Resultats globals: 4 registres trobats en 0.02 segons.
Articles, 3 registres trobats
Documents de recerca, 1 registres trobats
Articles 3 registres trobats  
1.
4 p, 131.8 KB Baseline hepatitis C virus resistance-associated substitutions present at frequencies lower than 15% may be clinically significant / Perales, Celia (Centro de Investigación Biomédica en Red (CIBER) de Enfermedades Hepáticas y Digestivas (CIBERehd) del Instituto de Salud Carlos III) ; Chen, Qian (Centro de Investigación Biomédica en Red (CIBER) de Enfermedades Hepáticas y Digestivas (CIBERehd) del Instituto de Salud Carlos III) ; Soria, Maria Eugenia (Liver Unit, Liver Disease Laboratory-Viral Hepatitis, Internal Medicine Department, Vall d'Hebron Institut of Research (VHIR)-Vall d'Hebron University Hospital(HUVH), Barcelona, Spain) ; Gregori, Josep (Roche Diagnostics SL, Sant Cugat del Vallès, Barcelona, Spain) ; Garcia-Cehic, Damir (Centro de Investigación Biomédica en Red (CIBER) de Enfermedades Hepáticas y Digestivas (CIBERehd) del Instituto de Salud Carlos III, Madrid, Spain) ; Nieto-Aponte, Leonardo (Liver Pathology Unit, Department of Biochemistry and Microbiology, HUVH, Barcelona, Spain) ; Castells, Lluis (Centro de Investigación Biomédica en Red (CIBER) de Enfermedades Hepáticas y Digestivas (CIBERehd) del Instituto de Salud Carlos III) ; Imaz, Arkaitz (HIV and STD Unit, Infectious Diseases Department, Bellvitge University Hospital-Bellvitge Biomedical Research Institut (IDIBELL), Hospitalet de Llobregat, Barcelona, Spain) ; Llorens-Revull, Meritxell (Hospital Universitari Vall d'Hebron) ; Domingo, Esteban (Virology and Microbiology Department, Centro de Biología Molecular "Severo Ochoa" (CSIC-UAM), Campus de Cantoblanco, Madrid, Spain) ; Buti, Maria (Universitat Autònoma de Barcelona. Departament de Medicina) ; Esteban, Juan Ignacio (Universitat Autònoma de Barcelona. Departament de Medicina) ; Rodriguez Frias, Francisco (Universitat Autònoma de Barcelona. Departament de Medicina) ; Quer, Josep (Universitat Autònoma de Barcelona. Departament de Medicina)
Controversy is ongoing about whether a minority mutant present at frequencies below 15% may be clinically relevant and should be considered to guide treatment. Resistance-associated substitution (RAS) studies were performed in patients before and at failure of antiviral treatments using Next-generation hepatitis C virus (HCV) sequencing (NGS). [...]
2018 - 10.2147/IDR.S172226
Infection and drug resistance, Vol. 11 (november 2018) , p. 2207-2210  
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17 p, 839.2 KB Molecular and Functional Bases of Selection against a Mutation Bias in an RNA Virus / de la Higuera, Ignacio (Centro de Biología Molecular "Severo Ochoa" (CSIC-UAM)) ; Ferrer-Orta, Cristina (Institut de Biologia Molecular de Barcelona (CSIC)) ; de Ávila, Ana I. (Centro de Biología Molecular "Severo Ochoa" (CSIC-UAM)) ; Perales, Celia (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Sierra, Macarena (Centro de Biología Molecular "Severo Ochoa" (CSIC-UAM)) ; Singh, Kamalendra (Christopher S. Bond Life Sciences Center, University of Missouri) ; Sarafianos, Stefan G. (Christopher S. Bond Life Sciences Center, University of Missouri) ; Dehouck, Yves (Machine Learning Group, Université Libre de Bruxelles (ULB)) ; Bastolla, Ugo (Centro de Biología Molecular "Severo Ochoa" (CSIC-UAM)) ; Verdaguer, Nuria (Institut de Biologia Molecular de Barcelona (CSIC)) ; Domingo, Esteban (Centro de Biología Molecular "Severo Ochoa" (CSIC-UAM)) ; Universitat Autònoma de Barcelona
The selective pressures acting on viruses that replicate under enhanced mutation rates are largely unknown. Here, we describe resistance of foot-and-mouth disease virus to the mutagen 5-fluorouracil (FU) through a single polymerase substitution that prevents an excess of A to G and U to C transitions evoked by FU on the wild-type foot-and-mouth disease virus, while maintaining the same level of mutant spectrum complexity. [...]
2017 - 10.1093/gbe/evx075
Genome biology and evolution, Vol. 9 (may 2017) , p. 1212-1228  
3.
21 p, 1.8 MB Resistance of Hepatitis C Virus to Inhibitors : Complexity and Clinical Implications / Perales, Celia (Hospitals Vall d'Hebron (Barcelona, Catalunya). Laboratori de Malalties Hepàtiques) ; Quer, Josep (Hospitals Vall d'Hebron (Barcelona, Catalunya). Laboratori de Malalties Hepàtiques) ; Gregori, Josep (Hospitals Vall d'Hebron (Barcelona, Catalunya). Laboratori de Malalties Hepàtiques) ; Esteban Mur, Juan Ignacio (Hospitals Vall d'Hebron (Barcelona, Catalunya). Laboratori de Malalties Hepàtiques) ; Domingo, Esteban (Centro de Biologia Molecular Severo Ochoa (Madrid, Espanya))
Selection of inhibitor-resistant viral mutants is universal for viruses that display quasi-species dynamics, and hepatitis C virus (HCV) is no exception. Here we review recent results on drug resistance in HCV, with emphasis on resistance to the newly-developed, directly-acting antiviral agents, as they are increasingly employed in the clinic. [...]
2015 - 10.3390/v7112902
Viruses, Vol. 7 N. 11 (November 2015) , p. 5746-5766  

Documents de recerca 1 registres trobats  
1.
123 p, 3.1 MB Caracterización molecular del perfil de resistencias del virus de la hepatitis C después del fallo terapéutico a antivirales de acción directa mediante secuenciación masiva / Chen, Qian, autor. ; Quer, Josep, supervisor acadèmic. ; Perales Viejo, Celia, supervisor acadèmic. ; Gregori i Font, Josep, supervisor acadèmic. ; Universitat Autònoma de Barcelona. Departament de Medicina
La infección crónica por el virus de la hepatitis C constituye un problema de salud pública a nivel mundial por su contribución al desarrollo de enfermedades hepáticas avanzadas y carcinoma hepatocelular. [...]
Chronic hepatitis C infection is considered as a major public health issue worldwide due to its linkage to the development of advanced liver diseases and hepatocellular carcinoma. Currently, the availability of highly efficient and well-tolerated antiviral therapies based on combinations of direct acting antivirals (DAAs) has provided sustained virological response (SVR) in nearly 95% of patients. [...]

[Barcelona] : Universitat Autònoma de Barcelona, 2019.  

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1 Perales, Cristina
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