esther (Institut de Diagnòstic Ambiental i Estudis de l'Aigua) ;
Grimalt, Joan (Institut de Diagnòstic Ambiental i Estudis de l'Aigua) ;
Pastor Benito, Susana (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Marcos Dauder, Ricardo (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Abramsson-Zetterberg, Lilianne (National Food Administration, Uppsala, Sweden) ;
Pedersen, Marie (University of Copenhagen) ;
Grummt, Tamara (German Environment Agency) ;
Junek, Ralf (German Environment Agency) ;
Barreiro, Esther (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Heederik, Dick (Institute for Risk Assessment Sciences (IRAS), Utrecht) ;
Spithoven, Jack (Institute for Risk Assessment Sciences (IRAS), Utrecht) ;
Critelli, Rossana (Italian Institute for Genomic Medicine (IIGM)) ;
Naccarati, Alessio (Italian Institute for Genomic Medicine (IIGM)) ;
Schmalz, Christina (University of Tübingen) ;
Zwiener, Christian (University of Tübingen) ;
Liu, Jiaqi (Hong Kong University of Science and Technology) ;
Zhang, Xiangru (Hong Kong University of Science and Technology) ;
Mitch, William (Stanford University) ;
Gracia-Lavedan, Esther (Universitat Pompeu Fabra) ;
Arjona, Lourdes (Universitat Pompeu Fabra) ;
De Bont, Jeroen (Institut de Salut Global de Barcelona) ;
Tarès, Lluïsa (Institut de Salut Global de Barcelona) ;
Vineis, Paolo (Imperial College London) ;
Kogevinas, M. (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Villanueva, Cristina (Institut de Salut Global de Barcelona)
Background: Swimming in pools is a healthy activity that entails exposure to disinfection by-products (DBPs), some of which are irritant and genotoxic. Objectives: We evaluated exposure to DBPs during swimming in a chlorinated pool and the association with short-term changes in genotoxicity and lung epithelium permeability biomarkers. [...]
2019 - 10.1016/j.envint.2019.104988
Environment International, Vol. 131 (october 2019) , p. 104988
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7 p, 508.5 KB |
Novel genetic variants in differentiated thyroid cancer and assessment of the cumulative risk
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Figlioli, Gisella (University of Pisa. Department of Biology) ;
Chen, Bowang (German Cancer Research Center (DKFZ). Molecular Genetic Epidemiology (Germany)) ;
Elisei, Rossella (University of Pisa. Department of Endocrinology and Metabolism (Italy)) ;
Romei, Cristina (University of Pisa. Department of Endocrinology and Metabolism (Italy)) ;
Campo, Chiara (University of Pisa. Department of Biology (Italy)) ;
Cipollini, Monica (University of Pisa. Department of Biology (Italy)) ;
Cristaudo, Alfonso (University of Pisa. Department of Endocrinology and Metabolism (Italy)) ;
Bambi, Franco (Blood Centre, Azienda Ospedaliero Universitaria A. Meyer (Italy)) ;
Paolicchi, Elisa (University of Pisa. Department of Biology (Italy)) ;
Hoffmann, Per (University of Basel (Suïssa). Department of Biomedicine) ;
Herms, Stefan (University of Basel (Suïssa). Department of Biomedicine) ;
Kalemba, Michał (Maria Sklodowska-Curie Memorial Cancer Center. Department of Nuclear Medicine and Endocrine Oncology (Poland)) ;
Kula, Dorota (Maria Sklodowska-Curie Memorial Cancer Center. Department of Nuclear Medicine and Endocrine Oncology (Poland)) ;
Pastor Benito, Susana (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Marcos Dauder, Ricardo (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Velázquez Henar, Antonia (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Jarząb, Barbara (Maria Sklodowska-Curie Memorial Cancer Center. Department of Nuclear Medicine and Endocrine Oncology (Poland)) ;
Landi, Stefano (University of Pisa. Department of Biology (Italy)) ;
Hemminki, Kari (Lund University. Center for Primary Health Care Research, Clinical Research Center (Sweden)) ;
Gemignani, Federica (University of Pisa. Department of Biology (Italy)) ;
Försti, Asta (Lund University. Center for Primary Health Care Research, Clinical Research Center (Sweden))
A genome-wide association study (GWAS) performed on a high-incidence Italian population followed by replications on low-incidence cohorts suggested a strong association of differentiated thyroid cancer (DTC) with single nucleotide polymorphisms (SNPs) at 9q22. [...]
2015 - 10.1038/srep08922
Scientific reports, Vol. 5 (March 2015) , art. 8922
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9.
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9 p, 421.4 KB |
An Epistatic Interaction between the PAX8 and STK17B Genes in Papillary Thyroid Cancer Susceptibility
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Landa, Iñigo (Centro Nacional de Investigaciones Oncológicas) ;
Boullosa, Cesar (Centro Nacional de Investigaciones Oncológicas) ;
Inglada Pérez, Lucia (Centro Nacional de Investigaciones Oncológicas) ;
Sastre Perona, Ana (Universidad Autónoma de Madrid. Instituto de Investigaciones Biomédicas "Alberto Sols") ;
Pastor Benito, Susana (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Velázquez, Antonia (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública) ;
Mancikova, Veronika (Centro Nacional de Investigaciones Oncológicas) ;
Ruiz Llorente, Sergio (Universidad Autónoma de Madrid. Instituto de Investigaciones Biomédicas "Alberto Sols") ;
Schiavi, Francesca (Institut d'Oncologia Vèneto. Clínica de Càncer Familiar i Oncoendocrinologia) ;
Marcos Dauder, Ricardo (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Malats, Núria (Centro Nacional de Investigaciones Oncológicas) ;
Opocher, Giuseppe (Veneto Institute of Oncology (Pàdua, Itàlia)) ;
Diaz Uriarte, Ramón (Universidad Autónoma de Madrid. Instituto de Investigaciones Biomédicas "Alberto Sols") ;
Santisteban, Pilar (Universidad Autónoma de Madrid. Instituto de Investigaciones Biomédicas "Alberto Sols") ;
Valencia, Alfonso (Centro Nacional de Investigaciones Oncológicas) ;
Robledo, Mercedes (Centro Nacional de Investigaciones Oncológicas)
Papillary Thyroid Cancer (PTC) is a heterogeneous and complex disease; susceptibility to PTC is influenced by the joint effects of multiple common, low-penetrance genes, although relatively few have been identified to date. [...]
2013 - 10.1371/journal.pone.0074765
PloS one, Vol. 8 Issue 9 (September 2013) , p. e74765
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10.
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5 p, 164.4 KB |
Possible role of WDR3 gene on genome stability in thyroid cancer patients
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García Quispes, Wilser Andrés (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Pastor Benito, Susana (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Galofré, Pere (Hospital Universitari Vall d'Hebron) ;
Biarnés, Josefina (Hospital Universitari de Girona Doctor Josep Trueta) ;
Castell-Conesa, Joan (Hospital Universitari Vall d'Hebron) ;
Velázquez Henar, Antonia (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Marcos Dauder, Ricardo (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
The role of the WDR3 gene on genomic instability has been evaluated in a group of 115 differentiated thyroid cancer (DTC) patients. Genomic instability has been measured according to the response of peripheral blood lymphocytes to ionizing radiation (0. [...]
2012 - 10.1371/journal.pone.0044288
PloS one, Vol. 7, Issue 9 (September 2012) , p. e44288
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