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19 p, 765.0 KB |
Abuse Potential of Cathinones in Humans : a Systematic Review
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Poyatos, Lourdes (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Torres, Adrian (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia) ;
Papaseit, Esther (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Pérez-Mañá, Clara (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Hladun, Olga (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia) ;
Núñez-Montero, Melani (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia) ;
de la Rosa, Georgina (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia) ;
Torrens, Marta (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
Fuster, Daniel (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Muga, Roberto (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Farre, Magi (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia)
Introduction and objective: Assessing the abuse potential of new substances with central nervous system activity is essential for preventing possible risks of misuse and addiction. The same methodology is recommended for the evaluation of the abuse potential of recreational drugs. [...]
2022 -  10.3390/jcm11041004
Journal of clinical medicine, Vol. 11 Núm. 4 (february 2022) , p. 1004
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14 p, 991.2 KB |
Acute Pharmacological Effects and Oral Fluid Biomarkers of the Synthetic Cannabinoid UR-144 and THC in Recreational Users
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Maida, Nunzia La (Università Politecnica delle Marche (Ancona, Itàlia). Department of Excellence of Biomedical Science and Public Health) ;
Papaseit, Esther (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia) ;
Martínez, Lucia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Pérez-Mañá, Clara (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Poyatos, Lourdes (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia) ;
Pellegrini, Manuela (Istituto Superiore di Sanità (Roma, Itàlia). National Centre on Addiction and Doping) ;
Pichini, Simona (Istituto Superiore di Sanità (Roma, Itàlia). National Centre on Addiction and Doping) ;
Pacifici, Roberta (Istituto Superiore di Sanità (Roma, Itàlia). National Centre on Addiction and Doping) ;
Ventura, Mireia (Associació Benestar i Desenvolupament (Barcelona)) ;
Galindo, Liliana (Associació Benestar i Desenvolupament (Barcelona)) ;
Busardò, Francesco Paolo (Università Politecnica delle Marche (Ancona, Itàlia). Department of Excellence of Biomedical Science and Public Health) ;
Farre, Magi (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia)
UR-144 is a synthetic cannabinoid found in herbal incenses for recreational use as a substitute of cannabis. It is a cannabinoid receptor agonist with effects on the central nervous system similar to those of THC. [...]
2021 - 10.3390/biology10040257
Biology, Vol. 10 Núm. 4 (march 2021)
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8 p, 1.4 MB |
Efficacy of linezolid on Treponema pallidum, the syphilis agent : A preclinical study
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Haynes, Austin M. (University of Washington. Department of Medicine) ;
Giacani, Lorenzo (University of Washington. Department of Global Health) ;
Mayans, Marti Vall (Institut Germans Trias i Pujol. Fundació de Lluita Contra la Sida) ;
Ubals, Maria (Institut Germans Trias i Pujol. Fundació de Lluita Contra la Sida) ;
Nieto, Carles (Laboratorio Reig Jofre) ;
Pérez-Mañá, Clara (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia) ;
Quintó, Llorenç (Hospital Clínic i Provincial de Barcelona) ;
Romeis, Emily (University of Washington. Department of Medicine) ;
Mitjà, Oriol (Institut Germans Trias i Pujol. Fundació de Lluita Contra la Sida)
Penicillin G, the current standard treatment for syphilis, has important drawbacks, but virtually no preclinical or clinical studies have been performed to identify viable alternatives. We tested, both in vitro and in vivo, three marketed antibiotics with adequate pharmacological properties to treat syphilis. [...]
2021 - 10.1016/j.ebiom.2021.103281
EBioMedicine, Vol. 65 (march 2021)
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13 p, 1013.2 KB |
Acute Pharmacological Effects of Oral and Intranasal Mephedrone : an observational study in humans
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Papaseit, Esther (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia) ;
Olesti, Eulàlia (Universitat Pompeu Fabra. Grup de Recerca en Farmacologia i Neurociències) ;
Pérez-Mañá, Clara (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia) ;
Torrens, Marta (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
Fonseca, Francina (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
Grifell, Marc (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
Ventura, Mireia (Associació Benestar i Desenvolupament) ;
de la Torre, Rafael (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Farre, Magi (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia)
Mephedrone (4-methylmethcathinone) is a synthetic cathinone with psychostimulant properties which remains one of the most popular new psychoactive substances (NPS). It is frequently used orally and/or intranasally. [...]
2021 - 10.3390/ph14020100
Pharmaceuticals, Vol. 14 Núm. 2 (2021) , p. 100
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14 p, 1.5 MB |
Disposition of Phytocannabinoids, Their Acidic Precursors and Their Metabolites in Biological Matrices of Healthy Individuals Treated with Vaporized Medical Cannabis
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Busardò, Francesco Paolo (Department of Excellence-Biomedical Sciences and Public Health, Università Politecnica delle Marche, 60121 Ancona, Italy) ;
Pérez-Acevedo, Ana Pilar (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Pacifici, Roberta (National Centre on Addiction and Doping, Istituto Superiore di Sanità, 00161 Rome, Italy) ;
Mannocchi, Giulio (School of Law, University of Camerino, 62032 Camerino, Italy) ;
Gottardi, Massimo (Comedical S.Rl, 38123 Trento, Italy) ;
Papaseit, Esther (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Pérez-Mañá, Clara (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Martin, Soraya (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Poyatos, Lourdes (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Pichini, Simona (National Centre on Addiction and Doping, Istituto Superiore di Sanità, 00161 Rome, Italy) ;
Farre, Magi (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia)
Inhalation by vaporization is a useful application mode for medical cannabis. In this study, we present the disposition of Δ9-tetrahydrocannabinol (THC), cannabidiol (CBD), their acidic precursors, and their metabolites in serum, oral fluid, and urine together with the acute pharmacological effects in 14 healthy individuals treated with vaporized medical cannabis. [...]
2021 - 10.3390/ph14010059
Pharmaceuticals, Vol. 14 (january 2021)
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21 p, 893.8 KB |
Oral Administration of Cannabis and Δ-9-tetrahydrocannabinol (THC) Preparations : A Systematic Review
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Poyatos, Lourdes (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Pérez-Acevedo, Ana Pilar (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Papaseit, Esther (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Pérez Mañá, Clara (Institut Germans Trias i Pujol) ;
Martin, Soraya (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Hladun, Olga (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Siles, Adrià (Institut Germans Trias i Pujol) ;
Torrens, Marta (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
Busardo, Francesco Paolo (Università Politecnica delle Marche, Ancona) ;
Farre, Magi (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Background and objective : Changes in cannabis legalization regimes in several countries have influenced the diversification of cannabis use. There is an ever-increasing number of cannabis forms available, which are gaining popularity for both recreational and therapeutic use. [...]
2020 - 10.3390/medicina56060309
Medicina, Vol. 56 (june 2020)
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10 p, 328.8 KB |
Cannabinoids : from pot to lab
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Papaseit, Esther (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia) ;
Pérez-Mañá, Clara (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia) ;
Pérez-Acevedo, Ana Pilar (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Hladun, Olga (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Torres-Moreno, M. Carmen (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Muga, Roberto (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Torrens, Marta (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
Farre, Magi (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia)
Cannabis is becoming increasingly present in our society. In recent years, the line between the natural (cannabis) and the synthetic (synthetic cannabinoids), the recreational (cannabis) and the medical (pharmaceutical cannabinoids and medical cannabis) has been crossed. [...]
2018 - 10.7150/ijms.27087
International Journal of Medical Sciences, Vol. 15 (august 2018) , p. 1286-1295
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12 p, 704.2 KB |
Data on the endogenous conversion of tyrosol into hydroxytyrosol in humans
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Boronat, Anna (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Mateus, Julian (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Soldevila-Domenech, Natalia (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Guerra, Mercè (Universitat Pompeu Fabra. Departament de Ciències Experimentals i de la Salut) ;
Rodríguez-Morató, Jose (Universitat Pompeu Fabra. Departament de Ciències Experimentals i de la Salut) ;
Varon, Carlota (Hospital Universitari Vall d'Hebron) ;
Muñoz Aguayo, Daniel (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Barbosa, Francina (Institut Català de la Salut) ;
Morales, Juan Carlos (Universitat de València. Institut d'Història de la Medicina i de la Ciència «López Piñero») ;
Gaedigk, Andreas (Division of Clinical Pharmacology, Toxicology, and Therapeutic Innovation, Children's Mercy Kansas City, Kansas City, MO, USA) ;
Langohr, Klaus (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Covas Planells, Maria Isabel (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Pérez-Mañá, Clara (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Fitó, Montserrat (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Tyndale, Rachel F. (University of Toronto. Departments of Pharmacology & Toxicology, and Psychiatry) ;
de la Torre, Rafael (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Universitat Autònoma de Barcelona
Here we present new and original data on the endogenous conversion of tyrosol (Tyr) into hydroxytyrosol (OHTyr) in humans and its effects on the cardiovascular system. A randomized, crossover, controlled clinical trial was performed with individuals at cardiovascular risk (n = 33). [...]
2019 - 10.1016/j.dib.2019.104787
Data in brief, Vol. 27 (december 2019) , p. 104787
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13 p, 839.9 KB |
Acute Effects of 2C-E in Humans : An Observational Study
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Papaseit, Esther (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia) ;
Olesti, Eulàlia (Universitat Pompeu Fabra. Departament de Ciències Experimentals i de la Salut) ;
Pérez-Mañá, Clara (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia) ;
Torrens, Marta (Drug Addiction Program, Institut de Neuropsiquiatria i Adiccions (INAD)) ;
Grifell, Marc (Energy Control, Associació Benestar i Desenvolupament) ;
Ventura, Mireia (Energy Control, Associació Benestar i Desenvolupament) ;
Pozo, Oscar J. (Institut Hospital del Mar d'Investigacions Mèdiques) ;
de Sousa Fernandes Perna, Elizabeth B. (Maastricht University. Department of Neuropsychology and Psychopharmacology) ;
Ramaekers, Johannes G. (Maastricht University. Department of Neuropsychology and Psychopharmacology) ;
de la Torre, Rafael (Universitat Pompeu Fabra. Departament de Ciències Experimentals i de la Salut) ;
Farre, Magi (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia)
2,5-Dimethoxy-4-ethylphenethylamine (2C-E) is psychedelic phenylethylamine, with a chemical structure similar to mescaline, used as new psychoactive substance (NPS). It inhibits norepinephrine and serotonin uptake and, more relevant, acts as a partial agonist of the serotonin 2A (5-HT), 2B (5-HT), and (5-HT) receptors. [...]
2020 - 10.3389/fphar.2020.00233
Frontiers in Pharmacology, Vol. 11 (march 2020)
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17 p, 1.4 MB |
Mephedrone and Alcohol Interactions in Humans
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Papaseit, Esther (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia) ;
Pérez Mañá, Clara (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia) ;
de Sousa Fernandes Perna, Elizabeth B. (Department of Neuropsychology and Psychopharmacology, Faculty of Psychology and Neuroscience, Maastricht University) ;
Olesti, Eulalia (Universitat Pompeu Fabra. Departament de Ciències Experimentals i de la Salut) ;
Mateus, Julian (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Kuypers, Kim PC (Department of Neuropsychology and Psychopharmacology, Faculty of Psychology and Neuroscience, Maastricht University) ;
Theunissen, Eef L. (Department of Neuropsychology and Psychopharmacology, Faculty of Psychology and Neuroscience, Maastricht University) ;
Fonseca, Francina, 1972- (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Torrens, Marta (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Ramaekers, Jan G. (Department of Neuropsychology and Psychopharmacology, Faculty of Psychology and Neuroscience, Maastricht University) ;
de la Torre, Rafael (Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición) ;
Farre, Magi (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia)
Mephedrone (4-MMC, mephedrone) is a synthetic cathinone derivative included in the class of new psychoactive substances. It is commonly used simultaneously with alcohol (ethanol). The aim of the present study was to evaluate the interactions on subjective, cardiovascular and hormone effects and pharmacokinetics between mephedrone and alcohol in humans. [...]
2020 - 10.3389/fphar.2019.01588
Frontiers in Pharmacology, Vol. 10 (january 2020)
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