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16 p, 5.4 MB HER2 and p95HER2 differentially regulate miRNA expression in MCF-7 breast cancer cells and downregulate MYB proteins through miR-221/222 and miR-503 / Gorbatenko, A. (Section for Cell Biology and Physiology. Department of Biology. Faculty of Science. University of Copenhagen) ; Søkilde, R. (Department of Clinical Sciences Lund. Oncology and Pathology. Faculty of Medicine. Lund University) ; Sorensen, E. E. (Section for Cell Biology and Physiology. Department of Biology. Faculty of Science. University of Copenhagen) ; Newie, I. (Department of Clinical Sciences Lund. Oncology and Pathology. Faculty of Medicine. Lund University) ; Persson, H. (Department of Clinical Sciences Lund. Oncology and Pathology. Faculty of Medicine. Lund University) ; Morancho, Beatriz (Vall d'Hebron Institut d'Oncologia) ; Arribas, Joaquín V (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Litman, T. (Department of International Health. Immunology and Microbiology. University of Copenhagen) ; Rovira, Carlos (Department of Clinical Sciences Lund. Oncology and Pathology. Faculty of Medicine. Lund University) ; Pedersen, S. F. (Section for Cell Biology and Physiology. Department of Biology. Faculty of Science. University of Copenhagen)
The HER2 oncogene and its truncated form p95HER2 play central roles in breast cancer. Here, we show that although HER2 and p95HER2 generally elicit qualitatively similar changes in miRNA profile in MCF-7 breast cancer cells, a subset of changes are distinct and p95HER2 shifts the miRNA profile towards the basal breast cancer subtype. [...]
2019 - 10.1038/s41598-019-39733-x
Scientific reports, Vol. 9 Núm. 1 (january 2019) , p. 3352  
Detailed record - Creative Commons

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