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11 p, 897.2 KB |
MRI Radiomic Signature of White Matter Hyperintensities Is Associated With Clinical Phenotypes
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Bretzner, Martin (University of Lille) ;
Bonkhoff, Anna K. (Massachusetts General Hospital) ;
Schirmer, Markus D. (Massachusetts General Hospital) ;
Hong, Sungmin (Massachusetts General Hospital) ;
Dalca, Adrian V. (Massachusetts Institute of Technology) ;
Donahue, Kathleen L. (Massachusetts General Hospital) ;
Giese, Anne-Katrin (Massachusetts General Hospital) ;
Etherton, Mark R. (Massachusetts General Hospital) ;
Rist, Pamela M. (Brigham and Women's Hospital) ;
Nardin, Marco (Massachusetts General Hospital) ;
Marinescu, Razvan (Massachusetts Institute of Technology) ;
Wang, Clinton (Massachusetts Institute of Technology) ;
Regenhardt, Robert W. (Massachusetts General Hospital) ;
Leclerc, Xavier (University of Lille) ;
Lopes, Renaud (Institut Pasteur de Lille) ;
Benavente, Oscar R. (Department of Medicine, University of British Columbia) ;
Cole, John W. (Department of Neurology, University of Maryland School of Medicine a) ;
Donatti, Amanda (School of Medical Sciences, University of Campinas (Brasil)) ;
Griessenauer, Christoph J. (Paracelsus Medical University) ;
Heitsch, Laura (Department of Neurology, Washington University School of Medicine) ;
Holmegaard, Lukas (Sahlgrenska Academy at University of Gothenburg) ;
Jood, Katarina (University of Gothenburg) ;
Jimenez-Conde, Jordi (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Kittner, Steven J. (Department of Neurology, University of Maryland School of Medicine) ;
Lemmens, Robin (University Hospitals Leuven) ;
Levi, Christopher R. (Department of Neurology, John Hunter Hospital) ;
McArdle, Patrick F. (Department of Medicine, University of Maryland School of Medicine) ;
McDonough, Caitrin W. (Department of Pharmacotherapy and Translational Research and Center for Pharmacogenomics, University of Florida) ;
Meschia, James F. (Mayo Clinic (Estats Units d'Amèrica)) ;
Phuah, Chia-Ling (Department of Neurology, Washington University School of Medicine) ;
Rolfs, Arndt (Centogene (Alemanya)) ;
Ropele, Stefan (Department of Neurology, Clinical Division of Neurogeriatrics, Medical University of Graz) ;
Rosand, Jonathan (Massachusetts General Hospital) ;
Roquer, Jaume (Department of Neurology, University of Miami) ;
Rundek, Tatjana (Department of Neurology, University of Miami) ;
Sacco, Ralph L. (Department of Neurology University of Miami) ;
Schmidt, Reinhold (Department of Neurology, Medical University of Graz) ;
Sharma, Pankaj (St. Peter's Hospitals (Regne Unit)) ;
Slowik, Agnieszka (Department of Neurology, Jagiellonian University Medical College) ;
Sousa, Alessandro (Department of Neurology, University of Maryland School of Medicine) ;
Stanne, Tara M. (University of Gothenburg) ;
Strbian, Daniel (Department of Neurology, Helsinki University Central Hospital) ;
Tatlisumak, Turgut (Department of Neurology, Sahlgrenska University Hospital) ;
Thijs, Vincent (Florey Institute of Neuroscience and Mental Health, Department of Neurology Austin Health) ;
Vagal, Achala (Department of Radiology, University of Cincinnati College of Medicine) ;
Wasselius, Johan (Skåne University Hospital (Suècia)) ;
Woo, Daniel (Department of Neurology and Rehabilitation Medicine, University of Cincinnati College of Medicine) ;
Wu, Ona (Massachusetts General Hospital) ;
Zand, Ramin (Department of Neurology, Geisinger) ;
Worrall, Bradford B. (Department of Neurology and Public Health Sciences, University of Virginia) ;
Maguire, Jane M. (University of Technology Sydney) ;
Lindgren, Arne (Department of Clinical Sciences Lund, Lund University) ;
Jern, Christina (Sahlgrenska Academy at University of Gothenburg) ;
Golland, Polina (Massachusetts Institute of Technology) ;
Kuchcinski, Grégory (University of Lille) ;
Rost, Natalia S. (Massachusetts General Hospital) ;
Universitat Autònoma de Barcelona
Neuroimaging measurements of brain structural integrity are thought to be surrogates for brain health, but precise assessments require dedicated advanced image acquisitions. By means of quantitatively describing conventional images, radiomic analyses hold potential for evaluating brain health. [...]
2021 -  10.3389/fnins.2021.691244
Frontiers in Neuroscience, Vol. 15 (july 2021)
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2.
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10 p, 678.7 KB |
Excessive White Matter Hyperintensity Increases Susceptibility to Poor Functional Outcomes After Acute Ischemic Stroke
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Hong, Sungmin (Massachusetts General Hospital) ;
Giese, Anne-Katrin (University Medical Center Hamburg-Eppendorf) ;
Schirmer, Markus D. (University Hospital Bonn) ;
Bonkhoff, Anna K. (Massachusetts General Hospital) ;
Bretzner, Martin (Université du Lille) ;
Rist, Pamela (Brigham and Women's Hospital) ;
Dalca, Adrian V. (Department of Radiology, Massachusetts General Hospital) ;
Regenhardt, Robert W. (Massachusetts General Hospital) ;
Etherton, Mark R. (Massachusetts General Hospital) ;
Donahue, Kathleen L. (Massachusetts General Hospital) ;
Nardin, Marco (Harvard Medical School) ;
Mocking, Steven J. T. (Massachusetts General Hospital) ;
McIntosh, Elissa C. (Massachusetts General Hospital) ;
Attia, John (University of Newcastle) ;
Benavente, Oscar R. (University of British Columbia) ;
Cole, John W. (University of Maryland. School of Medicine) ;
Donatti, Amanda (University of Campinas) ;
Griessenauer, Christoph J. (Research Institute of Neurointervention, Paracelsus Medical University) ;
Heitsch, Laura (Washington University School of Medicine) ;
Holmegaard, Lukas (University of Gothenburg) ;
Jood, Katarina (University of Gothenburg) ;
Jimenez-Conde, Jordi (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Roquer, Jaume (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Kittner, Steven J. (University of Maryland School of Medicine) ;
Lemmens, Robin (University Hospitals Leuven (Bèlgica)) ;
Levi, Christopher R. (John Hunter Hospital) ;
McDonough, Caitrin W. (University of Florida) ;
Meschia, James F. (Mayo Clinic (Estats Units d'Amèrica)) ;
Phuah, Chia-Ling (Department of Neurology, Washington University School of Medicine & Barnes-Jewish Hospital) ;
Rolfs, Arndt (Centogene AG (Alemanya)) ;
Ropele, Stefan (Department of Neurology, Medical University Graz) ;
Rosand, Jonathan (Massachusetts General Hospital) ;
Rundek, Tatjana (Department of Neurology, University of Miami) ;
Sacco, Ralph L. (Department of Neurology , University of Miami) ;
Schmidt, Reinhold (Department of Neurology, Medical University Graz) ;
Enzinger, Christian (Department of Neurology, Medical University Graz) ;
Sharma, Pankaj (St. Peter's and Ashford Hospitals) ;
Slowik, Agnieszka (Jagiellonian University Medical College) ;
Sousa, Alessandro (University of Campinas) ;
Stanne, Tara M. (University of Gothenburg) ;
Strbian, Daniel (University of Helsinki) ;
Tatlisumak, Turgut (Sahlgrenska University Hospital) ;
Thijs, Vincent (Austin Health (Austràlia)) ;
Vagal, Achala (University of Cincinnati College of Medicine) ;
Wasselius, Johan (Skåne University Hospital (Suècia)) ;
Woo, Daniel (University of Cincinnati College of Medicine) ;
Zand, Ramin (Geisinger (Estats Units d'Amèrica)) ;
McArdle, Patrick F. (University of Maryland School of Medicine) ;
Worrall, Bradford B. (University of Virginia) ;
Wu, Ona (Massachusetts General Hospital) ;
Jern, Christina (Department of University of Gothenburg) ;
Lindgren, Arne G. (Lund University. Department of Clinical Sciences) ;
Maguire, Jane (University of Technology Sydney) ;
Tomppo, Liisa (University of Helsinki) ;
Golland, Polina (Massachusetts Institute of Technology) ;
Rost, Natalia S. (Massachusetts General Hospital) ;
Universitat Autònoma de Barcelona
Objective: To personalize the prognostication of post-stroke outcome using MRI-detected cerebrovascular pathology, we sought to investigate the association between the excessive white matter hyperintensity (WMH) burden unaccounted for by the traditional stroke risk profile of individual patients and their long-term functional outcomes after a stroke. [...]
2021 - 10.3389/fneur.2021.700616
Frontiers in neurology, Vol. 12 (september 2021)
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12 p, 1.9 MB |
Sex-specific lesion pattern of functional outcomes after stroke
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Bonkhoff, Anna K. (J. Philip Kistler Stroke Research Center, Massachusetts General Hospital, Harvard Medical School) ;
Bretzner, Martin (Univ. Lille) ;
Hong, Sungmin (Massachusetts General Hospital (Boston)) ;
Schirmer, Markus D. (University Hospital Bonn (Bonn, Alemanya)) ;
Cohen, Alexander (Boston Children's Hospital (Boston, Estats Units d'Amèrica)) ;
Regenhardt, Robert W. (Massachusetts General Hospital (Boston)) ;
Donahue, Kathleen L. (Massachusetts General Hospital (Boston)) ;
Nardin, Marco J. (Massachusetts General Hospital (Boston)) ;
Dalca, Adrian Vasile (Massachusetts General Hospital (Boston)) ;
Giese, Anne-Katrin (University Medical Center Hamburg-Eppendorf) ;
Etherton, Mark R. (Massachusetts General Hospital (Boston)) ;
Hancock, Brandon L. (Massachusetts General Hospital (Boston)) ;
Mocking, Steven J. T. (Massachusetts General Hospital (Boston)) ;
McIntosh, Elissa C. (Massachusetts General Hospital (Boston)) ;
Attia, John (University of Newcastle) ;
Benavente, Oscar R. (University of British Columbia) ;
Bevan, Stephen (University of Lincoln) ;
Cole, John W. (University of Maryland School of Medicine) ;
Donatti, Amanda (University of Campinas) ;
Griessenauer, Christoph J. (Paracelsus Medical University) ;
Heitsch, Laura (Washington University School) ;
Holmegaard, Lukas (Sahlgrenska University Hospital (Suècia)) ;
Jood, Katarina (Sahlgrenska University Hospital (Suècia)) ;
Jimenez-Conde, Jordi (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Kittner, Steven J. (University of Maryland) ;
Lemmens, Robin (University Hospitals Leuven (Bèlgica)) ;
Levi, Christopher R. (John Hunter Hospital) ;
McDonough, Caitrin W. (University of Florida) ;
Meschia, James F. (Mayo Clinic (Jacksonville, Estats Units d'Amèrica)) ;
Phuah, Chia-Ling (Washington University School of Medicine) ;
Rolfs, Arndt (Centogene AG) ;
Ropele, Stefan (Medical University Graz) ;
Rosand, Jonathan (Massachusetts General Hospital (Boston)) ;
Roquer, Jaume (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Rundek, Tatjana (University of Miami) ;
Sacco, Ralph L. (University of Miami. Miller School of Medicine) ;
Schmidt, Reinhold (Medical University Graz) ;
Sharma, Pankaj (St Peter's and Ashford Hospital) ;
Slowik, Agnieszka (Jagiellonian University Medical College) ;
Söderholm, Martin (Skåne University Hospital (Suècia)) ;
Sousa, Alessandro (University of Campinas) ;
Stanne, Tara M. (University of Gothenburg) ;
Strbian, Daniel (Helsinki University Hospital) ;
Tatlisumak, Turgut (Sahlgrenska Academy at University of Gothenburg) ;
Thijs, Vincent (Austin Health) ;
Vagal, Achala (University of Cincinnati College of Medicine) ;
Wasselius, Johan (Skåne University Hospital (Suècia)) ;
Woo, Daniel (University of Cincinnati College of Medicine) ;
Zand, Ramin (Department of Neurology, Geisinger) ;
McArdle, Patrick F. (University of Maryland School of Medicine) ;
Worrall, Bradford B. (University of Virginia) ;
Jern, Christina (Sahlgrenska University Hospital (Suècia)) ;
Lindgren, Arne G. (Lund University) ;
Maguire, Jane (University of Technology Sydney) ;
Fox, Michael D. (Brigham and Women's Hospital (Boston, Estats Units d'Amèrica)) ;
Bzdok, Danilo (Mila-Quebec Artificial Intelligence Institute) ;
Wu, Ona (Boston Children's Hospital (Boston, Estats Units d'Amèrica)) ;
Rost, Natalia S. (Massachusetts General Hospital (Boston)) ;
Universitat Autònoma de Barcelona
Stroke represents a considerable burden of disease for both men and women. However, a growing body of literature suggests clinically relevant sex differences in the underlying causes, presentations and outcomes of acute ischaemic stroke. [...]
2022 - 10.1093/braincomms/fcac020
Brain Communications, Vol. 4 (february 2022)
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14 p, 3.0 MB |
Outcome after acute ischemic stroke is linked to sex-specific lesion patterns
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Bonkhoff, Anna K. (Massachusetts General Hospital (Boston)) ;
Schirmer, Markus D. (University Hospital Bonn (Bonn, Alemanya)) ;
Bretzner, Martin (Univ. Lille) ;
Hong, Sungmin (Massachusetts General Hospital (Boston)) ;
Regenhardt, Robert W. (Massachusetts General Hospital (Boston)) ;
Brudfors, Mikael (School of Biomedical Engineering & Imaging Sciences) ;
Donahue, Kathleen L. (Massachusetts General Hospital (Boston)) ;
Nardin, Marco J. (Massachusetts General Hospital (Boston)) ;
Dalca, Adrian Vasile (Massachusetts General Hospital (Boston)) ;
Giese, Anne-Katrin (University Medical Center Hamburg-Eppendorf) ;
Etherton, Mark R. (Massachusetts General Hospital (Boston)) ;
Hancock, Brandon L. (Massachusetts General Hospital (Boston)) ;
Mocking, Steven J. T. (Massachusetts General Hospital (Boston)) ;
McIntosh, Elissa C. (Massachusetts General Hospital (Boston)) ;
Attia, John (School of Medicine and Public Health) ;
Benavente, Oscar R. (University of British Columbia) ;
Bevan, Stephen (University of Lincoln) ;
Cole, John W. (University of Maryland School of Medicine and Veterans Affairs Maryland Health Care System) ;
Donatti, Amanda (Brazilian Institute of Neuroscience and Neurotechnology (BRAINN)) ;
Griessenauer, Christoph J. (Research Institute of Neurointervention) ;
Heitsch, Laura (Washington University School of Medicine & Barnes-Jewish Hospital) ;
Holmegaard, Lukas (Sahlgrenska University Hospital (Suècia)) ;
Jood, Katarina (Sahlgrenska University Hospital (Suècia)) ;
Jimenez-Conde, Jordi (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Kittner, Steven J. (University of Maryland School of Medicine and Veterans Affairs Maryland Health Care System) ;
Lemmens, Robin (University Hospitals Leuven (Bèlgica)) ;
Levi, Christopher R. (John Hunter Hospital) ;
McDonough, Caitrin W. (University of Florida) ;
Meschia, James F. (Mayo Clinic (Jacksonville, Estats Units d'Amèrica)) ;
Phuah, Chia-Ling (Washington University School of Medicine) ;
Rolfs, Arndt (Centogene AG) ;
Ropele, Stefan (Medical University Graz) ;
Rosand, Jonathan (Massachusetts General Hospital (Boston)) ;
Roquer, Jaume (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Rundek, Tatjana (University of Miami) ;
Sacco, Ralph L. (University of Miami) ;
Schmidt, Reinhold (Medical University Graz) ;
Sharma, Pankaj (St Peter's and Ashford Hospitals) ;
Slowik, Agnieszka (Jagiellonian University Medical College) ;
Söderholm, Martin (Skåne University Hospital (Suècia)) ;
Sousa, Alessandro (Brazilian Institute of Neuroscience and Neurotechnology (BRAINN)) ;
Stanne, Tara M. (the Sahlgrenska Academy at University of Gothenburg) ;
Strbian, Daniel (Helsinki University Hospital (Finlàndia)) ;
Tatlisumak, Turgut (Sahlgrenska University Hospital (Suècia)) ;
Thijs, Vincent (Austin Health) ;
Vagal, Achala (University of Cincinnati College of Medicine) ;
Wasselius, Johan (Skåne University Hospital (Suècia)) ;
Woo, Daniel (University of Cincinnati College of Medicine) ;
Zand, Ramin (Geisinger) ;
McArdle, Patrick F. (University of Maryland School of Medicine) ;
Worrall, Bradford B. (University of Virginia) ;
Jern, Christina (Sahlgrenska University Hospital (Suècia)) ;
Lindgren, Arne G. (Lund University) ;
Maguire, Jane (University of Technology Sydney) ;
Bzdok, Danilo (Mila - Quebec Artificial Intelligence Institute) ;
Wu, Ona (Massachusetts General Hospital (Boston)) ;
Rost, Natalia S. (Massachusetts General Hospital (Boston)) ;
Universitat Autònoma de Barcelona
Acute ischemic stroke affects men and women differently. In particular, women are often reported to experience higher acute stroke severity than men. We derived a low-dimensional representation of anatomical stroke lesions and designed a Bayesian hierarchical modeling framework tailored to estimate possible sex differences in lesion patterns linked to acute stroke severity (National Institute of Health Stroke Scale). [...]
2021 - 10.1038/s41467-021-23492-3
Nature communications, Vol. 12 (june 2021)
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11 p, 168.8 KB |
Genetic variants in CETP increase risk of intracerebral hemorrhage
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Anderson, Christopher D. (Broad Institute of MIT and Harvard) ;
Falcone, Guido J. (Departments of Epidemiology and Biostatistics, Harvard T. H. Chan School of Public Health) ;
Phuah, Chia-Ling (Broad Institute of MIT and Harvard) ;
Radmanesh, Farid (Broad Institute of MIT and Harvard) ;
Brouwers, H. Bart (Broad Institute of MIT and Harvard) ;
Battey, Thomas W. K. (Broad Institute of MIT and Harvard) ;
Biffi, Alessandro (Division of Psychiatry, Department of Psychiatry, MGH) ;
Peloso, Gina M. (Broad Institute of MIT and Harvard) ;
Liu, Dajiang J. (Institute of Personalized Medicine, Penn State College of Medicine) ;
Ayres, Alison M. (J. Philip Kistler Stroke Research Center, Department of Neurology, MGH) ;
Goldstein, Joshua N. (Department of Emergency Medicine, MGH) ;
Viswanathan, Anand (J. Philip Kistler Stroke Research Center, Department of Neurology, MGH) ;
Greenberg, Steven M. (J. Philip Kistler Stroke Research Center, Department of Neurology, MGH) ;
Selim, Magdy (Beth Israel Deaconess Medical Center) ;
Meschia, James F. (Mayo Clinic (Jacksonville, Estats Units d'Amèrica)) ;
Brown, Devin L. (University of Michigan Health System) ;
Worrall, Bradford B. (University of Virginia Health System) ;
Silliman, Scott L. (University of Florida College of Medicine) ;
Tirschwell, David L. (University of Washington) ;
Flaherty, Matthew L. (University of Cincinnati College of Medicine) ;
Kraft, Peter (Departments of Epidemiology and Biostatistics, Harvard T. H. Chan School of Public Health) ;
Jagiella, Jeremiasz M. (Jagiellonian University Medical College) ;
Schmidt, Helena (Medical University Graz) ;
Hansen, Björn M. (Skåne University Hospital (Suècia)) ;
Jimenez-Conde, Jordi (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Giralt Steinhauer, Eva (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Elosua, Roberto (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Cuadrado-Godia, Elisa (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Soriano Tàrraga, Carolina (Institut Hospital del Mar d'Investigacions Mèdiques) ;
van Nieuwenhuizen, Koen M. (University Medical Center Utrecht) ;
Klijn, Catharina J. M. (Donders Institute for Brain, Cognition, and Behavior, Radboud University Medical Center) ;
Rannikmae, Kristiina (University of Edinburgh) ;
Samarasekera, Neshika (University of Edinburgh) ;
Salman, Rustam Al-Shahi (University of Edinburgh) ;
Sudlow, Catherine L. (University of Edinburgh) ;
Deary, Ian J. (University of Edinburgh) ;
Morotti, Andrea (Neurology Clinic, University of Brescia) ;
Pezzini, Alessandro (Neurology Clinic, University of Brescia) ;
Pera, Joanna (Jagiellonian University Medical College) ;
Urbanik, Andrzej (Jagiellonian University Medical College) ;
Pichler, Alexander (Medical University of Graz) ;
Enzinger, Christian (Medical University of Graz) ;
Norrving, Bo (Skåne University Hospital (Suècia)) ;
Montaner, Joan (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Fernandez-Cadenas, Israel (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Delgado Martínez, María Pilar (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Roquer González, Jaume (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Lindgren, Arne (Skåne University Hospital (Suècia)) ;
Slowik, Agnieszka (Jagiellonian University Medical College) ;
Schmidt, Reinhold (Medical University of Graz) ;
Kidwell, Chelsea S. (University of Arizona) ;
Kittner, Steven J. (Baltimore Veterans Administration Medical Center and University of Maryland School of Medicine) ;
Waddy, Salina P. (National Institutes of Health (Bethesda, Estats Units d'Amèrica)) ;
Langefeld, Carl D. (Wake Forest University) ;
Abecasis, Goncalo (University of Michigan School of Public Health) ;
Willer, Cristen J. (University of Michigan Medical School) ;
Kathiresan, Sekar (Cardiovascular Disease Prevention Center, MGH) ;
Woo, Daniel (University of Cincinnati College of Medicine) ;
Rosand, Jonathan (Broad Institute of MIT and Harvard) ;
Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)
In observational epidemiologic studies, higher plasma high-density lipoprotein cholesterol (HDL-C) has been associated with increased risk of intracerebral hemorrhage (ICH). DNA sequence variants that decrease cholesteryl ester transfer protein (CETP) gene activity increase plasma HDL-C; as such, medicines that inhibit CETP and raise HDL-C are in clinical development. [...]
2016 - 10.1002/ana.24780
Annals of neurology, Vol. 80 (october 2016) , p. 730-740
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