Results overview: Found 9 records in 0.02 seconds.
Articles, 9 records found
Articles 9 records found  
1.
15 p, 1007.8 KB An original phylogenetic approach identified mitochondrial haplogroup T1a1 as inversely associated with breast cancer risk in BRCA2 mutation carriers / Blein, Sophie (Université Lyon 1) ; Bardel, Claire (Université Claude Bernard Lyon 1) ; Danjean, Vincent (INRIA Rhône-Alpes (França)) ; McGuffog, Lesley (University of Cambridge) ; Healey, Sue (QIMR Berghofer (Australia)) ; Barrowdale, Daniel (University of Cambridge) ; Lee, Andrew (University of Cambridge) ; Dennis, Joe (University of Cambridge) ; Kuchenbaecker, Karoline B (University of Cambridge) ; Soucy, Penny (Laval University (Canadà)) ; Terry, Mary Beth (Columbia University) ; Chung, Wendy K (Columbia University College of Physicians and Surgeons) ; Goldgar, David E (University of Utah School of Medicine) ; Buys, Saundra S (University of Utah School of Medicine) ; Janavicius, Ramunas (State Research Institute (Lituania)) ; Tihomirova, Laima (Latvian Biomedical Research and Study Centre) ; Tung, Nadine (Beth Israel Deaconess Medical Center (Estats Units d'Amèrica)) ; Dorfling, Cecilia M (University of Pretoria) ; van Rensburg, Elizabeth J (University of Pretoria (Estats Units d'Amèrica)) ; Neuhausen, Susan L (Beckman Research Institute (Estats Units d'Amèrica)) ; Ding, Yuan Chun (Beckman Research Institute (Estats Units d'Amèrica)) ; Gerdes, Anne-Marie (Copenhagen University Hospital) ; Ejlertsen, Bent (Copenhagen University Hospital) ; Nielsen, Finn C (Copenhagen University Hospital) ; Hansen, Thomas VO (Copenhagen University Hospital) ; Osorio, Ana (Centro de Investigación Biomédica en Red de Enfermedades Raras) ; Benitez, Javier (Centro de Investigación Biomédica en Red de Enfermedades Raras) ; Conejero, Raquel Andrés (Hospital Clínico Universitario "Lozano Blesa" de Zaragoza) ; Segota, Ena (Clinical Cancer Genetics Community Research Network(Estats Units d'Amèrica)) ; Weitzel, Jeffrey N (Division of Clinical Cancer Genetics(Estats Units d'Amèrica)) ; Thelander, Margo (Walnut Creek (Estats Units d'Amèrica)) ; Peterlongo, Paolo (Istituto FIRC di Oncologia Molecolare) ; Radice, Paolo (Istituto di Ricovero e Cura a Carattere Scientifico) ; Pensotti, Valeria (Cogentech Cancer Genetic Test Laboratory (Itàlia)) ; Dolcetti, Riccardo (Centro di Riferimento Oncologico (Itàlia)) ; Bonanni, Bernardo (Istituto Europeo di Oncologia (Itàlia)) ; Peissel, Bernard (Istituto di Ricovero e Cura a Carattere Scientifico (Itàlia)) ; Zaffaroni, Daniela (Istituto di Ricovero e Cura a Carattere Scientifico (Itàlia)) ; Scuvera, Giulietta (Istituto di Ricovero e Cura a Carattere Scientifico (Itàlia)) ; Manoukian, Siranoush (Istituto di Ricovero e Cura a Carattere Scientifico (Itàlia)) ; Varesco, Liliana (Istituto di Ricovero e Cura a Carattere Scientifico (Itàlia)) ; Capone, Gabriele L (University of Florence, Florence) ; Papi, Laura (University of Florence, Florence) ; Ottini, Laura (Sapienza University) ; Yannoukakos, Drakoulis (Aristotle University of Thessaloniki School of Medicine) ; Konstantopoulou, Irene (Aghia Paraskevi Attikis) ; Garber, Judy (Dana-Farber Cancer Institute) ; Hamann, Ute (Deutsches Krebsforschungszentrum) ; Donaldson, Alan (St Michael's Hospital) ; Brady, Angela (Kennedy-Galton Centre) ; Brewer, Carole (Royal Devon & Exeter Hospital (Exeter, Regne Unit)) ; Foo, Claire (Liverpool Women's NHS Foundation Trust) ; Evans, D Gareth (Central Manchester University Hospitals NHS Foundation Trust) ; Frost, Debra (University of Cambridge, Worts Causeway) ; Eccles, Diana (Faculty of Medicine, University of Southampton, Southampton University Hospitals NHS Trust, Mailpoint 801, South Academic Block, PAH/G/MP105, Tremona Road, Southampton, SO16 6YD UK) ; Douglas, Fiona (Institute of Human Genetics, Northern Genetic Service (Regne Unit)) ; Cook, Jackie (Sheffield Children's Hospital) ; Adlard, Julian (Yorkshire Regional Genetics Service) ; Barwell, Julian (Leicestershire Clinical Genetics Service) ; Walker, Lisa (Churchill Hospital) ; Izatt, Louise (St Thomas' NHS Foundation Trust) ; Side, Lucy E (Great Ormond Street Hospital for Children (Londres)) ; Kennedy, M John (St James's Hospital, James's Street) ; Tischkowitz, Marc (Addenbrookes Hospital (Cambridge, Regne Unit)) ; Rogers, Mark T (University Hospital of Wales) ; Porteous, Mary E (Western General Hospital) ; Morrison, Patrick J (Belfast City Hospital, Lisburn Road) ; Platte, Radka (University of Cambridge) ; Eeles, Ros (The Institute of Cancer Research and Royal Marsden NHS Foundation Trust) ; Davidson, Rosemarie (Yorkhill Hospitals) ; Hodgson, Shirley (St George's University of London) ; Cole, Trevor (Birmingham Women's Hospital Healthcare NHS Trust) ; Godwin, Andrew K (DUniversity of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160 USA) ; Isaacs, Claudine (Lombardi Comprehensive Cancer Center, MedStar Georgetown University Hospital, 3800 Reservoir Road NW, Washington, DC 20057 USA) ; Claes, Kathleen (Center for Medical Genetics, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium) ; De Leeneer, Kim (Center for Medical Genetics, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium) ; Meindl, Alfons (Division of Tumor Genetics, Department of Gynaecology and Obstetrics, University Hospital Klinikum Rechts der Isar, Technische Universität München, Ismaninger Strasse 22, 81675 Munich, Germany) ; Gehrig, Andrea (Center of Familial Breast and Ovarian Cancer, Department of Medical Genetics, Institut für Humangenetik, Biozentrum, Universität Würzburg, Am Hubland, 97074 Würzburg, Germany) ; Wappenschmidt, Barbara (Center for Molecular Medicine Cologne (CMMC), University of Cologne, Robert-Koch-Strasse 21, 50931 Cologne, Germany) ; Sutter, Christian (Department of Human Genetics, Institute of Human Genetics, University Hospital Heidelberg, Heidelberg, Germany) ; Engel, Christoph (Institute for Medical Informatics, Statistics and Epidemiology, Medical Faculty, University of Leipzig, Leipzig, Germany) ; Niederacher, Dieter (Department of Gynaecology and Obstetrics, University Hospital Düsseldorf, Heinrich-Heine University Düsseldorf, Moorenstrasse 5, 40225 Düsseldorf, Germany) ; Steinemann, Doris (Institute of Cell and Molecular Pathology, Centre for Pathology and Forensic and Genetic Medicine, Hannover Medical School, Carl-Neuberg-Strasse 1, 30625 Hannover, Germany) ; Plendl, Hansjoerg (Institute of Human Genetics, University Medical Center Schleswig-Holstein, Campus Kiel, Arnold-Heller-Strasse 3, D-24105 Kiel, Germany) ; Kast, Karin (Department of Gynecology and Obstetrics, University Hospital Carl Gustav Carus of Dresden, Technical University Dresden, Dresden, Germany) ; Rhiem, Kerstin (Center for Molecular Medicine Cologne (CMMC), University of Cologne, Robert-Koch-Strasse 21, 50931 Cologne, Germany) ; Ditsch, Nina (Division of Tumor Genetics, Department of Gynaecology and Obstetrics, University Hospital Klinikum Rechts der Isar, Technische Universität München, Ismaninger Strasse 22, 81675 Munich, Germany) ; Arnold, Norbert (Department of Gynecology and Obstetrics, University Medical Center Schleswig-Holstein, Campus Kiel, Arnold-Heller-Strasse 3, D-24105 Kiel, Germany) ; Varon-Mateeva, Raymonda (Institute of Medical Genetics and Human Genetics, Campus Virchow-Klinikum, Charité Berlin - Universtitätsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany) ; Schmutzler, Rita K (German Consortium of Hereditary Breast and Ovarian Cancer (GC-HBOC), Cologne, Germany) ; Preisler-Adams, Sabine (Institute of Human Genetics, University Hospital Münster, Vesaliusweg 12-14, 48149 Münster, Germany) ; Markov, Nadja Bogdanova (Institute of Human Genetics, University Hospital Münster, Vesaliusweg 12-14, 48149 Münster, Germany) ; Wang-Gohrke, Shan (University Hospital of Ulm (Alemanya)) ; de Pauw, Antoine (Department of Tumour Biology, Institut Curie, 26 rue d'Ulm 75248, Paris, cedex 05 France) ; Lefol, Cédrick (Department of Tumour Biology, Institut Curie, 26 rue d'Ulm 75248, Paris, cedex 05 France) ; Lasset, Christine (Unité de Prévention et d'Épidémiologie Génétique, Centre Léon Bérard, 28 rue Laenned, 69008 Lyon, France) ; Leroux, Dominique (Institut Albert Bonniot - Inserm U823, Université Joseph Fourier, Rond-point de la Chantourne, 38706 La Tronche, France) ; Rouleau, Etienne (Laboratoire d'Oncogénétique, Hôpital René Huguenin, Institut Curie, 35 rue Dailly, 92210 Saint-Cloud, France) ; Damiola, Francesca (Centre National de la Recherche Scientifique (França)) ; Dreyfus, Hélène (Institut Albert Bonniot - Inserm U823, Université Joseph Fourier, Rond-point de la Chantourne, 38706 La Tronche, France) ; Barjhoux, Laure (Centre National de la Recherche Scientifique (França)) ; Golmard, Lisa (Department of Tumour Biology, Institut Curie, 26 rue d'Ulm 75248, Paris, cedex 05 France) ; Uhrhammer, Nancy (Département d'Oncogénétique, Centre Jean Perrin, Université de Clermont-Ferrand, 58 rue Montalembert, BP 392, 63011 Clermont-Ferrand, France) ; Bonadona, Valérie (Unité de Prévention et d'Épidémiologie Génétique, Centre Léon Bérard, 28 rue Laenned, 69008 Lyon, France) ; Sornin, Valérie (Centre National de la Recherche Scientifique (França)) ; Bignon, Yves-Jean (Département d'Oncogénétique, Centre Jean Perrin, Université de Clermont-Ferrand, 58 rue Montalembert, BP 392, 63011 Clermont-Ferrand, France) ; Carter, Jonathan (Gynaecological Oncology, Sydney Cancer Centre, Royal Prince Alfred Hospital and University of Sydney, Missenden Road, Camperdown, NSW 2050 Australia) ; Van Le, Linda (Gynecologic Oncology Group, Department of OB-GYN, University of North Carolina at Chapel Hill, 103B Physicians' Office Building, CB# 7572, Chapel Hill, NC 27599-7572 USA) ; Piedmonte, Marion (Gynecologic Oncology Group Statistical and Data Center, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263-0001 USA) ; DiSilvestro, Paul A (Women & Infants Hospital, 1 Blackstone Place, Providence, RI 02905 USA) ; de la Hoya, Miguel (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos) ; Caldes, Trinidad (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos) ; Nevanlinna, Heli (Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Biomedicum Helsinki, PO Box 700, 00029 Helsinki, Finland) ; Aittomäki, Kristiina (Department of Clinical Genetics, Helsinki University Central Hospital, Biomedicum Helsinki 1, Haartmaninkatu 8, 00290 Helsinki, Finland) ; Jager, Agnes (Department of Medical Oncology, Family Cancer Clinic, Erasmus University Medical Center, PO Box 2040, 3000 CA Rotterdam, the Netherlands) ; van den Ouweland, Ans MW (Department of Clinical Genetics, Family Cancer Clinic, Erasmus University Medical Center, Rotterdam, the Netherlands) ; Kets, Carolien M (Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands) ; Aalfs, Cora M (Department of Clinical Genetics, Academic Medical Center, Amsterdam, the Netherlands) ; van Leeuwen, Flora E (Department of Epidemiology, Netherlands Cancer Institute, Amsterdam, the Netherlands) ; Hogervorst, Frans BL (Family Cancer Clinic, Netherlands Cancer Institute, Amsterdam, the Netherlands) ; Meijers-Heijboer, Hanne EJ (Department of Clinical Genetics, VU University Medical Center Amsterdam, De Boelelaan 1118, 1081 HV Amsterdam, the Netherlands) ; Oosterwijk, Jan C (Department of Genetics, University Medical Center, Groningen University, Groningen, the Netherlands) ; van Roozendaal, Kees EP (Department of Clinical Genetics, Maastricht University Medical Center, Maastricht, the Netherlands) ; Rookus, Matti A (Department of Epidemiology, Netherlands Cancer Institute, Amsterdam, the Netherlands) ; Devilee, Peter (Department of Pathology, Leiden University Medical Center, PO Box 9600, 2300 RC L1Q Leiden, the Netherlands) ; van der Luijt, Rob B (Department of Medical Genetics, University Medical Center Utrecht, Utrecht, the Netherlands) ; Olah, Edith (Department of Molecular Genetics, National Institute of Oncology, Ráth György u 7-9, PO Box 1525 Budapest PF 21, 1122 Budapest, Hungary) ; Diez, Orland (Vall d'Hebron Institut d'Oncologia) ; Teulé, Alex (Institut d'Investigació Biomèdica de Bellvitge) ; Lazaro, Conxi (Institut d'Investigació Biomèdica de Bellvitge) ; Blanco, Ignacio (Institut d'Investigació Biomèdica de Bellvitge) ; Del Valle, Jesús (Institut d'Investigació Biomèdica de Bellvitge) ; Jakubowska, Anna (Department of Genetics and Pathomorphology, Faculty of Medicine and Dentistry, Pomeranian Medical University, al Powstancow Wlkp 72, 70-111 Szczecin, Poland) ; Sukiennicki, Grzegorz (Department of Genetics and Pathomorphology, Faculty of Medicine and Dentistry, Pomeranian Medical University, al Powstancow Wlkp 72, 70-111 Szczecin, Poland) ; Gronwald, Jacek (Department of Genetics and Pathomorphology, Faculty of Medicine and Dentistry, Pomeranian Medical University, al Powstancow Wlkp 72, 70-111 Szczecin, Poland) ; Lubinski, Jan (Department of Genetics and Pathomorphology, Faculty of Medicine and Dentistry, Pomeranian Medical University, al Powstancow Wlkp 72, 70-111 Szczecin, Poland) ; Durda, Katarzyna (Department of Genetics and Pathomorphology, Faculty of Medicine and Dentistry, Pomeranian Medical University, al Powstancow Wlkp 72, 70-111 Szczecin, Poland) ; Jaworska-Bieniek, Katarzyna (Department of Genetics and Pathomorphology, Faculty of Medicine and Dentistry, Pomeranian Medical University, al Powstancow Wlkp 72, 70-111 Szczecin, Poland) ; Agnarsson, Bjarni A (Landspítali National University Hospital of Iceland and Faculty of Medicine, School of Health Sciences, University of Iceland School of Medicine, Sæmundargötu 2, 101 Reykjavik, Iceland) ; Maugard, Christine (Laboratoire de diagnostic génétique et Service d'Onco-hématologie, Les Hopitaux Universitaire de Strasbourg, Nouvel Hôpital Civil, 1 place de l'Hôpital, BP 426, 67091 Strasbourg, France) ; Amadori, Alberto (Immunology and Molecular Oncology Unit, Istituto Oncologico Veneto (IOV) - Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), via Gattamelata 64, 35128 Padua, Italy) ; Montagna, Marco (Immunology and Molecular Oncology Unit, Istituto Oncologico Veneto (IOV) - Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), via Gattamelata 64, 35128 Padua, Italy) ; Teixeira, Manuel R (Instituto de Ciências Biomédicas Abel Salazar (ICBAS), Instituto de Ciências Biomédicas Abel Salazar da Universidade do Porto, Rua de Jorge Viterbo Ferreira 228, 4050-313 Porto, Portugal) ; Spurdle, Amanda B (Department of Genetics and Computational Biology, QIMR Berghofer, Brisbane, Australia) ; Foulkes, William (Program in Cancer Genetics, Departments of Human Genetics and Oncology, McGill University, 546 Pine Avenue West, Montreal, QC J2W 1S6 Canada) ; Olswold, Curtis (Department of Health Sciences Research, Mayo Clinic, 200 First Street SW, Rochester, MN 55905 USA) ; Lindor, Noralane M (Department of Health Sciences Research, Mayo Clinic, 13400 East Shea Boulevard, Scottsdale, AZ 85259 USA) ; Pankratz, Vernon S (Department of Health Sciences Research, Mayo Clinic, 200 First Street SW, Rochester, MN 55905 USA) ; Szabo, Csilla I (National Human Genome Research Institute, National Institutes of Health, Building 31, Room 4B09, 31 Center Drive, MSC 2152, 9000 Rockville Pike, Bethesda, MD 20892-2152 USA) ; Lincoln, Anne (Clinical Genetics Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065 USA) ; Jacobs, Lauren (Clinical Genetics Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065 USA) ; Corines, Marina (Clinical Genetics Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065 USA) ; Robson, Mark (Clinical Genetics Research Laboratory, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065 USA) ; Vijai, Joseph (Clinical Genetics Research Laboratory, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065 USA) ; Berger, Andreas (Department of Obstetrics and Gynecology, Comprehensive Cancer Center Vienna, Medical University of Vienna, Universitätsklinik für Frauenheilkunde, AKH - Wien, Währinger Gürtel 18-20, 1090 Vienna, Austria) ; Fink-Retter, Anneliese (Department of Obstetrics and Gynecology, Comprehensive Cancer Center Vienna, Medical University of Vienna, Universitätsklinik für Frauenheilkunde, AKH - Wien, Währinger Gürtel 18-20, 1090 Vienna, Austria) ; Singer, Christian F (Department of Obstetrics and Gynecology, Comprehensive Cancer Center Vienna, Medical University of Vienna, Universitätsklinik für Frauenheilkunde, AKH - Wien, Währinger Gürtel 18-20, 1090 Vienna, Austria) ; Rappaport, Christine (Department of Obstetrics and Gynecology, Comprehensive Cancer Center Vienna, Medical University of Vienna, Universitätsklinik für Frauenheilkunde, AKH - Wien, Währinger Gürtel 18-20, 1090 Vienna, Austria) ; Kaulich, Daphne Geschwantler (Department of Obstetrics and Gynecology, Comprehensive Cancer Center Vienna, Medical University of Vienna, Universitätsklinik für Frauenheilkunde, AKH - Wien, Währinger Gürtel 18-20, 1090 Vienna, Austria) ; Pfeiler, Georg (Department of Obstetrics and Gynecology, Comprehensive Cancer Center Vienna, Medical University of Vienna, Universitätsklinik für Frauenheilkunde, AKH - Wien, Währinger Gürtel 18-20, 1090 Vienna, Austria) ; Tea, Muy-Kheng (Department of Obstetrics and Gynecology, Comprehensive Cancer Center Vienna, Medical University of Vienna, Universitätsklinik für Frauenheilkunde, AKH - Wien, Währinger Gürtel 18-20, 1090 Vienna, Austria) ; Greene, Mark H (Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD USA) ; Mai, Phuong L (Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD USA) ; Rennert, Gad (Ruth and Bruce Rappaport Faculty of Medicine, Technion - Israel Institute of Technology, 2 Horev Street, 34362 Haifa, Israel) ; Imyanitov, Evgeny N (NN Petrov Institute of Oncology, 68 Leningradskaya Street, Pesochny, 197758 St Petersburg Russia) ; Mulligan, Anna Marie (Keenan Research Centre, Li Ka Shing Knowledge Institute, St Michael's Hospital, 209 Victoria Street, Toronto, ON M5B 1T8 Canada) ; Glendon, Gord (Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital Joseph and Wolf Lebovic Health Complex, 600 University Avenue, Toronto, ON M5G 1X5 Canada) ; Andrulis, Irene L (Department of Molecular Genetics, University of Toronto, Medical Science Building, Room 4386, 1 King's College Circle, Toronto, ON M5S 1A8 Canada) ; Tchatchou, Sandrine (Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital Joseph and Wolf Lebovic Health Complex, 600 University Avenue, Toronto, ON M5G 1X5 Canada) ; Toland, Amanda Ewart (The Ohio State University Comprehensive Cancer Center - Arthur G James Cancer Hospital and Richard J Solove Research Institute (OSUCCC - James), 460 West 10th Avenue, Columbus, OH 43210 USA) ; Pedersen, Inge Sokilde (Aalborg University Hospital (Dinamarca)) ; Thomassen, Mads (Odense University Hospital (Dinamarca)) ; Kruse, Torben A (Odense University Hospital (Dinamarca)) ; Jensen, Uffe Birk (Aarhus University Hospital (Aarhus, Dinamarca)) ; Caligo, Maria A (Laboratorio di Genetica Oncologica, Divisione di Anatomia Patologica e di Diagnostica Molecolare ed Ultrastrutturale, Azienda Ospedaliero Universitaria Pisana - Ospedale S Chiara, via Roma 67, 56126 Pisa, Italy) ; Friedman, Eitan (Sheba Laboratory of Molecular Genetics, The Danek Gertner Institute of Human Genetics, Sheba Medical Center, Tel Hashomer, Ramat Gan, 52621 Tel Aviv, Israel) ; Zidan, Jamal (Institute of Oncology, Rivka Ziv Medical Center, Maimonides, 13100 Safed, Israel) ; Laitman, Yael (Sheba Laboratory of Molecular Genetics, The Danek Gertner Institute of Human Genetics, Sheba Medical Center, Tel Hashomer, Ramat Gan, 52621 Tel Aviv, Israel) ; Lindblom, Annika (Karolinska University Hospital) ; Melin, Beatrice (Oncology, Department of Radiation Sciences, Umeå University, SE-901 87 Umeå, Sweden) ; Arver, Brita (Department of Oncology-Pathology, Karolinska University Hospital, K7, Ärftlighetsmottagningen, Radiumhemmet, 171 76 Stockholm, Sweden) ; Loman, Niklas (Division of Oncology and Pathology, Department of Clinical Sciences, Lund University Hospital, Barngatan 2B, SE-221 85 Lund, Sweden) ; Rosenquist, Richard (Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, 751 85 Uppsala, Sweden) ; Olopade, Olufunmilayo I (Center for Clinical Cancer Genetics and Global Health, The University of Chicago, 5841 South Maryland Avenue, Chicago, IL 60637 USA) ; Nussbaum, Robert L (Department of Medicine and Genetics, University of California, San Francisco, CA USA) ; Ramus, Susan J (Department of Preventive Medicine, Keck School of Medicine, University of Southern California, 1441 Eastlake Avenue, Norris Comprehensive Cancer Center, NOR-4435, Los Angeles, CA 90089-9175 USA) ; Nathanson, Katherine L (Department of Medicine, Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, 3535 Market Street, Suite 750, Philadelphia, PA 19104-3309 USA) ; Domchek, Susan M (Department of Medicine, Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, 3535 Market Street, Suite 750, Philadelphia, PA 19104-3309 USA) ; Rebbeck, Timothy R (Department of Epidemiology and Biostatistics, Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, 3535 Market Street, Suite 750, Philadelphia, PA 19104-3309 USA) ; Arun, Banu K (Division of Cancer Medicine, Department of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center, Unit 1354, PO Box 301439, Houston, TX 77230-1439 USA) ; Mitchell, Gillian (Sir Peter MacCallum Department of Oncology, The University of Melbourne, Level 5, 161 Barry Street, Parkville, 3010 VIC Australia) ; Karlan, Beth Y (Women's Cancer Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, 8700 Beverly Boulevard, Los Angeles, CA 90048 USA) ; Lester, Jenny (Women's Cancer Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, 8700 Beverly Boulevard, Los Angeles, CA 90048 USA) ; Orsulic, Sandra (Women's Cancer Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, 8700 Beverly Boulevard, Los Angeles, CA 90048 USA) ; Stoppa-Lyonnet, Dominique (Faculté de Médecine, Université Paris Descartes, Sorbonne Paris Cité, 15 rue de l'école de médecine, 75006 Paris, France) ; Thomas, Gilles (Institut National du Cancer (INCa), La Fondation Synergie Lyon Cancer, Centre Léon Bérard, 28 rue Laënnec, 69008 Lyon, Cedex 08 France) ; Simard, Jacques (Centre de recherche du Centre hospitalier universitaire de Québec, Laval University, Charlesbourg, PQ Canada) ; Couch, Fergus J (Department of Laboratory Medicine and Pathology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905 USA) ; Offit, Kenneth (Clinical Genetics Research Laboratory, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065 USA) ; Easton, Douglas F (Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK) ; Chenevix-Trench, Georgia (Department of Genetics and Computational Biology, QIMR Berghofer, Brisbane, Australia) ; Antoniou, Antonis C (Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK) ; Mazoyer, Sylvie (Université Lyon 1, 69100 Villeurbanne, France) ; Phelan, Catherine M (Department of Cancer Epidemiology, Moffitt Cancer Center, 12902 Magnolia Drive, Tampa, FL 33612 USA) ; Sinilnikova, Olga M (Unité Mixte de Génétique Constitutionnelle des Cancers Fréquents, Hospices Civils de Lyon - Centre Léon Bérard, 69373 Lyon, Cedex 08 France) ; Cox, David G (Université Lyon 1, 69100 Villeurbanne, France) ; Universitat Autònoma de Barcelona
Individuals carrying pathogenic mutations in the BRCA1 and BRCA2 genes have a high lifetime risk of breast cancer. BRCA1 and BRCA2 are involved in DNA double-strand break repair, DNA alterations that can be caused by exposure to reactive oxygen species, a main source of which are mitochondria. [...]
2015 - 10.1186/s13058-015-0567-2
Breast cancer research, Vol. 17 (april 2015)  
2.
18 p, 1.0 MB Assessing Associations between the AURKA-HMMR-TPX2-TUBG1 Functional Module and Breast Cancer Risk in BRCA1/2 Mutation Carriers / Blanco, Ignacio (Institut d'Investigació Biomèdica de Bellvitge) ; Kuchenbaecker, Karoline (University of Cambridge) ; Cuadras, Daniel (Institut d'Investigació Biomèdica de Bellvitge) ; Wang, Xianshu (Mayo Clinic, Rochester, United States of America) ; Barrowdale, Daniel (University of Cambridge) ; de Garibay, Gorka Ruiz (Institut d'Investigació Biomèdica de Bellvitge) ; Librado, Pablo (Universitat de Barcelona) ; Sánchez-Gracia, Alejandro (Universitat de Barcelona) ; Rozas, Julio (Universitat de Barcelona) ; Bonifaci, Núria (Institut d'Investigació Biomèdica de Bellvitge) ; McGuffog, Lesley (University of Cambridge) ; Pankratz, Vernon S. (Mayo Clinic, Rochester, Minnesota) ; Islam, Abul (University of Dhaka) ; Mateo, Francesca (Institut d'Investigació Biomèdica de Bellvitge) ; Berenguer, Antoni (Institut d'Investigació Biomèdica de Bellvitge) ; Petit Montserrat, Anna (Institut d'Investigació Biomèdica de Bellvitge) ; Català, Isabel (Institut d'Investigació Biomèdica de Bellvitge) ; Brunet, Joan (Institut d'Investigació Biomèdica (Girona)) ; Feliubadaló, Lidia (Institut d'Investigació Biomèdica de Bellvitge) ; Tornero, Eva (Institut d'Investigació Biomèdica de Bellvitge) ; Benítez, Javier (Centro Nacional de Investigaciones Oncológicas) ; Osorio, Ana (Centro Nacional de Investigaciones Oncológicas) ; Ramon y Cajal, Teresa (Institut d'Investigació Biomèdica Sant Pau) ; Aittomäki, Kristiina (Helsinki University Central Hospital) ; Arun, Banu K. (University of Texas) ; Toland, Amanda E. (The Ohio State University, Columbus) ; Karlan, Beth Y. (Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Los Angeles) ; Walsh, Christine (Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Los Angeles) ; Lester, Jenny (Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Los Angeles) ; Greene, Mark H. (National Cancer Institute, Maryland, Rockville) ; Mai, Phuong L. (National Cancer Institute, Maryland, Rockville) ; Nussbaum, Robert L. (University of California San Francisco, San Francisco) ; Andrulis, Irene L. (Samuel Lunenfeld Research Institute, Mount Sinai Hospital, and Departments of Molecular Genetics and Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada) ; Domchek, Susan M. (The University of Pennsylvania School of Medicine, Philadelphia) ; Nathanson, Katherine L. (The University of Pennsylvania School of Medicine, Philadelphia) ; Rebbeck, Timothy R. (Abramson Cancer Center and Center for Clinical Epidemiology and Biostatistics, The University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America) ; Barkardottir, Rosa B. (Department of Pathology, Landspitali University Hospital and BMC, Faculty of Medicine, University of Iceland, Reykjavik, Iceland) ; Jakubowska, Anna (Pomeranian Medical University, Szczecin) ; Lubinski, Jan (Pomeranian Medical University, Szczecin) ; Durda, Katarzyna (Pomeranian Medical University, Szczecin) ; Jaworska-Bieniek, Katarzyna (Pomeranian Medical University, Szczecin) ; Claes, Kathleen (Ghent University, Ghent) ; Van Maerken, Tom (Ghent University, Ghent) ; Díez, Orland (Vall d'Hebron Institut d'Oncologia) ; Hansen, Thomas V. (Copenhagen University Hospital, Copenhagen) ; Jønson, Lars (Copenhagen University Hospital, Copenhagen) ; Gerdes, Anne-Marie (Copenhagen University Hospital, Copenhagen) ; Ejlertsen, Bent (Copenhagen University Hospital, Copenhagen) ; de la Hoya, Miguel (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos) ; Caldés, Trinidad (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos) ; Dunning, Alison M. (University of Cambridge) ; Oliver, Clare (University of Cambridge) ; Fineberg, Elena (University of Cambridge) ; Cook, Margaret (University of Cambridge) ; Peock, Susan (University of Cambridge) ; McCann, Emma (Glan Clwyd Hospital, Rhyl) ; Murray, Alex (Singleton Hospital, Swansea) ; Jacobs, Chris (Guy's and St. Thomas' National Health Service, London) ; Pichert, Gabriella (Guy's and St. Thomas' National Health Service, London) ; Lalloo, Fiona (Central Manchester University Hospitals National Health Service, Manchester) ; Chu, Carol (Yorkshire Regional Genetics Service, Leeds) ; Dorkins, Huw (Kennedy-Galton Centre, Harrow) ; Paterson, Joan (Addenbrookes Hospital (Cambridge, Regne Unit)) ; Ong, Kai-Ren (Birmingham Women's Hospital Healthcare National Health Service, Edgbaston, Birmingham) ; Teixeira, Manuel R. (Universidade do Porto) ; Hogervorst, Frans B. L. (Netherlands Cancer Institute, Amsterdam) ; van der Hout, Annemarie H. (University of Groningen) ; Seynaeve, Caroline (Erasmus University Medical Center, Rotterdam) ; van der Luijt, Rob B. (University Medical Center Utrecht, Utrecht) ; Ligtenberg, Marjolijn J. L. (Radboud university medical center, Nijmegen) ; Devilee, Peter (Leiden University Medical Center, Leiden) ; Wijnen, Juul T. (Leiden University Medical Center, Leiden) ; Rookus, Matti A. (Netherlands Cancer Institute, Amsterdam) ; Meijers-Heijboer, Hanne E. J. (Vrije Universiteit, Amsterdam) ; Blok, Marinus J. (Maastricht University Medical Center) ; van den Ouweland, Ans M. W. (Erasmus University Medical Center, Rotterdam) ; Aalfs, Cora M. (Department of Clinical Genetics, Amsterdam) ; Rodriguez, Gustavo C. (University of Chicago) ; Phillips, Kelly-Anne A. (Peter MacCallum Cancer Centre, East Melbourne) ; Piedmonte, Marion (Roswell Park Cancer Institute, Buffalo, New York) ; Nerenstone, Stacy R. (Hartford Hospital/Helen and Harry Gray Cancer Center) ; Bae-Jump, Victoria L. (University of North Carolina) ; O'Malley, David M. (Ohio State University, Hilliard) ; Ratner, Elena S. (Yale University School of Medicine) ; Schmutzler, Rita K. (Uniklinik Köln (Colònia, Alemanya)) ; Wappenschmidt, Barbara (Uniklinik Köln (Colònia, Alemanya)) ; Rhiem, Kerstin (University Hospital of Cologne, Cologne, Germany) ; Engel, Christoph (University of Leipzig) ; Meindl, Alfons (Technical University Munich) ; Ditsch, Nina (Ludwig-Maximilian University Munich) ; Arnold, Norbert (Kiel University Medical Center Schleswig-Holstein) ; Plendl, Hansjoerg J. (Kiel University Medical Center Schleswig-Holstein) ; Niederacher, Dieter (University Hospital Düsseldorf) ; Sutter, Christian (Heidelberg University Hospital (Alemanya)) ; Wang-Gohrke, Shan (University Hospital of Ulm (Alemanya)) ; Steinemann, Doris (Institute of Cell and Molecular Pathology, Hannover) ; Preisler-Adams, Sabine (University of Münster) ; Kast, Karin (Technical University Dresden) ; Varon-Mateeva, Raymonda (Institute of Human Genetics, Campus Virchov Klinikum, Charite Berlin) ; Gehrig, Andrea (Centre of Familial Breast and Ovarian Cancer, Institute of Human Genetics, University Würzburg, Würzburg, Germany) ; Bojesen, Anders (Vejle Hospital, Vejle) ; Pedersen, Inge Sokilde (Aalborg University Hospital (Dinamarca)) ; Sunde, Lone (Aarhus University Hospital (Aarhus, Dinamarca)) ; Jensen, Uffe Birk (Aarhus University Hospital (Aarhus, Dinamarca)) ; Thomassen, Mads (Odense University Hospital (Dinamarca)) ; Kruse, Torben A. (Odense University Hospital (Dinamarca)) ; Foretova, Lenka (Masaryk Memorial Cancer Institute, Brno) ; Peterlongo, Paolo (Fondazione Istituto di Oncologia MolecolarE, Milan) ; Bernard, Loris (Istituto Europeo di Oncologia, Milan) ; Peissel, Bernard (Fondazione Istituto Nazionale Tumori, Milan) ; Scuvera, Giulietta (Fondazione Istituto Nazionale Tumori, Milan) ; Manoukian, Siranoush (Fondazione Istituto Nazionale Tumori, Milan) ; Radice, Paolo (Fondazione Istituto Nazionale Tumori, Milan) ; Ottini, Laura ("Sapienza" University, Rome) ; Montagna, Marco (Istituto Oncologico Veneto, Padua) ; Agata, Simona (Istituto Oncologico Veneto, Padua) ; Maugard, Christine (Hopitaux Universitaire de Strasbourg) ; Simard, Jacques (Centre Hospitalier Universitaire de Québec Research Center and Laval University, Quebec City) ; Soucy, Penny (Centre Hospitalier Universitaire de Québec Research Center and Laval University, Quebec City) ; Berger, Andreas (Medical University of Vienna) ; Fink-Retter, Anneliese (Medical University of Vienna) ; Singer, Christian F. (Medical University of Vienna) ; Rappaport, Christine (Medical University of Vienna) ; Geschwantler-Kaulich, Daphne (Medical University of Vienna) ; Tea, Muy-Kheng (Medical University of Vienna) ; Pfeiler, Georg (Medical University of Vienna) ; John, Esther M. (Cancer Prevention Institute of California) ; Miron, Alex (Dana-Farber Cancer Institute, Boston, Massachusetts) ; Neuhausen, Susan L. (Beckman Research Institute of City of Hope, Duarte) ; Terry, Mary Beth (Columbia University) ; Chung, Wendy K. (Columbia University) ; Daly, Mary B. (Fox Chase Cancer Center, Philadelphia, Pennsylvania) ; Goldgar, David E. (University of Utah School of Medicine, Salt Lake City) ; Janavicius, Ramunas (Vilnius University Hospital Santariskiu Clinics) ; Dorfling, Cecilia M. (University of Pretoria, Arcadia) ; van Rensburg, Elisabeth J. (University of Pretoria, Arcadia) ; Fostira, Florentia (National Centre for Scientific Research Demokritos, Athens) ; Konstantopoulou, Irene (National Centre for Scientific Research Demokritos, Athens) ; Garber, Judy (Harvard Medical School, Boston) ; Godwin, Andrew K. (University of Kansas Medical Center, Kansas City) ; Olah, Edith (National Institute of Oncology, Budapest) ; Narod, Steven A. (University of Toronto) ; Rennert, Gad (Clalit National Israeli Cancer Control Center) ; Paluch, Shani Shimon (Chaim Sheba Medical Center, Ramat Gan) ; Laitman, Yael (Institute of Human Genetics, Ramat Gan) ; Friedman, Eitan (Tel Aviv University, Ramat Aviv) ; Liljegren, Annelie (Karolinska University Hospital, Stockholm) ; Rantala, Johanna (Karolinska University Hospital, Sweeden) ; Stenmark-Askmalm, Marie (Linköping University, Sweeden) ; Loman, Niklas (Lund University Hospital, Sweeden) ; Imyanitov, Evgeny N. (N.N. Petrov Institute of Oncology, St.-Petersburg) ; Hamann, Ute (German Cancer Research Center (DKFZ), Heidelberg) ; Spurdle, Amanda B. (Queensland Institute of Medical Research (QIMR) Berghofer Medical Research Institute, Brisbane) ; Healey, Sue (Queensland Institute of Medical Research (QIMR) Berghofer Medical Research Institute, Brisbane) ; Weitzel, Jeffrey N. (Clinical Cancer Genetics, City of Hope, Duarte, California) ; Herzog, Josef (Clinical Cancer Genetics, City of Hope, Duarte, California) ; Margileth, David (St. Joseph Hospital of Orange, Duarte, California) ; Gorrini, Chiara (University Health Network, Toronto) ; Esteller, Manel (Institució Catalana de Recerca i Estudis Avançats) ; Gómez Moruno, Antonio (Institut d'Investigació Biomèdica de Bellvitge) ; Sayols, Sergi (Institut d'Investigació Biomèdica de Bellvitge) ; Vidal, Enrique (Institut d'Investigació Biomèdica de Bellvitge) ; Heyn, Holger (Institut d'Investigació Biomèdica de Bellvitge) ; Stoppa-Lyonnet, Dominique (Université Paris Descartes, Sorbonne Paris Cité, Paris, France) ; Léoné, Melanie (Hospices Civils de Lyon-Centre Léon Bérard, Lyon) ; Barjhoux, Laure (Université Lyon 1) ; Fassy-Colcombet, Marion (Institut Curie, Paris) ; de Pauw, Antoine (Institut Curie, Paris) ; Lasset, Christine (Université Lyon 1) ; Ferrer, Sandra Fert (Hôtel Dieu Centre Hospitalier, Chambéry) ; Castera, Laurent (Department of Tumour Biology, Institut Curie, Paris) ; Berthet, Pascaline (Centre François Baclesse, Caen, France) ; Cornelis, François (Genetic Unit, Avicenne Hospital, Clermont-Ferrand) ; Bignon, Yves-Jean (Université de Clermont-Ferrand) ; Damiola, Francesca (Centre de Recherche en Cancérologie de Lyon) ; Mazoyer, Sylvie (Centre de Recherche en Cancérologie de Lyon) ; Sinilnikova, Olga M. (Centre de Recherche en Cancérologie de Lyon) ; Maxwell, Christopher A. (University of British Columbia, Vancouver) ; Vijai, Joseph (Memorial Sloan-Kettering Cancer Center, New York) ; Robson, Mark (Memorial Sloan-Kettering Cancer Center, New York) ; Kauff, Noah (Memorial Sloan-Kettering Cancer Center, New York) ; Corines, Marina J. (Memorial Sloan-Kettering Cancer Center, New York) ; Villano, Danylko (Memorial Sloan-Kettering Cancer Center, New York) ; Cunningham, Julie (Mayo Clinic, Rochester, Minnesota, United States of America) ; Lee, Adam (Mayo Clinic, Rochester, Minnesota) ; Lindor, Noralane (Mayo Clinic, Scottsdale, Arizona) ; Lázaro, Conxi (Institut d'Investigació Biomèdica de Bellvitge) ; Easton, Douglas F. (University of Cambridge) ; Offit, Kenneth (Memorial Sloan-Kettering Cancer Center, New York) ; Chenevix-Trench, Georgia (Queensland Institute of Medical Research, Brisbane, Australia) ; Couch, Fergus J. (Mayo Clinic, Rochester, Minnesota) ; Antoniou, Antonis C. (University of Cambridge) ; Pujana, Miguel Angel (Institut d'Investigació Biomèdica de Bellvitge)
While interplay between BRCA1 and AURKA-RHAMM-TPX2-TUBG1 regulates mammary epithelial polarization, common genetic variation in HMMR (gene product RHAMM) may be associated with risk of breast cancer in BRCA1 mutation carriers. [...]
2015 - 10.1371/journal.pone.0120020
PloS one, Vol. 10 (april 2015)  
3.
22 p, 1.6 MB Functional mechanisms underlying pleiotropic risk alleles at the 19p13.1 breast-ovarian cancer susceptibility locus / Lawrenson, Kate (Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center) ; Kar, Siddhartha (Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge) ; McCue, Karen (QIMR Berghofer Medical Research Institute (Brisbane, Austràlia)) ; Kuchenbaeker, Karoline (Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge) ; Michailidou, Kyriaki (Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge) ; Tyrer, Jonathan (Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge) ; Beesley, Jonathan (QIMR Berghofer Medical Research Institute (Brisbane, Austràlia)) ; Ramus, Susan J. (Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center) ; Li, Qiyuan (Department of Medical Oncology, The Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute) ; Delgado, Melissa K. (Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center) ; Lee, Janet M. (Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center) ; Aittomäki, Kristiina (Helsinki University Hospital) ; Andrulis, Irene L. (Department of Molecular Genetics, University of Toronto) ; Anton-Culver, Hoda (Department of Epidemiology, Genetic Epidemiology Research Institute, School of Medicine, University of California Irvine) ; Arndt, Volker (Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ)) ; Arun, Banu K. (University of Texas MD Anderson Cancer Center) ; Arver, Brita (Department of Oncology, Karolinska University Hospital) ; Bandera, Elisa V. (Cancer Prevention and Control, Rutgers Cancer Institute of New Jersey) ; Barile, Monica (Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia) ; Barkardottir, Rosa B. (Department of Pathology, Landspitali University Hospital and BMC (Biomedical Centre), Faculty of Medicine, University of Iceland) ; Barrowdale, Daniel (Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge) ; Beckmann, Matthias W. (University Hospital Erlangen, Department of Gynecology and Obstetrics, Friedrich-Alexander-University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN) ; Benitez, Javier (Centro de Investigación Biomédica en Red de Enfermedades Raras) ; Berchuck, Andrew (Department of Obstetrics and Gynecology, Duke University Medical Center) ; Bisogna, Maria (Gynecology Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center) ; Bjorge, Line (Centre for Cancer Biomarkers, Department of Clinical Science, University of Bergen) ; Blomqvist, Carl (Department of Oncology, Helsinki University Hospital, University of Helsinki) ; Blot, William (International Epidemiology Institute) ; Bogdanova, Natalia (Gynaecology Research Unit, Hannover Medical School) ; Bojesen, Anders (Department of Clinical Genetics, Vejle Hospital) ; Bojesen, Stig E. (Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital) ; Bolla, Manjeet K. (Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge) ; Bonanni, Bernardo (Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia) ; Børresen-Dale, Anne-Lise (K.G. Jebsen Center for Breast Cancer Research, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo) ; Brauch, Hiltrud (German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ)) ; Brennan, Paul (International Agency for Research on Cancer) ; Brenner, Hermann (Division of Preventive Oncology, German Cancer Research Center (DKFZ)) ; Bruinsma, Fiona (Cancer Epidemiology Centre, Cancer Council Victoria) ; Brunet, Joan (Institut d'Investigació Biomèdica (Girona)) ; Buhari, Shaik Ahmad (Department of Surgery, National University Health System) ; Burwinkel, Barbara (Department of Obstetrics and Gynecology, University of Heidelberg) ; Butzow, Ralf (Department of Pathology, Helsinki University Central Hospital) ; Buys, Saundra S. (Department of Medicine, Huntsman Cancer Institute, University of Utah School of Medicine) ; Cai, Qiuyin (Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine) ; Caldes, Trinidad (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos) ; Campbell, Ian (Cancer Genetics Laboratory, Peter MacCallum Cancer Centre) ; Canniotto, Rikki (Cancer Pathology & Prevention, Division of Cancer Prevention and Population Sciences, Roswell Park Cancer Institute) ; Chang-Claude, Jenny (University Cancer Center Hamburg (UCCH), University Medical Center Hamburg-Eppendorf) ; Chiquette, Jocelyne (Unité de recherche en santé des populations, Centre des maladies du sein Deschênes-Fabia, Centre de recherche FRSQ du Centre hospitalier affilié universitaire de Québec) ; Choi, Ji-Yeob (Department of Biomedical Sciences, Seoul National University College of Medicine) ; Claes, Kathleen B. M. (Center for Medical Genetics, Ghent University) ; Cook, Linda S. (Division of Epidemiology and Biostatistics, Department of Internal Medicine, University of New Mexico) ; Cox, Angela (Sheffield Cancer Research, Department of Oncology, University of Sheffield) ; Cramer, Daniel W. (Brigham and Women's Hospital (Boston, Estats Units d'Amèrica)) ; Cross, Simon S. (Academic Unit of Pathology, Department of Neuroscience, University of Sheffield) ; Cybulski, Cezary (Department of Genetics and Pathology, Pomeranian Medical University) ; Czene, Kamila (Karolinska Institutet (Estocolm, Suècia). Department of Medical Epidemiology and Biostatistics) ; Daly, Mary B. (Department of Clinical Genetics, Fox Chase Cancer Center) ; Damiola, Francesca (INSERM U1052, CNRS UMR5286, Université Lyon, Centre de Recherche en Cancérologie de Lyon) ; Dansonka-Mieszkowska, Agnieszka (Department of Pathology and Laboratory Diagnostics the Maria Sklodowska Curie Memorial Cancer Center and Institute of Oncology) ; Darabi, Hatef (Karolinska Institutet (Estocolm, Suècia). Department of Medical Epidemiology and Biostatistics) ; Dennis, Joe (Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge) ; Devilee, Peter (Department of Human Genetics, Leiden University Medical Center) ; Diez, Orland (Vall d'Hebron Institut d'Oncologia) ; Doherty, Jennifer A. (Department of Community and Family Medicine, Section of Biostatistics & Epidemiology, The Geisel School of Medicine at Dartmouth) ; Domchek, Susan M. (Department of Medicine, Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania) ; Dorfling, Cecilia M. (Department of Genetics, University of Pretoria) ; Dörk, Thilo (Gynaecology Research Unit, Hannover Medical School) ; Dumont, Martine (Genomics Center, Centre Hospitalier Universitaire de Québec Research Center, Laval University) ; Ehrencrona, Hans (Department of Clinical Genetics, Lund University Hospital) ; Ejlertsen, Bent (Department of Oncology, Rigshospitalet, Copenhagen University Hospital) ; Ellis, Steve (Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge) ; Engel, Christoph (Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig) ; Lee, Eunjung (Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center) ; Evans, D. Gareth (Genomic Medicine, Manchester Academic Health Sciences Centre, Institute of Human Development, Manchester University, Central Manchester University Hospitals NHS Foundation Trust) ; Fasching, Peter A. (University of California at Los Angeles, David Geffen School of Medicine, Department of Medicine, Division of Hematology and Oncology) ; Feliubadalo, Lidia (Institut d'Investigació Biomèdica de Bellvitge) ; Figueroa, Jonine (Division of Cancer Epidemiology and Genetics, National Cancer Institute) ; Flesch-Janys, Dieter (Department of Cancer Epidemiology, Clinical Cancer Registry, University Medical Center Hamburg-Eppendorf) ; Fletcher, Olivia (Division of Breast Cancer Research, The Institute of Cancer Research) ; Flyger, Henrik (Department of Breast Surgery, Herlev Hospital, Copenhagen University Hospital) ; Foretova, Lenka (Masaryk Memorial Cancer Institute and Medical Faculty MU) ; Fostira, Florentia (Molecular Diagnostics Laboratory, (INRASTES) Institute of Nuclear and Radiological Sciences and Technology, National Centre for Scientific Research 'Demokritos', Aghia Paraskevi Attikis) ; Foulkes, William D. (Program in Cancer Genetics, Departments of Human Genetics and Oncology, McGill University, Montreal) ; Fridley, Brooke L. (Biostatistics and Informatics Shared Resource, University of Kansas Medical Center) ; Friedman, Eitan (Susanne Levy Gertner Oncogenetics Unit, Sheba Medical Center) ; Frost, Debra (Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge) ; Gambino, Gaetana (University Hospital of Pisa (Pisa, Itàlia)) ; Ganz, Patricia A. (UCLA Schools of Medicine and Public Health, Division of Cancer Prevention & Control Research, Jonsson Comprehensive Cancer Center) ; Garber, Judy (Cancer Risk and Prevention Clinic, Dana-Farber Cancer Institute) ; García-Closas, Montserrat (Division of Genetics and Epidemiology, The Institute of Cancer Research) ; Gentry-Maharaj, Aleksandra (Women's Cancer, UCL EGA Institute for Women's Health) ; Ghoussaini, Maya (Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge) ; Giles, Graham G. (Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne) ; Glasspool, Rosalind (Cancer Research UK Clinical Trials Unit, The Beatson West of Scotland Cancer Centre) ; Godwin, Andrew K. (Department of Pathology and Laboratory Medicine, University of Kansas Medical Center) ; Goldberg, Mark S. (Department of Medicine, McGill University) ; Goldgar, David E. (Department of Dermatology, Huntsman Cancer Institute, University of Utah School of Medicine) ; González-Neira, Anna (Human Cancer Genetics Program, Spanish National Cancer Research Centre) ; Goode, Ellen L. (Department of Health Sciences Research, Mayo Clinic) ; Goodman, Marc T. (Community and Population Health Research Institute, Department of Biomedical Sciences, Cedars-Sinai Medical Center) ; Greene, Mark H. (Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health) ; Gronwald, Jacek (Department of Genetics and Pathology, Pomeranian Medical University) ; Guénel, Pascal (University Paris-Sud) ; Haiman, Christopher A. (Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center) ; Hall, Per (Karolinska Institutet (Estocolm, Suècia). Department of Medical Epidemiology and Biostatistics) ; Hallberg, Emily (Department of Health Sciences Research, Mayo Clinic) ; Hamann, Ute (Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ)) ; Hansen, Thomas V. O. (Center for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital) ; Harrington, Patricia A. (Department of Oncology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory) ; Hartman, Mikael (Saw Swee Hock School of Public Health, National University of Singapore) ; Hassan, Norhashimah (Cancer Research Initiatives Foundation, Subang Jaya) ; Healey, Sue (QIMR Berghofer Medical Research Institute (Brisbane, Austràlia)) ; Heitz, Florian (Department of Gynecology and Gynecologic Oncology, Dr Horst Schmidt Kliniken Wiesbaden) ; Herzog, Josef (Clinical Cancer Genetics, for the City of Hope Clinical Cancer Genetics Community Research Network) ; Høgdall, Estrid (Department of Virus, Lifestyle and Genes, Danish Cancer Society Research Center) ; Høgdall, Claus K. (Department of Gynecology, Rigshospitalet, University of Copenhagen) ; Hogervorst, Frans B. L. (Family Cancer Clinic, Netherlands Cancer Institute) ; Hollestelle, Antoinette (Department of Medical Oncology, Family Cancer Clinic, Erasmus MC Cancer Institute) ; Hopper, John L. (Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne) ; Hulick, Peter J. (Center for Medical Genetics, NorthShore University Health System) ; Huzarski, Tomasz (Department of Genetics and Pathology, Pomeranian Medical University) ; Imyanitov, Evgeny N. (N.N. Petrov Institute of Oncology) ; Isaacs, Claudine (Lombardi Comprehensive Cancer Center, Georgetown University) ; Ito, Hidemi (Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute) ; Jakubowska, Anna (Department of Genetics and Pathology, Pomeranian Medical University) ; Janavicius, Ramunas (State Research Institute Centre for Innovative Medicine) ; Jensen, Allan (Department of Gynecology, Rigshospitalet, University of Copenhagen) ; John, Esther M. (Department of Epidemiology, Cancer Prevention Institute of California) ; Johnson, Nichola (Division of Breast Cancer Research, The Institute of Cancer Research) ; Kabisch, Maria (Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ)) ; Kang, Daehee (Department of Preventive Medicine, Seoul National University College of Medicine) ; Kapuscinski, Miroslav (Centre for Epidemiology and Biostatistics, University of Melbourne) ; Karlan, Beth Y. (Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center) ; Khan, Sofia (Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital) ; Kiemeney, Lambertus A. (Radboud University Medical Centre, Radboud Institute for Health Sciences) ; Kjaer, Susanne Kruger (Department of Gynecology, Rigshospitalet, University of Copenhagen) ; Knight, Julia A. (Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto) ; Konstantopoulou, Irene (Molecular Diagnostics Laboratory, (INRASTES) Institute of Nuclear and Radiological Sciences and Technology, National Centre for Scientific Research 'Demokritos', Aghia Paraskevi Attikis) ; Kosma, Veli-Matti (Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland) ; Kristensen, Vessela (Oslo University Hospital (Oslo, Noruega)) ; Kupryjanczyk, Jolanta (Department of Pathology and Laboratory Diagnostics the Maria Sklodowska Curie Memorial Cancer Center and Institute of Oncology) ; Kwong, Ava (Department of Surgery, The University of Hong Kong) ; de la Hoya, Miguel (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos) ; Laitman, Yael (Susanne Levy Gertner Oncogenetics Unit, Sheba Medical Center) ; Lambrechts, Diether (Laboratory for Translational Genetics, Department of Oncology, University of Leuven) ; Le, Nhu (Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center) ; De Leeneer, Kim (Center for Medical Genetics, Ghent University) ; Lester, Jenny (Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center) ; Levine, Douglas A. (Gynecology Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center) ; Li, Jingmei (Karolinska Institutet (Estocolm, Suècia). Department of Medical Epidemiology and Biostatistics) ; Lindblom, Annika (Department of Molecular Medicine and Surgery, Karolinska Institutet) ; Long, Jirong (Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine) ; Lophatananon, Artitaya (Division of Health Sciences, Warwick Medical School, Warwick University) ; Loud, Jennifer T. (Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health) ; Lu, Karen (Department of Gynecologic Oncology, The University of Texas MD Anderson Cancer Center) ; Lubinski, Jan (Department of Genetics and Pathology, Pomeranian Medical University) ; Mannermaa, Arto (Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland) ; Manoukian, Siranoush (Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS (Istituto Di Ricovero e Cura a Carattere Scientifico) Istituto Nazionale Tumori (INT)) ; Le Marchand, Loic (University of Hawaii Cancer Center) ; Margolin, Sara (Department of Oncology - Pathology, Karolinska Institutet) ; Marme, Frederik (National Center for Tumour Diseases, University of Heidelberg) ; Massuger, Leon F. A. G. (Department of Gynaecology, Radboud University Medical Centre) ; Matsuo, Keitaro (Department of Preventive Medicine, Kyushu University Faculty of Medical Sciences) ; Mazoyer, Sylvie (INSERM U1052, CNRS UMR5286, Université Lyon, Centre de Recherche en Cancérologie de Lyon) ; McGuffog, Lesley (Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge) ; McLean, Catriona (Anatomical Pathology, The Alfred Hospital) ; McNeish, Iain (Institute of Cancer Sciences, University of Glasgow, Wolfson Wohl Cancer Research Centre, Beatson Institute for Cancer Research) ; Meindl, Alfons (Division of Gynaecology and Obstetrics, Technische Universität München) ; Menon, Usha (Women's Cancer, UCL EGA Institute for Women's Health) ; Mensenkamp, Arjen R. (Department of Human Genetics, Radboud University Medical Centre) ; Milne, Roger L. (Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne) ; Montagna, Marco (Immunology and Molecular Oncology Unit, Instituto Oncologico Veneto IOV, IRCCS) ; Moysich, Kirsten B. (Department of Cancer Prevention and Control, Roswell Park Cancer Institute) ; Muir, Kenneth (Institute of Population Health, University of Manchester) ; Mulligan, Anna Marie (Department of Laboratory Medicine and Pathobiology, University of Toronto) ; Nathanson, Katherine L. (Department of Medicine, Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania) ; Ness, Roberta B. (The University of Texas School of Public Health) ; Neuhausen, Susan L. (Department of Population Sciences, Beckman Research Institute of City of Hope) ; Nevanlinna, Heli (Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital) ; Nord, Silje (K.G. Jebsen Center for Breast Cancer Research, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo) ; Nussbaum, Robert L. (Department of Medicine and Genetics, University of California) ; Odunsi, Kunle (Department of Gynecological Oncology, Roswell Park Cancer Institute) ; Offit, Kenneth (Department of Medicine, Memorial Sloan-Kettering Cancer Center) ; Olah, Edith (Department of Molecular Genetics, National Institute of Oncology) ; Olopade, Olufunmilayo I. (Center for Clinical Cancer Genetics and Global Health, University of Chicago Medical Center) ; Olson, Janet E. (Department of Health Sciences Research, Mayo Clinic) ; Olswold, Curtis (Department of Health Sciences Research, Mayo Clinic) ; O'Malley, David (The Ohio State University and the James Cancer Center) ; Orlow, Irene (Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center) ; Orr, Nick (Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research) ; Osorio, Ana (Centro de Investigación Biomédica en Red de Enfermedades Raras) ; Park, Sue Kyung (Department of Surgery, Seoul National University College of Medicine) ; Pearce, Celeste L. (Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center) ; Pejovic, Tanja (Knight Cancer Institute, Oregon Health and Science University) ; Peterlongo, Paolo (IFOM, The FIRC (Italian Foundation for Cancer Research) Institute of Molecular Oncology) ; Pfeiler, Georg (Department of Obstetrics and Gynecology, Comprehensive Cancer Center, Medical University of Vienna) ; Phelan, Catherine M. (Department of Cancer Epidemiology, Moffitt Cancer Center) ; Poole, Elizabeth M. (Department of Epidemiology, Harvard TH Chan School of Public Health) ; Pylkäs, Katri (Laboratory of Cancer Genetics and Tumour Biology, Department of Clinical Chemistry and Biocenter Oulu, University of Oulu) ; Radice, Paolo (Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine, Fondazione IRCCS (Istituto Di Ricovero e Cura a Carattere Scientifico) Istituto Nazionale dei Tumori (INT)) ; Rantala, Johanna (Karolinska University Hospital) ; Rashid, Muhammad Usman (Department of Basic Sciences, Shaukat Khanum Memorial Cancer Hospital and Research Centre (SKMCH & RC)) ; Rennert, Gad (Clalit National Israeli Cancer Control Center and Department of Community Medicine and Epidemiology, Carmel Medical Center and B. Rappaport Faculty of Medicine) ; Rhenius, Valerie (Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge) ; Rhiem, Kerstin (Centre of Familial Breast and Ovarian Cancer, Department of Gynaecology and Obstetrics and Centre for Integrated Oncology (CIO), Center for Molecular Medicine Cologne (CMMC), University Hospital of Cologne) ; Risch, Harvey A. (Department of Chronic Disease Epidemiology, Yale School of Public Health) ; Rodriguez, Gus (Division of Gynecologic Oncology, NorthShore University HealthSystem) ; Rossing, Mary Anne (Department of Epidemiology, University of Washington) ; Rudolph, Anja (Division of Cancer Epidemiology, German Cancer Research Center (DKFZ)) ; Salvesen, Helga B. (Centre for Cancer Biomarkers, Department of Clinical Science, University of Bergen) ; Sangrajrang, Suleeporn (National Cancer Institute) ; Sawyer, Elinor J. (Research Oncology, Guy's Hospital, King's College London) ; Schildkraut, Joellen M. (Cancer Control and Population Sciences, Duke Cancer Institute) ; Schmidt, Marjanka K. (Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital) ; Schmutzler, Rita K. (Center of Familial Breast and Ovarian Cancer, University Hospital of Cologne) ; Sellers, Thomas A. (Department of Cancer Epidemiology, Moffitt Cancer Center) ; Seynaeve, Caroline (Department of Medical Oncology, Family Cancer Clinic, Erasmus MC Cancer Institute) ; Shah, Mitul (Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge) ; Shen, Chen-Yang (School of Public Health, China Medical University) ; Shu, Xiao-Ou (Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine) ; Sieh, Weiva (Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine) ; Singer, Christian F. (Department of Obstetrics and Gynecology, Comprehensive Cancer Center, Medical University of Vienna) ; Sinilnikova, Olga M. (INSERM U1052, CNRS UMR5286, Université Lyon 1, Centre de Recherche en Cancérologie de Lyon) ; Slager, Susan (Department of Health Sciences Research, Mayo Clinic) ; Song, Honglin (Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge) ; Soucy, Penny (Genomics Center, Centre Hospitalier Universitaire de Québec Research Center, Laval University) ; Southey, Melissa C. (Department of Pathology, University of Melbourne) ; Stenmark-Askmalm, Marie (Division of Clinical Genetics, Department of Clinical and Experimental Medicine, Linköping University) ; Stoppa-Lyonnet, Dominique (Université Paris Descartes, Sorbonne Paris Cité) ; Sutter, Christian (Institute of Human Genetics, Department of Human Genetics, University Hospital Heidelberg) ; Swerdlow, Anthony (Division of Genetics and Epidemiology, The Institute of Cancer Research) ; Tchatchou, Sandrine (Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital) ; Teixeira, Manuel R. (Biomedical Sciences Institute (ICBAS), Porto University) ; Teo, Soo H. (Cancer Research Initiatives Foundation, Subang Jaya) ; Terry, Kathryn L. (Brigham and Women's Hospital (Boston, Estats Units d'Amèrica)) ; Terry, Mary Beth (Department of Epidemiology, Mailman School of Public Health, Columbia University) ; Thomassen, Mads (Odense University Hospital (Dinamarca)) ; Tibiletti, Maria Grazia (UO Anatomia Patologica, Ospedale di Circolo-Università dell'Insubria) ; Tihomirova, Laima (Latvian Biomedical Research and Study Centre) ; Tognazzo, Silvia (Immunology and Molecular Oncology Unit, Istituto Oncologico Veneto IOV - IRCCS (Istituto Di Ricovero e Cura a Carattere Scientifico)) ; Toland, Amanda Ewart (Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University) ; Tomlinson, Ian (Wellcome Trust Centre for Human Genetics and Oxford Biomedical Research Centre, University of Oxford) ; Torres, Diana (Institute of Human Genetics, Pontificia Universidad Javeriana, Cra. 7 #40-62) ; Truong, Thérèse (University Paris-Sud) ; Tseng, Chiu-chen (Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center) ; Tung, Nadine (Department of Medical Oncology, Beth Israel Deaconess Medical Center) ; Tworoger, Shelley S. (Department of Epidemiology, Harvard TH Chan School of Public Health) ; Vachon, Celine (Department of Health Sciences Research, Mayo Clinic) ; van den Ouweland, Ans M. W. (Department of Clinical Genetics, Erasmus University Medical Center) ; van Doorn, Helena C. (Department of Gynecology, Family Cancer Clinic, Erasmus MC Cancer Institute) ; van Rensburg, Elizabeth J. (Department of Genetics, University of Pretoria) ; Van't Veer, Laura J. (Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital) ; Vanderstichele, Adriaan (University Hospitals Leuven (Bèlgica)) ; Vergote, Ignace (University Hospitals Leuven (Bèlgica)) ; Vijai, Joseph (Department of Medicine, Memorial Sloan-Kettering Cancer Center) ; Wang, Qin (Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge) ; Wang-Gohrke, Shan (University Hospital Ulm, 89069 Ulm) ; Weitzel, Jeffrey N. (Clinical Cancer Genetics, for the City of Hope Clinical Cancer Genetics Community Research Network) ; Wentzensen, Nicolas (Division of Cancer Epidemiology and Genetics, National Cancer Institute) ; Whittemore, Alice S. (Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine) ; Wildiers, Hans (University Hospitals Leuven (Bèlgica)) ; Winqvist, Robert (Laboratory of Cancer Genetics and Tumour Biology, Department of Clinical Chemistry and Biocenter Oulu, University of Oulu) ; Wu, Anna H. (Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center) ; Yannoukakos, Drakoulis (Molecular Diagnostics Laboratory, IRRP, National Centre for Scientific Research 'Demokritos') ; Yoon, Sook-Yee (University Malaya Cancer Research Institute, Faculty of Medicine, University Malaya Medical Centre, University Malaya) ; Yu, Jyh-Cherng (Department of Surgery, Tri-Service General Hospital, National Defense Medical Center) ; Zheng, Wei (Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine) ; Zheng, Ying (Shanghai Center for Disease Control and Prevention) ; Khanna, Kum Kum (QIMR Berghofer Medical Research Institute (Brisbane, Austràlia)) ; Simard, Jacques (Genomics Center, Centre Hospitalier Universitaire de Québec Research Center, Laval University) ; Monteiro, Alvaro N. (Cancer Epidemiology Program, Division of Population Sciences, H. Lee Moffitt Cancer Center & Research Institute) ; French, Juliet D. (QIMR Berghofer Medical Research Institute (Brisbane, Austràlia)) ; Couch, Fergus J. (Department of Laboratory Medicine and Pathology, Mayo Clinic) ; Freedman, Matthew L. (Department of Medical Oncology, The Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute) ; Easton, Douglas F. (Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge) ; Dunning, Alison M. (Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge) ; Pharoah, Paul D. (Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge) ; Edwards, Stacey L. (QIMR Berghofer Medical Research Institute (Brisbane, Austràlia)) ; Chenevix-Trench, Georgia (QIMR Berghofer Medical Research Institute (Brisbane, Austràlia)) ; Antoniou, Antonis C. (Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge) ; Gayther, Simon A. (Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center) ; Universitat Autònoma de Barcelona
A locus at 19p13 is associated with breast cancer (BC) and ovarian cancer (OC) risk. Here we analyse 438 SNPs in this region in 46,451 BC and 15,438 OC cases, 15,252 BRCA1 mutation carriers and 73,444 controls and identify 13 candidate causal SNPs associated with serous OC (P =9. [...]
2016 - 10.1038/ncomms12675
Nature communications, Vol. 7 (09 2016)  
4.
19 p, 1.8 MB Fine-Scale Mapping at 9p22.2 Identifies Candidate Causal Variants That Modify Ovarian Cancer Risk in BRCA1 and BRCA2 Mutation Carriers / Vigorito, Elena (Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom) ; Kuchenbaecker, Karoline B. (Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom) ; Beesley, Jonathan (Department of Genetics, QIMR Berghofer Medical Research Institute, Herston Road, Brisbane, Australia, 4029) ; Adlard, Julian (Yorkshire Regional Genetics Service, Chapel Allerton Hospital, Leeds, United Kingdom) ; Agnarsson, Bjarni A. (Department of Pathology, University Hospital (Landspitali) and University of Iceland School of Medicine, Hringbraut, 101 Reykjavik, Iceland) ; Andrulis, Irene L. (Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada) ; Arun, Banu K. (Department of Breast Medical Oncology and Clinical Cancer Genetics Program, University Of Texas MD Anderson Cancer Center, 1515 Pressler Street, CBP 5, Houston, TX, United States of America) ; Barjhoux, Laure (Bâtiment Cheney D, Centre Léon Bérard, 28 rue Laënnec, Lyon, France) ; Belotti, Muriel (Service de Génétique Oncologique, Institut Curie, 26, rue d'Ulm, Paris Cedex 05, France) ; Benitez, Javier (Human Genetics Group, Spanish National Cancer Centre (CNIO), Madrid, Spain, and Human Genotyping (CEGEN) Unit, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO), Madrid, Spain) ; Berger, Andreas (Dept of OB/GYN, Medical University of Vienna, Vienna, Austria) ; Bojesen, Anders (Department of Clinical Genetics, Vejle Hospital, Kabbeltoft 25, Vejle, Denmark) ; Bonanni, Bernardo (Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia (IEO), via Ripamonti 435, 20141 Milan, Italy) ; Brewer, Carole (Royal Devon & Exeter Hospital (Exeter, Regne Unit)) ; Caldes, Trinidad (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos) ; Caligo, Maria A. (University Hospital of Pisa (Pisa, Itàlia)) ; Campbell, Ian (Research Division, Peter MacCallum Cancer Centre, Locked Bag 1, A'Beckett Street, Melbourne, VIC 8006, Australia) ; Chan, Salina B. (Divisadero Street, C415, San Francisco, CA 94143-1714, United States of America) ; Claes, Kathleen B. M. (Center for Medical Genetics, Ghent University, De Pintelaan 185, 9000 Gent, Belgium) ; Cohn, David E. (Ohio State University Columbus Cancer Council GYN Oncology, 3651 Ridge Mill Drive, Columbus, OH 43026, United States of America) ; Cook, Jackie (Sheffield Clinical Genetics Service, Sheffield Children's Hospital, Sheffield, United Kingdom) ; Daly, Mary B. (Department of Clinical Oncology, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA, United States of America) ; Damiola, Francesca (Bâtiment Cheney D, Centre Léon Bérard, 28 rue Laënnec, Lyon, France) ; Davidson, Rosemarie (Department of Clinical Genetics, South Glasgow University Hospitals, Glasgow, United Kingdom) ; de Pauw, Antoine (Service de Génétique Oncologique, Institut Curie, 26, rue d'Ulm, Paris Cedex 05, France) ; Delnatte, Capucine (Unité d'oncogénétique, ICO-Centre René Gauducheau, Boulevard Jacques Monod, 44805 Nantes Saint Herblain Cedex, France) ; Diez, Orland (Vall d'Hebron Institut d'Oncologia) ; Domchek, Susan M. (Department of Medicine, Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, 3400 Civic Center Boulevard, Philadelphia, PA 19104, United States of America) ; Dumont, Martine (Genomics Center, Centre Hospitalier Universitaire de Québec Research Center and Laval University, 2705 Laurier Boulevard, Quebec City (Quebec), Canada) ; Durda, Katarzyna (Department of Genetics and Pathology, Pomeranian Medical University, Polabska 4, Szczecin, Poland) ; Dworniczak, Bernd (Institute of Human Genetics, University of Münster, Münster, Germany) ; Easton, Douglas F. (Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom) ; Eccles, Diana (University of Southampton Faculty of Medicine, Southampton University Hospitals NHS Trust, Southampton, United Kingdom) ; Edwinsdotter Ardnor, Christina (Department of Radiation Sciences, Oncology, Umeå University, Umea, Sweden) ; Eeles, Ros (Oncogenetics Team, The Institute of Cancer Research and Royal Marsden NHS Foundation Trust, Sutton, United Kingdom) ; Ejlertsen, Bent (Department of Oncology, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, DK-2100 Copenhagen, Denmark) ; Ellis, Steve (Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, United Kingdom) ; Evans, D. Gareth (Genomic Medicine, Manchester Academic Health Sciences Centre, Institute of Human Development, Manchester University, Central Manchester University Hospitals NHS Foundation Trust, Manchester, United Kingdom) ; Feliubadalo, Lidia (Institut d'Investigació Biomèdica de Bellvitge) ; Fostira, Florentia (Molecular Diagnostics Laboratory, (INRASTES) Institute of Nuclear and Radiological Sciences and Technology, National Centre for Scientific Research "Demokritos", Patriarchou Gregoriou & Neapoleos str., Aghia Paraskevi, Attiki, Athens, Greece) ; Foulkes, William D. (Program in Cancer Genetics, Departments of Human Genetics and Oncology, McGill University, Montreal, Quebec, Canada) ; Friedman, Eitan (The Susanne Levy Gertner Oncogenetics Unit, Institute of Human Genetics, Chaim Sheba Medical Center, Ramat Gan 52621, and Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv 69978, Israel) ; Frost, Debra (Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, United Kingdom) ; Gaddam, Pragna (Clinical Cancer Genetics Laboratory, Memorial Sloane Kettering Cancer Center, New York, NY, United States of America) ; Ganz, Patricia A. (UCLA Schools of Medicine and Public Health, Division of Cancer Prevention & Control Research, Jonsson Comprehensive Cancer Center, 650 Charles Young Drive South, Room A2-125 HS, Los Angeles, CA 90095-6900, United States of America) ; Garber, Judy (Cancer Risk and Prevention Clinic, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA, United States of America) ; García-Barberán, Vanesa (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos) ; Gauthier-Villars, Marion (Service de Génétique Oncologique, Institut Curie, 26, rue d'Ulm, Paris Cedex 05, France) ; Gehrig, Andrea (Centre of Familial Breast and Ovarian Cancer, Department of Medical Genetics, Institute of Human Genetics, University Würzburg, Würzburg, Germany) ; Gerdes, Anne-Marie (Department of Clinical Genetics, Rigshospitalet 4062, Blegdamsvej 9, København Ø, Denmark) ; Giraud, Sophie (Service de Génétique Moléculaire et Clinique, Hospices Civils de Lyon, Lyon cedex 04, France) ; Godwin, Andrew K. (Department of Pathology and Laboratory Medicine, 3901 Rainbow Boulevard, 4019 Wahl Hall East, MS 3040, University of Kansas Medical Center, Kansas City, Kansas, United States of America) ; Goldgar, David E. (Department of Dermatology, University of Utah School of Medicine, 30 North 1900 East, SOM 4B454, Salt Lake City, UT 84132, United States of America) ; Hake, Christopher R. (City of Hope Clinical Cancer Genetics Community Research Network, 1500 East Duarte Road, Duarte, CA 91010, United States of America) ; Hansen, Thomas V. O. (Center for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, DK-2100 Copenhagen, Denmark) ; Healey, Sue (Department of Genetics, QIMR Berghofer Medical Research Institute, Herston Road, Brisbane, Australia, 4029) ; Hodgson, Shirley (Medical Genetics Unit, St George's, University of London, London, United Kingdom) ; Hogervorst, Frans B. L. (Family Cancer Clinic, Netherlands Cancer Institute, P.O. Box 90203, 1000 BE, Amsterdam, The Netherlands) ; Houdayer, Claude (Service de Génétique Oncologique, Institut Curie, 26, rue d'Ulm, Paris Cedex 05, France) ; Hulick, Peter J. (Center for Medical Genetics, NorthShore University Health System, University of Chicago Pritzker School of Medicine, 1000 Central Street, Suite 620, Evanston, IL 60201, United States of America) ; Imyanitov, Evgeny N. (N.N. Petrov Institute of Oncology, St.-Petersburg 197758, Russia) ; Isaacs, Claudine (Lombardi Comprehensive Cancer Center, Georgetown University, 3800 Reservoir Road NW, Washington, DC, United States of America) ; Izatt, Louise (Clinical Genetics, Guy's and St. Thomas' NHS Foundation Trust, London, United Kingdom) ; Izquierdo, Angel (Institut d'Investigació Biomèdica (Girona)) ; Jacobs, Lauren (Clinical Genetics Research Laboratory, Dept. of Medicine, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY, United States of America) ; Jakubowska, Anna (Department of Genetics and Pathology, Pomeranian Medical University, Polabska 4, Szczecin, Poland) ; Janavicius, Ramunas (Vilnius University Hospital Santariskiu Clinics, Hematology, oncology and transfusion medicine center, Dept. of Molecular and Regenerative Medicine, Santariskiu st., State Research Institute Centre for Innovative medicine, Zygymantu st. 9, Vilnius, Lithuania) ; Jaworska-Bieniek, Katarzyna (Department of Genetics and Pathology, Pomeranian Medical University, Polabska 4, Szczecin, Poland) ; Jensen, Uffe Birk (Aarhus University Hospital (Aarhus, Dinamarca)) ; John, Esther M. (Department of Epidemiology, Cancer Prevention Institute of California, 2201 Walnut Avenue, Suite 300, Fremont, CA 94538, United States of America) ; Vijai, Joseph (Clinical Genetics Research Laboratory, Dept. of Medicine, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10044, United States of America) ; Karlan, Beth Y. (Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, 8700 Beverly Boulevard, Suite 290W, Los Angeles, CA, United States of America) ; Kast, Karin (Department of Gynaecology and Obstetrics, University Hospital Carl Gustav Carus, Technical University Dresden, Dresden, Germany) ; Investigators, KConFab (Kathleen Cuningham Consortium for Research into Familial Breast Cancer, Peter MacCallum Cancer Center, Melbourne, Australia) ; Khan, Sofia (Helsinki University Hospital) ; Kwong, Ava (The Hong Kong Hereditary Breast Cancer Family Registry, Cancer Genetics Center, Hong Kong Sanatorium and Hospital, Hong Kong China) ; Laitman, Yael (The Susanne Levy Gertner Oncogenetics Unit, Institute of Human Genetics, Chaim Sheba Medical Center, Ramat Gan 52621, Israel) ; Lester, Jenny (Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, 8700 Beverly Boulevard, Suite 290W, Los Angeles, CA, United States of America) ; Lesueur, Fabienne (Genetic Epidemiology of Cancer team, Inserm U900, Institut Curie, Mines ParisTech, 26 rue d'Ulm, 75248 Paris cedex 05, France) ; Liljegren, Annelie (Karolinska University Hospital) ; Lubinski, Jan (Department of Genetics and Pathology, Pomeranian Medical University, Polabska 4, Szczecin, Poland) ; Mai, Phuong L. (Clinical Genetics Branch, DCEG, NCI, NIH, 9609 Medical Center Drive, Room 6E-454, Bethesda, MD, United States of America) ; Manoukian, Siranoush (Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS (Istituto Di Ricovero e Cura a Carattere Scientifico) Istituto Nazionale Tumori (INT), Via Giacomo Venezian 1, 20133 Milan, Italy) ; Mazoyer, Sylvie (Bâtiment Cheney D, Centre Léon Bérard, 28 rue Laënnec, Lyon, France) ; Meindl, Alfons (Department of Gynaecology and Obstetrics, Division of Tumor Genetics, Klinikum rechts der Isar, Technical University Munich, Munich, Germany) ; Mensenkamp, Arjen R. (Department of Human Genetics, Radboud university medical centre, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands) ; Montagna, Marco (Immunology and Molecular Oncology Unit, Veneto Institute of Oncology IOV-IRCCS, Via Gattamelata 64, Padua, Italy) ; Nathanson, Katherine L. (Department of Medicine, Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, 3400 Civic Center Boulevard, Philadelphia, PA 19104, United States of America) ; Neuhausen, Susan L. (Department of Population Sciences, Beckman Research Institute of City of Hope, Duarte, CA, United States of America) ; Nevanlinna, Heli (Helsinki University Hospital) ; Niederacher, Dieter (Department of Gynaecology and Obstetrics, University Hospital Düsseldorf, Heinrich-Heine University Düsseldorf, Düsseldorf, Germany) ; Olah, Edith (Department of Molecular Genetics, National Institute of Oncology, Budapest, Hungary) ; Olopade, Olufunmilayo I. (The University of Chicago Medicine, 5841 South Maryland Avenue, MC 2115 Chicago, IL 60637) ; Ong, Kai-ren (West Midlands Regional Genetics Service, Birmingham Women's Hospital Healthcare NHS Trust, Edgbaston, Birmingham, United Kingdom) ; Osorio, Ana (Centro Nacional de Investigaciones Oncológicas) ; Park, Sue Kyung (Department of Preventive Medicine, Seoul National University College of Medicine, Department of Biomedical Science, Seoul National University Graduate School, and Cancer Research Institute, Seoul National University, 103 Daehak-ro, Jongno-gu, Seoul 110-799, Korea) ; Paulsson-Karlsson, Ylva (Department of Immunology, Genetics and Pathology, Uppsala University, SE-751 85 Uppsala, Sweden) ; Pedersen, Inge Sokilde (Aalborg University Hospital (Dinamarca)) ; Peissel, Bernard (Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS (Istituto Di Ricovero e Cura a Carattere Scientifico) Istituto Nazionale Tumori (INT), Via Giacomo Venezian 1, 20133 Milan, Italy) ; Peterlongo, Paolo (IFOM, The FIRC (Italian Foundation for Cancer Research) Institute of Molecular Oncology, c/o IFOM-IEO campus, via Adamello 16, 20139 Milan, Italy) ; Pfeiler, Georg (Medical University of Vienna, Währinger Gürtel 18-20, 1090 Vienna, Austria) ; Phelan, Catherine M. (Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida, United States of America) ; Piedmonte, Marion (NRG Oncology, Statistics and Data Management Center, Roswell Park Cancer Institute, Elm St & Carlton St, Buffalo, NY 14263, United States of America) ; Poppe, Bruce (Center for Medical Genetics, Ghent University, De Pintelaan 185, 9000 Gent, Belgium) ; Pujana, Miquel Angel (Institut d'Investigació Biomèdica de Bellvitge) ; Radice, Paolo (Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predicted Medicine, Fondazione IRCCS (Istituto Di Ricovero e Cura a Carattere Scientifico) Istituto Nazionale Tumori (INT), c/o Amaedeolab, via GA Amadeo 42, 20133 Milan, Italy) ; Rennert, Gad (Clalit National Israeli Cancer Control Center and Department of Community Medicine and Epidemiology, Carmel Medical Center and B. Rappaport Faculty of Medicine, 7 Michal St., Haifa 34362, Israel) ; Rodriguez, Gustavo C. (Division of Gynecologic Oncology, NorthShore University HealthSystem, Univ of Chicago, 2650 Ridge Avenue Suite 1507 Walgreens, Evanston, IL 60201, United States of America) ; Rookus, Matti A. (Department of Epidemiology, Netherlands Cancer Institute, P.O. Box 90203, 1000 BE, Amsterdam, The Netherlands) ; Ross, Eric A. (Biostatistics and Bioinformatics Facility, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, United States of America) ; Schmutzler, Rita Katharina (Center for Hereditary Breast and Ovarian Cancer, Medical Faculty, University Hospital Cologne, Cologne, Germany) ; Simard, Jacques (Genomics Center, Centre Hospitalier Universitaire de Québec Research Center and Laval University, 2705 Laurier Boulevard, Quebec City (Quebec), Canada) ; Singer, Christian F. (Dept of OB/GYN, Medical University of Vienna, Vienna, Austria, and Waehringer Guertel 18-20, A 1090 Vienna, Austria) ; Slavin, Thomas P. (Clinical Cancer Genetics, City of Hope, 1500 East Duarte Road, Duarte, California 91010, United States of America) ; Soucy, Penny (Genomics Center, Centre Hospitalier Universitaire de Québec Research Center and Laval University, 2705 Laurier Boulevard, Quebec City (Quebec), Canada) ; Southey, Melissa (Genetic Epidemiology Laboratory, Department of Pathology, University of Melbourne, Parkville, Victoria, Australia) ; Steinemann, Doris (Institute of Cell and Molecular Pathology, Hannover Medical School, Hannover, Germany) ; Stoppa-Lyonnet, Dominique (Service de Génétique Oncologique, Institut Curie, 26, rue d'Ulm, Paris Cedex 05, France) ; Sukiennicki, Grzegorz (Department of Genetics and Pathology, Pomeranian Medical University, Polabska 4, Szczecin, Poland) ; Sutter, Christian (Institute of Human Genetics, Department of Human Genetics, University Hospital Heidelberg, Heidelberg, Germany) ; Szabo, Csilla I. (National Human Genome Research Institute, National Institutes of Health, Building 50, Room 5312, 50 South Drive, MSC 004, Bethesda, MD 20892-8004, United States of America) ; Tea, Muy-Kheng (Dept of OB/GYN, Medical University of Vienna, Vienna, Austria, and Waehringer Guertel 18-20, A 1090 Vienna, Austria) ; Teixeira, Manuel R. (Department of Genetics, Portuguese Oncology Institute, Rua Dr. António Bernardino de Almeida, 4200-072 Porto, Portugal) ; Teo, Soo-Hwang (Cancer Research Initiatives Foundation, Sime Darby Medical Centre, 1 Jalan SS12/1A, Subang Jaya, 47500 Malaysia) ; Terry, Mary Beth (Department of Epidemiology, Columbia University, New York, NY, United States of America) ; Thomassen, Mads (Odense University Hospital (Dinamarca)) ; Tibiletti, Maria Grazia (UO Anatomia Patologica, Ospedale di Circolo-Università dell'Insubria, Via O.Rossi 9, 21100 Varese, Italy) ; Tihomirova, Laima (Latvian Biomedical Research and Study Centre, Ratsupites str 1, Riga, Latvia) ; Tognazzo, Silvia (Immunology and Molecular Oncology Unit, Veneto Institute of Oncology IOV-IRCCS, Via Gattamelata 64, Padua, Italy) ; van Rensburg, Elizabeth J. (Cancer Genetics Laboratory, Department of Genetics, University of Pretoria, Private Bag X323, Arcadia 0007, South Africa) ; Varesco, Liliana (Unit of Hereditary Cancer, Department of Epidemiology, Prevention and Special Functions, IRCCS (Istituto Di Ricovero e Cura a Carattere Scientifico) AOU San Martino-IST Istituto Nazionale per la Ricerca sul Cancro, largo Rosanna Benzi 10, 16132 Genoa, Italy) ; Varon-Mateeva, Raymonda (Institute of Human Genetics, Campus Virchov Klinikum, Charite Berlin, Berlin, Germany) ; Vratimos, Athanassios (Molecular Diagnostics Laboratory, (INRASTES) Institute of Nuclear and Radiological Sciences and Technology, National Centre for Scientific Research "Demokritos" Patriarchou Gregoriou & Neapoleos str., Aghia Paraskevi, Attiki, Athens, Greece) ; Weitzel, Jeffrey N. (Clinical Cancer Genetics, City of Hope, 1500 East Duarte Road, Duarte, California 91010, United States of America) ; McGuffog, Lesley (Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom) ; Kirk, Judy (Westmead Hospital) ; Toland, Amanda Ewart (Divison of Human Cancer Genetics, Departments of Internal Medicine and Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, The Ohio State University, 998 Biomedical Research Tower, Columbus, OH, United States of America) ; Hamann, Ute (Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 580, 69120 Heidelberg, Germany) ; Lindor, Noralane (Department of Health Sciences Research, Mayo Clinic, 13400 E. Scottsdale Blvd., Scottsdale, AZ, United States of America) ; Ramus, Susan J. (Department of Preventive Medicine, Keck School of Medicine, University of Southern California, California, United States of America) ; Greene, Mark H. (Clinical Genetics Branch, DCEG, NCI, NIH, 9609 Medical Center Drive, Room 6E-454, Bethesda, MD, United States of America) ; Couch, Fergus J. (Department of Laboratory Medicine and Pathology, and Health Sciences Research, Mayo Clinic, 200 First Street SW, Rochester, Minnesota, United States of America) ; Offit, Kenneth (Clinical Genetics Research Laboratory, Dept. of Medicine, Cancer Biology and Genetics, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10044, United States of America) ; Pharoah, Paul D. P. (Department of Oncology, University of Cambridge, Cambridge, United Kingdom) ; Chenevix-Trench, Georgia (Department of Genetics, QIMR Berghofer Medical Research Institute, Herston Road, Brisbane, Australia, 4029) ; Antoniou, Antonis C. (Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom) ; Universitat Autònoma de Barcelona
Population-based genome wide association studies have identified a locus at 9p22. 2 associated with ovarian cancer risk, which also modifies ovarian cancer risk in BRCA1 and BRCA2 mutation carriers. We conducted fine-scale mapping at 9p22. [...]
2016 - 10.1371/journal.pone.0158801
PloS one, Vol. 11 (july 2016)  
5.
14 p, 1.9 MB The FANCM :p.Arg658* truncating variant is associated with risk of triple-negative breast cancer / Figlioli, Gisella (The FIRC Institute for Molecular Oncology) ; Bogliolo, Massimo (Institut d'Investigació Biomèdica Sant Pau) ; Catucci, Irene (The FIRC Institute for Molecular Oncology) ; Caleca, Laura (Istituto Nazionale dei Tumori, Department of Research) ; Viz Lasheras, Sandra (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Pujol, Roser (Institut d'Investigació Biomèdica Sant Pau) ; Kiiski, Johanna I. (University of Helsinki, Department of Obstetrics and Gynecology) ; Muranen, Taru A. (University of Helsinki, Department of Obstetrics and Gynecology) ; Barnes, Daniel R. (University of Cambridge, Department of Public Health and Primary Care) ; Dennis, Joe (University of Cambridge, Department of Public Health and Primary Care) ; Michailidou, Kyriaki (The Cyprus Institute of Neurology & Genetics, Department of Electron Microscopy) ; Bolla, Manjeet K. (University of Cambridge, Department of Public Health and Primary Care) ; Leslie, Goska (University of Cambridge, Department of Public Health and Primary Care) ; Aalfs, Cora M. (Amsterdam UMC, Department of Clinical Genetics) ; Adank, Muriel A. (The Netherlands Cancer Institute (NKI) (Netherlands)) ; Adlard, Julian (Chapel Allerton Hospital) ; Agata, Simona (Veneto Institute of Oncology) ; Cadoo, Karen (Memorial Sloan Kettering Cancer Center) ; Agnarsson, Bjarni A. (University of Iceland, School of Medicine) ; Ahearn, Thomas (National Cancer Institute) ; Aittomäki, Kristiina (University of Helsinki, Department of Clinical Genetics) ; Ambrosone, Christine B. (Roswell Park Cancer Institute) ; Andrews, Lesley (Nelune Comprehensive Cancer Care Centre) ; Anton-Culver, Hoda (University of California Irvine, Department of Epidemiology) ; Antonenkova, Natalia N. (N.N. Alexandrov Research Institute of Oncology and Medical Radiology) ; Arndt, Volker (German Cancer Research Center) ; Arnold, Norbert (University Hospital of Schleswig-Holstein, Department of Gynaecology and Obstetrics) ; Aronson, Kristan J. (Queen's University, Department of Public Health Sciences) ; Arun, Banu K. (University of Texas, Department of Breast Medical Oncology) ; Asseryanis, Ella (Medical University of Vienna, Dept of OB/GYN and Comprehensive Cancer Center) ; Auber, Bernd (Institute of Human Genetics) ; Auvinen, Päivi (University of Eastern Finland, Translational Cancer Research Area) ; Azzollini, Jacopo (Fondazione Istituto Nazionale dei Tumori di Milano, Department of Medical Oncology and Hematology) ; Balmaña Gelpí, Judith (Hospital Universitari Vall d'Hebron) ; Barkardottir, Rosa B. (University of Iceland) ; Barrowdale, Daniel (University of Cambridge, Department of Public Health and Primary Care) ; Barwell, Julian (University Hospitals of Leicester) ; Beane Freeman, Laura E. (National Cancer Institute) ; Beauparlant, Charles Joly (Centre Hospitalier Universitaire de Québec - Université Laval) ; Beckmann, Matthias W. (Friedrich-Alexander-University Erlangen-Nuremberg, Department of Gynecology and Obstetrics) ; Behrens, Sabine (German Cancer Research Center) ; Benitez, Javier (Centro Nacional de Investigaciones Oncológicas) ; Berger, Raanan (Chaim Sheba Medical Center. The Institute of Oncology) ; Bermisheva, Marina (Institute of Biochemistry and Genetics) ; Blanco, Amie M. (University of California San Francisco) ; Blomqvist, Carl (Örebro University Hospital, Department of Oncology) ; Bogdanova, Natalia V. (Hannover Medical School) ; Bojesen, Anders (Aarhus University Hospital (Aarhus, Dinamarca)) ; Bojesen, Stig E. (University of Copenhagen) ; Bonanni, Bernardo (IEO, European Institute of Oncology) ; Borg, Ake (Skåne University Hospital (Suècia)) ; Brady, Angela F. (London North West University Hospitals) ; Brauch, Hiltrud (German Cancer Research Center) ; Brenner, Hermann (German Cancer Research Center) ; Brüning, Thomas (Institute of the Ruhr University Bochum) ; Burwinkel, Barbara (University of Heidelberg) ; Buys, Saundra S. (Huntsman Cancer Institute, Department of Medicine) ; Caldés, Trinidad (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos) ; Caliebe, Almuth (University Hospital of Schleswig-Holstein) ; Caligo, Maria A. (University Hospital of Pisa (Pisa, Itàlia)) ; Campa, Daniele (University of Pisa, Department of Biology) ; Campbell, Ian G. (The University of Melbourne, Department of Oncology) ; Canzian, Federico (German Cancer Research Center) ; Castelao, Jose E. (Instituto de Investigación Sanitaria Galicia Sur) ; Chang-Claude, Jenny (University Medical Center Hamburg-Eppendorf) ; Chanock, Stephen J. (National Cancer Institute) ; Claes, Kathleen B. M. (Ghent University, Centre for Medical Genetics) ; Clarke, Christine L. (University of Sydney, Westmead Institute for Medical Research) ; Collavoli, Anita (University and University Hospital of Pisa, Department of Laboratory Medicine) ; Conner, Thomas A. (Huntsman Cancer Institute) ; Cox, David G. (Cancer Research Center of Lyon) ; Cybulski, Cezary (Pomeranian Medical University, Department of Genetics and Pathology) ; Czene, Kamila (Karolinska Institutet (Estocolm, Suècia). Department of Medical Epidemiology and Biostatistics) ; Daly, Mary B. (Fox Chase Cancer Center, Department of Clinical Genetics) ; de la Hoya, Miguel (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos) ; Devilee, Peter (Leiden University Medical Center, Department of Human Genetics) ; Diez, Orland (Hospital Universitari Vall d'Hebron) ; Ding, Yuan Chun (Beckman Research Institute of City of Hope, Department of Population Sciences) ; Dite, Gillian S. (The University of Melbourne) ; Ditsch, Nina (Ludwig Maximilian University of Munich, Department of Gynecology and Obstetrics) ; Domchek, Susan M. (Perelman School of Medicine at the University of Pennsylvania, Department of Medicine) ; Dorfling, Cecilia M. (University of Pretoria, Department of Genetics) ; dos-Santos-Silva, Isabel (London School of Hygiene and Tropical Medicine, Department of Non-Communicable Disease Epidemiology) ; Durda, Katarzyna (Pomeranian Medical University, Department of Genetics and Pathology) ; Dwek, Miriam (University of Westminster, Department of Biomedical Sciences) ; Eccles, Diana M. (University of Southampton, Cancer Sciences Academic Unit) ; Ekici, Arif B. (Friedrich-Alexander University Erlangen-Nuremberg) ; Eliassen, A. Heather (Harvard T.H. Chan School of Public Health, Department of Epidemiology) ; Ellberg, Carolina (Lund University, Department of Cancer Epidemiology) ; Eriksson, Mikael (Karolinska Institutet (Estocolm, Suècia). Department of Medical Epidemiology and Biostatistics) ; Evans, D. Gareth (Manchester University NHS Foundation Trust) ; Fasching, Peter A. (University of California at Los Angeles, Department of Medicine Division of Hematology and Oncology) ; Figueroa, Jonine (Cancer Research UK Edinburgh Centre) ; Flyger, Henrik (Copenhagen University Hospital) ; Foulkes, William D. (McGill University, Departments of Human Genetics and Oncology) ; Friebel, Tara M. (Dana-Farber Cancer Institute (Boston, Estats Units d'Amèrica)) ; Friedman, Eitan (Tel Aviv University) ; Gabrielson, Marike (Karolinska Institutet (Estocolm, Suècia). Department of Medical Epidemiology and Biostatistics) ; Gaddam, Pragna (Memorial Sloan-Kettering Cancer Center (Nova York, Estats Units d'Amèrica)) ; Gago-Dominguez, Manuela (University of California San Diego) ; Gao, Chi (Harvard T.H. Chan School of Public Health (Boston, Estats Units d'Amèrica)) ; Gapstur, Susan M. (American Cancer Society) ; Garber, Judy (Dana-Farber Cancer Institute (Boston, Estats Units d'Amèrica)) ; García-Closas, Montserrat (National Cancer Institute) ; García-Sáenz, José A. (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos) ; Gaudet, Mia M. (American Cancer Society) ; Gayther, Simon A. (Cedars Sinai Heart Institute) ; Giles, Graham G. (Monash University, Department of Epidemiology and Preventive Medicine) ; Glendon, Gord (Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital) ; Godwin, Andrew K. (Kansas University Medical Center, Department of Pathology and Laboratory Medicine) ; Goldberg, Mark S. (McGill University) ; Goldgar, David E. (University of Utah School of Medicine, Department of Dermatology) ; Guénel, Pascal (University Paris-Sud, University Paris-Saclay) ; Gutierrez-Barrera, Angelica M. (University of Texas, Department of Breast Medical Oncology and Clinical Genetics Program) ; Haeberle, Lothar (University Hospital Erlangen) ; Haiman, Christopher A. (University of Southern California, Department of Preventive Medicine) ; Håkansson, Niclas (Karolinska Institutet, Institute of Environmental Medicine) ; Hall, Per (Södersjukhuset, Department of Oncology) ; Hamann, Ute (German Cancer Research Center) ; Harrington, Patricia A. (University of Cambridge, Department of Oncology) ; Hein, Alexander (University Hospital Erlangen) ; Heyworth, Jane (The University of Western Australia) ; Hillemanns, Peter (Hannover Medical School, Gynaecology Research Unit) ; Hollestelle, Antoinette (Erasmus MC Cancer Institute) ; Hopper, John L. (The University of Melbourne) ; Hosgood, H. Dean (Albert Einstein College of Medicine) ; Howell, Anthony (University of Manchester, Division of Cancer Sciences) ; Hu, Chunling (Mayo Clinic, Department of Laboratory Medicine and Pathology) ; Hulick, Peter J. (The University of Chicago Pritzker School of Medicine) ; Hunter, David J. (University of Oxford) ; Imyanitov, Evgeny N. (N.N. Petrov Institute of Oncology) ; Isaacs, Claudine (Georgetown University) ; Jakimovska, Milena (Macedonian Academy of Sciences and Arts) ; Jakubowska, Anna (Pomeranian Medical University) ; James, Paul (Peter MacCallum Cancer Center) ; Janavicius, Ramunas (State Research Institute Innovative Medicine Center) ; Janni, Wolfgang (University Hospital of Ulm (Alemanya)) ; John, Esther M. (Stanford University School of Medicine, Department of Medicine) ; Jones, Michael E. (The Institute of Cancer Research) ; Jung, Audrey (German Cancer Research Center) ; Kaaks, Rudolf (German Cancer Research Center) ; Karlan, Beth Y. (Cedars Sinai Heart Institute) ; Khusnutdinova, Elza (Bashkir State Medical University, Department of Medical Genetics) ; Kitahara, Cari M. (National Cancer Institute) ; Konstantopoulou, Irene (National Centre for Scientific Research 'Demokritos') ; Koutros, Stella (National Cancer Institute) ; Kraft, Peter (Harvard T.H. Chan School of Public Health (Boston, Estats Units d'Amèrica)) ; Lambrechts, Diether (University of Leuven, Department of Human Genetics) ; Lazaro, Conxi (Institut d'Investigació Biomèdica de Bellvitge) ; Le Marchand, Loic (University of Hawaii Cancer Center, Epidemiology Program) ; Lester, Jenny (Cedars Sinai Heart Institute) ; Lesueur, Fabienne (Mines ParisTech) ; Lilyquist, Jenna (Mayo Clinic, Department of Health Sciences Research) ; Loud, Jennifer T. (National Cancer Institute, Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics) ; Lu, Karen H. (University of Texas MD Anderson Cancer Center, Department of Gynecologic Oncology) ; Luben, Robert N. (University of Cambridge, Department of Public Health and Primary Care) ; Lubinski, Jan (Pomeranian Medical University, Department of Genetics and Pathology) ; Mannermaa, Arto (Kuopio University Hospital, Imaging Center, Department of Clinical Pathology) ; Manoochehri, Mehdi (German Cancer Research Center) ; Manoukian, Siranoush (Istituto Nazionale dei Tumori di Milano) ; Margolin, Sara (Karolinska Institutet, Department of Clinical Science and Education) ; Martens, John W. M. (Erasmus MC Cancer Institute) ; Maurer, Tabea (University Medical Center Hamburg-Eppendorf) ; Mavroudis, Dimitrios (University Hospital of Heraklion, Department of Medical Oncology) ; Mebirouk, Noura (Mines ParisTech) ; Meindl, Alfons (Ludwig Maximilian University of Munich, Department of Gynecology and Obstetrics) ; Menon, Usha (University College London) ; Miller, Austin (Roswell Park Cancer Institute) ; Montagna, Marco (Veneto Institute of Oncology) ; Nathanson, Katherine L. (University of Pennsylvania, Department of Medicine) ; Neuhausen, Susan L. (Beckman Research Institute of City of Hope, Department of Population Sciences) ; Newman, William G. (Manchester University NHS Foundation Trust) ; Nguyen-Dumont, Tu (The University of Melbourne, Department of Clinical Pathology) ; Nielsen, Finn Cilius (Copenhagen University Hospital, Center for Genomic Medicine) ; Nielsen, Sarah (The University of Chicago, Center for Clinical Cancer Genetics) ; Nikitina-Zake, Liene (Latvian Biomedical Research and Study Centre) ; Offit, Kenneth (Memorial Sloan-Kettering Cancer Center, Clinical Genetics Service, Department of Medicine) ; Olah, Edith (National Institute of Oncology, Department of Molecular Genetics) ; Olopade, Olufunmilayo I. (The University of Chicago) ; Olshan, Andrew F. (University of North Carolina at Chapel Hill, Department of Epidemiology) ; Olson, Janet E. (Mayo Clinic, Department of Health Sciences Research) ; Olsson, Håkan (Lund University, Department of Cancer Epidemiology, Clinical Sciences) ; Osorio, Ana (Spanish Network on Rare Diseases) ; Ottini, Laura (University La Sapienza, Department of Molecular Medicine) ; Peissel, Bernard (Istituto Nazionale dei Tumori di Milano) ; Peixoto, Ana (Portuguese Oncology Institute, Department of Genetics) ; Peto, Julian (London School of Hygiene and Tropical Medicine, Department of Non-Communicable Disease Epidemiology) ; Plaseska-Karanfilska, Dijana (Macedonian Academy of Sciences and Arts) ; Pocza, Timea (National Institute of Oncology, Department of Molecular Genetics) ; Presneau, Nadege (University of Westminster, Department of Biomedical Sciences) ; Pujana, Miquel Angel (Institut d'Investigació Biomèdica de Bellvitge) ; Punie, Kevin (University Hospitals Leuven (Bèlgica)) ; Rack, Brigitte (University Hospital of Ulm (Alemanya)) ; Rantala, Johanna (Karolinska Institutet, Clinical Genetics) ; Rashid, Muhammad U. (Shaukat Khanum Memorial Cancer Hospital and Research Centre, Department of Basic Sciences) ; Rau-Murthy, Rohini (Memorial Sloan-Kettering Cancer Center, Department of Medicine) ; Rennert, Gad (Clalit National Cancer Control Center) ; Lejbkowicz, Flavio (Clalit National Cancer Control Center) ; Rhenius, Valerie (University of Cambridge, Centre for Cancer Genetic Epidemiology, Department of Oncology) ; Romero, Atocha (Hospital Universitario Puerta de Hierro Majadahonda (Madrid)) ; Rookus, Matti A. (The Netherlands Cancer Institute, Department of Epidemiology) ; Ross, Eric A. (Fox Chase Cancer Center) ; Rossing, Maria (Copenhagen University Hospital) ; Rudaitis, Vilius (Vilnius University, Institute of Clinical Medicine) ; Ruebner, Matthias (University Hospital Erlangen. Friedrich-Alexander University Erlangen-Nuremberg, Department of Gynaecology and Obstetrics) ; Saloustros, Emmanouil (University Hospital of Larissa, Department of Oncology) ; Sanden, Kristin (University of Wisconsin, Cancer Center at ProHealth Care) ; Santamariña, Marta (Instituto de Investigación Sanitaria de Santiago (IDIS)) ; Scheuner, Maren T. (University of California San Francisco, Cancer Genetics and Prevention Program) ; Schmutzler, Rita K. (University of Cologne, Center for Molecular Medicine Cologne) ; Schneider, Michael (University Hospital Erlangen) ; Scott, Christopher (Mayo Clinic, Department of Health Sciences Research) ; Senter, Leigha (The Ohio State University, Department of Internal Medicine) ; Shah, Mitul (University of Cambridge, Department of Oncology) ; Sharma, Priyanka (University of Kansas Medical Center, Department of Internal Medicine) ; Shu, Xiao-Ou (Vanderbilt University School of Medicine, Department of Medicine) ; Simard, Jacques (Université Laval) ; Singer, Christian F. (Medical University of Vienna) ; Sohn, Christof (University of Heidelberg) ; Soucy, Penny (Université Laval) ; Southey, Melissa C. (The University of Melbourne, Department of Clinical Pathology) ; Spinelli, John J. (University of British Columbia, School of Population and Public Health) ; Steele, Linda (Beckman Research Institute of City of Hope, Department of Population Sciences) ; Stoppa-Lyonnet, Dominique (Université Paris Descartes) ; Tapper, William J. (University of Southampton) ; Teixeira, Manuel R. (University of Porto) ; Terry, Mary Beth (Columbia University, Department of Epidemiology) ; Thomassen, Mads (Odense University Hospital (Dinamarca)) ; Thompson, Jennifer (NorthShore University HealthSystem, Center for Medical Genetics) ; Thull, Darcy L. (University of Pittsburgh School of Medicine, Department of Medicine) ; Tischkowitz, Marc (University of Cambridge, Department of Medical Genetics) ; Tollenaar, Rob A.E.M. (Leiden University Medical Center, Department of Surgery) ; Torres, Diana (Pontificia Universidad Javeriana) ; Troester, Melissa A. (University of North Carolina at Chapel Hill) ; Truong, Thérèse (University Paris-Sud) ; Tung, Nadine (Beth Israel Deaconess Medical Center, Department of Medical Oncology) ; Untch, Michael (Helios Clinics Berlin-Buch, Department of Gynecology and Obstetrics) ; Vachon, Celine M. (Mayo Clinic, Department of Health Sciences Research) ; van Rensburg, Elizabeth J. (University of Pretoria, Department of Genetics) ; van Veen, Elke M. (Manchester University NHS Foundation Trust) ; Vega, Ana (Instituto de Investigación Sanitaria de Santiago (IDIS)) ; Viel, Alessandra (Centro di Riferimento Oncologico di Aviano) ; Wappenschmidt, Barbara (University of Cologne, Center for Molecular Medicine Cologne) ; Weitzel, Jeffrey N. (City of Hope, Clinical Cancer Genetics) ; Wendt, Camilla (Karolinska Institutet (Estocolm, Suècia)) ; Wieme, Greet (Ghent University, Centre for Medical Genetics) ; Wolk, Alicja (Uppsala University, Department of Surgical Sciences) ; Yang, Xiaohong R. (National Cancer Institute) ; Zheng, Wei (Vanderbilt University School of Medicine) ; Ziogas, Argyrios (University of California Irvine, Department of Epidemiology) ; Zorn, Kristin K. (University of Pittsburgh School of Medicine) ; Dunning, Alison M. (University of Cambridge, Department of Oncology) ; Lush, Michael (University of Cambridge, Department of Public Health and Primary Care) ; Wang, Qin (University of Cambridge, Department of Public Health and Primary Care) ; McGuffog, Lesley (University of Cambridge, Department of Public Health and Primary Care) ; Parsons, Michael T. (QIMR Berghofer Medical Research Institute, Department of Genetics and Computational Biology) ; Pharoah, Paul D. P. (University of Cambridge, Centre for Cancer Genetic Epidemiology, Department of Oncology) ; Fostira, Florentia (National Centre for Scientific Research 'Demokritos') ; Toland, Amanda E. (The Ohio State University, Department of Cancer Biology and Genetics) ; Andrulis, Irene L. (University of Toronto, Department of Molecular Genetics) ; Ramus, Susan J. (The Kinghorn Cancer Centre, Garvan Institute of Medical Research) ; Swerdlow, Anthony J. (The Institute of Cancer Research) ; Greene, Mark H. (National Cancer Institute, Clinical Genetics Branch) ; Chung, Wendy K. (Columbia University, Departments of Pediatrics and Medicine) ; Milne, Roger L. (Monash University) ; Chenevix-Trench, Georgia (QIMR Berghofer Medical Research Institute, Department of Genetics and Computational Biology) ; Dörk, Thilo (Hannover Medical School) ; Schmidt, Marjanka K. (The Netherlands Cancer Institute (NKI) (Netherlands)) ; Easton, Douglas F. (University of Cambridge, Department of Oncology) ; Radice, Paolo (Istituto Nazionale dei Tumori) ; Hahnen, Eric (University of Cologne) ; Antoniou, Antonis C. (University of Cambridge, Department of Public Health and Primary Care) ; Couch, Fergus J. (Mayo Clinic, Department of Laboratory Medicine and Pathology) ; Nevanlinna, Heli (University of Helsinki, Department of Obstetrics and Gynecology) ; Surrallés i Calonge, Jordi (Institut d'Investigació Biomèdica Sant Pau) ; Peterlongo, Paolo (The FIRC Institute for Molecular Oncology)
Breast cancer is a common disease partially caused by genetic risk factors. Germline pathogenic variants in DNA repair genes BRCA1, BRCA2, PALB2, ATM, and CHEK2 are associated with breast cancer risk. [...]
2019 - 10.1038/s41523-019-0127-5
NPJ breast cancer, Vol. 5 (November 2019) , art. 38  
6.
11 p, 1.8 MB Decapping protein EDC4 regulates DNA repair and phenocopies BRCA1 / Hernández Viedma, Gonzalo (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Ramírez de Haro, Ma. José (María José) (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Minguillón Pedreño, Jordi (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Quiles, Paco (Institut Català d'Oncologia) ; Ruiz de Garibay G. (Institut Català d'Oncologia) ; Aza-Carmona, Miriam (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Bogliolo, Massimo (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Pujol i Calvet, M. Roser (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Prados-Carvajal, Rosario (Universidad de Sevilla. Departamento de Genética) ; Fernández-Rodríguez, Juana (Institut d'Investigació Biomèdica de Bellvitge) ; García, Nadia (Institut Català d'Oncologia) ; López, Adrià (Institut Català d'Oncologia) ; Gutiérrez-Enríquez, Sara (Vall d'Hebron Institut d'Oncologia) ; Diez, Orland (Vall d'Hebron Institut d'Oncologia) ; Benítez, Javier (Centro de Investigación Biomédica en Red de Enfermedades Raras) ; Salinas, Mónica (Institut Català d'Oncologia) ; Teulé, Àlex (Institut Català d'Oncologia) ; Brunet, Joan (Institut Català d'Oncologia) ; Radice, Paolo (Istituto Nazionale dei Tumori (Milà)) ; Peterlongo, Paolo (Istituto Nazionale dei Tumori (Milà)) ; Schindler, Detlev (Universität Würzburg. Department of Human Genetics) ; Huertas, Pablo (Universidad de Sevilla. Departamento de Genética) ; Puente, Xose P. (Universidad de Oviedo. Department de Bioquímica y Biología Molecular) ; Lázaro, Coxi (Institut Català d'Oncologia) ; Pujana. Miguel Ángel (Institut Català d'Oncologia) ; Surrallés i Calonge, Jordi (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
BRCA1 is a tumor suppressor that regulates DNA repair by homologous recombination. Germline mutations in BRCA1 are associated with increased risk of breast and ovarian cancer and BRCA1 deficient tumors are exquisitely sensitive to poly (ADP-ribose) polymerase (PARP) inhibitors. [...]
2018 - 10.1038/s41467-018-03433-3
Nature communications, Vol. 9 (2018) , art. 967  
7.
12 p, 371.6 KB DNA Glycosylases Involved in Base Excision Repair May Be Associated with Cancer Risk in BRCA1 and BRCA2 Mutation Carriers / Osorio, Ana (Centro de Investigación Biomédica en Red de Enfermedades Raras) ; Milne, Roger L. (Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia) ; Kuchenbaecker, Karoline (Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom) ; Vaclová, Tereza (Centro Nacional de Investigaciones Oncológicas) ; Pita, Guillermo (Centro Nacional de Investigaciones Oncológicas) ; Alonso, Rosario (Centro Nacional de Investigaciones Oncológicas) ; Peterlongo, Paolo (IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy) ; Blanco Guillermo, Ignacio (Institut Català d'Oncologia) ; de la Hoya, Miguel (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos) ; Duran, Mercedes (Institute of Biology and Molecular Genetics, Universidad de Valladolid (IBGM-UVA), Valladolid, Spain) ; Diez, Orland (Vall d'Hebron Institut d'Oncologia) ; Ramon y Cajal, Teresa (Institut d'Investigació Biomèdica Sant Pau) ; Konstantopoulou, Irene (Molecular Diagnostics Laboratory IRRP, National Centre for Scientific Research Demokritos Aghia Paraskevi Attikis, Athens, Greece) ; Martínez-Bouzas, Cristina (Hospital Universitario de Cruces (Barakaldo, País Basc)) ; Andrés Conejero, Raquel (Hospital Clínico Universitario "Lozano Blesa" de Zaragoza) ; Soucy, Penny (Centre Hospitalier Universitaire de Québec. Cancer Genomics Laboratory) ; McGuffog, Lesley (Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom) ; Barrowdale, Daniel (Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom) ; Lee, Andrew (Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom) ; SWE-BRCA, None (Department of Oncology, Lund University, Lund, Sweden) ; Arver, Brita (Karolinska University Hospital) ; Rantala, Johanna (Karolinska University Hospital) ; Loman, Niklas (Department of Oncology, Lund University Hospital, Lund, Sweden) ; Ehrencrona, Hans (Department of Clinical Genetics, Lund University Hospital, Lund, Sweden) ; Olopade, Olufunmilayo I. (Center for Clinical Cancer Genetics and Global Health, University of Chicago Medical Center, Chicago, Illinois, United States of America) ; Beattie, Mary S. (Departments of Medicine, Epidemiology, and Biostatistics, University of California, San Francisco, San Francisco, California, United States of America) ; Domchek, Susan M. (Abramson Cancer Center and Department of Medicine, The University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America) ; Nathanson, Katherine (Abramson Cancer Center and Department of Medicine, The University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America) ; Rebbeck, Timothy R. (Abramson Cancer Center and Center for Clinical Epidemiology and Biostatistics, The University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America) ; Arun, Banu K. (University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America) ; Karlan, Beth Y. (Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America) ; Walsh, Christine (Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America) ; Lester, Jenny (Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America) ; John, Esther M. (Department of Epidemiology, Cancer Prevention Institute of California, Fremont, California, United States of America) ; Whittemore, Alice S. (Department of Health Research & Policy, Stanford University School of Medicine, Stanford, California, United States of America) ; Daly, Mary B. (Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States of America) ; Southey, Melissa (Genetic Epidemiology Laboratory, Department of Pathology, University of Melbourne, Parkville, Australia) ; Hopper, John (Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, University of Melbourne, Melbourne, Victoria, Australia) ; Terry, Mary Beth (Department of Epidemiology, Columbia University, New York, New York, United States of America) ; Buys, Saundra S. (Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, Utah, United States of America) ; Janavicius, Ramunas (Vilnius University Hospital Santariskiu Clinics, Hematology, oncology and transfusion medicine center, Department of Molecular and Regenerative Medicine, Vilnius, Lithuania) ; Dorfling, Cecilia M. (Department of Genetics, University of Pretoria, Pretoria, South Africa) ; van Rensburg, Elizabeth J. (Department of Genetics, University of Pretoria, Pretoria, South Africa) ; Steele, Linda (Beckman Research Institute of City of Hope (Duarte, Estats Units d'Amèrica). Department of Population Sciences) ; Neuhausen, Susan L. (Beckman Research Institute of City of Hope (Duarte, Estats Units d'Amèrica). Department of Population Sciences) ; Ding, Yuan Chun (Beckman Research Institute of City of Hope (Duarte, Estats Units d'Amèrica). Department of Population Sciences) ; Hansen, Thomas v. O. (Center for Genomic Medicine, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark) ; Jønson, Lars (Center for Genomic Medicine, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark) ; Ejlertsen, Bent (Department of Oncology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark) ; Gerdes, Anne-Marie (Department of Clinical Genetics, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark) ; Infante, Mar (Institute of Biology and Molecular Genetics, Universidad de Valladolid (IBGM-UVA), Valladolid, Spain) ; Herráez, Belén (Centro Nacional de Investigaciones Oncológicas) ; Moreno, Leticia Thais (Centro Nacional de Investigaciones Oncológicas) ; Weitzel, Jeffrey N. (Clinical Cancer Genetics, City of Hope, Duarte, California, United States of America) ; Herzog, Josef (Clinical Cancer Genetics, City of Hope, Duarte, California, United States of America) ; Weeman, Kisa (Clinical Cancer Genetics, City of Hope, Duarte, California, United States of America) ; Manoukian, Siranoush (Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT), Milan, Italy) ; Peissel, Bernard (Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT), Milan, Italy) ; Zaffaroni, Daniela (Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT), Milan, Italy) ; Scuvera, Giulietta (Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT), Milan, Italy) ; Bonanni, Bernardo (Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia, Milan, Italy) ; Mariette, Frederique (IFOM, Fondazione Istituto FIRC di Oncologia Molecolare and Cogentech Cancer Genetic Test Laboratory, Milan, Italy) ; Volorio, Sara (IFOM, Fondazione Istituto FIRC di Oncologia Molecolare and Cogentech Cancer Genetic Test Laboratory, Milan, Italy) ; Viel, Alessandra (Division of Experimental Oncology 1, Centro di Riferimento Oncologico, IRCCS, Aviano, Italy) ; Varesco, Liliana (Unit of Hereditary Cancer, Department of Epidemiology, Prevention and Special Functions, IRCCS AOU San Martino - IST Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy) ; Papi, Laura (Unit of Medical Genetics, Department of Biomedical, Experimental and Clinical Sciences, University of Florence, Florence, Italy) ; Ottini, Laura (Department of Molecular Medicine, "Sapienza" University, Rome, Italy) ; Tibiletti, Maria Grazia (UO Anatomia Patologica, Ospedale di Circolo-Università dell'Insubria, Varese, Italy) ; Radice, Paolo (Unit of Molecular bases of genetic risk and genetic testing, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT), Milan, Italy) ; Yannoukakos, Drakoulis (Molecular Diagnostics Laboratory IRRP, National Centre for Scientific Research Demokritos Aghia Paraskevi Attikis, Athens, Greece) ; Garber, Judy (Dana-Farber Cancer Institute (Boston, Estats Units d'Amèrica)) ; Ellis, Steve (Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom) ; Frost, Debra (Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom) ; Platte, Radka (Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom) ; Fineberg, Elena (Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom) ; Evans, Gareth (Genetic Medicine, Manchester Academic Health Sciences Centre, Central Manchester University Hospitals NHS Foundation Trust, Manchester, United Kingdom) ; Lalloo, Fiona (Genetic Medicine, Manchester Academic Health Sciences Centre, Central Manchester University Hospitals NHS Foundation Trust, Manchester, United Kingdom) ; Izatt, Louise (South East Thames Regional Genetics Service, Guy's Hospital London, United Kingdom) ; Eeles, Ros (Oncogenetics Team, The Institute of Cancer Research and Royal Marsden NHS Foundation Trust, London, United Kingdom) ; Adlard, Julian (Yorkshire Regional Genetics Service, Leeds, United Kingdom) ; Davidson, Rosemarie (Ferguson-Smith Centre for Clinical Genetics, Yorkhill Hospitals, Glasgow, United Kingdom) ; Cole, Trevor (West Midlands Regional Genetics Service, Birmingham Women's Hospital Healthcare NHS Trust, Edgbaston, Birmingham, United Kingdom) ; Eccles, Diana (Wessex Clinical Genetics Service, Princess Anne Hospital, Southampton, United Kingdom) ; Cook, Jackie (Sheffield Clinical Genetics Service, Sheffield Children's Hospital, Sheffield, United Kingdom) ; Hodgson, Shirley (Clinical Genetics Department, St Georges Hospital, University of London, London, United Kingdom) ; Brewer, Carole (Royal Devon & Exeter Hospital (Exeter, Regne Unit)) ; Tischkowitz, Marc (Addenbrookes Hospital (Cambridge, Regne Unit)) ; Douglas, Fiona (Institute of Human Genetics, Centre for Life, Newcastle Upon Tyne Hospitals NHS Trust, Newcastle upon Tyne, United Kingdom) ; Porteous, Mary (South East of Scotland Regional Genetics Service, Western General Hospital, Edinburgh, United Kingdom) ; Side, Lucy (Great Ormond Street Hospital for Children (Londres)) ; Walker, Lisa (Oxford Regional Genetics Service, Churchill Hospital, Oxford, United Kingdom) ; Morrison, Patrick (Northern Ireland Regional Genetics Centre, Belfast City Hospital, Belfast, United Kingdom) ; Donaldson, Alan (South West Regional Genetics Service, Bristol, United Kingdom) ; Kennedy, John (Trinity College Dublin) ; Foo, Claire (Cheshire & Merseyside Clinical Genetics Service, Liverpool Women's NHS Foundation Trust, Liverpool, United Kingdom) ; Godwin, Andrew K. (Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, Kansas, United States of America) ; Schmutzler, Rita Katharina (Centre of Familial Breast and Ovarian Cancer and Centre for Integrated Oncology (CIO), University Hospital of Cologne, Cologne, Germany) ; Wappenschmidt, Barbara (Centre of Familial Breast and Ovarian Cancer and Centre for Integrated Oncology (CIO), University Hospital of Cologne, Cologne, Germany) ; Rhiem, Kerstin (Centre of Familial Breast and Ovarian Cancer and Centre for Integrated Oncology (CIO), University Hospital of Cologne, Cologne, Germany) ; Engel, Christoph (Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany) ; Meindl, Alfons (Department of Gynaecology and Obstetrics, Division of Tumor Genetics, Klinikum rechts der Isar, Technical University Munich, Munich, Germany) ; Ditsch, Nina (Department of Gynaecology and Obstetrics, Division of Tumor Genetics, Klinikum rechts der Isar, Technical University Munich, Munich, Germany) ; Arnold, Norbert (Department of Gynecology and Obstetrics, University Medical Center Schleswig-Holstein, Campus Kiel, Kiel, Germany) ; Plendl, Hans Jörg (Institute of Human Genetics, University Medical Center Schleswig-Holstein, Campus Kiel, Kiel, Germany) ; Niederacher, Dieter (Department of Gynaecology and Obstetrics, University Hospital Düsseldorf, Heinrich-Heine University Düsseldorf, Düsseldorf, Germany) ; Sutter, Christian (Institute of Human Genetics, Department of Human Genetics, University Hospital Heidelberg, Heidelberg, Germany) ; Wang-Gohrke, Shan (University Hospital of Ulm (Alemanya)) ; Steinemann, Doris (Institute of Cell and Molecular Pathology, Hannover Medical School, Hannover, Germany) ; Preisler-Adams, Sabine (Institute of Human Genetics, University of Münster, Münster, Germany) ; Kast, Karin (Department of Gynaecology and Obstetrics, University Hospital Carl Gustav Carus, Technical University Dresden, Dresden, Germany) ; Varon-Mateeva, Raymonda (Institute of Human Genetics, Campus Virchov Klinikum, Charite Berlin, Berlin, Germany) ; Gehrig, Andrea (Centre of Familial Breast and Ovarian Cancer, Department of Medical Genetics, Institute of Human Genetics, University Würzburg, Würzburg, Germany) ; Stoppa-Lyonnet, Dominique (Université Paris Descartes, Sorbonne Paris Cité, Paris, France) ; Sinilnikova, Olga M. (Centre National de la Recherche Scientifique (França)) ; Mazoyer, Sylvie (Centre National de la Recherche Scientifique (França)) ; Damiola, Francesca (Centre National de la Recherche Scientifique (França)) ; Poppe, Bruce (Center for Medical Genetics, Ghent University, Ghent, Belgium) ; Claes, Kathleen (Center for Medical Genetics, Ghent University, Ghent, Belgium) ; Piedmonte, Marion (Gynecologic Oncology Group Statistical and Data Center, Roswell Park Cancer Institute, Buffalo, New York, United States of America) ; Tucker, Kathy (Prince of Wales Hospital (Australia)) ; Backes, Floor (Ohio State University, Columbus Cancer Council, Columbus, Ohio, United States of America) ; Rodríguez, Gustavo (Division of Gynecologic Oncology, NorthShore University HealthSystem, Evanston, Illinois, United States of America) ; Brewster, Wendy (Division of Gynecologic Oncology, NorthShore University HealthSystem, Chicago, Illinois, United States of America) ; Wakeley, Katie (For Tufts Medical Center, Boston, Massachusetts, United States of America) ; Rutherford, Thomas (Yale University School of Medicine, New Haven, Connecticut, United States of America) ; Caldés, Trinidad (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos) ; Nevanlinna, Heli (Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland) ; Aittomäki, Kristiina (Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland) ; Rookus, Matti A. (Department of Epidemiology, Netherlands Cancer Institute, Amsterdam, The Netherlands) ; van Os, Theo A. M. (Department of Clinical Genetics, Academic Medical Center, Amsterdam, The Netherlands) ; van der Kolk, Lizet (Family Cancer Clinic, Netherlands Cancer Institute, Amsterdam, The Netherlands) ; de Lange, J. L. (Department of Epidemiology, Netherlands Cancer Institute, Amsterdam, The Netherlands) ; Meijers-Heijboer, Hanne E. J. (Amsterdam Universitair Medische Centra (Amsterdam, Països Baixos)) ; van der Hout, A. H. (University of Groningen, University Medical Center Groningen, Department of Genetics, Groningen, The Netherlands) ; van Asperen, Christi J. (Department of Clinical Genetics, Leiden University Medical Center Leiden, Leiden, The Netherlands) ; Gómez Garcia, Encarna B. (Department of Clinical Genetics and GROW, School for Oncology and Developmental Biology, MUMC, Maastricht, The Netherlands) ; Hoogerbrugge, Nicoline (Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands) ; Collée, J. Margriet (Department of Clinical Genetics, Family Cancer Clinic, Erasmus University Medical Center, Rotterdam, The Netherlands) ; van Deurzen, Carolien H. M. (Department of Pathology, Family Cancer Clinic, Erasmus University Medical Center, Rotterdam, The Netherlands) ; van der Luijt, Rob B. (Department of Medical Genetics, University Medical Center Utrecht, Utrecht, The Netherlands) ; Devilee, Peter (Department of Human Genetics & Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands) ; HEBON, None (The Hereditary Breast and Ovarian Cancer Research Group, Netherlands Cancer Institute, Amsterdam, The Netherlands) ; Olah, Edith (Department of Molecular Genetics, National Institute of Oncology, Budapest, Hungary) ; Lázaro, Conxi (Institut d'Investigació Biomèdica de Bellvitge) ; Teulé, Alex (Institut d'Investigació Biomèdica de Bellvitge) ; Menéndez, Mireia (Institut d'Investigació Biomèdica de Bellvitge) ; Jakubowska, Anna (Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland) ; Cybulski, Cezary (Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland) ; Gronwald, Jacek (Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland) ; Lubinski, Jan (Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland) ; Durda, Katarzyna (Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland) ; Jaworska-Bieniek, Katarzyna (Postgraduate School of Molecular Medicine, Warsaw Medical University, Warsaw, Poland) ; Johannsson, Oskar Th. (Department of Oncology, Landspitali University Hospital and BMC, Faculty of Medicine, University of Iceland, Reykjavik Iceland) ; Maugard, Christine (Laboratoire de Diagnostic Génétique et Service d'Onco-hématologie, Hopitaux Universitaire de Strasbourg, CHRU Nouvel Hôpital Civil, Strasbourg, France) ; Montagna, Marco (Veneto Institute of Oncology (Pàdua, Itàlia)) ; Tognazzo, Silvia (Veneto Institute of Oncology (Pàdua, Itàlia)) ; Teixeira, Manuel R. (Department of Genetics, Portuguese Oncology Institute, Porto, and Biomedical Sciences Institute (ICBAS), Porto University, Porto, Portugal) ; Healey, Sue (Department of Genetics and Computational Biology, Queensland Institute of Medical Research, Brisbane, Australia) ; Investigators, kConFab (Kathleen Cuningham Consortium for Research into Familial Breast Cancer, Peter MacCallum Cancer Center, Melbourne, Australia) ; Olswold, Curtis (Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, United States of America) ; Guidugli, Lucia (Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, United States of America) ; Lindor, Noralane (Center for Individualized Medicine, Mayo Clinic, Scottsdale, Arizona, United States of America) ; Slager, Susan (Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, United States of America) ; Szabo, Csilla I. (Center for Translational Cancer Research, Department of Biological Sciences, University of Delaware, Newark, Delaware, United States of America) ; Vijai, Joseph (Memorial Sloan Kettering Cancer Center) ; Robson, Mark (Clinical Genetics Service, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America) ; Kauff, Noah (Clinical Genetics Service, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America) ; Zhang, Liying (Diagnostic Molecular Genetics Laboratory, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America) ; Rau-Murthy, Rohini (Clinical Genetics Service, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America) ; Fink-Retter, Anneliese (Department of OB/GYN and Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria) ; Singer, Christian F. (Department of OB/GYN and Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria) ; Rappaport, Christine (Department of OB/GYN and Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria) ; Geschwantler Kaulich, Daphne (Department of OB/GYN and Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria) ; Pfeiler, Georg (Department of OB/GYN and Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria) ; Tea, Muy-Kheng (Department of OB/GYN and Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria) ; Berger, Andreas (Department of OB/GYN and Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria) ; Phelan, Catherine M. (Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida, United States of America) ; Greene, Mark H. (National Cancer Institute (Rockville, Estats Units d'Amèrica)) ; Mai, Phuong L. (National Cancer Institute (Rockville, Estats Units d'Amèrica)) ; Lejbkowicz, Flavio (Clalit National Israeli Cancer Control Center, Haifa, Israel) ; Andrulis, Irene L (Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada, and Cancer Care Ontario, Departments of Molecular Genetics and Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada) ; Mulligan, Anna Marie (University of Toronto) ; Glendon, Gord (Ontario Cancer Genetics Network: Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada) ; Toland, Amanda Ewart (Division of Human Cancer Genetics, Departments of Internal Medicine and Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, United States of America) ; Bojesen, Anders (Department of Clinical Genetics, Vejle Hospital, Vejle, Denmark) ; Pedersen, Inge Sokilde (Aalborg University Hospital (Dinamarca)) ; Sunde, Lone (Aarhus University Hospital (Aarhus, Dinamarca)) ; Thomassen, Mads (Odense University Hospital (Dinamarca)) ; Kruse, Torben A. (Odense University Hospital (Dinamarca)) ; Jensen, Uffe Birk (Aarhus University Hospital (Aarhus, Dinamarca)) ; Friedman, Eitan (Sheba Medical Center, Tel Aviv, Israel) ; Laitman, Yael (Sheba Medical Center, Tel Aviv, Israel) ; Shimon, Shani Paluch (Sheba Medical Center, Tel Aviv, Israel) ; Simard, Jacques (Canada Research Chair in Oncogenetics, Cancer Genomics Laboratory, Centre Hospitalier Universitaire de Québec and Laval University, Quebec City, Canada) ; Easton, Douglas F. (Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom) ; Offit, Kenneth (Memorial Sloan Kettering Cancer Center) ; Couch, Fergus J. (Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, United States of America) ; Chenevix-Trench, Georgia (Department of Genetics and Computational Biology, Queensland Institute of Medical Research, Brisbane, Australia) ; Antoniou, Antonis C. (Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom) ; Benitez, Javier (Centro Nacional de Investigaciones Oncológicas) ; Universitat Autònoma de Barcelona
Single Nucleotide Polymorphisms (SNPs) in genes involved in the DNA Base Excision Repair (BER) pathway could be associated with cancer risk in carriers of mutations in the high-penetrance susceptibility genes BRCA1 and BRCA2, given the relation of synthetic lethality that exists between one of the components of the BER pathway, PARP1 (poly ADP ribose polymerase), and both BRCA1 and BRCA2. [...]
2014 - 10.1371/journal.pgen.1004256
PLoS Genetics, Vol. 10 (april 2014)  
8.
21 p, 1.7 MB Individuals with FANCM biallelic mutations do no develop Fanconi anemia, but show risk for breast cancer, chemotherapy sensitivity toxicity and may display chromosome fragility / Catucci, Irene (Fondazione Italiana per la Ricerca sul Cancro) ; Osorio, Ana (Centro Nacional de Investigaciones Oncológicas) ; Arver, Brita (Karolinska Institutet (Estocolm, Suècia)) ; Neidhardt, Guido (Centrum für Integrierte Onkologie) ; Bogliolo, Massimo (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Zanardi, Federica (Fondazione Italiana per la Ricerca sul Cancro) ; Riboni, Mirko (Fondazione Italiana per la Ricerca sul Cancro) ; Minardi, Simone (Fondazione Italiana per la Ricerca sul Cancro) ; Pujol i Calvet, M. Roser (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Azzollini, Jacopo (Fondazione IRCCS Istituto Nazionale dei Tumori Foundation) ; Peissel, Bernard (Fondazione IRCCS Istituto Nazionale dei Tumori Foundation) ; Manoukian, Siranoush (Fondazione IRCCS Istituto Nazionale dei Tumori Foundation) ; Vecchi, De, Giovanna (Fondazione Italiana per la Ricerca sul Cancro) ; Casola, Stefano (Fondazione Italiana per la Ricerca sul Cancro) ; Hauke, Jan (Universität zu Köln. Zentrum für Molekulare Medizin Köln) ; Richters, Lisa (Universität zu Köln. Zentrum für Molekulare Medizin Köln) ; Rhiem, Kerstin (Universität zu Köln. Zentrum für Molekulare Medizin Köln) ; Schmutzler, Rita K. (Universität zu Köln. Zentrum für Molekulare Medizin Köln) ; Wallander,Karin (Karolinska Institutet (Estocolm, Suècia)) ; Törngren, Therese (University of Lund. Department of Clinical Sciences) ; Borg, Åke (University of Lund. Department of Clinical Sciences) ; Radice, Paolo (Fondazione IRCCS Istituto Nazionale dei Tumori Foundation) ; Surrallés i Calonge, Jordi (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Hahnen, Eric (Universität zu Köln. Zentrum für Molekulare Medizin Köln) ; Ehrencrona, Hans (University of Lund. Department of Clinical Genetics) ; Kvist, Anders (University of Lund. Department of Clinical Sciences) ; Benítez, Javier (Centro de Investigación Biomédica en Red de Enfermedades Raras) ; Peterlongo, Paolo (Fondazione Italiana per la Ricerca sul Cancro)
PurposeMonoallelic germ-line mutations in the BRCA1/FANCS, BRCA2/FANCD1 and PALB2/FANCN genes confer high risk of breast cancer. Biallelic mutations in these genes cause Fanconi anemia (FA), characterized by malformations, bone marrow failure, chromosome fragility, and cancer predisposition (BRCA2/FANCD1 and PALB2/FANCN), or an FA-like disease presenting a phenotype similar to FA but without bone marrow failure (BRCA1/FANCS). [...]
2017 - 10.1038/gim.2017.123
Genetics in Medicine, Vol. 20 (April 2018) p. 452-457  
9.
14 p, 2.9 MB Exploring the link between MORF4L1 and risk of breast cancer / Martrat, Griselda (Institut d'Investigació Biomèdica de Bellvitge) ; Maxwell, Christopher A. (Institut d'Investigació Biomèdica de Bellvitge) ; Tominaga, Emiko (The University of Texas Health Science Center at San Antonio) ; Porta de la Riva, Montserrat (Institut d'Investigació Biomèdica de Bellvitge) ; Bonifaci, Núria (Institut d'Investigació Biomèdica de Bellvitge) ; Gomez-Baldo, Laia (Institut d'Investigació Biomèdica de Bellvitge) ; Bogliolo, Massimo (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Lazaro, Conxi (Institut d'Investigació Biomèdica de Bellvitge) ; Blanco Guillermo, Ignacio (Institut d'Investigació Biomèdica de Bellvitge) ; Brunet, Joan (Hospital Universitari de Girona Doctor Josep Trueta) ; Aguilar, Helena (Institut d'Investigació Biomèdica de Bellvitge) ; Fernández-Rodríguez, Juana (Hospital Universitari de Girona Doctor Josep Trueta) ; Seal, Sheila (Institute of Cancer Research (Sutton, Regne Unit)) ; Renwick, Anthony (Institute of Cancer Research (Sutton, Regne Unit)) ; Rahman, Nazneen (Institute of Cancer Research (Sutton, Regne Unit)) ; Kühl, Julia (University of Würzburg. Department of Human Genetics (Würzburg, Alemanya)) ; Neveling, Kornelia (University of Würzburg. Department of Human Genetics (Würzburg, Alemanya)) ; Schindler, Detlev (University of Würzburg. Department of Human Genetics (Würzburg, Alemanya)) ; Ramírez de Haro, Ma. José (María José) (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Castellà, María (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Hernández Viedma, Gonzalo (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Easton, Douglas F. (University of Cambridge. Department of Public Health and Primary Care) ; Peock, Susan (University of Cambridge. Department of Public Health and Primary Care) ; Cook, Margaret (University of Cambridge. Department of Public Health and Primary Care) ; Oliver, Clare T. (University of Cambridge. Department of Public Health and Primary Care) ; Frost, Debra (University of Cambridge. Department of Public Health and Primary Care) ; Platte, Radka (University of Cambridge. Department of Oncology) ; Evans, D. Gareth (Central Manchester University Hospitals NHS Foundation Trust (Manchester, Regne Unit)) ; Lalloo, Fiona (Central Manchester University Hospitals NHS Foundation Trust (Manchester, Regne Unit)) ; Eeles, Rosalind (The Institute of Cancer Research (Sutton, Regne Unit)) ; Izatt, Louise (Guy's and St Thomas NHS Foundation Trust (Londres, Regne Unit)) ; Chu, Carol (Yorkshire Regional Genetics Service (Leeds, Regne Unit)) ; Davids, Rosemarie (Ferguson-Smith Centre for Clinical Genetics (Glasgow, Regne Unit)) ; Ong, Kai-Ren (Birmingham Women's Hospital Healthcare NHS Trust (Birmingham, Regne Unit)) ; Cook, Jackie (Sheffield Children's Hospital (Sheffield, Regne Unit)) ; Douglas, Fiona (Newcastle Upon Tyne Hospitals NHS Trust (Newcastle, Regne Unit)) ; Hodgson, Shirley (University of London. St George's Hospital) ; Brewer, Carole (Royal Devon & Exeter Hospital (Exeter, Regne Unit)) ; Morrison, Patrick J. (Northern Ireland Regional Genetics Centre (Belfast, Regne Unit)) ; Porteous, Mary (South East of Scotland Regional Genetics Service (Edimburg, Regne Unit)) ; Peterlongo, Paolo (Fondazione IRCCS Istituto Nazionale Tumori (Milà, Itàlia)) ; Manoukian, Siranoush (Fondazione IRCCS INT (Milà, Itàlia)) ; Peissel, Bernard (Fondazione IRCCS INT (Milà, Itàlia)) ; Zaffaroni, Daniela (Fondazione IRCCS INT (Milà, Itàlia)) ; Roversi, Gaia (Fondazione IRCCS INT (Milà, Itàlia)) ; Barile, Monica (Istituto Europeo di Oncologia (Milà, Itàlia)) ; Viel, Alessandra (Centro di Riferimento Oncologico (Aviano, Itàlia)) ; Pasini, Barbara (University of Turin. Department of Genetics, Biology and Biochemistry (Torí, Itàlia)) ; Ottini, Laura (Sapienza University of Rome. Department of Molecular Medicine) ; Putignano, Anna Laura (University of Florence. Department of Clinical Physiopathology (Florència, Itàlia)) ; Savarese, Antonella (Regina Elena Cancer Institute (Roma, Itàlia)) ; Bernard, Loris (IEO. Department of Experimental Oncology (Milà, Itàlia)) ; Radice, Paolo (Fondazione IRCCS Istituto Nazionale Tumori (Milà, Itàlia)) ; Healey, Sue (Queensland Institute of Medical Research. Division of Genetics and Population Health (Brisbane, Austràlia)) ; Spurdle, Amanda (Queensland Institute of Medical Research. Division of Genetics and Population Health (Brisbane, Austràlia)) ; Chen, Xiaoqing (Queensland Institute of Medical Research. Division of Genetics and Population Health (Brisbane, Austràlia)) ; Beesley, Jonathan (Queensland Institute of Medical Research. Division of Genetics and Population Health (Brisbane, Austràlia)) ; Rookus, Matti A. (The Netherlands Cancer Institute. Department of Epidemiology (Amsterdam, Països Baixos)) ; Verhoef, Senno (The Netherlands Cancer Institute. Family Cancer Clinic (Amsterdam, Països Baixos)) ; Tilanus-Linthorst, Madeleine A. (Erasmus MC-Daniel den Hoed Cancer Center (Rotterdam, Països Baixos)) ; Vreeswijk, Maaike P. (Leiden University Medical Center. Center for Human and Clinical Genetics (Leiden, Països Baixos)) ; Asperen, Christi J. (Leiden University Medical Center. Center for Human and Clinical Genetics (Leiden, Països Baixos)) ; Bodmer, Danielle (Radboud University Nijmegen Medical Center. Department of Human Genetics (Nijmegen, Països Baixos)) ; Ausems, Margreet G. E. M. (University Medical Center Utrecht. Department of Medical Genetics (Utrecht, Països Baixos)) ; van Os, Theo A. (Academic Medical Center, Department of Clinical Genetics (Amsterdam, Països Baixos)) ; Blok, Marinus J. (University Hospital Maastricht. Department of Clinical Genetics (Maastricht, Països Baixos)) ; Meijers-Heijboer, Hanne E. J. (VU Medical Center. Department of Clinical Genetics (Amsterdam, Països Baixos)) ; Hogervorst, Frans B. L. (The Netherlands Cancer Institute. Family Cancer Clinic (Amsterdam, Països Baixos)) ; Goldgar, David E. (University of Utah School of Medicine. Department of Dermatology (Salt Lake City, Estats Units d'Amèrica)) ; Buys, Saundra (Huntsman Cancer Institute (Salt Lake City, Estats Units d'Amèrica)) ; John, Esther M. (Cancer Prevention Institute of California (Fremont, Estats Units d'Amèrica)) ; Miron, Alexander (Dana-Farber Cancer Institute (Boston, Estats Units d'Amèrica). Department of Cancer Biology) ; Southey, Melissa (The University of Melbourne. Melbourne School of Population Health (Austràlia)) ; Daly, Mary B. (Fox Chase Cancer Center. Division of Population Science (Philadelphia, Estats Units d'Amèrica)) ; Harbst, Katja (Lund University. Department of Oncology (Lund, Suècia)) ; Borg, Åke (Lund University. Department of Oncology (Lund, Suècia)) ; Rantala, Johanna (Karolinska University Hospital) ; Barbany-Bustinza, Gisela (Karolinska University Hospital) ; Ehrencrona, Hans (Uppsala University. Departament of Genetics and Pathology (Uppsala, Suècia)) ; Stenmark-Askmalm, Marie (Hälsouniversitetet Universitetssjukhuset. Department of Oncology (Linköping, Suècia)) ; Kaufman, Bella (Chaim Sheba Medical Center. The Institute of Oncology (Ramat Gan, Israel)) ; Laitman, Yael (Chaim Sheba Medical Center (Israel)) ; Milgrom, Roni (Chaim Sheba Medical Center (Israel)) ; Friedman, Eitan (Chaim Sheba Medical Center (Israel)) ; Domchek, Susan M. (University of Pennsylvania School of Medicine. Abramson Cancer Center (Philadelphia, Estats Units d'Amèrica)) ; Nathanson, Katherine L. (University of Pennsylvania School of Medicine. Abramson Cancer Center (Philadelphia, Estats Units d'Amèrica)) ; Rebbeck, Timothy R. (University of Pennsylvania School of Medicine. Abramson Cancer Center (Philadelphia, Estats Units d'Amèrica)) ; Johannsson, Oskar Thor (20A Landspitali-LSH v/Hringbraut. Department of Oncology (Reykjavik, Islàndia)) ; Couch, Fergus J. (Mayo Clinic. Department of Laboratory Medicine and Pathology (Rochester, Estats Units d'Amèrica)) ; Wang, Xianshu (Mayo Clinic. Department of Laboratory Medicine and Pathology (Rochester, Estats Units d'Amèrica)) ; Fredericksen, Zachary (Mayo Clinic. Department of Health Sciences Research (Rochester, Estats Units d'Amèrica)) ; Cuadras, Daniel (Institut d'Investigació Biomèdica de Bellvitge) ; Morros, Rosa (South East of Scotland Regional Genetics Service, Western General Hospital (Edimburg, Regne Unit)) ; Pientka, Friederike K. (University of Lübeck. Center for Structural and Cell Biology in Medicine (Lübeck, Alemanya)) ; Depping, Reinhard (University of Lübeck. Center for Structural and Cell Biology in Medicine (Lübeck, Alemanya)) ; Caldés, Trinidad (Hospital Clínico San Carlos (Madrid)) ; Osorio, Ana (Centro Nacional de Investigaciones Oncológicas) ; Benítez, Javier (Centro Nacional de Investigaciones Oncológicas) ; Bueren, Juan (Centro de Investigaciones Energéticas, Medioambientales, y Tecnológicas (Madrid, Espanya)) ; Heikkinen, Tuomas (Helsinki University Central Hospital. Department of Obstetrics and Gynecology (Helsinki, Finlàndia)) ; Surrallés i Calonge, Jordi (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Pujana, Miguel Angel (Institut d'Investigació Biomèdica de Bellvitge) ; Tominaga, Kaoru (The University of Texas Health Science Center at San Antonio) ; Cerón, Julián (Institut d'Investigació Biomèdica de Bellvitge) ; Antoniou, Antonis C. (University of Cambridge. Department of Public Health and Primary Care) ; Fert Ferrer, Sandra (Hôtel Dieu Centre Hospitalier (Chambéry, França)) ; Collonge-Rame, Marie-Agnès (Centre Hospitalier Universitaire de Besançon (Besançon, França)) ; Mortemousque, Isabelle (Centre Hospitalier Universitaire Bretonneau (Tours, França)) ; McGuffog, Lesley (University of Cambridge. Department of Public Health and Primary Care) ; Chenevix-Trench, Georgia (Queensland Institute of Medical Research (Brisbane, Austràlia)) ; Pereira-Smith, Olivia M. (The University of Texas Health Science Center at San Antonio) ; Nevanlinna, Heli (Helsinki University Central Hospital. Department of Obstetrics and Gynecology (Helsinki, Finlàndia)) ; Hamann, Ute (Deutsches Krebsforschungszentrum (Heidelberg, Alemanya)) ; Torres, Diana (Pontificia Universidad Javeriana. Instituto de Genética Humana (Bogota, Colòmbia)) ; Caligo, Maria Adelaide (University Hospital of Pisa (Pisa, Itàlia)) ; Godwin, Andrew K. (University of Kansas Medical Center. Department of Pathology and Laboratory MedicineCenter (Kansas, Estats Units d'Amèrica)) ; Imyanitov, Evgeny N. (N.N. Petrov Institute of Oncology. Laboratory of Molecular Oncology (Sant Petersburg, Rússia)) ; Janavicius, Ramunas (Vilnius University Hospital Santariskiu Clinics. Hematology, Oncology and Transfusion Medicine Center (Vilnius, Lituània)) ; Sinilnikova, Olga M. (Centre Hospitalier Universitaire de Lyon. Unité Mixte de Génétique Constitutionnelle des Cancers Fréquents (Lyon, França)) ; Stoppa-Lyonnet, Dominique (Institut Curie) ; Mazoyer, Sylvie (Université Lyon 1. Cancer Research Center of Lyon (Lyon, França)) ; Verny-Pierre, Carole (Université Lyon 1. Cancer Research Center of Lyon (Lyon, França)) ; Castera, Laurent (Institut Curie) ; de Pauw, Antoine (Institut Curie) ; Bignon, Yves-Jean (Université de Clermont-Ferrand. Département d'Oncogénétique (Clermont-Ferrand, França)) ; Uhrhammer, Nancy (Université de Clermont-Ferrand. Département d'Oncogénétique (Clermont-Ferrand, França)) ; Peyrat, Jean-Philippe (Centre Oscar Lambret. Laboratoire d'Oncologie Moléculaire Humaine (Lille, França)) ; Vennin, Philippe (Centre Oscar Lambret. Consultation d'Oncogénétique (Lille, França)) ; The Kathleen Cuningham Foundation Consortium for Research into Familial Breast Cancer (kConFab) ; The Netherlands Cancer Institute. Hereditary Breast and Ovarian Cancer Group (HEBON) ; University of Utah School of Medicine. Breast Cancer Family Registry (Salt Lake City, Estats Units d'Amèrica) ; Lund University. Swedish Breast Cancer Study (Lund, Suècia) ; Fédération Nationale des Centres de Lutte Contre le Cancer. Groupe Génétique et Cancer (Lyon, França)
Introduction: Proteins encoded by Fanconi anemia (FA) and/or breast cancer (BrCa) susceptibility genes cooperate in a common DNA damage repair signaling pathway. To gain deeper insight into this pathway and its influence on cancer risk, we searched for novel components through protein physical interaction screens. [...]
2011 - 10.1186/bcr2862
Breast cancer research, Vol. 13, Núm. R40 (4 2011) -14  

See also: similar author names
1 Peterlongo, P.
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