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16 p, 2.1 MB |
Treatment with Hydrogen-Rich Water Improves the Nociceptive and Anxio-Depressive-like Behaviors Associated with Chronic Inflammatory Pain in Mice
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Coral-Pérez, Santiago (Institut d'Investigació Biomèdica Sant Pau) ;
Martínez-Martel, Ignacio (Institut d'Investigació Biomèdica Sant Pau) ;
Martínez-Serrat, Maria (Institut d'Investigació Biomèdica Sant Pau) ;
Batallé Melgarejo, Gerard (Institut d'Investigació Biomèdica Sant Pau) ;
Bai, Xue (Institut d'Investigació Biomèdica Sant Pau) ;
Leite-Panissi, C.R.A. (Department of Psychology. Faculty of Philosophy Science and Letters of Ribeirão Preto. University of São Paulo) ;
Pol, Olga (Institut d'Investigació Biomèdica Sant Pau) ;
Universitat Autònoma de Barcelona
Chronic inflammatory pain is manifested in many diseases. The potential use of molecular hydrogen (H) as a new therapy for neurological disorders has been demonstrated. Recent studies prove its analgesic properties in animals with neuropathic pain, but the possible antinociceptive, antidepressant, and/or anxiolytic actions of H during persistent inflammatory pain have not been investigated. [...]
2022 -  10.3390/antiox11112153
Antioxidants, Vol. 11 Núm. 11 (november 2022) , p. 2153
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9 p, 628.7 KB |
Serum Levels of CXCL13 Are Associated With Teriflunomide Response in Patients With Multiple Sclerosis
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Fissolo, Nicolás (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Pappolla, Agustin (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Río, Jordi (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Villar, Luisa M. (Hospital Universitario Ramón y Cajal (Madrid)) ;
Pérez-Hoyos, Santiago (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Sánchez, Alex (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Gutierrez, Lucía (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Montalban, Xavier (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Comabella, Manuel (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Universitat Autònoma de Barcelona
BACKGROUND AND OBJECTIVES: To identify biomarkers associated with treatment response in patients with multiple sclerosis (MS) treated with the oral therapies teriflunomide, dimethyl fumarate (DMF), and fingolimod. [...]
2023 - 10.1212/NXI.0000000000200050
Neurology® neuroimmunology & neuroinflammation, Vol. 10 Núm. 1 (january 2023)
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11 p, 299.2 KB |
Efavirenz versus boosted atazanavir-containing regimens and immunologic, virologic, and clinical outcomes : A prospective study of HIV-positive individuals
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Cain, Lauren E. (Harvard T.H. Chan School of Public Health (Boston, Estats Units d'Amèrica)) ;
Caniglia, Ellen C. (Harvard T.H. Chan School of Public Health (Boston, Estats Units d'Amèrica)) ;
Phillips, Andrew (University College London) ;
Olson, Ashley ;
Muga, Roberto (Institut Germans Trias i Pujol) ;
Pérez Hoyos, Santiago ;
Abgrall, Sophie ;
Costagliola, Dominique ;
Rubio, Rafael ;
Jarrín, Inma ;
Bucher, Heiner ;
Fehr, Jan ;
van Sighem, Ard ;
Reiss, Peter ;
Dabis, François ;
Vandenhende, Marie-Anne ;
Logan, Roger ;
Robins, James ;
Sterne, Jonathan A C ;
Justice, Amy ;
Tate, Janet ;
Touloumi, Giota ;
Paparizos, Vasilis ;
Esteve, Anna ;
Casabona-Barbarà, Jordi ;
Seng, Rémonie ;
Meyer, Laurence ;
Jose, Sophie ;
Sabin, Caroline A ;
Hernán, Miguel A ;
HIV CAUSAL Collaboration ;
Universitat Autònoma de Barcelona.
Departament de Medicina
Objective: To compare regimens consisting of either ritonavir-boosted atazanavir or efavirenz and a nucleoside reverse transcriptase inhibitor (NRTI) backbone with respect to clinical, immunologic, and virologic outcomes. [...]
2016 - 10.1097/MD.0000000000005133
Medicine, Vol. 95 Núm. 41 (2016) , art. e5133
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4.
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21 p, 1.1 MB |
Transcranial optical monitoring for detecting intracranial pressure alterations in children with benign external hydrocephalus : a proof-of-concept study
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Maruccia, Federica (ICFO-Insitut de Ciències Fotòniques) ;
Tagliabue, Susanna (ICFO-Insitut de Ciències Fotòniques) ;
Fischer, Jonas B. (HemoPhotonics) ;
Kacprzak, Michał (Nalecz Institute of Biocybernetics and Biomedical Engineering) ;
Pérez-Hoyos, Santiago (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Rosas, Katiuska (Hospital Universitari Vall d'Hebron) ;
Álvarez, Ignacio Delgado (Hospital Universitari Vall d'Hebron) ;
Sahuquillo Barris, Juan (Universitat Autònoma de Barcelona) ;
Durduran, Turgut (Institució Catalana de Recerca i Estudis Avançats) ;
Poca Pastor, María Antonia (Universitat Autònoma de Barcelona)
Benign external hydrocephalus (BEH) is considered a self-limiting pathology with a good prognosis. However, some children present a pathological intracranial pressure (ICP) characterized by quantitative and qualitative alterations (the so-called B-waves) that can lead to neurological sequelae. [...]
2022 - 10.1117/1.NPh.9.4.045005
Neurophotonics, Vol. 9 (november 2022)
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19 p, 4.6 MB |
Hydrogen-rich water as a novel therapeutic strategy for the affective disorders linked with chronic neuropathic pain in mice
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Martínez-Serrat, Maria (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Martínez-Martel, Ignacio (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Coral-Pérez, Santiago (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Bai, Xue (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Batallé Melgarejo, Gerard (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Pol, Olga (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Institut d'Investigació Biomèdica Sant Pau
Neuropathic pain manifested with allodynia and hyperalgesia usually becomes a chronic condition accompanied with mood disorders. Clinical therapies for neuropathic pain are still unsatisfactory with notable side effects. [...]
2022 - 10.3390/antiox11091826
Antioxidants, Vol. 11, Issue 9 (September 2022) , art. 1826
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11 p, 1.1 MB |
Dynamics of Emergency Cardiovascular Hospital Admissions and In-Hospital Mortality During the COVID-19 Pandemic : Time Series Analysis and Impact of Socioeconomic Factors
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Álvarez-Martín, Claudia (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Ribera, A (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Marsal, Josep Ramon (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Ariza-Solé, Albert (Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares) ;
Pérez-Hoyos, Santiago (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Oristrell, Gerard (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Soriano-Colomé, Toni (Hospital Universitari Vall d'Hebron) ;
Romaguera, Rafael (Institut d'Investigació Biomèdica de Bellvitge) ;
Pijoan, Jose Ignacio (Instituto de Investigación Sanitaria Biocruces Bizkaia) ;
Lidón, Rosa M. (Hospital Universitari Vall d'Hebron) ;
Mauri, Josepa (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Ferreira-Gonzalez, Ignacio (Hospital Universitari Vall d'Hebron)
This study aimed to evaluate the decline in urgent cardiovascular hospital admissions and in-hospital mortality during the COVID pandemic in two successive waves, and to evaluate differences by sex, age, and deprivation index subgroups. [...]
2022 - 10.3389/fcvm.2022.935850
Frontiers in Cardiovascular Medicine, Vol. 9 (april 2022)
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7 p, 427.0 KB |
Unhealthy Alcohol Use, HIV Infection and Risk of Liver Fibrosis in Drug Users with Hepatitis C
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Muga, Roberto (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Sanvisens, Arantza (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Fuster, Daniel (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Tor Aguilera, Jordi (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Martínez, Elisenda (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Pérez-Hoyos, Santiago (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Muñoz, Alvaro (Johns Hopkins University. Bloomberg School of Public Health) ;
Universitat Autònoma de Barcelona
To analyze alcohol use, clinical data and laboratory parameters that may affect FIB-4, an index for measuring liver fibrosis, in HCV-monoinfected and HCV/HIV-coinfected drug users. Patients admitted for substance abuse treatment between 1994 and 2006 were studied. [...]
2012 - 10.1371/journal.pone.0046810
PloS one, Vol. 7 (october 2012)
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15 p, 1.8 MB |
L-ferritin : One gene, five diseases; from hereditary hyperferritinemia to hypoferritinemia-report of new cases
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Cadenas, Beatriz (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Fita-Torró, Josep (BloodGenetics SL. Esplugues de Llobregat) ;
Bermúdez-Cortés, Mar (Hospital Universitario Virgen de la Arrixaca (Múrcia)) ;
Hernandez-Rodriguez, Inés (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Fuster, José Luis (Hospital Universitario Virgen de la Arrixaca (Múrcia)) ;
Llinares, María Esther (Hospital Universitario Virgen de la Arrixaca (Múrcia)) ;
Galera, Ana (Hospital Universitario Virgen de la Arrixaca (Múrcia)) ;
Romero, Julia Lee (Biomedical Engineering Department. University of Texas at Austin) ;
Pérez-Montero, Santiago (BloodGenetics SL. Esplugues de Llobregat) ;
Tornador, Cristian (BloodGenetics SL. Esplugues de Llobregat) ;
Sánchez-Fernández, Mayka (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Universitat Autònoma de Barcelona
Ferritin is a multimeric protein composed of light (L-ferritin) and heavy (H-ferritin) subunits that binds and stores iron inside the cell. A variety of mutations have been reported in the L-ferritin subunit gene (FTL gene) that cause the following five diseases: (1) hereditary hyperferritinemia with cataract syndrome (HHCS), (2) neuroferritinopathy, a subtype of neurodegeneration with brain iron accumulation (NBIA), (3) benign hyperferritinemia, (4) L-ferritin deficiency with autosomal dominant inheritance, and (5) L-ferritin deficiency with autosomal recessive inheritance. [...]
2019 - 10.3390/ph12010017
Pharmaceuticals, Vol. 12 Núm. 1 (2019) , p. 17
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10.
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12 p, 2.1 MB |
The long-term outcomes of CIS patients in the Barcelona inception cohort : Looking back to recognize aggressive MS
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Tintoré, Mar (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Arrambide, Georgina (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Otero-Romero, Susana (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Carbonell-Mirabent, Pere (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Río, Jordi (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Tur, Carmen (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Comabella, Manuel (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Nos, Carlos (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Arévalo, María Jesús (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Anglada, Elisenda (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Menendez, Rebeca (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Midaglia, Luciana (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Galan, Ingrid (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Vidal-Jordana, Angela (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Castilló, Joaquín (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Mulero, P. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Zabalza, Ana (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Rodríguez-Acevedo, Breogán (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Rodriguez, Marta (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Espejo, Carmen (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Sequeira, Joao (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Mitjana, Raquel (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
de Barros, Andrea (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Pareto, Deborah (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Auger, Cristina (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Pérez-Hoyos, Santiago (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Sastre-Garriga, Jaume (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Rovira, Alex (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Montalban, Xavier (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Universitat Autònoma de Barcelona
To explore the long-term outcomes of patients with clinically isolated syndromes from the Barcelona cohort. We selected patients with a follow-up longer than 10 years to (1) estimate the risks of multiple sclerosis (MS) and disability accumulation according to the baseline number of T2 lesions and to compare treated versus untreated patients and early versus delayed treatment, and (2) to study baseline features of patients with aggressive MS (Expanded Disability Status Scale (EDSS) ⩾6. [...]
2019 - 10.1177/1352458519877810
Multiple sclerosis, Vol. 26 (october 2019) , p. 1658-1669
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